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Fea.ibility,effica.y,a.d sa.ety of a.ima.-a.sisted a.tivities with visiting dogs in inpa.ient pedia.ric oncology

World Journa. of Pedia.rics 2024年第9期20卷 915-924页

作者： Ka.ja.Steff ma.imilia. Gra.ema.n Kira.Osterma.n Sa.a. Christina.Goretzki Peter-micha.l Ra.h Dirk Reinha.dt micha.l m.schündeln Pedia.ric Hema.ology a.d Oncology Department of Pediatrics ⅢUniversity of Duisburg-EssenHufelandstr.5545122EssenGermany Depa.tment of Psychology Medical School HamburgHamburgGermany Pedia.ric Infectiology Department of Pediatrics ⅠUniversity of Duisburg-EssenEssenGermany Institute of medica. microbiology University of Duisburg-EssenEssenGermany

Ba.kground Childhood ca.cer enta.ls a.hea.y burden for pa.ients a.d their *** a.va.ces in overa.l surviva. ra.es ha.e increa.ingly brought long-term qua.ity of life into ***-a.sisted a.tivities(a.a.)ha.e long been hypothesized to a.levia.e the burden on pedia.ric pa.ients a.d their peers in the hospita. ***,their use in inpa.ient pedia.ric oncology ha. been a.sensitive issue ma.nly due to the fea. of infections,resulting in a.la.k of *** study presents da.a.on the fea.ibility,sa.ety,a.d effica.y of a.a. from a.single Germa. *** Between 2018 a.d 2022,60 pa.ients(media. a.e=10.3 yea.s)dia.nosed with ma.igna.cy a.d undergoing trea.ment were visited by a. intervention dog(tota. visits=100).Pa.ients were screened for infections a. per hospita. policy,with a.ditiona. microbiologica. testing performed ba.ed on *** dog wa. screened for huma. pa.hogens a.d *** da.a.a.d hospita.iza.ions were a.a.yzed from two months prior to the first visit until two months a.ter the la.t *** of being in the hospita.,both with a.d without pla.ned a.ima.-a.sisted interventions a.d pre-a.d post-intervention sta.e stress,were mea.ured using a.va.ida.ed visua. a.a.ogue sca.e(0-10).Results Pa.ients benefited from a.a.,showing increa.ed a.cepta.ce of being in the hospita.(media.:7.25 vs.4.50,Pa.d decrea.ed media. sta.e stress ra.ings one hour a.ter the visit compa.ed to one hour before the visit(1.00 vs.4.25,Pa. increa.ed number of infections or unpla.ned hospita.iza.ions,a.d no zoonoses were *** microbia. screening tests of the dog were *** a.a. with visiting dogs in inpa.ient pedia.ric oncology a.e fea.ible a.d *** they hold promise for enha.cing pa.ients’well-being,further prospective studies a.e needed.

关键词： a.ima.-a.sisted a.tivities a.ima.-a.sisted interventions a.ima.-a.sisted thera.y Fea.ibility Infection control Inpa.ient pedia.ric oncology Sa.ety Stress response Thera.y dog Visiting dog

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Neurogenesis dyna.ics in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1565-1581页

作者： moa.ia. m.Na.fa. Depa.tment of Psychology a.d Neuroscience Duke UniversityDurhamNCUSA Depa.tment of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult neurogenesis persists a.ter birth in the subventricula. zone, with new neurons migra.ing to the gra.ule cell la.er a.d glomerula. la.ers of the olfa.tory bulb, where they integra.e into existing circuitry a. inhibitory interneurons. The genera.ion of these new neurons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit remodeling triggered by memory a.d lea.ning processes. However, the presence of these neurons, coupled with the cellula. diversity within the olfa.tory bulb, presents a. ongoing cha.lenge in understa.ding its network orga.iza.ion a.d function. moreover,the continuous integra.ion of new neurons in the olfa.tory bulb pla.s a.pivota. role in regula.ing olfa.tory informa.ion processing. This a.a.tive process responds to cha.ges in epithelia. composition a.d contributes to the forma.ion of olfa.tory memories by modula.ing cellula. connectivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n regions. The role of a.ult neurogenesis in olfa.tory bulb functions rema.ns a.topic of deba.e. Nevertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound mitra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly impa.ts output, network beha.ior, a.d syna.tic pla.ticity, which a.e crucia. for olfa.tory perception a.d memory. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on termina.s origina.ing from cortica. a.d subcortica. regions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors rela.ed to olfa.tion, these complex a.d highly interconnected processes ha.e not been comprehensively studied a. a.whole. Therefore, this ma.uscript a.ms to discuss our current understa.ding a.d explore how neura. pla.ticity a.d olfa.tory neurogenesis contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These mecha.isms a.e thought to support olfa.tory lea.ning a.d memory, potentia.ly through increa.ed

关键词： network a.a.ta.ility neurogenesis neurona. communica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory memory syna.tic pla.ticity

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mitochondria.cGa.–STING a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.ma.ing-a.socia.ed neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.molecula. Severo Ochoa.CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the La.in senescens, mea.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

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Bra.n-penetra.ing neurotrophic fa.tor mimetics: HER-096 a. a.disea.e-modifying thera.y for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.Holmström Henri J.Huttunen Hera.tis Pha.ma.Plc EspooFinland

Neurotrophic fa.tors a. a.thera.eutic a.proa.h in neurodegenera.ive disea.es:a.ma.or unmet need in the field of centra. nervous system disea.es is disea.e-modifying *** for deca.es there ha.e been va.ious symptoma.ic trea.ments a.a.la.le to a.levia.e the symptoms of the disea.e,disea.e-modifica.ion,*** tha. stop,significa.tly dela.,or reverse the progression of the disea.e,ha. been turned out to a.difficult goa. to a.hieve.

关键词： disea.es trea.ment thera.eutic

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在高压工况下通过应用齿轮传动压缩机节省功率和成本

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工程设计学报 1999年第3期6卷 48-52页

作者： m.Sta.k m.schⅹlch 毛谦德柏林GHHBORSIG透平机械有限公司北京理工大学机械工程系 100081

ＧＨＨＢＯＲＳＩＧ透平机械公司建造了世界上首台１０级齿轮传动压缩机，并且成功地进行了试验。该机器在一个俄罗斯的尿素合成装置中用于压缩二氧化碳至２００ｂａｒ。与在这种情况下通常使用的多室式单轴压缩机相比，新的... 详细信息

ＧＨＨＢＯＲＳＩＧ透平机械公司建造了世界上首台１０级齿轮传动压缩机，并且成功地进行了试验。该机器在一个俄罗斯的尿素合成装置中用于压缩二氧化碳至２００ｂａｒ。与在这种情况下通常使用的多室式单轴压缩机相比，新的解法明显地降低了成本和功率。本文介绍了新式压缩机的技术特点，特别着重于齿轮传动和控制方面。此外还叙述了压缩机各级的热动力设计特色。

关键词：压缩机齿轮传动高压工况设计功率成本

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NECa. fa.ily of neurona. ca.cium-binding proteins in hea.th a.d disea.e

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1236-1243页

作者： Diones Bueno micha.l K.E.scha.er Sudena.Wa.g micha.l J.schmeisser a.el methner Institute for molecula. medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Depa.tment of a.esthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of a.a.omy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-termina. EF-ha.d ca.cium-binding proteins 1–3(NECa.1–3) constitute a.fa.ily of predomina.tly neurona. proteins cha.a.terized by the presence of a. lea.t one EF-ha.d ca.cium-binding doma.n a.d a.functiona.ly less well cha.a.terized C-termina. a.tibiotic biosynthesis monooxygena.e doma.n. a.l three fa.ily members were initia.ly discovered due to their intera.tions with other proteins. NECa.1 a.socia.es with syna.tota.min-1, a.critica. neurona. protein involved in membra.e tra.ficking a.d syna.tic vesicle exocytosis. NECa.2 intera.ts with predomina.tly stria.a. G-protein-coupled receptors, while NECa.3 pa.tners with a.yloid-β a. precursor protein-binding fa.ily a.members 2 a.d 3, key regula.ors of a.yloid-β production. This demonstra.es the ca.a.ity of the fa.ily for intera.tions with va.ious cla.ses of proteins. NECa. proteins exhibit distinct subcellula. loca.iza.ions: NECa.1 is found in the nucleus a.d cytosol, NECa.2 resides in endosomes a.d the pla.ma.membra.e, a.d NECa.3 is present in the endopla.mic reticulum a.d Golgi a.pa.a.us. The a.tibiotic biosynthesis monooxygena.e doma.n, a. evolutiona.ily a.cient component, is a.in to a.ypica. heme oxygena.es in proka.yotes but is not wellcha.a.terized in vertebra.es. Proka.yotic a.tibiotic biosynthesis monooxygena.e doma.ns typica.ly form dimers, suggesting tha. ca.cium-media.ed conforma.iona. cha.ges in NECa. proteins ma. induce a.tibiotic biosynthesis monooxygena.e doma.n dimeriza.ion, potentia.ly a.tiva.ing some enzyma.ic properties. However, the substra.e for this enzyma.ic a.tivity rema.ns uncerta.n. a.terna.ively, ca.cium-media.ed conforma.iona. cha.ges might influence protein intera.tions or the subcellula. loca.iza.ion of NECa. proteins by controlling the a.a.la.ility of protein–protein intera.tion doma.ns situa.ed between the EF ha.ds a.d the a.tibiotic biosynthesis monooxygena.e doma.n. This review summa.izes wha. is known a.out genomic orga.iza.ion, tissue expression, intra.ellula. loca.iza.ion, intera.

关键词： ca.cium EF ha.d mitochondria nervous system signa. tra.sduction

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Sea.ch for microglia.specific peptides:a.va.ces in the discovery toolbox

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 471-472页

作者： Iva. Sa.a.ia.Kyle m.Koss Depa.tment of Surgery University of ArizonaTucsonAZUSA

Uncontrolled a.d chronic infla.ma.ory sta.es in the centra. nervous system(CNS)a.e the ha.lma.k of neurodegenera.ive pa.hology a.d every injury or stroke-rela.ed *** key media.ors of these neuroinfla.ma.ory sta.es a.e glia. cells known a. microglia.the resident immune cell a. the core of the infla.ma.ory event,a.d a.troglia.which enca.sula.e infla.ma.ory insults in proteoglyca.-rich sca. *** gliotic sca. blocks significa.t portions of hea.thy a.ona. networking,preventing *** most neuroinfla.ma.ion is exclusively ba.ed on the responses of sa.d microglia.their phenotypes a.e suggested to follow those of ma.ropha.es;m1 a.d m2 a.e opposites of pro-a.d ***,microglia. phenotypes ha.e been identified to be on a. infla.ma.ory spectrum encompa.sing developmenta.,homeosta.ic,a.d repa.a.ive beha.iors a. opposed to their a.ility to a.fect deva.ta.ing cell dea.h ca.ca.es a.d sca. tissue forma.ion.

关键词： infla.ma.ion pa.hology dea.h

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SBL-JP-0004: a.promising dua. inhibitor of Ja.2 a.d PI3KCD a.a.nst ga.tric ca.cer

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Oncology resea.ch 2025年第1期33卷 235-243页

作者： Ha.sa. m Otifi Depa.tment of Pa.hology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Ba.kground:Ga.tric ca.cer (GC) rema.ns a.globa. hea.th burden a.d is often cha.a.terized by heterogeneous molecula. profiles a.d resista.ce to conventiona. thera.ies. The phosphoinositide 3-kina.e a.d PI3K a.d Ja.us kina.e (Ja.) signa. tra.sducer a.d a.tiva.or of tra.scription (Ja.-STa.) pa.hwa.s pla. pivota. roles in GC progression, ma.ing them a.tra.tive ta.gets for thera.eutic interventions.methods:This study a.plied a.computa.iona. a.d molecula. dyna.ics simula.ion a.proa.h to identify a.d cha.a.terize SBL-JP-0004 a. a.potentia. dua. inhibitor of Ja.2 a.d PI3KCD kina.es. Ka.OIII a.d SNU-5 GC cells were used for eva.ua.ion.Results:SBL-JP-0004 exhibited a.robust binding a.finity for Ja.2 a.d PI3KCD kina.es, a. evidenced by molecula. docking scores a.d molecula. dyna.ics simula.ions. Binding intera.tions a.d Gibbs binding free energy estima.es confirmed sta.le a.d fa.ora.le intera.tions with ta.get proteins. SBL-JP-0004 displa.ed a. ha.f-ma.ima. inhibitory concentra.ion (IC) va.ue of 118.9 nm a.a.nst Ja.2 kina.e a.d 200.9 nm a.a.nst PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell prolifera.ion in Ka.OIII a.d SNU-5 cells, with ha.f-ma.ima. growth inhibitory concentra.ion (GI) va.ues of 250.8 a.d 516.3 nm, respectively. a.significa.t eleva.ion in the ea.ly pha.e a.optosis (28.53% in Ka.OIII cells a.d 26.85% in SNU-5 cells) a.d la.e pha.e a.optosis (17.37% in Ka.OIII cells a.d 10.05% in SNU-5 cells) were observed with SBL-JP-0004 trea.ment compa.ed to 2.1% a.d 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 a. a.promising dua. inhibitor ta.geting Ja.2 a.d PI3KCD kina.es for trea.ing GC a.d wa.ra.t further preclinica. a.d clinica. investiga.ions to va.ida.e its utility in clinica. settings.

关键词： Dua. inhibition Ga.tric ca.cer (GC) Ja.2 molecula. docking molecula. dyna.ics simula.ion PI3KCD SBL-JP-0004

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CT对甲状旁腺腺瘤的定位诊断价值

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放射学实践 1991年第4期6卷 156-158页

作者： a.Goldma.n W.ma.er. m.sch nberg. 汪玲 Ra.iologische Klinik und Poliklinik der Universit t Ulm.a.teilung Rntgendia.nostik Chirurgische Universit tsklinik und Poliklinik der Universit t Ulm 同济医科大学附属同济医院

CT对原发性甲状旁腺机能亢进时增大的甲状旁腺术前定位诊断的敏感性文献报道为33～88%,平均为56%.因为大多数报道来自80年代初,所以使用分辨能力明显改善的现代扫描机可能提高其敏感性.本研究的目的在于研究CT对近几年我院病例的诊断价值.

关键词：甲状旁腺腺瘤 CT 定位诊断

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Counting a.d mea.uring pa.ticles sized from soot to pollen

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China.Pa.ticuology 2007年第5期5卷 359-361页

作者： ma.tin schmidt Sven schütz Lea.der mlter Pa.a. GmbH Greschbachstr. 3b76229 KarlsruheGermany

For number concentra.ion mea.urements of superfine pa.ticles a.condensa.ion nucleus counter （CNC） is frequently used. The combina.ion of a.new CNC module with a.white light a.rosol spectrometer a.d a.pa.sive collector ma.es possible a.cura.e time-resolved determina.ion of pa.ticle number within the overa.l size ra.ge of 10 nm to 40 μm a.d a. concentra.ions up to 10^5 pa.ticles/cm^3. With the a.rosol spectrometer a.high time-resolved pa.ticle size determina.ion is a.so possible in the size ra.ge of 0.3-40 μm up to the sa.e high number concentra.ions of 10^5 pa.ticles/cm^3.

关键词： CNC Pa.ticles Size

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