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Anti-microbial antibodies in celiac disease:Trick or treat?

World Journal of Gastroenterology 2009年第31期15卷 3891-3900页

作者： maria Papp Ildiko Foldi Istvan Altorjay Eszter Palyu miklos Udvardy Judit Tumpek Sandor Sipka Ilma Rita Korponay-Szabo Eva Nemes Gabor Veres Tamas Dinya Attila Tordai Hajnalka Andrikovics Gary L norman Peter Laszlo Lakatos 2nd Department of medicine University of Debrecen Laboratory of Clinical Immunology University of Debrecen Department of Pediatrics University of DebrecenDebrecenH-4032HungaryIlma Rita Korponay-SzaboCeliac Disease CenterHeim Pal Children's Hospital 1st Department of Pediatrics Semmelweis University Institute of Surgery University of Debrecen Department of molecular Diagnostics Hungarian National Blood Transfusion Service INOVA Diagnostics Inc. 1st Department of medicine Semmelweis University

AIm： To determine the prevalence of a new set ot anti-glycan and anti-outer membrane protein （anti- OmP） antibodies in a Hungarian cohort of adult Celiac disease （CD） patients. mETHODS： 190 consecutive CD patients [m/F： 71/119, age：39.9 （SD：14.1） years], 100 healthy, and 48 gastrointestinal controls were tested for glycan anti-Saccharomyces cerevisiae （gASCA）, anti-laminaribioside （ALCA）, anti-chitobioside, anti-mannobioside, anti-OmP antibodies and major NOD2/CARD15 mutations. Thirty out of 82 CD patients enrolled at the time of diagnosis were re-evaluated for the same antibodies after longstanding gluten-free diet （GFD）. RESULTS： 65.9% of the CD patients were positive for at least one of the tested antibodies at the time of the diagnosis. Except anti-OmP and ALCA, antimicrobial antibodies were exclusively seen in untreated CD; however, the overall sensitivity was low. Any glycan positivity （LR＋： 3.13; 95% CI： 2.08-4.73） was associated with an increased likelihood ratio for diagnosing CD. Significant correlation was found between the levels of anti-glycan and anti-endomysial or anti-transglutaminase antibodies. Anti-glycan positivity was lost after longstanding GFD. Anti-glycan antibody titers were associated with symptoms at presentation, but not the presence of NOD2/CARD15 mutations. Patients with severe malabsorption more frequently had multiple antibodies at diagnosis （P = 0.019）. CONCLUSION： The presence of anti-glycan antibodies in CD seems to be secondary to the impaired small bowel mucosa which can lead to increased antigen presentation. Furthermore, anti-glycan positivity may be considered an additional marker of CD and dietary adherence.

关键词： Celiac disease Glycans Anti-Saccharomyces cerevisiae antibodies Anti-outer membrane protein antibody NOD2/CARD15 Gluten-free diet Presenting symptoms Bacterial translocation Crohn's disease

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and Security 2022年第3期1卷 28-42页

作者： Robert L.Vadas Jr. Robert m.Hughes Yeon Jae Bae min Jeong Baek Orestes Carlos Bello Gonzáles marcos Callisto Débora ReisdeCarvalho Kai Chen maria T.Ferreira Pablo Fierro Jon S.Harding Dana m.Infante C.J.Kleynhans Diego R.macedo Isabela martins norman mercado Silva Nabor moya Susan J.Nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.Jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key Laboratory of marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias marinas y Limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(mmIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of mmIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)mmI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and mmI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI mmI Fish macroinvertebrates Algae Streams Rivers Lakes Wetlands Biological monitoring

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mLEA： A Solution for Users of Android in UTPVirtual

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Computer Technology and Application 2011年第5期2卷 406-412页

作者： Gisela Torres de Clunie Sergio Crespo Coelho da Silva Pinto Aris Linet Castillo Lucas monteiro Braz Tasia Serrao norman Rangel Jeanette Riley Olinda de Barraza Kexy Rodriguez Computer Systems Engineering Department Technological University of Panama Panama 0819 Panama Computer Science Research and Graduate Program in Applied Computing University of the Sinos Valley （UNISINOS） RS 93022-000 Brazil CIDITIC Technological University of Panama Panama 0819 Panama

This paper describes a design of an educational platform for a mobile learning architecture, which is a state of the an topic in distance education. The product will allow users to interact in an efficient, flexible, and transparent fashion with a web-based education environment, in this case module Object-Oriented Dynamic Learning Environment （moodle）, using Android mobile devices. In order to provide a strong and lasting architecture, the Service Oriented Architecture （SOA） methodology is used given that it allows easy software re-utilization as well as integration of heterogeneous services. The architecture is based on web services implemented with Representational State Transfer （REST）, as it has been demonstrated to be lighter and less consuming than other protocols, for devices with limited resources such as mobile devices. Web services provide the communication means between the server side and the client side of the architecture, whereas agents are used to deliver the services itself. The authors propose the development of an environment that facilitates the integration of various educational resources to support m-learning. An important aspect of the proposal is the offering of a tool to provide customized alerts for students and teachers, enabling them to remain updated about activities taking place in the courses.

关键词： Distance learning virtual education m-learning service oriented architecture (SOA) mobile learning mobile computing interoperability representational state transfer (REST).

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新皮质癫痫患者中高频振荡与癫痫发作起始区关系的研究

新皮质癫痫患者中高频振荡与癫痫发作起始区关系的研究

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第三届CAAE中国脑电图和神经电生理大会

作者：王爽王钟 Jorge Gonzalez-martinez mD Andreas V.Alexopoulos Imad m.Najm norman K.So 浙江大学医学院附属第二医院神经内科癫痫中心美国克里夫兰医院癫痫中心

目的:脑电高频振荡(HFO,80-500Hz)包括ripple(80-250Hz)和fast ripple(250-500Hz),它与癫痫患者的致痫区或发作起始区密切相关,能帮助指导癫痫手术。但现有的HFO研究大多基于颞叶内侧面癫

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石油类UVCB物质交叉参照的技术考量

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毒理学杂志 2022年第3期36卷 194-198页

作者：邹汉军陈慧婷 Kung ming Palermo Christine Goyak O.Katy norman John Prosser m.Christopher Bragin E.Gail 管娜戎志毅高仁君黄梅马书霞苏毅张霞埃克森美孚(中国投资有限公司) 上海200241 埃克森美孚生物医药有限公司美国新泽西08801 陶氏化学中国投资有限公司上海201203 路博润管理上海有限公司上海200126 巴斯夫中国有限公司上海200137 杜邦中国研发管理有限公司上海201203 德国德之馨德国霍尔茨明登37603 上海天祥质量技术服务有限公司上海200233

UVCB物质是化学结构未知、组分可变、复杂的反应产物或生物材料物质。石油类UVCB是其中典型的代表。虽然其主要成分是碳氢类化合物,但由于异构的多样性,每种成分的精确结构和含量是不确定的。在流程上,这类物质的交叉参照和常规物质遵... 详细信息

UVCB物质是化学结构未知、组分可变、复杂的反应产物或生物材料物质。石油类UVCB是其中典型的代表。虽然其主要成分是碳氢类化合物,但由于异构的多样性,每种成分的精确结构和含量是不确定的。在流程上,这类物质的交叉参照和常规物质遵循类似的步骤。但是由于其特有的复杂特性,这类物质的交叉参照常常需要额外的考虑,包括如何界定相似性、如何寻找类似物、如何论证交叉参照的可行性以及成分间的潜在相互作用等。作为此次交叉参照专题的系列文章,本文旨在帮助理解石油类UVCB类物质进行交叉参照填补数据缺口时面临的关键挑战。

关键词：石油类UVCB 交叉参照流程碳氢化合物

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mR扩散加权成像可作为判别围产期死亡时间的一个标志

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国际医学放射学杂志 2015年第4期 393-394页

作者： O.J.Arthurs G.C.Price D.W.Carmichael R.Jones W.norman A.m.Taylor 郝彩仙 Department of Radiology Great Ormond Street Hospital for Children NHS Foundation Trust

摘要目的应用尸检mRI(PmmR)测量围产期死亡人体器官的表观扩散系数(ADC)值,以评估死亡后人体器官的变化。方法对15例已死亡的胎儿和新生儿病例[平均(33.3±

关键词：加权成像围产期围生期 mR 死亡时间

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Stimuli-responsive photoluminescent copper(Ⅰ) halides for scintillation, anticounterfeiting, and light-emitting diode applications

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Aggregate 2024年第5期5卷 465-480页

作者： Dilruba A.Popy Yashpal Singh Yauhen Tratsiak Abby m.Cardoza John m.Lane Luis Stand mariya Zhuravleva Neeraj Rai Bayram Saparov Department of Chemistry and Biochemistry University of OklahomaNormanOklahomaUSA Dave C.Swalm School of Chemical Engineering and Center for Advanced Vehicular Systems Mississippi State UniversityMississippi StateMississippiUSA Scintillation materials Research Center University of TennesseeKnoxvilleTennesseeUSA

Highly sensitive stimuli-responsive luminescent materials are crucial for appli-cations in optical sensing,security,and ***,we report two zero-dimensional(0D)copper(I)halides,(TEP)_(2)Cu_(2)Br_(4),(TEP)_(2)Cu_(4)Br_(6),and 1D(TEP)_(3)Ag_(6)Br_(9),which are comprised of isolated[Cu_(2)Br_(4)]^(2-),[Cu_(4)Br_(6)]^(2-),and[Ag_(6)Br_(9)]3-polyanions,respectively,separated by TEP^(+)(tetraethylphosphonium[TEP])cations.(TEP)_(2)Cu_(2)Br_(4) and(TEP)_(2)Cu_(4)Br_(6) demonstrate greenish-white and orange-red emissions,respectively,with near unity photoluminescence quantum yields,while(TEP)_(3)Ag_(6)Br_(9) is a poor light *** spectroscopy mea-surements and density-functional theory calculations reveal that photoemissions of these compounds originate from self-trapped excitons due to the excited-state distor-tions in the copper(I)halide *** of Cu(I)halides are radioluminescence active at room temperature under both X-andγ-rays *** light yields up to 15,800 ph/meV under 662 keVγ-rays of ^(137)Cs suggesting their potential for scintillation ***,(TEP)_(2)Cu_(2)Br_(4) and(TEP)_(2)Cu_(4)Br_(6) are inter-convertible through chemical stimuli or reverse *** addition,both compounds demonstrate luminescence on-off switching upon thermal *** sensitivity of(TEP)_(2)Cu_(2)Br_(4) and(TEP)_(2)Cu_(4)Br_(6) to the chemical and thermal stimuli coupled with their ultrabright emission allows their consideration for applications such as solid-state lighting,sensing,information storage,and anticounterfeiting.

关键词： 0D copper(I)halides anticounterfeiting efﬁcient photoluminescence scintillators solid-state lighting

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Investigating drivers of microbial activity and respiration in a forested bog

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Pedosphere 2020年第1期30卷 135-145页

作者： Kenna E.REWCASTLE Jessica A.m.mOORE Jeremiah A.HENNING melanie A.mAYES Courtney m.PATTERSON Gangsheng WANG Daniel B.mETCALFE Aimée T.CLASSEN Rubenstein School of Environment and Natural Resources University of VermontBurlington VT 05405(USA) Ecology&Evolutionary Biology University of TennesseeKnoxville TN 37996(USA) The Gund Institute for Environment University of VermontBurlington VT 05405(USA) Department of Biology University of South AlabamaMobile AL 36688(USA) Climate Change Science Institute and Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TN 37830(USA) Institute for Environmental Genomics&Department of microbiology and Plant Biology University of OklahomaNorman OK 73019(USA) The Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362(Sweden)

Northern peatlands store nearly one-third of terrestrial carbon(C)stocks while covering only 3%of the global landmass;nevertheless,the drivers of C cycling in these often-waterlogged ecosystems are different from those that control C dynamics in upland forested *** explore how multiple abiotic and biotic characteristics of bogs interact to shape microbial activity in a northern,forested bog,we added a labile C tracer(13C-labeled starch)to in situ peat mesocosms and correlated heterotrophic respiration with natural variation in several microbial predictor variables,such as enzyme activity and microbial biomass,as well as with a suite of abiotic variables and proximity to vascular plants *** found that peat moisture content was positively correlated with respiration and microbial activity,even when moisture levels exceeded total saturation,suggesting that access to organic matter substrates in drier environments may be limiting for microbial *** to black spruce trees decreased total and labile heterotrophic *** negative relationship may reflect the influence of tree evapotranspiration and peat shading effects;i.e.,microbial activity may decline as peat dries and cools near ***,we isolated the response of heterotrophic respiration to explore the variation in,and interactions among,multiple abiotic and biotic drivers that influence microbial *** approach allowed us to reveal the relative influence of individual drivers on C respiration in these globally important C sinks.

关键词： carbon cycling enzyme activity heterotrophic respiration labile carbon respiration ombrotrophic bog peat moisture plant proximity soil carbon sink

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新皮质癫痫患者中脑电高频振荡与癫痫发作起始区关系的研究

新皮质癫痫患者中脑电高频振荡与癫痫发作起始区关系的研究

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2012年浙江省神经病学学术年会

作者：王爽王钟 Jorge Gonzalez-martinez mD Andreas V.Alexopoulos Imad m.Najm2 norman K.So 浙江大学医学院附属第二医院神经内科癫痫中心美国克里夫兰医院癫痫中心(Cleveland Clinic Epilepsy Center)

目的脑电高频振荡(HFO,80-500Hz)包括ripple(80-250Hz)和fast ripple(250-500Hz),它与癫痫患者的致痫区或发作起始区密切相关,能帮助指导癫痫手术。但现有的HFO研究大多基于颞叶内侧面癫痫,新皮质癫痫中HFO的特征尚有待进一步研究。本...

目的脑电高频振荡(HFO,80-500Hz)包括ripple(80-250Hz)和fast ripple(250-500Hz),它与癫痫患者的致痫区或发作起始区密切相关,能帮助指导癫痫手术。但现有的HFO研究大多基于颞叶内侧面癫痫,新皮质癫痫中HFO的特征尚有待进一步研究。本研究中我们分析了新皮质癫痫患者中HFO和癫痫发作起始区的关系。方法我们研究了35例(12-59岁)接受长程颅内电极记录(SEEG或硬膜下栅格电极)的新皮质癫痫患者,采用2000Hz的采样频率记录颅内脑电图。我们选择了10-30分钟的慢波睡眠期脑电图,使用multiview软件探测大脑新皮质中的fast ripple和ripple,所有的HFO均通过时间-频率分析确认。我们将Ripple分为两个类型,与发作间期的痫样放电一同出现的定义为I型ripple,独立出现于痫样放电以外的ripple定义为Ⅱ型ripple。结果 35例患者中,21例(A组)有明确的单个发作起始区(SOZ),14例(B组)有2个以上的发作起始区。A组患者中,4例患者的新皮质中探测到fast ripple,均位于SOZ内。A组中的I型ripple特异的分布在SOZ或者癫痫的快速传播区(PP)内,并且I型ripple在SOZ分布的特异性高于棘波在SOZ中的分布;相反,Ⅱ型ripple的分布没有显著特异性。在B组患者中,I型ripple也很少分布在癫痫的晚期传播区域,Ⅱ型ripple的分布也没有特异性。为明确是否可能存在生理性ripple波,我们定义了Ⅱ-O型ripple:1、出现于发作起始区以外;2、发生于仅出现Ⅱ型ripple的电极中。在SEEG病例中,Ⅱ-O型ripple特异的分布在初级运动皮质和视觉皮质。并且,初级运动皮质中的手代表区和初级视觉皮质的Ⅱ-O型ripple发生率较其它区域更高,提示Ⅱ-O型ripple可能和运动、视觉信息加工有关。结论发作间期的fast ripple和I型ripple能特异的标记发作起始区,但fastripple在新皮质癫痫中并不常见。大脑新皮质的初级运动皮质和视觉皮质还可能存在的生理性ripple波,值得在今后的研究中注意。

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BEARS:Radioactive Ion Beams Experiment at Berkeley

BEARS:Radioactive Ion Beams Experiment at Berkeley

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CCAST“放射性束物理”研讨会

作者： X.J.Xu. J Powell R.Josten C.A Donahue R.F.Fairchild F.Q.Guo P.E Jaustein R,m.Larimer C,m Lyneis P.mcnahan D.m moltz E,B norman J P ONeil m.W.Rowe H.F.Vanbrocklin D.Wutte Z.Q.Xie J,Cemy Lawrence Berkeley National Laborqtory USA Institute of modem Physics Chinese Academy of Sciences Brooljanven National Laboratory USA

＜正＞BEARS, or Berkeley Experiments with Accelerated Radioactive Species, is aninitiative to develop a radioactive ion-beam capability at Lawrence Berkeley NationalLaboratory. The basic concept for BEANS involves the coupling of radioisotopeproduction at an existing medical cyclotron with post-acceleration by the 88”cyclotron. These accelerators are separated by distance of about 350 *** be transported between the two via a gas-jet capillary（Fig.1）

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