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In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation

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Light(Science & Applications) 2023年第5期12卷 877-893页

作者： Osamu Yasuhiko Kozo takeuchi Central Research Laboratory Hamamatsu Photonics K.K5000 HirakuchiHamakita-kuHamamatsu 434-8601 ShizuokaJapan

Refractive index(RI)is considered to be a fundamental physical and biophysical parameter in biological imaging,as it governs light-matter interactions and light propagation while reflecting cellular *** tomography enables volumetric visualization of RI distribution,allowing biologically relevant analysis of a ***,multiple scattering(mS)and sample-induced aberration(SIA)caused by the inhomogeneity in RI distribution of a thick sample make its visualization *** paper proposes a deep RI tomographic approach to overcome mS and SIA and allow the enhanced reconstruction of thick samples compared to that enabled by conventional linear-model-based RI *** proposed approach consists of partial RI reconstruction using multiple holograms acquired with angular diversity and their backpropagation using the reconstructed partial RI map,which unambiguously reconstructs the next partial *** this operation efficiently reconstructs the entire RI tomogram while suppressing mS and *** visualized a multicellular spheroid of diameter 140μm within minutes of reconstruction,thereby demonstrating the enhanced deep visualization capability and computational efficiency of the proposed method compared to those of conventional RI ***,we quantified the high-RI structures and morphological changes inside multicellular spheroids,indicating that the proposed method can retrieve biologically relevant information from the RI *** from the excellent biological interpretability of RI distributions,the label-free deep visualization capability of the proposed method facilitates a noninvasive understanding of the architecture and time-course morphological changes of thick multicellular specimens.

关键词： properties refractive overcome

Deep learning ferroelectric polarization distributions from STEm data via with and without atom finding

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npj Computational materials 2021年第1期7卷 1342-1352页

作者： Christopher T.Nelson Ayana Ghosh mark Oxley Xiaohang Zhang maxim Ziatdinov Ichiro takeuchi Sergei V.Kalinin Center for Nanophase materials Sciences Oak Ridge National LaboratoryOak RidgeTNUSA Computational Sciences and Engineering Division Oak Ridge National LaboratoryOak RidgeTNUSA Department of materials Science and Engineering University of MarylandCollege ParkMDUSA

Over the last decade,scanning transmission electron microscopy(STEm)has emerged as a powerful tool for probing atomic structures of complex materials with picometer precision,opening the pathway toward exploring ferroelectric,ferroelastic,and chemical phenomena on the atomic *** to date extracting a polarization signal from lattice coupled distortions in STEm imaging rely on discovery of atomic positions from intensity maxima/minima and subsequent calculation of polarization and other order parameter fields from the atomic ***,we explore the feasibility of polarization mapping directly from the analysis of STEm images using deep convolutional neural networks(DCNNs).In this approach,the DCNN is trained on the labeled part of the image(i.e.,for human labelling),and the trained network is subsequently applied to other *** explore the effects of the choice of the descriptors(centered on atomic columns and grid-based),the effects of observational bias,and whether the network trained on one composition can be applied to a different *** analysis demonstrates the tremendous potential of the DCNN for the analysis of high-resolution STEm imaging and spectral data and highlights the associated limitations.

关键词： Deep network ferroelectric

Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide

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World Journal of Gastroenterology 1999年第6期5卷 477-482页

作者： H Yamamoto, m Umeda, H mizoguchi, S Kato and K takeuchi Kyoto Phamaceutical University 日本

AIm To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. mETHODS AND RESULTS Oral administration of NH 2Cl (120*!mm) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAmE) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAmE. Topical application of NH 2Cl (20*!mm) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mm) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAmE sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins.

关键词： irsogladine rebamipide monochloramine gastric mucosal lesions rats comparative study

Role of bacterial and genetic factors in gastric cancer in Costa Rica

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World Journal of Gastroenterology 2009年第2期15卷 211-218页

作者： Sergio A Con Hiroaki takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong Centro Digestivo Doctores Con-mediplaza Pavas 245-1200 San José Costa Rica Department of Clinical Laboratory medicine Kochi Medical School Kochi University Nankoku-city Kochi 783-8505 Japan Department of Public Health Kochi Medical School Kochi University Nankoku-city Kochi 783-8505 Japan

AIm： To evaluate several risk factors for gastric cancer （GC） in Costa Rican regions with contrasting GC incidence rate （GCIR）. mETHODS： According to GCIR, 191 Helicobacter pylori （H pylori）-positive patients were classified into groups A （high GCIR, n = 101） and B （low GCIR, n = 90）. Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin （IL）-1β and IL-10 by PCRRFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS： Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach （mixed strain infection） were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR （P = 0.026 and 0.041, respectively）. IL- 1β＋3954_T/C （OR 2.1, 1.0-4.3）, IL-1RN^＊2/L （OR 3.5, 1.7-7.3） and IL-10-592_C/A （OR 3.2, 1.5-6.8） were individually associated with GC, and a combination of these cytokine polymorphisms with Hpylori vacA slb and ml further increased the risk （OR 7.2, 1.4-36.4）. CONCLUSION： Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of Hpylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica.

关键词： Costa Rica Gastric cancer Helicobacterpylori Host genetic factors

Correlation Study Between Suspended Particulate matter and DOAS Data

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Advances in Atmospheric Sciences 2006年第3期23卷 461-467页

作者：司福祺刘建国谢品华张玉钧刘文清 Hiroaki KUZE Nofel LAGROSAS Nobuo takeuchi Key Laboratory of Environmental Optics & Technology Center for Environmental Remote Sensing

Continuous data of aerosol optical thickness monitored using differential optical absorption spectroscopy （DOAS） are correlated with the concentration of ground-measured suspended particulate matter （SPm）. A high correlation is found between the DOAS and the ground SPm data, making it possible to calculate the mass extinction efficiency of the aerosols in the atmosphere. It is found that the value of mean mass extinction efficiency （mEE） varies over a range of 2.6-13.7 m^2 g^-1, with smaller and larger values occurring for size distributions dominated by coarse and fine particles, respectively.

关键词： Aerosol differential optical absorption spectroscopy suspended particulate matter mass extinction efficiency

Late Quaternary Geomorphology of the Tonami Plain and Activity of the Tonami-Heiya Fault Zone, Toyama Prefecture, Central Japan

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International Journal of Geosciences 2016年第7期7卷 962-976页

作者： Toshio Kamishima Akira takeuchi Graduate School of Science and Engineering University of Toyama Toyama Japan

The Holocene alluvial fans and flood plains formed by the Sho and Oyabe Rivers spread out in the Tonami plain from the central through the northern parts in the Toyama Prefecture, central Japan. Along the foot of the surrounding mountains and hills, higher, middle and lower terraces of late Pleistocene-Holocene in age are distributed. These terraces have been displaced, by the reverse dip-slip activities of Tonami-heiya fault zone in a sense of upheaval in the mountains side, even during the Holocene time. We examined stratigraphic cross section utilizing borehole data and geomorphologically analyzed 5 m-DEm data in order to elucidate the fault trace of the Isurugi fault which Tonami-heiya fault zone. As the results, the northern segment of Isurugi fault seems to run along the northeastern foot of Hodatsu Hills and extends underground through the lower-most Oyabe River into the Toyama Bay. Consequently, its total length reaches about 30 km. In the southern segment, a continuous fault scarplet was recognized to cut across the lower dissected fans. The slip-rate of Isurugi fault is estimated to be 0.31 - 0.64 m/kyr. In the Hokuriku region, reverse faulting and related folding with strike in a NE-SW direction have occurred during the late Quaternary. The hinge line of block movement due to the activities of the Tonami-heiya fault zone is revealed to have shifted from the mountain side into the plain side within the Holocene time. In conclusion, the Quaternary folding and faulting associated with the crustal warping at a wavelength of about 20 km is currently in progress, causing both the subsidence of Tonami plain and the upheaval of surrounding mountains and hills.

关键词： Tectonic Geomorphology Late Quaternary Active Fault Tonami Plain Central Japan

Combinatorial Synthesis and High-Throughput Characterization of microstructure and Phase Transformation in Ni-Ti-Cu-V Quaternary Thin-Film Library

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Engineering 2020年第6期6卷 637-643页

作者： Naila m.Al Hasan Huilong Hou Suchismita Sarkar Sigurd Thienhaus Apurva mehta Alfred Ludwig Ichiro takeuchi Department of materials Science and Engineering University of MarylandCollege ParkMD 20742USA Stanford Synchrotron Radiation Lightsource SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA Werkstoffe der mikrotechnik Ruhr-Universitat BochumBochum 44801Germany

Ni-Ti-based shape memory alloys(SmAs)have found widespread use in the last 70 years,but improving their functional stability remains a key quest for more robust and advanced *** for their ability to retain their processed shape as a result of a reversible martensitic transformation,SmAs are highly sensitive to compositional *** with ternary and quaternary elements to finetune the lattice parameters and the thermal hysteresis of an SmA,therefore,becomes a challenge in materials *** materials science allows streamlining of the synthesis process and data management from multiple characterization *** this study,a composition spread of Ni-Ti-Cu-V thin-film library was synthesized by magnetron co-sputtering on a thermally oxidized Si ***-dependent phase transformation temperature and microstructure were investigated and determined using high-throughput wavelength dispersive spectroscopy,synchrotron X-ray diffraction,and temperature-dependent resistance *** the 177 compositions in the materials library,32 were observed to have shape memory effect,of which five had zero or near-zero thermal *** compositions provide flexibility in the operating temperature regimes that they can be used in.A phase map for the quaternary system and correlations of functional properties are discussed w让h respect to the local microstructure and composition of the thin-film library.

关键词： Ni-Ti-Cu-V alloys Combinatorial materials science Quaternary alloys Shape memory alloys Thin-film library Elastocaloric cooling Thermoelastic cooling Phase transformation High-throughput characterization Property mapping machine learning

Development of 3D crystallographic orientation measurement for grain deformation analysis in aluminum alloy

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Transactions of Nonferrous metals Society of China 2014年第7期24卷 2094-2101页

作者： m.KOBAYASHI H.TODA D.J.LECLERE T.KAmIKO K.UESUGI A.takeuchi Y.SUZUKI Department of mechanical Engineering Toyohashi University of Technology Department of mechanical Engineering Kyushu University Japan Synchrotron Radiation Research Institute

Development of inhomogeneous deformation is an interest matter in material engineering. Synchrotron radiation tomography provides 3D distribution map of local strain in polycrystalline aluminum alloy by tracking microstructural features. To perform further deep analysis on development of inhomogeneous deformation, crystallographic grain orientation is necessary. Three-dimensional X-ray diffraction technique was developed. A new crystallographic orientation measurement method was described in 3D space, utilizing grain boundary tracking （GBT） information.

关键词： synchrotron radiation X-ray tomography X-ray diffraction plastic deformation crystallographic orientation

微囊藻毒素-LR对人肝癌HT17细胞周期及细胞凋亡的影响

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环境与健康杂志 2011年第6期28卷 496-498页

作者：农清清 takeuchi T Komatsu m 张志勇何敏广西医科大学公共卫生学院职业卫生与环境卫生学教研室广西南宁530021 广西医科大学博士后科研流动站日本鹿儿岛大学医齿学综合研究科环境医学研究室

目的研究微囊藻毒素-LR(mC-LR)对人肝癌HT17细胞周期、凋亡的影响及其可能的作用机制。方法调整HT17细胞密度为1×104/孔,分别设终浓度为0(溶剂对照,0.1%DmSO)、0.05、0.1、0.2、0.4、0.8、2.0、5.0μmol/L的mC-LR染毒组和去铁敏(DFO,1 ... 详细信息

目的研究微囊藻毒素-LR(mC-LR)对人肝癌HT17细胞周期、凋亡的影响及其可能的作用机制。方法调整HT17细胞密度为1×104/孔,分别设终浓度为0(溶剂对照,0.1%DmSO)、0.05、0.1、0.2、0.4、0.8、2.0、5.0μmol/L的mC-LR染毒组和去铁敏(DFO,1 mmol/L)染毒组以及mC-LR(0.8μmol/L)+DFO(1 mmol/L)染毒组培养24 h,采用四甲基偶氮噻唑蓝(mTT)法检测细胞生长情况。调整HT17细胞密度为1×105/孔,分别设终浓度为0(溶剂对照)、mC-LR(0.8μmol/L)染毒组和DFO(1 mmol/L)染毒组以及DFO(1 mmol/L)+mC-LR(0.8μmol/L)染毒组培养24、48 h,采用流式细胞术检测细胞周期和细胞凋亡情况。结果高剂量(≥0.8μmol/L)mC-LR染毒24 h后细胞存活率明显低于溶剂对照组(PmC-LR染毒组细胞存活率高于0.8μmol/L mC-LR染毒组(PmC-LR染毒24、48 h后G0/G1期细胞所占比例和细胞凋亡率均增高,S期细胞所占比例下降(PmC-LR染毒组与mC-LR染毒组染毒24 h后各期细胞所占比例无差异(P>0.05)。DFO+mC-LR染毒组染毒24 h后细胞凋亡率低于mC-LR染毒组(PmC-LR可导致HT17细胞在G0/G1期发生阻滞及细胞凋亡,可能与其诱发的氧化应激、蛋白质磷酸化状态紊乱有关。

关键词：微囊藻毒素-LR 细胞周期细胞凋亡