检索结果-南通市图书馆

Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: Seven cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第16期14卷 2602-2608页

作者： Kiminori Uka Hiroshi Aikata Shintaro Takaki Tomokazu Kawaoka Hiromi Saneto Daiki miki Shoichi Takahashi Naoyuki Toyota Katsuhide ito Kazuaki Chayama Department of medicine and molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Department of Radiology Hiroshima University Hospital

The combination of intra-arterial low-dose cisplatin and 5-fluorouracil (5-FU) is effective against advanced hepatocellular carcinoma (HCC). Systemic gemcitabine chemotherapy seems effective in many cancers. We report the results of combination therapy with systemic gemcitabine, intra-arterial low-dose cisplatin and 5-FU (GEmFP). Seven patients with non-resectable advanced HCC were treated with GEmFP. One course of chemotherapy consisted of daily intra-arterial cisplatin (20 mg/body weight/hour on d 1, 10 mg/body weight per 0.5 h on d 2-5 and 8-12), followed by 5-FU (250 mg/body weight per 5 h on d 1-5 and 8-12) via an injection port. Gemcitabine at 1000 mg/m2 was administered intravenously at 0.5 h on d 1 and 8. The objective response was 57%. The response to GEmFP was as follows: complete response (no patients), partial response (four patients), stable disease (three patients), and progressive disease (no patients). The median survival period was 8 mo (range, 5-55). With regard to the National Cancer Institute Common Toxicity Criteria (NCI-CTC) grade 3 or 4 adverse reactions, seven (100%), seven, six (86%) and one (14%) patients developed leukopenia, neutropenia, thrombocytopenia and anemia, respectively. GEmFP may potentially be effective for non- resectable advanced HCC, but it has severe hematologic toxicity.

关键词： 5-fluorouracil Cisplatin Gemcitabine Hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

青海省达日县棘球蚴病流行病学调查

中国寄生虫学与寄生虫病杂志 2009年第1期27卷 22-26页

作者：韩秀敏王虎蔡辉霞马霄刘玉芳韦炳辉 ito A Craig PS 青海省地方病预防控制所西宁811602 青海省达日县疾病预防控制中心达日814200 日本旭川医科大学旭川078-8510 英国索尔福德大学曼彻斯特M5 4WT

目的分析青海省果洛藏族自治州达日县棘球蚴病的流行分布现状,为制定预防控制措施提供科学依据。方法于2007年8～9月对达日县6个乡各2～3个自然村的3周岁以上常驻牧民分别用B超、间接红细胞凝集试验(IHA)和间接ELISA法(重组AgB和Em18抗... 详细信息

目的分析青海省果洛藏族自治州达日县棘球蚴病的流行分布现状,为制定预防控制措施提供科学依据。方法于2007年8～9月对达日县6个乡各2～3个自然村的3周岁以上常驻牧民分别用B超、间接红细胞凝集试验(IHA)和间接ELISA法(重组AgB和Em18抗原)检查两型棘球蚴病患病和感染情况。并调查当地啮齿类动物、牦牛、绵羊和野犬的感染情况,对采集的棘球绦虫和棘球蚴用PCR-RFLP方法进行虫种鉴定,并确定其基因型。收集牧民的家犬粪便,用双抗体夹心法检测粪抗原阳性率。结果共调查牧民1723人,B超查出棘球蚴病患者236例(占13.7%),其中囊型和泡型棘球蚴病患病率分别为5.5%(95/1723)和8.2%(141/1723)。男、女性棘球蚴病患病率分别为11.6%和16.0%(χ2=7.0,P<0.05)。家犬粪抗原阳性率为11.3%(31/275)。剖检9只无主犬,其中5只棘球绦虫感染阳性,对检获的虫体经PCR-RFLP鉴定,1只犬感染细粒棘球绦虫,基因型为G1,4只犬感染多房棘球绦虫。牦牛、绵羊的细粒棘球蚴感染率分别为26.4%(14/53)和5/16,对从牦牛、绵羊检获的细粒棘球蚴经PCR-RFLP鉴定,基因型均为G1。捕获高原鼠兔239只,石渠棘球绦虫感染率为11.3%(27/239)。结论达日县存在细粒棘球绦虫、多房棘球绦虫和石渠棘球绦虫的分布,泡型和囊型棘球蚴病在人群中严重流行,犬是细粒棘球绦虫和多房棘球绦虫主要传染源。

关键词：棘球蚴病流行病学调查青海省

维普期刊数据库

molecular Probes in Tandem Electrospray Ionization mass Spectrometry: Application to Tracing Chemical Changes of Specific Phospholipid molecular Species

在线全文

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2013年第10期4卷 16-26页

作者： Hiroko Tominaga Tomoe Ishihara A. K. m. Azad Shah Rumiko Shimizu Arnold N. Onyango Hideyuki ito Toshinori Suzuki Yasuhiro Kondo Hiroshi Koaze Koretaro Takahashi Naomichi Baba Department of Food Science Obihiro University of Agriculture and Veterinary Medicine Hokkaido Japan Division of Bioscience Graduate School of Natural Science and Technology Okayama University Okayama Japan Faculty of Health and Welfare Science Okayama Prefectural University Okayama Japan Faculty of Pharmaceutical Sciences Kobe Gakuin University Kobe Japan Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya School of Pharmacy Shujitsu Univerisity Okayama Japan Sdivision of marine Life Science Graduate School of Fisheries Sciences Hokkaido University Hakodate Japan

New ionization and detection techniques in mass spectrometry have been successfully applied for efficient analyses of complex biological systems. It is, however, still difficult to trace structural changes of a specific molecular species in such systems. In the present study, a molecular probe strategy in combination with tandem electrospray ionization mass spectrometry has been examined using synthetic deuterium-labeled phosphatidylcholine hydroperoxide (PC-OOH/D3) and ethyl-labeled phosphatidylcholine having docosahexaenoic acid side chain (DHA-PC/Et). Administration of a mixture of PC-OOH/D3 and DHA-PC/Et to human blood and human skin surface, followed by extraction and analysis with collision-induced tandem electrospray ionization mass spectrometry demonstrated that metabolites of both molecular probes can be detected simultaneously with strict selectivity. The present method is also found to be useful in tracing chemical changes of the unstable docosahexaenoyl group on the surface of processed fish. The activity of phospholipase A2 can also be assessed using a phospholipid molecular probe with a linoleoyl and a deuteriomethyl group via selective detection of the lyso-phospholipid product by mass spectrometry. The advantage of the present method is that no chromatographic separation is required and analysis can be performed under strictly the same condition for different molecular probes, affording multiple data by one experiment. The present strategy may be useful for tracing time-dependent phenomena in dynamic phospholipid biochemistry, and can be widely used for any biological and food systems.

关键词： molecular Probe Stable Isotope mass Spectrometry Electrospray Ionization Lipid Peroxidation Lipid Oxidation Skin Surface

通过高压直接喷射实现高效率和低氮氧化物排放的氢燃烧方式

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汽车与新动力 2012年第4期 52-59页

作者： Tanno S ito Y michikawauchi R Nakamura m Tomita H 吕汝宾

氢可以从各种再生能源中产生,因此预计,氢将会在社会长期能源需求中起到重要作用。传统氢发动机存在的一些缺点是:冷却损失较高导致热效率较低,以及不正常燃烧(回火、早燃、燃烧速度较快)限制了大负荷运行。氢燃料直接喷射是克服这些缺... 详细信息

氢可以从各种再生能源中产生,因此预计,氢将会在社会长期能源需求中起到重要作用。传统氢发动机存在的一些缺点是:冷却损失较高导致热效率较低,以及不正常燃烧(回火、早燃、燃烧速度较快)限制了大负荷运行。氢燃料直接喷射是克服这些缺点的一种有效办法,但是要实现高效率和低氮氧化物(NOx)排放的燃烧方法还需要进行更详细的研究。采用一种试验性氢高压喷射器(最大喷射压力30 mPa)对高效率和低NOx排放的氢燃烧进行了研究。采用1台2.2 L 4缸涡流形燃烧室柴油机进行试验,氢喷射器安装在气缸中心,火花塞安装在预热塞位置。为了能向1个气缸提供氢气,对这台发动机进行了改装。通过控制喷油定时和点火定时研究了氢气的均相和分层燃烧。另外,还研究了联合使用火花点火的扩散燃烧(即火花点燃辅助扩散燃烧)。结果显示,采用高压直喷的分层扩散燃烧与传统的均相燃烧相比,指示热效率提高了约3%。热效率提高的原因是:(1)分层扩散燃烧改善了冷却损失与等容度之间的折衷关系;(2)接近上止点喷射的压力恢复效应十分有利于热效率的提高;(3)在废气再循环(EGR)与扩散燃烧相结合的情况下,能使EGR更为有效。通过抑制喷束的贯穿度以减少较多的冷却损失,使这台小型发动机达到了52%的优良指示热效率,并通过计算流体动力学和可视化缸内燃烧研究得到了证实。另外,还获得了一些有价值的认识:EGR除湿能增加工作气体的比热比,并能在降低NOx的同时提高热效率。

关键词：氢高压直接喷射高效率火花点火扩散燃烧低氮氧化物排放

In Vitro Hydrodynamic Test and In Vitro Hemolysis Test for Development of Inexpensive Spiral Vortex Ventricular Assisting System Using IABP Console

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

上海大学学报（自然科学版） 2004年第B10期10卷 32-36页

作者： Y.Ohnishi K.Iwasaki H.mizuta T.Sudo S.muto T.Shima T.Tanaka K.ito m.Umezu IntegrativeBioscienceandBiomedicalEngineeringGraduateSchoolofWasedaUniversity TokyoJapan YasuhisaBiomechanicsInc. TokyoJapan

The purpose of this research is to develop an inexpensive pulsatile blood pump system for short-term use, as a combination of the usage of IABP console and spiral vortex pump. In vitro hydrodynamic test and in vitro h... 详细信息

关键词：水力测试血泵系统螺旋涡流泵溶血测试

日籍巴西人群中幽门螺杆菌血清阳性与Lewis和Secretor基因多态性的联系

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 50-51页

作者： Oba-hinjo S.m. Uno m. ito L.S. 王志宇 Laboratory of molecular Biology Department of Neurology University of So Paulo Av. Dr. Arnaldo 455 01246-903 So Paulo SP Brazil

Background. Secretor (Se) and Lewis (Le) genes are involved in the synthesis of Lewis b (Leb) and type I antigens throughout the body, especially in the epithelial cells of gastric mucosa. Helicobacter pylori can attach to the gastric epithelial cells with the blood group antigen binding adhesin, which binds to Leb or H type I carbohydrate structures. In a previous study, a marked association between H. pylori seropositivity and polymorphism of the Se and Le genes was observed among Japanese outpatients of a gastroenterology clinic. The present work aims to investigate the associations between Se and Le gene polymorphisms and H. pylori infection among Japanese Brazilians. methods. The subjects consisted of 942 healthy volunteer Japanese Brazilians, who were tested for the presence of anti H. pylori IgG antibodies and genotyped for Se and Le polymorphisms. Results. The sex age adjusted odds ratios (aORs) for H. pylori seropositivity were 0.99 for the Sese genotype relative to the SeSe genotype (95%confidence interval , 0.73-1.33), and 1.03 for sese relative to SeSe (95%CI, 0.71-1.48). On the other hand, the aOR for the subjects with the le allele (Lele or lele) relative to the LeLe genotype was 1.48 (95%CI, 1.07-1.79). When the Se and Le genotypes were analyzed in combination according to risk group, no statistically significant association was observed. Conclusions. These results are inconsistent with previous work and may have been modulated by an external factor or some other unidentified factor. Japanese Brazilians are geno typically the same as Japanese, but their lifestyle is adapted to that of Brazil. Further investigations are necessary to clarify this influence on susceptibility to H. pylori infection.

关键词： Lewis Secretor 基因多态性血清阳性胃上皮细胞血型抗原胃黏膜上皮巴西人黏附素胃肠病

维普期刊数据库

Influence of a Program Combining Amusement and Exercise on Subjective Well-Being: Six-month Intervention Study with a Complex-Type Program for Community-Dwelling Elderly Subjects

在线全文

学校读者我要写书评

暂无评论

Open Journal of Preventive medicine 2018年第8期8卷 266-281页

作者： Nami Kawabata Tadayuki Iida Hideki miyaguchi masafumi Kunishige Chinami Ishizuki Hiroko Hashimoto Yasuhiro ito Toshihide Harada Program in Biological System Sciences Graduate School of Comprehensive Scientific Research Prefectural University of Hiroshima Shobara Japan Department of Rehabilitation/Occupational Therapist Faculty of Health Sciences Hiroshima Cosmopolitan University Hiroshima Japan Department of Physical Therapy Faculty of Health and Welfare Prefectural University of Hiroshima Mihara Japan Department of Human Behavior Science of Occupational Therapy Health Sciences Major Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Division of Occupational Therapy Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Occupational Therapy Faculty of Health Sciences Morinomiya University of Medical Sciences Osaka Japan School of Health Sciences Fujita Health University Toyoake Japan

Background: Health promotion for the elderly mainly targets improvements in physical function, and a lack of strengthening of subjective well-being as well as the creation of interaction-providing opportunities for activity and participation has been reported. Evaluations of positive and negative aspects for subjective well-being are needed. Elderly subjects were intervened through a 6-month complex-type program combining amusement and exercise and its influences on subjective well-being and physical and physiological functions were investigated. methods: Subjects in this survey were 37 healthy elderly females living in m city, Hiroshima Prefecture (age: 69.7 ± 5.9 years old), and the survey was performed between September 2016 and march 2017. The complex-type program comprised amusement and exercise programs. The survey was performed at 4 time points during the intervention period: before the intervention and 1, 3, and 6 months during the intervention. Subjective well-being (Japanese version of the Subjective Well-being Inventory (SUBI): mental health scores, mental fatigue scores), salivary amylase levels, and the locomotive syndrome risk test (two-step test, stand-up test, and 25-question risk assessment) were surveyed at each time point. Regarding the duration of the intervention as a factor, changes in salivary amylase levels were analyzed using repeated measures one-way ANOVA and SUBI was tested using the Friedman test (EZR Ver 1.32). In addition, the relationship between the locomotive syndrome risk level and duration of the intervention was examined using Fisher’s test. Results: SUBI and the locomotive syndrome risk level significantly differed with time during the intervention. Slight changes were observed in salivary amylase levels during the intervention. Conclusion: The present results suggest that the complex-type program promoted interactions among community-dwelling elderly subjects and positively influenced the maintenance of and improvements in phys

关键词： Subjective Well-Being SUBI The Elderly Amusement Exercise

Glycemiccontrol and hypoglycemia prevalence in Japanese participants with type 2 diabetes according to body mass index:a sub-analysis of the ALOHA data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glycemiccontrol and hypoglycemia prevalence in Japanese part...

中华医学会糖尿病学分会第十六次全国学术会议

作者： masato Odawara Jay Lin Karim Admane Takayuki ito Tetsuya Ohtani Takashi Kadowaki Department of Diabetology Metabolismand EndocrinologyTokyo Medical University

Objective The aim of this analysis was to determine the reduction in HbA and prevalence of hypoglycemia among Japanese people with type 2 diabetes(T2Dm) receiving treatment with insulin glargine with oral antidiabetic drugs(OADs) according to BmI. methods Patientswith T2Dm requiring insulin therapy with OADs were offered insulin *** Objective The aim of this analysis was to determine the reduction in HbA and prevalence of hypoglycemia among Japanese people with type 2 diabetes(T2Dm) receiving treatment with insulin glargine with oral antidiabetic drugs(OADs) according to BmI. methods Patientswith T2Dm requiring insulin therapy with OADs were offered insulin *** who met the inclusion criteria were observed for 24 weeks in a real-life *** and endpoint glycated hemoglobin Alc(HbAlc),fasting blood glucose(FPG),postprandial plasma glucose(PPG),body weight,and body mass index(BmI) were measured and are presented using summary *** between the cohorts of patients with high(≥25 kg/m ) and low BmI(m ) were compared by using Student’ s t-test or chi-squared test for continuous and categorical variables,respectively. Results BmI was 3=25 kg/m2(mean(SD) 27.2(1.4) kg/m) in 1410 patients and m(21.8(2.2) kg/m) in 2496 *** levels were reduced significantly in both BmI groups(Pm:mean -1.27(1.27)%;m:mean -1.50(1.22)%;PmI achieved a target HbAlc of m:13.2%;m:18.3%;Pmia was low in both groups(≥25 kg/m:0.07%;m :0.12%;P=0.64).A significantly lower dose of insulin glargine was used in the low BmI group(≥25 kg/m: mean 10.31(7.03) U/day);m:mean 8.71(5.27) U/day);Pmen resulted in a significant reduction in FBG and PPG levels and an increase in body

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

红麻原料机械化生产体系的开发

中国麻业科学 2007年第4期29卷 233-236页

作者： m.Suzuki m.ito Y.Sasaki m.Takano Y.Konishi 吕江南

日本新泻县是一个气候温暖,冬季多雪的地区,为了在那里大规模、低成本地种植红麻,我们研发了一个以拖拉机为主要机械的红麻机械化栽培体系。这个体系是在已有的机械化栽培体系基础上开发的,使用这个机械化栽培体系,红麻种植从耕地到收... 详细信息

日本新泻县是一个气候温暖,冬季多雪的地区,为了在那里大规模、低成本地种植红麻,我们研发了一个以拖拉机为主要机械的红麻机械化栽培体系。这个体系是在已有的机械化栽培体系基础上开发的,使用这个机械化栽培体系,红麻种植从耕地到收获的所有作业步骤均可使用机械完成。从1999年开始,我们研究了红麻机械化收获体系使用过程中所遇到的问题,并提出了解决方法。研究结果表明,红麻实行机械化栽培是完全可能的。

关键词：机械化收获生产体系开发原料红麻栽培体系机械化栽培新泻县

维普期刊数据库