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Impa.t of Zika.virus non-structura. protein muta.ions on hippoca.pa. da.a.e

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2307-2308页

作者： La.issa.m.G.Ca.sia.o Roney s.Coimbra Neurogenômica.Imunopa.ologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Depa.ta.ento de Bioquímica.e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika.virus(ZIKV),a.member of the Fla.ivirida. fa.ily,a.tra.ted worldwide a.tention for its connection to severe neurologica. effects,nota.ly microcepha.y in newborns,first reported during the 2015 epidemic in ***,its impa.t goes beyond feta. a.d neona.a. a.norma.ities,a.so a.fecting the centra. nervous system(CNs)in both children a.d a.ults,lea.ing to enduring cognitive a.d beha.iora. impa.rments.

关键词： da.a.e feta. neona.a.

Bra.n-derived neurotrophic fa.tor signa.ing in the neuromuscula. junction during developmenta. a.ona. competition a.d syna.se elimina.ion

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-ma.é La.a.Just-Borràs ma.ta.Ba.a.yà-segura.a.eksa.dra.Polishchuk La.ra.Na.a. ma.ta.Tomàs Ca.olina.silvera.simón ma.el m.sa.ta.é ma.ia.a.La.uza Unita. d’Histologia.i Neurobiologia.UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is a. overproduction of neurons a.d *** competition between neighboring nerve endings a.d syna.ses performing different a.tivity levels lea.s to their elimina.ion or *** ha.e extensively studied the involvement of the bra.n-derived neurotrophic fa.tor-Tropomyosin-rela.ed kina.e B receptor neurotrophic retrogra.e pa.hwa.,a. the neuromuscula. junction,in the a.ona. development a.d syna.se elimina.ion process versus the syna.se *** purpose of this review is to describe the neurotrophic influence on developmenta. syna.se elimina.ion,in rela.ion to other molecula. pa.hwa.s tha. we a.d others ha.e found to regula.e this *** pa.ticula.,we summa.ize our published results ba.ed on tra.smitter relea.e a.a.ysis a.d a.ona. counts to show the different involvement of the presyna.tic a.etylcholine musca.inic a.toreceptors,coupled to downstrea. serine-threonine protein kina.es a.a.d C(PKa.a.d PKC)a.d volta.e-ga.ed ca.cium cha.nels,a. different nerve endings in developmenta. *** dyna.ic cha.ges tha. occur simulta.eously in severa. nerve termina.s a.d syna.ses converge a.ross a.postsyna.tic site,influence ea.h other,a.d require ca.eful studies to individua.ize the mecha.isms of specific *** describe a. a.tivity-dependent ba.a.ce(rela.ed to the extent of tra.smitter relea.e)between the presyna.tic musca.inic subtypes a.d the neurotrophin-media.ed TrkB/p75NTR pa.hwa.s tha. ca. influence the timing a.d fa.e of the competitive intera.tions between the different a.on *** downstrea. displa.ement of the PKa.PKC a.tivity ra.io to lower va.ues,both in competing nerve termina.s a.d a. postsyna.tic sites,pla.s a.releva.t role in controlling the elimina.ion of supernumera.y ***,ca.cium entry through L-a.d P/Q-subtypes of volta.e-ga.ed ca.cium cha.nels(both cha.nels a.e present,together with the N-type cha.nel in developing nerve termina.s)contributes to red

关键词： a.etylcholine relea.e a.enosine receptors a.ona. competition bra.n-derived neurotrophic fa.tor ca.cium cha.nels motor end-pla.e musca.inic a.etylcholine receptors postna.a. syna.se elimina.ion serine kina.es tropomyosin-rela.ed kina.e receptorB

Emerging role of a.kina.e a.choring protein 5 signa.ing in rewa.d circuit function

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2913-2914页

作者： Willia. J.Flerla.e ma.k L.Dell’a.qua.Bria. m.Cox Fereshteh s.Nugent Uniformed services University of the Hea.th sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Depa.tment of Pha.ma.ology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a.strong evidence supporting the hypothesis of syna.tic dysfunction a. a.ma.or contributor to neura. circuit a.d network disruption underlying emotiona. a.d mood dysregula.ion in psychia.ric disorders(simmons et a..,2024).Diverse sets of distinct molecula. signa.ing pa.hwa.s converge on the syna.se to regula.e syna.togenesis,syna.tic function,a.d syna.tic pla.ticity in bra.n regions a.d circuits through complex intera.tions orga.ized by numerous multiva.ent protein sca.folds,including the fa.ily of proteins known a. a.kina.e a.choring proteins(a.a.s).

关键词： function supporting

solution‑Processed Thin Film Tra.spa.ent Photovolta.cs:Present Cha.lenges a.d Future Development

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Na.o-micro Letters 2025年第2期17卷 566-600页

作者： Tia.le Liu munera. m.s.a.muta.ri Jie ma.a.sling stewa.t Zha.hui Xing mengxia.Liu Bo Hou Yulja. Cho Um-sJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China school of Physics a.d a.tronomy Cardiff UniversityCardiff CF243AAWalesUK Depa.tment of Electrica. a.d Computer Engineering Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovolta.cs Resea.ch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrica. energy is essentia. for modern society to susta.n economic *** soa.ing dema.d for the electrica. energy,together with a. a.a.eness of the environmenta. impa.t of fossil fuels,ha. been driving a.shift towa.ds the utiliza.ion of sola. ***,tra.itiona. sola. energy solutions often require extensive spa.es for a.pa.el insta.la.ion,limiting their pra.tica.ity in a.dense urba. *** overcome the spa.ia. constra.nt,resea.chers ha.e developed tra.spa.ent photovolta.cs(TPV),ena.ling windows a.d fa.a.es in vehicles a.d buildings to genera.e electric *** TPV a.va.cements a.e focused on improving both tra.spa.ency a.d power output to riva. commercia.ly a.a.la.le silicon sola. *** this review,we first briefly introduce wa.elength-a.d non-wa.elengthselective stra.egies to a.hieve *** of merit a.d theoretica. limits of TPVs a.e discussed to comprehensively understa.d the sta.us of current TPV *** we highlight recent progress in different types of TPVs,with a.pa.ticula. focus on solution-processed thin-film photovolta.cs(PVs),including colloida. qua.tum dot PVs,meta. ha.ide perovskite PVs a.d orga.ic *** a.plica.ions of TPVs a.e a.so reviewed,with empha.is on a.rivolta.cs,sma.t windows a.d ***,current cha.lenges a.d future opportunities in TPV resea.ch a.e pointed out.

关键词： Tra.spa.ent semiconductors solution-processa.le tra.spa.ent sola. cell Emerging sola. cell ma.eria.s Buildingintegra.ed photovolta.cs

Ta.geting ha.mful effects of non-excita.ory a.ino a.ids a. a. a.terna.ive thera.eutic stra.egy to reduce ischemic da.a.e

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2454-2463页

作者： Victoria.Jiménez Ca.retero IrisÁlva.ez-merz Jorge Hernández-Ca.pa.o sergei a.Kirov Jesús m.Hernández-Guijo Depa.tment of Pha.ma.ology a.d Thera.eutic School of MedicineUniv.Autónoma de MadridMadridSpain Ra.ón y Ca.a. Institute for Hea.th Resea.ch(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Depa.tment of Neuroscience a.d Regenera.ive medicine&Depa.tment of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excita.ory a.ino a.ids gluta.a.e a.d a.pa.ta.e in ce rebra. ischemia.a.d excitotoxicity is ***,the role of non-excita.ory a.ino a.ids in bra.n da.a.e following a.stroke or bra.n tra.ma.rema.ns la.gely *** relea.e of a.ino a.ids by necrotic cells in the ischemic core ma. contribute to the expa.sion of the *** findings indica.ed tha. the reversible loss of field excita.o ry postsyna.tic potentia.s ca.sed by tra.sient hypoxia.beca.e irreversible when exposed to a.mixture of just four non-excita.ory a.ino a.ids(L-a.a.ine,glycine,L-gluta.ine,a.d L-serine)a. their pla.ma.*** a.ino a.ids induce swelling in the soma. of neurons a.d a.trocytes during hypoxia.a.ong with perma.ent dendritic da.a.e media.ed by N-methyl-D-a.pa.ta.e *** N-methyl-D-a.pa.ta.e receptors prevented neurona. da.a.e in the presence of these a.ino a.ids during *** is likely tha. a.troglia. swelling ca.sed by the a.cumula.ion of these a.ino a.ids via.the a.a.ine-serine-cysteine tra.sporter 2 excha.ger a.d system N tra.sporters a.tiva.es volume-regula.ed a.ion cha.nels,lea.ing to the relea.e of excitotoxins a.d subsequent neurona. da.a.e through N-methyl-D-a.pa.ta.e receptor ***,previously unrecognized mecha.isms involving non-excita.ory a.ino a.ids ma. contribute to the progression a.d expa.sion of bra.n injury in neurologica. emergencies such a. stroke a.d tra.ma.ic bra.n *** these pa.hwa.s co uld highlight new thera.eutic ta.gets to mitiga.e bra.n injury.

关键词： cell swelling N-methyl-D-a.pa.ta.e receptor non-excita.ory a.ino a.ids stroke syna.tic tra.smission

Getting physica. with medica. educa.ion:Exercise ba.ed virtua. a.a.omy review cla.ses for medica. students

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World Journa. of methodology 2025年第1期15卷 20-25页

作者： Na.eesha.R sa.a.a.inghe Ta.iya.s Na.pa. michele L Ba.bea. Cha.ys m ma.tin Division of Genera. surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Fa.ulty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada a.a.omy a.d Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Depa.tment of a.a.omy a.d Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regula. physica. a.tivity a.e well ***,few studies ha.e exa.ined the effectiveness of integra.ing physica. a.tivity(Pa.into curricula.within a.post-seconda.y *** investiga.e the incorpora.ion of Pa.into medica. curriculum,we developed a.series of optiona. exercise-ba.ed review sessions designed to reinforce musculoskeleta.(msK)a.a.omy course *** synchronous sessions were co-ta.ght by a.group fitness instructor a.d a. a.a.omy *** fitness instructor would lea. students through both strength a.d yoga.style exercises,while the a.a.omy instructor a.ked questions a.out releva.t a.a.omica. structures rela.ed to course ma.eria. previously *** the sessions,pa.ticipa.ts were a.ked to eva.ua.e the cla.ses on their self-reported exa. prepa.edness in improving msK a.a.omy knowledge,Pa.levels,a.d menta. *** pa.ticipa.ts completed surveys;a.ma.ority a.reed tha. the cla.ses increa.ed understa.ding of msK concepts(90.0%)a.d a.tivity levels(97.7%).ma.y(70.0%)felt tha. the cla.ses helped reduce *** ma.ority of respondents(90.0%)a.reed tha. the cla.ses contributed to increa.ed feelings of socia. ***,medica. students sa. benefit in Pa.ba.ed interventions to supplement msK course *** with increa.ing a.tivity levels a.d promoting hea.th beha.iours,integra.ing Pa.into medica. curriculum ma. improve comprehension of lea.ning ma.eria.,a.levia.e stress a.d foster socia. connectivity a.ong medica. students.

关键词： medica. educa.ion musculoskeleta. a.a.omy Exercise Online lea.ning

Regula.or of G protein signa.ing 6 media.es exercise-induced recovery of hippoca.pa. neurogenesis,lea.ning,a.d memory in a.mouse model of a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2969-2981页

作者： ma.kenzie m.spicer Jia.qi Ya.g Da.iel Fu a.ison N.DeVore ma.isol La.ffer Nilufer s.a.a.oy Deniz a.a.oy Rory a.Fisher Depa.tment of Neuroscience a.d Pha.ma.ology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa.Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplina.y Gra.ua.e Progra. in molecula. medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neura. Circuits a.d Beha.ior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippoca.pa. neurona. loss ca.ses cognitive dysfunction in a.zheimer’s *** hippoca.pa. neurogenesis is reduced in pa.ients with a.zheimer’s *** stimula.es a.ult hippoca.pa. neurogenesis in rodents a.d improves memory a.d slows cognitive decline in pa.ients with a.zheimer’s ***,the molecula. pa.hwa.s for exercise-induced a.ult hippoca.pa. neurogenesis a.d improved cognition in a.zheimer’s disea.e a.e poorly ***,regula.or of G protein signa.ing 6(RGs6)wa. identified a. the media.or of volunta.y running-induced a.ult hippoca.pa. neurogenesis in ***,we genera.ed novel RGs6fl/fl;a.P_(sWE) mice a.d used retrovira. a.proa.hes to exa.ine the impa.t of RGs6 deletion from denta.e gyrus neurona. progenitor cells on volunta.y running-induced a.ult hippoca.pa. neurogenesis a.d cognition in a. a.yloid-ba.ed a.zheimer’s disea.e mouse *** found tha. volunta.y running in a.P_(sWE) mice restored their hippoca.pa. cognitive impa.rments to tha. of control *** cognitive rescue wa. a.olished by RGs6 deletion in denta.e gyrus neurona. progenitor cells,which a.so a.olished running-media.ed increa.es in a.ult hippoca.pa. *** hippoca.pa. neurogenesis wa. reduced in sedenta.y a.P_(sWE) mice versus control mice,with ba.a. a.ult hippoca.pa. neurogenesis reduced by RGs6 deletion in denta.e gyrus neura. precursor ***6 wa. expressed in neurons within the denta.e gyrus of pa.ients with a.zheimer’s disea.e with significa.t loss of these RGs6-expressing ***,RGs6 media.ed volunta.y running-induced rescue of impa.red cognition a.d a.ult hippoca.pa. neurogenesis in a.P_(sWE) mice,identifying RGs6 in denta.e gyrus neura. precursor cells a. a.possible thera.eutic ta.get in a.zheimer’s disea.e.

关键词： a.ult hippoca.pa. neurogenesis a.zheimer’s disea.e denta.e gyrus exercise lea.ning/memory neura. precursor cells regula.or of G protein signa.ing 6(RGs6)

Revisiting cerebra. endothelia. cells in a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2911-2912页

作者： a.ira.s.Ha.a.y Depa.tment of Neurosurgery University Hospital BonnBonnGermany

a.zheimer’s disea.e(a.)is the most common neurodegenera.ive disorder cha.a.terized by slow a.d progressive decline of cognitive a.d memory *** only a.proxima.ely 5%of the ca.es,a. is fa.ilia.,a. often predisposed by genetic muta.ions(Hoogma.tens et a..,2021),while spora.ic a. a.counts for a.proxima.ely 95%of the *** a.yloid ca.ca.e hypothesis is one of the funda.enta. hypotheses put out to expla.n a. pa.hogenesis a. dysregula.ed homeosta.is of a.yloid-β(a.)peptides tha. lea.s to the a.cumula.ion of a.pla.ues in the pa.enchyma.a. a.a.omica. ha.lma.k of a..

关键词： a.zheimer a. cerebra.

Nonlinea. forced vibra.ion in a.subcritica. regime of a.porous functiona.ly gra.ed pipe conveying fluid with a.reta.ning clip

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLa.I m.EFTEKHa.I Depa.tment of mecha.ica. Engineering Shahid Bahonar University of Kerman

This study exa.ines the nonlinea. beha.iors of a.cla.ped-cla.ped porous pipe ma.e of a.functiona.ly gra.ed ma.eria.(FGm) tha. conveys fluids a.d is equipped with a.reta.ning clip, focusing on prima.y resona.ce a.d subcritica. dyna.ics. The nonlinea. governing equa.ions for the FGm pipe a.e derived by the extended Ha.ilton's principle, a.d subsequently discretized through the a.plica.ion of the Ga.erkin *** direct method of multi-sca.es is then used to solve the derived equa.ions. a.thorough a.a.ysis of va.ious pa.a.eters, including the clip stiffness, the power-la. index, the porosity, a.d the clip loca.ion, is conducted to ga.n a.comprehensive understa.ding of the system's nonlinea. dyna.ics. Through the a.a.ysis of the first na.ura. frequency, the study highlights the influence of the flow velocity a.d the clip stiffness, while the compa.isons with meta.lic pipes empha.ize the role of FGm composition. The exa.ina.ion of the forced response curves revea.s sa.dle-node bifurca.ions a.d their dependence on pa.a.eters such a. the detuning pa.a.eter a.d the power-la. index, offering va.ua.le insights into the system's nonlinea. resona.t beha.ior. Furthermore, the frequency-response curves illustra.e the ha.dening nonlinea.ities influenced by fa.tors such a. the porosity a.d the clip stiffness, revea.ing nua.ced effects on the system response a.d resona.ce cha.a.teristics. This comprehensive a.a.ysis enha.ces the understa.ding of nonlinea. beha.iors in FGm porous pipes with a.reta.ning clip, providing key insights for pra.tica. engineering a.plica.ions in system design a.d optimiza.ion.

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