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sBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-sTAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize sBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and sNU-5 GC cells were used for evaluation.Results:sBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. sBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. sBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and sNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in sNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in sNU-5 cells) were observed with sBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight sBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD sBL-JP-0004

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synthesis and evaluation of some novel additives as antioxidants and corrosion inhibitors for petroleum fractions

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Petroleum science 2014年第1期11卷 161-173页

作者： Ahmed El-mekabaty osman m. O. Habib Department of Chemistry Faculty of Science Mansoura University

Benzoxazinone 2 was prepared and reacted with formamide,acetamide,some primary aromatic amines and heterocyclic amines giving the corresponding quinazolone derivatives 3-15 *** reaction of benzoxazinone 2 with hydrazine hydrate and phenyl hydrazine was also *** compounds of the synthesized products were evaluated as antioxidants and corrosion inhibitors for gasoline engine lubricating *** highest antioxidant activities were obtained with compounds *** optimum concentration recommended for these new additives was found to be *** for 1L ofoil for compounds *** addition,some of the highly effective antioxidant additives,namely 10-15,were thermally analyzed by using thermogravimetric analysis （TGA） and differential thermal gravimetric analysis （DTGA） techniques and the results indicated that compounds are thermally stable and could be used under thermal ***,a comparison of the oxidation stability between the tested oil containing the prepared products and lubricating oil containing commercial additives was also studied.

关键词： Benzoxazinone quinazolinone thermal stability antioxidant additives anticorrosive additives

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Frenet Curve Couples in Three Dimensional Lie Groups

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Computer modeling in Engineering & sciences 2022年第12期133卷 653-671页

作者： osman Zeki Okuyucu Department of mathematics Faculty of Science and ArtsBilecik Seyh Edebali UniversityBilecikTurkey

In this study,we examine the possible relations between the Frenet planes of any given two curves in three dimensional Lie groups with left invariant *** explain these possible relations in nine cases and then introdu... 详细信息

关键词： Curves lie groups curvatures Frenet plane

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Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Coronavirus Detection Using Two step-As Clustering and Ensemble Neural Network model

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Computers, materials & Continua 2022年第6期71卷 6307-6331页

作者： Ahmed Hamza osman Department of Information system Faculty of Computing and Information Technology King Abdulaziz University RabighSaudi Arabia

This study presents a model of computer-aided intelligence capable of automatically detecting positive COVID-19 instances for use in regular medical *** proposed model is based on an Ensemble boosting Neural Network architecture and can automatically detect discriminatory features on chestX-ray images through Two step-As clustering algorithm with rich filter families,abstraction and weight-sharing *** contrast to the generally used transformational learning approach,the proposed model was trained before and after *** compilation procedure divides the datasets samples and categories into numerous sub-samples and subcategories and then assigns new group labels to each new group,with each subject group displayed as a distinct *** retrieved characteristics discriminant cases were used to feed the multiple Neural Network method,which was then utilised to classify the *** Two step-As clustering method has been modified by pre-aggregating the dataset before applying multiple Neural Network algorithm to detect COVID-19 cases from chest X-ray *** formultiple Neural Network and Two step-As clustering algorithms were optimised by utilising Ensemble Bootstrap Aggregating algorithm to reduce the number of hyper parameters they *** testswere carried out using theCOVID-19 public radiology database,and a cross-validationmethod ensured *** proposed classifier with an accuracy of 98.02%percent was found to provide the most efficient outcomes *** result is a lowcost,quick and reliable intelligence tool for detecting COVID-19 infection.

关键词： Two step-As clustering ensemble learning bootstrap aggregating multiple neural network covid-19 X-ray images

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the Pubmed database was completed to identify relevant studies published up to march *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Formally Analyzing Expected Time Complexity of Algorithms Using Theorem Proving

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Journal of Computer science & Technology 2010年第6期25卷 1305-1320页

作者： osman Hasan sofiène Tahar Department of Electrical and Computer Engineering Concordia University

Probabilistic techniques are widely used in the analysis of algorithms to estimate the computational complexity of algorithms or a computational ***,such analyses are performed using paper-and-pencil proofs and the results are sometimes validated using simulation *** techniques are informal and thus may result in an inaccurate *** this paper,we propose a formal technique for analyzing the expected time complexity of algorithms using higher-order-logic theorem *** approach calls for mathematically modeling the algorithm along with its inputs,using indicator random variables,in higher-order *** model is then used to formally reason about the expected time complexity of the underlying algorithm in a theorem *** paper includes the higher-order-logic formalization of indicator random variables,which are fundamental to the proposed *** order to illustrate the practical effiectiveness and utilization of the proposed infrastructure,the paper also includes the analysis of algorithms for three well-known problems,i.e.,the hat-check problem,the birthday paradox and the hiring problem.

关键词： formal method higher-order logic probability theory theorem proving birthday paradox hat-check problem hiring problem

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Electronic structure Analysis of UsiO_4

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Communications in Theoretical Physics 2010年第5期53卷 903-906页

作者： osman murat zkendir Faculty of Tarsus Technical Education University of Mersin

Uranium is a member of Actinides and plays important role in nuclear science and technology. Electronicand structural investigations of actinide compounds attract major interest in science. The electronic structure andchemical bonding of coffinite UsiO_4 are investigated by X-ray Absorption Fine structure spectroscopy (XAFs). U L_3-edge absorption spectrum in UsiO_4 is compared with U L_3-edge spectra in UO_2 and UTe due to their different electronicand chemical structures. The study presents XANEs (x-ray Absorption Near-Edge structure) and Extended XAFs(EXAFs) calculations of UsiO_4 thin films. The full multiple scattering approach has been applied to the calculation ofU L_3 edge XANEs spectra of UsiO_4, UO_2 and UTe, based on different choices of one electron potentials according toUranium coordinations by using the real space multiple scattering method FEFF 8.2 code.

关键词： electronic structure X-ray spectra thin-film structure other materials

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Achieving superlubricity in DLC films by controlling bulk, surface, and tribochemistry

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Friction 2014年第2期2卷 140-155页

作者： Ali ERDEmIR osman ERYILmAZ Energy systems Division Argonne National Laboratory9700 S.Cass AvenueArgonneIL 60439USA

superlubricity refers to a sliding regime in which contacting surfaces move over one another without generating much adhesion or friction[1].From a practical application point of view,this will be the most ideal tribological situation for many moving mechanical systems mainly because friction consumes large amounts of energy and causes greenhouse gas emissions[2].superlubric sliding can also improve performance and durability of these *** this paper,we attempt to provide an overview of how controlled or targeted bulk,surface,or tribochemistry can lead to superlubricity in diamond-like carbon(DLC)***,we show that how providing hydrogen into bulk and near surface regions as well as to sliding contact interfaces of DLC films can lead to super-low friction and *** of hydrogen into bulk DLC or near surface regions can be done during deposition or through hydrogen plasma treatment after the *** can also be fed into the sliding contact interfaces of DLCs during tribological testing to reduce *** to favorable tribochemical interactions,these interfaces become very rich in hydrogen and thus provide super-low friction after a brief run-in *** of the method used,when sliding surfaces of DLC films are enriched in hydrogen,they then provide some of the lowest friction coefficients(i.e.,down to 0.001).Time-of-flight secondary ion mass spectrometer(TOF-sIms)is used to gather evidence on the extent and nature of tribochemical interactions with *** on the tribological and surface analytical findings,we provide a mechanistic model for the critical role of hydrogen on superlubricity of DLC films.

关键词： superlubricity diamond-like carbon TOF-sIms test environment lubrication mechanisms

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Estimating the Properties of Ground-Waste-Brick mortars Using DNN and ANN

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Computer modeling in Engineering & sciences 2019年第1期118卷 207-228页

作者： Abdulkadir Karaci Hasbi Yaprak osman Ozkaraca Ilhami Demir osman simsek Department of Computer Engineering Kastamonu UniversityKastamonuTurkey Department of Civil Engineering Kastamonu UniversityKastamonuTurkey Department of Information systems Engineering Mugla Sitki Kocman UniversityTurkey Department of Civil Engineering Kirikkale UniversityKirikkaleTurkey Department of Civil Engineering Gazi UniversityAnkaraTurkey.

In this study,deep-neural-network(DNN)-and artificial-neural-network(ANN)-based models along with regression models have been developed to estimate the pressure,bending and elongation values of ground-brick(GB)-added mortar *** study is aimed at utilizing GB as a mineral additive in concrete in the ratios 0.0%,2.5%,5.0%,7.5%,10.0%,12.5%and 15.0%.In this study,756 mortar samples were produced for 84 different series and were cured in tap water(W),5%sodium sulphate solution(ss5)and 5%ammonium nitrate solution(AN5)for 7 days,28 days,90 days and 180 *** developed DNN models have three inputs and two hidden layers with 20 neurons and one output,whereas the ANN models have three inputs,one output and one hidden layer with 15 ***-five previously obtained experimental sample datasets were used to train these developed models and to generate the regression ***-nine non-training-attributed datasets were used to test the *** these test values were attributed to the trained DNN,ANN and regression models,the brick-dust pressure as well as the bending and elongation values have been observed to be very close to the experimental *** only a small fraction(30%)of the experimental data were used for training,both the models performed the estimation process at a level that was in accordance with the opinions of *** fact that this success has been achieved using very little training data shows that the models have been appropriately *** addition,the DNN models exhibited better performance as compared with that exhibited by the ANN *** regression model is a model whose performance is worst and unacceptable;further,the prediction error is observed to be considerably *** conclusion,ANN-and DNN-based models are practical and effective to estimate these values.

关键词： Deep neural network artificial neural networks ground-brick pressure,bending elongation

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