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multi-solutions with specific geometrical wave structures to a nonlinear evolution equation in the presence of the linear superposition principle

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Communications in Theoretical Physics 2023年第1期75卷 5-14页

作者： Hajar F Ismael Tukur Abdulkadir sulaiman m.s.osman Department of mathematics Faculty of ScienceUniversity of ZakhoZakhoIraq Department of Computer Engineering Biruni UniversityIstanbulTurkey Department of mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt

Lump solutions are one of the most common solutions for nonlinear evolution *** study aspires to investigate the generalized Hietarintatype *** auspiciously provide multiple m-lump *** the other hand,collision phenomena to multiple m-lump waves with soliton wave solutions are also *** the collision,the amplitude of the lump will change significantly over the processes,whereas the amplitude of the soliton will just minimally *** it is of paramount importance,we use suitable values of parameter to put out the physical features of the reported results through three dimensional and contour *** results presented express physical features of lump and lump interaction phenomena of different kinds of nonlinear physical ***,this study serves to enrich nonlinear dynamics and provide insight into how nonlinear waves propagate.

关键词： the generalized Hietarintatype equation m-lump waves interaction phenomena hirota bilinear method

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser mulla Yousef Katib Asim m Almughamsi Duaa s Alkhayat mohamed mosaad samir T Alfotih Rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King salman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNm staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (Os).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in Os among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in Os (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the Os in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and Os (-value = 0.02). CTP class B had the longest survival. BsC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in Os among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for Os were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with Os.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

On dynamical behavior for optical solitons sustained by the perturbed Chen–Lee–Liu model

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Communications in Theoretical Physics 2022年第7期74卷 41-48页

作者： sibel Tarla Karmina K Ali Resat Yilmazer m.s.osman Department of mathematics Faculty of ScienceFirat UniversityElazigTurkey Department of mathematics Faculty of ScienceUniversity of ZakhoZakhoIraq Department of mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt

This study investigates the perturbed Chen–Lee–Liu model that represents the propagation of an optical pulse in plasma and optical *** generalized exponential rational function method is used for this *** a result,we obtain some non-trivial solutions such as the optical singular,periodic,hyperbolic,exponential,trigonometric soliton *** aim to express the pulse propagation of the generated solutions,by taking specific values for the free parameters existed in the obtained *** obtained results show that the generalized exponential rational function technique is applicable,simple and effective to get the solutions of nonlinear engineering and physical ***,the acquired solutions display rich dynamical evolutions that are important in practical applications.

关键词： perturbed Chen-Lee-Liu model generalized exponential rational function method analytical solutions

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

One-pot multicomponent synthesis, spectroscopy, Crystal structures and Theoretical Calculations of 3-Cyano-4-(4-hydroxy-3-methoxyphenyl)-6-phenyl-2(1H)-pyridinone and 3-Cyano-4-chlorophenyl-6-(4-tolyl)-2(1H)-pyridinone

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Chinese Journal of structural Chemistry 2019年第3期38卷 448-463页

作者： mUHAmmAD Nadeem Arshad HAssAN m.Faidallah ABDULLAH m.Asiri osman I.osman FAIsAL m.s.Aqlan Chemistry Department Faculty of Science King Abdulaziz University Centre of Excellence for Advanced materials Research (CEAmR) King Abdulaziz University Department of Chemistry University of Jeddah Department of Chemistry University of IBB

Pyridinone derivatives are of great interest in medicinal chemistry where they were found to be potent to various diseases. Their metal complexes added more value to their applications. Here, we have synthesized two 2-pyridinone derivatives(3-cyano-4-(4-hydroxy-3-methoxyphenyl)-6-phenyl-2(1 H)-pyridinone and 3-cyano-4-chlorophenyl-6-(4-tolyl)-2(1 H)-pyridinone) using one-pot multicomponent system. They were well characterized using spectroscopic techniques like nuclear magnetic resonance(NmR-1 H & 13 C), Fourier transform infrared(FT-IR) and UV/Vis spectroscopy. The final structures were determined using single-crystal X-ray diffraction technique which helps us to determine their geometries. Density functional theory(DFT) and time-dependent density functional theory(TD-DFT) with suitable basis-sets of calculations have correctly simulated these spectroscopic parameters. The intramolecular charge transfer(ICT) of both substrates has been discussed using natural bond orbital(NBO) technique. molecular electrostatic potential(mEP) surfaces showed their reactive locations for intermolecular charge transfer. Compared to p-nitroaniline(pNA), both substrates were shown to have substantial molecular hyperpolarizability.

关键词： crystal structures NBO one-pot multicomponent system 2-pyridinone TD-DFT

Effect of ion and electron beam irradiation on surface morphology and optical properties of PVA

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Nuclear science and Techniques 2015年第6期26卷 74-79页

作者： H.m.Eyssa m.osman s.A.Kandil m.m.Abdelrahman Radiation Chemistry Department National Center for Radiation Research and Technology Atomic Energy Authority (second research reactor) Cyclotron Project Nuclear Research Center Egypitation Atomic Energy Authority Accelerators & Ion sources Dept. Nuclear Research CenterAtomic Energy Authority

Polyvinyl alcohol(PVA) is a well-known friendly polymer for paper-making, textiles, and a variety of coatings, biomedical applications such as artificial pancreas, synthetic vitreous body, wound dressing, artificial skin,and cardiovascular device. In this paper, ion/electron beam is employed to get insight into the irradiation effect on surface morphology and optical properties of PVA polymer. UV-Vis spectra are recorded to investigate the effect of induced defects on the optical band gap and the formed carbon clusters size. scanning electron microscopy(sEm) is used to relate and investigate surface morphology and optical properties of the target polymer with different doses(15, 30 and 60 min). Also, PVA polymer is subjected to theoretical studies by using semi-empirical Pm7 quantum chemical method.

关键词：电子束辐照光学性质表面形貌聚乙烯醇离子扫描电子显微镜乙烯醇聚合物紫外-可见光谱

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong miao michael s.Wolfe Computational medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-Em structures drug design intramembrane proteolysis molecular dynamics Notch

Investigation of soliton solutions with different wave structures to the(2+1)-dimensional Heisenberg ferromagnetic spin chain equation

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Communications in Theoretical Physics 2020年第3期72卷 7-13页

作者： m.s.osman K U Tariq Ahmet Bekir A Elmoasry Nasser s Elazab m Younis mahmoud Abdel-Aty Department of mathematics Faculty of ScienceCairo UniversityGizaEgypt Department of mathematics Faculty of Applied ScienceUmm Alqura UniversityMakkah 21955Saudi Arabia school of mathematics and statistics Huazhong University of Science and TechnologyWuhan 430074China Department of mathematics Mirpur University of Science and TechnologyMirpur(AJK)10250Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey mathematics department College of ScienceMajmaah UniversitySaudi Arabia Punjab University College of Information Technology University of the PunjabLahore 54590Pakistan Department of mathematics Faculty of ScienceSohag UniversitySohagEgypt Applied science University Bahrain

The principal objective of this article is to construct new and further exact soliton solutions of the(2+1)-dimensional Heisenberg ferromagnetic spin chain equation which investigates the nonlinear dynamics of magnets and explains their ordering in ferromagnetic *** solutions are exerted via the new extended FAN sub-equation *** successfully obtain dark,bright,combined bright-dark,combined dark-singular,periodic,periodic singular,and elliptic wave solutions to this equation which are interesting classes of nonlinear excitation presenting spin dynamics in classical and semi-classical continuum Heisenberg systems.3D figures are illustrated under an appropriate selection of *** applied technique is suitable to be used in gaining the exact solutions of most nonlinear partial/fractional differential equations which appear in complex phenomena.

关键词： soliton solutions Heisenberg ferromagnetic equation FAN sub-equation method