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Colonic schistosomiasis mimicking cancer,polyp,and inflammatory bowel disease:Five case reports and review of literature

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 472-482页

作者： Sebhatleab T mulate Abdulsemed m Nur Abel T Tasamma Rodas T Annose Esmael m dawud Kinfe W Ekubazgi Hailemichael D mekonnen Hidaya Y mohammed meron B Hailemeskel Shimelis A Yimer Department of Internal medicine Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Internal medicine Division of Gastroenterology and HepatologyAddis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Internal medicine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 9086Ethiopia Department of Internal medicine Hawassa UniversityHawassa PO Box 05Ethiopia Department of Internal medicine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia Department of Pathology Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Pathology St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia Department of Pathology Ethio Tebib General HospitalAddis Ababa 1111Ethiopia

BACKGROUND Schistosomiasis,officially named as a neglected tropical disease by The World Health Organization,is a serious parasitic disease caused by trematode flukes of the genus *** is a common infectious disease,endemic in more than 78 *** disease can involve various organs and poses far-reaching public health *** SUmmARY Here,we present a series of five patients with variable presentations:an asymptomatic patient who was diagnosed with colonic schistosomiasis upon screening colonoscopy;2 patients with clinical suspicion of colonic cancer;and 2 patients with a clinical diagnosis of inflammatory bowel *** patients were subsequently confirmed to have colonic schistosomiasis after colonoscopy and histopathologic *** clinical manifestations,colonoscopy features and histologic findings of the patients are *** of the patients showed significant clinical improvement following administration of oral *** Intestinal schistosomiasis can present with features mimicking other gastrointestinal *** disease should be a diagnostic consideration in patients who live in or have traveled to endemic areas.

关键词： Schistosomiasis Schistosoma Colon Polyp Ethiopia Case report

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Redesigning crop varieties to win the race between climate change and food security

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molecular Plant 2023年第10期16卷 1590-1611页

作者： Kevin V.Pixley Jill E.Cairns Santiago Lopez-Ridaura Chris O.Ojiewo m.ryam.abba dawud Inoussa Drabo Taye mindaye Baloua Nebie Godfrey Asea Biswanath Das Happy Daudi Haile Desmae Benoit Joseph Batieno Ousmane Boukar Clare T.m.mukankusi Stanley T.Nkalubo Sarah J.Hearne Kanwarpal S.Dhugga Harish Gandhi Sieglinde Snapp Ernesto Adair Zepeda-Villarreal International maize and Wheat Improvement Center(CImmYT) TexcocoMexico International maize and Wheat Improvement Center(CImmYT) HarareZimbabwe International maize and Wheat Improvement Center(CImmYT) NairobiKenya Lake Chad Research Institute(LCRI) MaidiguriNigeria International maize and Wheat Improvement Center(CImmYT) DakarSenegal Ethiopian Institute of Agricultural Research(EIAR) Addis AbabaEthiopia National Agricultural Research Organization(NARO) KampalaUganda Tanzania Agricultural Research Institute(TARI) NaliendeleTanzania Institut de l'Environnement et de Recherches Agricoles(INERA) OuagadougouBurkina Faso International Institute of Tropicl Agriculture(IITA) KanoNigeria Alliance of Bioversity International and CIAT KampalaUganda

Climate change poses daunting challenges to agricultural production and food *** temperatures,shifting weather patterns,and more frequent extreme events have already demonstrated their effects on local,regional,and global agricultural *** varieties that withstand climate-related stresses and are suitable for cultivation in innovative cropping systems will be crucial to maximize risk avoidance,productivity,and profitability under climate-changed *** surveyed 588 expert stakeholders to predict current and novel traits that may be essential for future pearl millet,sorghum,maize,groundnut,cowpea,and common bean varieties,particularly in sub-Saharan *** then review the current progress and prospects for breeding three prioritized future-essential traits for each of these *** predict that most current breeding priorities will remain important,but that rates of genetic gain must increase to keep pace with climate challenges and consumer ***,the predicted future-essential traits include innovative breeding targets that must also be prioritized;for example,(1)optimized rhizosphere microbiome,with benefits for P,N,and water use efficiency,(2)optimized performance across or in specific cropping systems,(3)lower nighttime respiration,(4)improved stover quality,and(5)increased early *** further discuss cutting-edge tools and approaches to discover,validate,and incorporate novel genetic diversity from exotic germplasm into breeding populations with unprecedented precision,accuracy,and *** conclude that the greatest challenge to developing crop varieties to win the race between climate change and food security might be our innovativeness in defining and boldness to breed for the traits of tomorrow.

关键词： climate change food security crop breeding cropping systems expert survey sub-Saharan Africa

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Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains

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Asian Journal of Andrology 2021年第2期23卷 178-187页

作者： Junaid Kashir Bhavesh V mistry maha Adel Gumssani muhammad Rajab Reema Abu-Dawas Falah Almohanna michail Nomikos Celine Jones Raed Abu-dawud Nadya Al-Yacoub Kevin Coward F Anthony Lai Abdullah m Assiri College of medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Comparative medicine King Faisal Specialist Hospital and Research CentreRiyadh 11211Saudi Arabia College of medicine QU HealthQatar UniversityDoha PO Box 2713Qatar Nuffield Department of Women’s and Reproductive Health University of OxfordLevel 3Women’s CentreJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Biomedical Research Centre Qatar UniversityDoha PO Box 2713Qatar

Sperm-specific phospholipase C zeta(PLCζ)initiates intracellular calcium(Ca2+)transients which drive a series of concurrent events collectively termed oocyte *** investigations have linked abrogation and absence/reduction of PLCζwith forms of male infertility in humans where oocyte activation ***,very few studies have examined potential relationships between PLCζand advancing male age,both of which are increasingly considered to be major effectors of male *** efforts in humans may be hindered by inherent PLCζvariability within the human population,alongside a lack of sufficient controllable ***,utilizing immunoblotting,immunofluorescence,and quantitative reverse transcription PCR(qRT-PCR)we examined for the first time PLCζprotein levels and localization patterns in sperm,and PLCζmRNA levels within testes,from mice at 8 weeks,12 weeks,24 weeks,and 36 weeks of age,from two separate strains of mice,C57BL/6(B6;inbred)and CD1(outbred).Collectively,advancing male age generally diminished levels and variability of PLCζprotein and mRNA in sperm and testes,respectively,when both strains were ***,advancing male age altered the predominant pattern of PLCζlocalization in mouse sperm,with younger mice exhibiting predominantly post-acrosomal,and older mice exhibiting both post-acrosomal and acrosomal populations of PLCζ.However,the specific pattern of such decline in levels of protein and mRNA was ***,our results demonstrate a negative relationship between advancing male age and PLCζlevels and localization patterns,indicating that aging male mice from different strains may serve as useful models to investigate PLCζin cases of male infertility and subfertility in humans.

关键词： ageing fertilization male infertility oocyte activation phospholipase C zeta sperm

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Lipid Peroxidation and Some Antioxidant Enzymes Evaluation in Apple Cider Vinegar (ACV) Treated male and Female Wistar Rats Exposed to Chronic Restraint Stress

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Advances in Enzyme Research 2018年第3期6卷 21-28页

作者： R. A. Abdulrauf F. A. dawud N. S. Emmanuel H. D. muhammad A. S. Dange B. A. David A. E. Ogweje A. U. Alexander m. Yahuza Department of Human Physiology Faculty of Basic Medical Sciences College of Health Sciences Ahmadu Bello University Zaria Kaduna State Nigeria

This study was designed to assess the effect to apple cider vinegar (ACV) on oxidative stress biomarkers in male and female Wistar rats exposed to chronic restraint stress. Severe and persistent stress elevates reactive oxygen species (ROS) production by metabolic and physiological processes;causing cellular damage. Thirty (30) Adult Wistar rats of both sexes weighing about 150 - 200 g were divided into 3 groups each consisting of a male and female subgroup and given the following treatments once a day for 21 days: Normal control group received 0.5 ml distilled water orally, the restraint stress (RS) group was exposed to chronic restraint stress 6 hours daily while the Apple cider vinegar (ACV)-treated group received 4 ml/kg of apple cider vinegar orally in addition to chronic restraint stress 6 hours daily. The rats were sacrificed after the experimental period and blood was collected via cardiac puncture for assessing oxidative stress biomarkers. ACV (4 ml/kg) treatment decreased lipid peroxidation (mDA) and serum catalase (CAT) activity while upregulating endogenous superoxide dismutase (SOD) activity. The findings of this study show that the female Wistar rats are more predisposed to the antioxidant effect of ACV than the males.

关键词： Apple Cider Vinegar Superoxide Dismutase malondialdehyde Catalase

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