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World Journal of gastroenterology 2018年第21期24卷 2311-2319页

作者： lászló Szapáry Benedek Tinusz Nelli Farkas Katalin m.rta lajos Szakó Agnes meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra mikó Dezso Csupor Péter Hegyi Balint Eross Institute for Translational medicine Medical SchoolUniversity of PécsPécs 7624Hungary Institute of Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of gastroenterology First Department of MedicineMedical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy Faculty of PharmacyUniversity of SzegedSzeged 6720Hungary

AIm To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal *** A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment *** Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(mD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(mD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SmD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid *** Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research.

关键词： Intralesional steroid meta-analysis Benign refractory esophageal stricture Dilation

Abscisic Acid Connects Phytohormone Signaling with RNA metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self- Controlled RNA Virus

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Plant Communications 2020年第5期1卷 111-128页

作者： Fabio Pasin Hongying Shan Beatriz garcía maren müller David San león m.rta ludman David H.Fresno Károly Fátyol Sergi munné-Bosch Guillermo Rodrigo Juan Antonio garcía Centro Nacional de Biotecnología(CNB-CSIC) 28049 MadridSpain Agricultural Biotechnology Research Center Academia Sinica11529 TaipeiTaiwan Departamento de Biologı´a Evolutiva Ecologı´a y Ciencias AmbientalesFacultad de Biologı´aUniversidad de Barcelona08028 BarcelonaSpain Agricultural Biotechnology Institute National Agricultural Research and Innovation Centre2100 Godoll}oHungary Institute for Integrative Systems Biology(I2SysBio) CSIC-University of Valencia46980 PaternaSpain Present address:College of Horticulture and gardening Tianjin Agricultural University300384 TianjinChina

A complex network of cellular receptors,RNA targeting pathways,and small-molecule signaling provides robust plant immunity and tolerance to *** maximize their fitness,viruses must evolve control mechanisms to balance host immune evasion and plant-damaging *** genus Potyvirus comprises plant viruses characterized by RNA genomes that encode large polyproteins led by the P1 protease.A P1 autoinhibitory domain controls polyprotein processing,the release of a downstream functional RNAsilencing suppressor,and viral ***,we show that P1Pro,a plum pox virus clone that lacks the P1 autoinhibitory domain,triggers complex reprogramming of the host transcriptome and high levels of abscisic acid(ABA)accumulation.A meta-analysis highlighted ABA connections with host pathways known to control RNA stability,turnover,maturation,and *** changes triggered by P1Pro infection or ABA showed similarities in host RNA abundance and *** and hormone treatment assays showed that ABA promotes plant resistance to potyviral ***,quantitative mathematical modeling of viral replication in the presence of defense pathways supported self-control of polyprotein processing kinetics as a viral mechanism that attenuates the magnitude of the host antiviral ***,our findings indicate that ABA is an active player in plant antiviral immunity,which is nonetheless evaded by a self-controlled RNA virus.

关键词： abscisic acid antiviral immune evasion mathematical modeling viral polyprotein processing Potyvirus RNA metabolism

Compared efficacy of preservation solutions on the outcome of liver transplantation:meta-analysis

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World Journal of gastroenterology 2018年第16期24卷 1812-1824页

作者： Agnes lilla Szilágyi Péter mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András garami margit Solymár Erika Pétervári m.rta Balaskó Gábor Veres lászló Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann Institute of Surgical Research University of SzegedSzeged H-6720Hungary Institute of Bioanalysis University of PécsPécs H-7624Hungary Institute for Translational medicine and First Department of medicine University of PécsPécs H-7624Hungary mTA-SZTE Translational gastroenterology Research Group Szeged H-6720Hungary János Szentágothai Research Center University of PécsPécs H-7624Hungary 1^st Department of Paediatrics University of SemmelweisBudapest H-1085Hungary Department of Cardiology 1^st Department of MedicineUniversity of PécsPécs H-7624Hungary

AIm To compare the effects of the four most commonly used preservation solutions on the outcome of liver *** A systematic literature search was performed using mEDlINE, Scopus, EmBASE and the Cochrane library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDl) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges lopez(IGl-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESUlTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGl-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGl-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGl-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGl-1 solutions were associated with nearly equivalent *** Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDls, but further well-designed clinical trials are warranted.

关键词： liver transplantation Preservation solution Primary non-function One-year post-transplant graft survival Systematic review meta-analysis

Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients

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World Journal of gastroenterology 2010年第2期16卷 176-183页

作者： Veronika Csngei luca Járomi EnikSáfrány Csilla Sipeky lili magyari Bernadett Faragó Judit Bene Noémi Polgár lilla lakner Patrícia Sarlós m.rta Varga Béla melegh Department of medical Genetics University of Pécs Department of medicine and gastroenterology Markusovszky Hospital 3rd Department of Internal medicine University of Pécs 3rd Department of medicine and gastroenterology Réthy Pál Hospital

AIm:To investigate the interaction of interleukin-23 receptor(Il23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16l1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. mETHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were *** and specific genotype combinations of a total of eight variants were *** variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and l1007fs rs2066847),ATG16l1(rs2241880)and Il23R (rs1004819,rs2201841)genes were genotyped by PCR-RFlP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESUlTS:The association of ATG16l1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both Il23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;Plogistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that Il23R,ATG16l1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease *** also analysed the specific combina- tions by pair of individual ATG16l1,Il23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk *** almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one *** highest OR was found for Il23R rs2201841 homozygous genotype with combination of positive CARD15 status(PlUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci.

关键词： Gene interaction Interleukin-23 receptor Autophagy-related 16-like 1 IBD5 Caspase recruitment domain-containing protein 15 Crohn’s disease Inflammatory bowel disease

One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis

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World Journal of gastroenterology 2023年第28期29卷 4466-4480页

作者： mahmoud Obeidat Brigitta Teutsch Anett Rancz Edina Tari Katalin m.rta Dániel Sándor Veres Nóra Hosszúfalusi Emese mihály Péter Hegyi Bálint Erőss Centre for Translational medicine Semmelweis UniversityBudapest 1085Hungary Institute for Translational medicine Medical SchoolUniversity of PécsPécs 7623Hungary Department of Internal medicine and Hematology Semmelweis UniversityFaculty of MedicineBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest 1083Hungary Department of Biophysics and Radiation Biology Semmelweis UniversityBudapest 1085Hungary

BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal ***,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal *** To determine the pooled event rates in the available literature and specify them based on the bleeding *** The protocol was registered on PROSPERO in advance(CRD42021283258).A systematic search was performed in three databases(Pubmed,EmBASE,and CENTRAl)on 14^(th) October *** proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by Higgins and Thompson’s I^(2) *** Joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias *** Reference Citation Analysis(https://***/)tool was applied to obtain the latest highlight *** We identified 11589 records,of which 220 studies were eligible for data *** overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal *** proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all *** One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively.

关键词： gastrointestinal bleeding Hemodynamic instability Shock meta-analysis Statistics Review

Body-mass index correlates with severity and m.rtality in acute pancreatitis: A meta-analysis

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World Journal of gastroenterology 2019年第6期25卷 729-743页

作者： Dalma Dobszai Péter mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra mikó lajos Szakó Agnes meczker Roland Hágendorn Katalin m.rta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group Institute for Translational medicine Medical SchoolUniversity of PécsPécs 7624Hungary Clinical medicine Doctoral School University of SzegedSzeged 6720Hungary Institute for Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy University of SzegedSzeged 6720Hungary Division of gastroenterology First Department of MedicineUniversity of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Center University of PécsPécs 7624 Hungary mTA-SZTE momentum Translational gastroenterology Research Group University of SzegedSzeged 6720Hungary 不详

BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BmI) affects the outcome of the *** To quantify the association between subgroups of BmI and the severity and m.rtality of *** A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and meta-Analysis(PRISmA) Protocols. Three databases(Pubmed, EmBASE and the Cochrane library) were searched for articles containing data on BmI, disease severity and m.rtality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(mD) were pooled using the random effects model with the DerSimonian-laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number *** A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BmI. BmI mI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BmI(OR = 2.87, 95%CI: 1.90-4.35, P mportantly,the mean BmI of patients with severe AP is higher than that of the non-severe group(mD = 1.79, 95%CI: 0.89-2.70, P gards m.rtality, death rates among AP patients are the highest in the underweight and obese subgroups. A BmI lmost two-fold increase in risk of m.rtality compared to normal BmI(OR = 1.82, 95%CI: 1.32-2.50, P m.rtality

关键词： Acute pancreatitis Body-mass index Obesity Severity m.rtality Prognostic meta-analysis

Restoration of energy level in the early phase of acute pediatric pancreatitis

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World Journal of gastroenterology 2017年第6期23卷 957-963页

作者： Dóra mosztbacher Nelli Farkas margit Solymár gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin m.rta Alexandra mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky First Department of Pediatrics Semmelweis University Institute for Translational medicine University of Pécs Institute for Bioanalyses University of Pécs Department of gastroenterology First Department of MedicineUniversity of Pécs Department of Translational medicine First Department of MedicineUniversity of Pécs First Department of Surgery Semmelweis University Hungarian Academy of Sciences-University of Szeged Momentum Gastroenterology Multidisciplinary Research Group Heim Pál Children’s Hospital

Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISmA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub med: 131; EmBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better pres

关键词： pediatric pancreatitis enteral nutrition nil per os diet ATP restoration length of hospitalization

Does Surgery Benefit Postmenopausal Overweight Women with Pelvic Floor Dysfunction?

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Open Journal of Therapy and Rehabilitation 2014年第3期2卷 114-119页

作者： m.rta Hock Balázs Domány József Bódis János garai Department of Obstetrics and Gynaecology Faculty of Medicine University of Pécs Pécs Hungary Institute of Pathophysiology and Gerontology Faculty of Medicine University of Pécs Pécs Hungary Institute of Physiotherapy and Sport Sciences Faculty of Health Sciences University of Pécs Pécs Hungary mTA-PTE Human Reproduction Scientific Research Group Pécs Hungary

Introduction: Pelvic floor muscle function of 30 overweight postmenopausal women prior to and after colporrhahpy was monitored in this study. material and methods: Patients diagnosed with cystokele or combined cystorectokele was involved. 1 mg oral estriol and local estriol cream were administered for 30 days preoperatively. Pelvic floor muscle function was monitored by surface electromyography 1 month before (1st) 1 day prior to surgery (2nd), and six weeks after the surgery (3rd measurement). Body composition parameters (intra- and extracellular water and body fat) were also measured. Results: The ability to relax significantly improved (p = 0.03) in the preoperative period (between 1st and 2nd occasions). Six weeks after surgery a non-significant (p = 0.054) decrease in average muscle activity was detected when compared with values obtained before the surgery. muscle-activity declined significantly from the first to the last measurements (p = 0.005). Conclusion: Our results confirm that postmenopausal obese women who undergo anterior or posterior colporrhaphy need a follow-up concerning pelvic floor muscle function and suggest that physiotherapy started the earliest possible may aid in preserving postoperative functionality on the long run.

关键词： Pelvic Floor muscle Function Operative Period Body Composition Postmenopause Obesity

Complications of learning Curve in Supratentorial Intraventricular Region. The Concept of Fast Daily Fresh Cadaver Practice. (Technical Note for Training method)

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Open Journal of modern Neurosurgery 2022年第4期12卷 233-247页

作者： Csókay András Péter Forró Josvai Attila Gergely Csókay Jäckel m.rta Hungarian Deffence Forces medical Center Budapest Hungary Department of maxillofacial Surgery Semmelweis University Budapest Hungary

Background: The difficulty of learning curve in different microsurgical regions is one of the most challenging factors that affect neurosurgeon’s life. Two of the delicate areas are the suprasellar intraventricular and pontocerebellar region. High level of microsurgery or endoscopic surgery requires virtuosity, which can not be learnt only by assisting. Even among the well skilled neurosurgeons who work in big centers we can often hear “in spite of centralization there are not enough operations available to keep the high level of our skills”. The situation of surgeons working at mid centers is more difficult especially on duties. methods: Huge number of scientific articles demonstrate the importance of different types of cadaver practice, but always did not pay enough attention to the daily fast fresh cadaver exercises. Focusing on lifelong every day practice we examined the difficulties of learning curve in intraventricular and pontocerebellar region and try to give some useful advice for practicing on fresh cadavers on a daily basis. We offer a simple endovascular fresh cadaver model for practicing. Results: We have performed more than 800 quick (60 - 90 minutes long) routine practice sessions in these two regions during last 18 years. We found that implantation a modelized pathology and removing it by microscopical or endoscopic way without causing injuries to sensitive structures seems to be the most practical way of fast everyday training. Nerves and vascular bypass sutures are also excellent practical method. Conclusions: We have focused on daily fast fresh cadaver practice as a novel training method like used in professional sport and art. After 18 years experience we can state that, for mastering the microsurgery of pontocerebellar and intraventricular region, which is one of the most challenging regions minimum 100 fresh cadaver practice sessions need before performing the operation. We believe this region should be part of fast fresh cadaver microsurgical

关键词： Cadaver Practice Fresh Cadaver Practice Neurosurgical Training Endovascular Training