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Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+strains:An immunohistochemical study

引用

World Journal of Gastroenterology 2006年第12期12卷 1865-1873页

作者： Vera Todorovic Neda Drndarevic Olivera mitrovic Institutefor medicalResearch Aleksandra sokic-milutinovic Tomica milosavljevic marjan micev Ivan Nikolic Thomas Wex Peter malfertheiner Institute for medical Research Department for Immunohistochemistry and Electron MicroscopyBelgradeSerbia and Montenegro Clinic for Gastroenterology and Hepatology Institute for Digestive DiseasesClinical Center of SerbiaBelgradeSerbia and Montenegro Pathology Department Institute for Digestive DiseasesClinical Center of SerbiaBelgradeSerbia and Montenegro Institute of Histology and Embryology Faculty of MedicineUniversity of NisSerbia and Montenegro Clinic for Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke UniversityMagdeburgGermany

AIm： To investigate the expression of different cytokeratins （CKs） in gastric epithelium of adult patients with chronic gastritis infected with Helicobacter pylori （H pylon） cagA ＋ strains. mETHODS： The expression of CK 7, 8, 18, 19 and 20 was studied immunohistochemically in antral gastric biopsies of 84 patients. All the CKs were immunostained in cagA＋Hpylori gastritis （57 cases）, non-Hpylori gastritis （17 cases） and normal gastric mucosa （10 cases）. RESULTS： In cagA＋ H pylori gastritis, CK8 was expressed comparably to the normal antral mucosa from surface epithelium to deep glands. Distribution of CK18 and CK 19 was unchanged, i.e. transmucosal, but intensity of the expression was different in foveolar region in comparison to normal gastric mucosa. Cytokeratin 18 immunoreactivity was significantly higher in the foveolar epithelium of H pylori-positive gastritis compared to both Hpylori-negative gastritis and controls. On the contrary, decrease in CK19 immunoreactivity occurred in foveolar epithelium of H pylori-positive gastritis. In both normal and inflamed antral mucosa without Hpyloriinfection, CK20 was expressed stronglyl moderately and homogenously in surface epithelium and upper foveolar region, but in H pylod -induced gastritis significant decrease of expression in foveolar region was noted. Generally, in both normal antral mucosa and H pylori-negative gastritis, expression of CK7 was not observed, while in about half cagA＋ H pylori-infected patients, moderate focal CK7 immunoreactivity of the neck and coiled gland areas was registered, especially in areas with more severe inflammatory infiltrate. CONCLUSION： Alterations in expression of CK 7, 18, 19 and 20 together with normal expression of CK8 occur in antral mucosa of H pylori-associated chronic gastritis in adult patients infected with cagA＋ strains. Alterations in different cytokeratins expression might contribute to weakening of epithelial tight junctions observed in H pylori-infected gastric m

关键词： cytokeratin 7 cytokeratin 8 cytokeratin18 cytokeratin19 cytokeratin20 Helicobacter pylori Gastritis CagA

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