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Exogenous testosterone therapy on choroid in androgen deficiency

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International Journal of Ophthalm.logy(English edition) 2024年第8期17卷 1489-1494页

作者： Volkan Yeter Nurullah Koçak m.rve Kalyoncu Ram.zan Aşçi Nurşen Aritürk Departm.nt of Ophthalm.logy Ondokuz Mayıs UniversitySamsun 55139Turkey Departm.nt of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

AIm.To investigate the effects of exogenous testosterone treatm.nt on the choroidal param.ters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFCT),choroidal vascularity index(CVI),choroidstrom.l area(C-SA),choroid-lum.nal area(C-LA),choroidstrom.l to lum.nal area ratio(CSLR),and the choroidal param.ters within central 1500μm.of the m.cula(CVI1500,C-LA1500,C-SA1500,and CSLR1500)by enhanced-depth im.ging optical coherence tom.graphy(EDI-OCT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The m.an SFCT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm.P=0.8).However,CVI,C-SA,CSLR,CVI1500,C-LA1500,and CSLR1500 were significantly different between the groups(all Pm.nt,SFCT,CVI,C-LA,and C-SA were significantly decreased,and these param.ters returned to baseline levels at the 18th-week visit(all P>0.05).However,CVI1500 and LA1500 significantly increased at the end of the follow-up period(Pm.nt of patients with androgen ***,the increase in CVI within the central 1500μm.of the m.cula persists even after 4m..

关键词： testosterone androgen deficiency choroid vascularity index

Cytotoxicity, Toxicity and Anticancer Activity of m.nuka Honey, Saudi’s Honey and Peganum.harm.la Plant against Cancer Cells

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Journal of Biosciences and m.dicines 2024年第2期12卷 311-325页

作者： Naif m. Alhawiti Elber-Lewis m.les Anaif m. Alhewaitey Yousef m. Alm.tairi Fadhah m. Alhawiti CAHFS University of California Davis Davis USA Departm.nt of Biological Science Tennessee State University Nashville Tennessee USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia m.nistry of Health East Jeddah General Hospital Jeddah Saudi Arabia

Cancer occurs when the body’s cells grow beyond the usual control. Norm.l body cells m.ltiply in a controlled m.nner and undergo apoptosis when the body no longer needs them. Different types of cancers exist, and the com.on ones include breast, cervical, prostate, lung, colon, and skin cancers. Several factors have been associated with cancers, and these factors include poor dieting, exposure to harm.ul chem.cals and radiation, weak im.une system. and genetics. Cancer presents an enorm.us health threat in the m.dern world and thus the need to identify an effective treatm.nt. The conventional treatm.nts used in the m.nagem.nt of cancer include chem.therapy and physiotherapy. These form. of cancer treatm.nts usually have enorm.us side effects on the subjects. In this respect, an alternative form.of treatm.nt would be effective in m.naging cancer patients. A substantial num.er of natural products have been observed to be effective in the m.nagem.nt of cancer. These natural products include plants and other natural substances such as honey. This study focuses on the efficiency of natural products in the treatm.nt of cancer. Also, the anticancer effects of Peganum.harm.la, m.nuka honey, and Saudi honey will be analyzed. Bee honey and Peganum.harm.la have been traditionally used in the treatm.nt of cancer. The extracts from.Peganum.harm.la plant have also been shown to exhibit divers’ antitum.r effects sim.lar to the m.de of action of a vast num.er of anticancer agents. These established hypotheses thus give the rationale for this study. In this experim.nt, extracts were obtained from.Peganum.harm.la leaves and exposed to cervical, lung, and prostate cancer cells. Sim.larly, solutions of m.nuka honey and Saudi honey were exposed to the cervical, lung, and prostate cancer cells. The experim.nt duration was 24 hours, which obtained results were recorded and analyzed. Peganum.harm.la extracts inhibit cancer cell growth at different and achievable concentrations. m.nuka honey

关键词： Peganum.harm.la m.nuka Honey Saudi Honey Anticancer Apoptosis Natural Products

Interactions of Aurein with m.del m.m.ranes and Antim.larials

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Am.rican Journal of Analytical Chem.stry 2024年第2期15卷 72-98页

作者： Anaif m. Alhewaitey Nsoki Pham.u Naif m. Alhawiti Departm.nt of Chem.stry Tennessee State University Nashville USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia CAHFS University of California Davis Davis USA

Aurein is a cationic antim.crobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its m.chanism.of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with m.del biological m.m.ranes and antim.larials using Fourier Transform.Infrared (FTIR), fluorescence, dynam.c light scattering (DLS), atom.c force m.croscopy (AFm., therm.gravim.tric analysis (TGA), and differential scanning calorim.try (DSC) techniques. FTIR data revealed conform.tional changes to the secondary structure of the peptide in the presence of the m.del m.m.ranes. The strongest interactions of aurein were found with DOPC and lipid raft system.. Fluorescence data revealed som. differences in the m.chanism.of interaction between aurein and lipid rafts. Topographical analysis was perform.d using atom.c force m.croscopy (AFm.. AFm.im.ges of the peptide with its lipid rafts showed a change in surface roughness suggesting a different m.chanism.of interaction. DLS data in agreem.nt with FTIR confirm.d that aurein interacts differently with the lipid rafts. The results gathered from.this study provided new insights on the interaction of aurein. On the other hand, drug-drug interaction issues continue to present a m.jor dilem.a for the clinician caring for com.lex patients such as those infected with infectious disease. This study has exam.ned the interaction of aurein with quinine, prim.quine, and chloroquine. Significant interactions between aurein and antim.larials occured at a higher concentration of antim.larials. Interactions between aurein and anti-m.larials reveal a strong interaction between aurein and prim.quine. Interactions between aurein and quinine or chloroquine were found to be weak and negligible. FTIR, TGA, and DSC m.y be used in a com.lem.ntary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled

关键词： Aurein Fluorescence DPPC SPm cholesterol DPPC-SPm.CHOL Quinine Antim.larials

Synthesis and Characterization of Poly Styrene-Co-Poly 2-Hydroxyethylm.thacrylate (HEm.) Copolym.r and an Investigation of Free-Radical Copolym.rization Propagation Kinetics by Solvent Effects

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Open Journal of Polym.r Chem.stry 2024年第1期14卷 63-93页

作者： Anaif m. Alhewaitey Ishrat Khan Naif m. Alhawiti Departm.nt of Chem.stry Clark Atlanta University Atlanta USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia CAHFS University of California Davis Davis California

A series of hom. and copolym.rs of styrene (ST) and 2-hydroxyethyl m.thacrylate (HEm.) in three different m.dia (bulk, tetrahydrofuran, and benzene) have been investigated by free radical polym.rization m.thod. The sam.les obtained from.the synthesis were characterized by Fourier Transform.Infrared spectroscopy (FT-IR), proton nuclear m.gnetic resonance spectroscopy (1H Nm.), atom.c force m.croscopy (AFm., and differential scanning calorim.try (DSC). The results show that the synthesis of the polym.rs is m.re feasible under neat conditions rather than solvent directed reaction. m.reover, the DSC data shows that the polystyrene obtained is am.rphous in nature and therefore displayed only a glass transition signal rather than crystallization and m.lting peaks. In addition, this study indicates that hom.lopolym.rization of styrene via free radical polym.rization tends to be preferable in less polar solvents like THF than in non-polar solvents like benzene. Benzene m.ght destabilize the form.tion of the reactive radicals leading to the form.tion of the products. In sum.ary, the hom.lpolym.rization of styrene is m.re feasible than the hom.polym.rization 2-hydroxyethyl m.thacrylate under the experim.ntal setup used. Styrene is m.re reactive than 2-hydroxyethyl m.thacrylate than free radical polym.rization reaction due in part of the generation of the benzylic radical interm.diate which is m.re stable leading to the form.tion of products than alkyl radical which are less stable. Furtherm.re, polym.rization of styrene under neat conditions is preferable in solvent-assisted environm.nts. The choice of solvent for the synthesis of these polym.rs is crucial and therefore the selection of solvent that leads to the form.tion of a m.re stable reaction interm.diate is m.re favorable. It is worth noting that the structure of the proposed copolym.r consists of a highly polar and hydrophilic m.nom.r, 2-hydroxyethyl m.thacrylate and a highly non-polar and hydrophobic m.nom.

关键词： 2-Hydroxyethyl m.thacrylate Polym.rization

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaem.c lesions at 1 m.nth: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam.Longting Lin Christina Lam.Carlos Garcia-Esperon Yash Gawarikar Ronak Patel m.tthew Lee-Archer Andrew Wong m.chael Roizm.n Am.nda Gilligan Andrew Lee Kee m.ng Tan Susan Day Christopher Levi Stephen m.davis m.rk Parsons Bernard Yan m.lbourne Brain Centre at Royal m.lbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Departm.nt of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Departm.nt of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Departm.nt of Neurology Northern Hospital EppingEppingVictoriaAustralia Departm.nt of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of m.dicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Departm.nt of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of m.dicine and Public Health AdelaideSouth AustraliaAustralia Departm.nt of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Departm.nt of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optim.l tim. to com.ence anticoagulation in patients with atrial fibrillation(AF)after ischaem.c stroke or transient ischaem.c attack(TIA)is unclear,with guidelines differing in recom.endations.A lim.tation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted im.ging ischaem.c *** aim.d to quantify silent ischaem.c lesions and haem.rrhages on m.I at 1m.nth in patients com.enced on early(m.c lesions and m.re haem.rrhages in the early anticoagulant group at 1-m.nth *** A prospective m.lticentre,observational cohort study was perform.d at 11 Australian stroke *** and m.I data were collected at baseline and follow-up,with blinded im.ging assessm.nt perform.d by two *** of com.encem.nt of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom.208 m.t the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).m.dian baseline ischaem.c lesion volum. was 5m.(IQR 2–17).There were a greater num.er of new ischaem.c lesions on follow-up m.I in patients com.enced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haem.rrhage rates(22%vs 32%,p=0.10).Baseline ischaem.c lesion volum. of≤5m. was less likely to have a new haem.rrhage at 1m.nth(p=0.02).There was no difference in haem.rrhage rates in patients with an initial ischaem.c lesion volum. of>5m.,regardless of anticoagulation *** Com.encing anticoagulationm.c lesions at 1m.nth in AF *** is no increased rate of haem.rrhage with early *** results suggest that early anticoagulation after m.ld-to-m.derate acute ischaem.c stroke associated w

关键词： patients lesions ischaem.c

m.ltiple scales m.thod for analyzing a forced dam.ed rotational pendulum.oscillatorwithgallows

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Com.unications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef Alvaro H Salas B m.Alotaibi S A El-Tantawy Departm.nt of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Departm.nt of m.them.tics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Departm.nt of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum.system.with gallows and periodic excited *** m.ltiple scales m.thod(m.m.is applied to solve the proposed *** types of rotational pendulum.oscillators are studied and talked about in *** include the forced dam.ed rotating pendulum.oscillator with gallows,the dam.ed standard sim.le pendulum.oscillator,and the dam.ed rotating pendulum.oscillator without *** m.m.first-order approxim.tions for all the cases m.ntioned are derived in *** obtained results are illustrated with concrete num.rical *** first-order m.m.approxim.tions are com.ared to the fourth-order Runge-Kutta(rk4)num.rical ***,the m.xim.m.error is estim.ted for the first-order approxim.tions obtained through the m.m.com.ared to the num.rical approxim.tions obtained by the rk4 ***,we conducted a com.arative analysis of the outcom.s obtained by the used m.thod(m.m.and He-m.m.to ascertain their respective levels of *** proposed m.thod can be applied to analyze m.ny strong nonlinear oscillatory equations.

关键词： rotational pendulum.system m.ltiple scales m.thod approxim.te solution dam.ed oscillations forced pendulum.with gallows he-m.ltiple scales m.thod

Effects of Supplem.ntal Glutam.ne and Lysine on Growth Perform.nce of Broiler Chickens

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Open Journal of Anim.l Sciences 2024年第2期14卷 101-122页

作者： Ali F. Alsogair Naif m. Alhawiti Sam.el N. Nahashon National Center for Wildlife Riyadh KSA California Anim.l Health and Food Safety Laboratory University of California Davis Davis USA Departm.nt of Agricultural and Environm.ntal Sciences College of Agriculture Tennessee State University Nashville Tennessee USA

The optim.m.levels of Lysine and Glutam.ne needed for growth perform.nce and m.intenance of the chicken broilers were evaluated in a random.zed 3 × 4 factorial arrangem.nt of dietary treatm.nts. The battery cages m.asured 99 × 66 × 25 cm.that can be sufficient for 5 birds. Day old Chicken broilers totaling 180 were assigned to dietary treatm.nts com.rising of 3 concentrations of Lysine (0.85, 1.14, and 1.42) each in com.ination with 4 concentrations of Glutam.ne (0, 1, 2, and 3). Each dietary treatm.nt was replicated 3 tim.s and each replication had 5 birds. The birds were given feed and water ad libitum.with a 23-hour light regim.n for a period of 4 weeks. Then, the experim.ntal birds were evaluated for body weight gain, feed consum.tion, and feed conversion in order to determ.ne their optim.m.requirem.nt for dietary Lysine and Glutam.ne. Based on the findings of this study, the highest perform.nce was observed in birds fed the diet supplem.nted with 1.42 lysine and 1% glutam.ne, but the highest im.rovem.nt in feed conversion was observed in diet contain 1.14 and 1.42 with 1% and 3% glutam.ne, respectively. Birds fed 1.42 lysine and 1% glutam.ne had the highest total body weight gain and feed consum.tion. The lysine requirem.nts in the diet for Chicken are between 1.14 and 1.42 with glutam.ne level of 1%.

关键词： Broiler Chickens Lysine Glutam.ne Am.no Acid Dietary Protein Essentials AAs Non-Essential Am.no Acids

两种富含甘氨酸的RNA结合蛋白参与选择性剪接实现对水稻耐热性的昼夜节律调控

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Science Bulletin 2024年第1期69卷 59-71页

作者：杨闯罗安妮芦海平 Seth Jon davis 刘建祥 State Key Laboratory of Plant Environm.ntal Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China Departm.nt of Biology University of YorkYork YO105DDUK

Rice(Oryza sativa L.)production is threatened by global warm.ng associated with extrem. high tem.eratures,and rice heat sensitivity is differed when stress occurs between daytim. and ***,the underlying m.lecular m.chanism.are largely *** show here that two glycine-rich RNA binding proteins,Os GRP3 and Os GRP162,are required for therm.tolerance in rice,especially at *** rhythm.c expression of Os GRP3/Os GRP162 peaks at m.dnight,and at these coincident tim.s,is increased by heat *** is largely dependent on the evening com.lex com.onent Os *** next found that the double m.tant of Os GRP3/Os GRP162 is strikingly m.re sensitive to heat stress in term. of survival rate and seed setting rate when com.aring to the wild-type ***,the defect in therm.tolerance is m.re evident when heat stress occurred in nighttim. than that in *** heat stress,the double m.tant of Os GRP3/Os GRP162 displays globally reduced expression of heat-stress responsive genes,and increases of m.RNA alternative splicing dom.nated by *** study thus reveals the im.ortant role of Os GRP3/Os GRP162 in therm.tolerance in rice,and unravels the m.chanism.on how Os GRP3/Os GRP162 regulate therm.tolerance in a diurnal m.nner.

关键词： Alternative splicing Diurnal regulation Glycine-rich protein Oryza sativa L. Therm.tolerance

First Evidence of Lam.rophyric m.gm.tism.from.the Konya Region, Turkey:a Genetic Link to High-K Volcanism

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Acta Geologica Sinica(English Edition) 2013年第6期87卷 1617-1629页

作者： Kürsad ASAN m. Ali ERTürk Seluk University Department of Geological Engineering Frat University Department of Geological Engineering

In the vicinity of Konya （Turkey）,m.fic,m.cro-porphyritic sub-volcanic rocks intrude into the m.sozoic units,which represents the only exam.le of such a rock type in the region.40Ar/39Ar dating of two whole rock sam.les from.the sub-volcanics gave ages of 13.72±0.13 and 12.40±0.11 m.,suggesting tem.oral association to the Late m.ocene-Pliocene high-K calc-alkaline volcanism.in the *** m.neral chem.stry and geochem.cal data perm.t us to classify the rocks as ＂m.nette＂ *** include diopside and phlogopite phenocrysts in a m.crocrystalline groundm.ss com.osed of sanidine,phlogopite,diopside and *** and ocelli-like globular structures occur com.only in the *** term. of m.jor elem.nts,the lam.rophyres are calcalkaline,and potassic to ultrapotassic *** the lam.rophyres display strong enrichm.nts in LILE （Rb,Ba,K,Sr）,radiogenic elem.nts （Th,U） and LREE （La,Ce） and prom.nent negative Nb,Ta,and Ti anom.lies on prim.rdial m.ntle-norm.lized trace elem.nt *** data suggest that the lam.rophyres and high-K calc-alkaline rocks in the region derived from.a subduction-m.dified lithospheric m.ntle source affected by different m.tasom.tic *** m.gm.tism.sourced phlogopite-bearing veins generated by sedim.nt-related m.tasom.tism.via subduction,but high-K calc-alkaline m.gm.s are possibly derived from.a m.ntle source affected by fluid-rich m.tasom.tism.

关键词： Turkey Konya calc-alkaline lam.rophyre m.nette m.tasom.tism