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Exogenous testosterone therapy on choroid in androgen deficiency

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1489-1494页

作者： Volkan Yeter Nurullah Koçak merve Kalyoncu Ramazan Aşçi Nurşen Aritürk Department of Ophthalmology Ondokuz Mayıs UniversitySamsun 55139Turkey Department of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

AIm:To investigate the effects of exogenous testosterone treatment on the choroidal parameters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFCT),choroidal vascularity index(CVI),choroidstromal area(C-sa),choroid-luminal area(C-LA),choroidstromal to luminal area ratio(CSLR),and the choroidal parameters within central 1500μm of the macula(CVI1500,C-LA1500,C-sa1500,and CSLR1500)by enhanced-depth imaging optical coherence tomography(EDI-OCT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The mean SFCT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm(P=0.8).However,CVI,C-sa,CSLR,CVI1500,C-LA1500,and CSLR1500 were significantly different between the groups(all Pment,SFCT,CVI,C-LA,and C-sa were significantly decreased,and these parameters returned to baseline levels at the 18th-week visit(all P>0.05).However,CVI1500 and LA1500 significantly increased at the end of the follow-up period(Pment of patients with androgen ***,the increase in CVI within the central 1500μm of the macula persists even after 4mo.

关键词： testosterone androgen deficiency choroid vascularity index

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用于BOF过程中动态终点控制的新取样方式和分析方法(英文)

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冶金分析 2006年第5期26卷 8-15页

作者： m.Wauters V.Tusset J.Knevels R.meilland Thomas Bjrk A.Bengston Centrum of Research in metallurgy LiègeBelgium Heraeus-Electronite HouthalenBelgium Arcelor Research sa Maizières les MetzFrance Korrosions-och metallforskningsinstitutet StockholmSweden

为了实现缩短出钢时间从而提高碱性氧气转炉(BOF)的生产效率,与熔融分析控制相关的过程如停吹、提枪或倾炉都要避免。为了达到这个目标,建立了一种用于控制BOF过程的新方法。该方法采用了一种新颖的、可在吹炼过程中进行炉渣和钢同时收... 详细信息

为了实现缩短出钢时间从而提高碱性氧气转炉(BOF)的生产效率,与熔融分析控制相关的过程如停吹、提枪或倾炉都要避免。为了达到这个目标,建立了一种用于控制BOF过程的新方法。该方法采用了一种新颖的、可在吹炼过程中进行炉渣和钢同时收集的非均相取样器,并应用了为此专门设计的激光分析方法(LIBS)。使用该方法,目标是尽可能快地完成非均相取样器收集的炉渣和钢的分析(Fe,C,P,S等元素)。除了建立非均相临线取样方法外,还建立了一种基于LIBS的特殊分析程序,当分析过程中移动非均相样品时,用于识别来自炉渣和钢的激光光束。与冶金模型相结合,由非均相取样器得来的数据经过处理后,可动态评价精炼进展状况并规定矫正行为,从而实现安全直接的出钢。预期的效益在于减少再吹炼的比率、节省出钢时间(预计每炉能缩短23min),同时延长耐火炉衬的寿命,提高生产产量。

关键词：碱性氧气顶吹转炉动态终点控制取样 LIBS

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Sequential treatment with doxorubicin and zoledronic acid has no additive effects in an aggressive model of established bone metastases

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Journal of Cancer metastasis and Treatment 2019年第2期4卷 87-99页

作者： mari I.Suominen Rami Käkönen Jukka P.Rissanen Jussi m.HaIIeen Pirkko Härkönen sanna-maria Käkönen Pharmatest Services Ltd. Turku FI-20520Finland Aurexel Life Sciences Ltd. Askainen FI-21240Finland PreclinApps Ltd. Raisio FI-21200Finland Institute of Biomedicine University of TurkuTurku 20520Finland

Aim: Bisphosphonates are used as an adjuvant treatment in breast cancer bone metastasis patients, often simultaneously with chemotherapeutic agents. Interestingly, their sequential combination has been reported to have synergistic anti-tumor effects on bone metastases in preclinical models. We studied the effects of doxorubicin (DOX) and zoledronic acid (ZOL) and their combination on established bone metastases in the mDA-mB-231(sa) GFP bone metastasis model. methods: Tumor burden and osteolytic bone lesions were quantitated by fluorescence imaging and radiography, respectively. The mice were randomized in four groups receiving vehicle, DOX, ZOL or both DOX and ZOL in a sequential combination on day 14. Serum m.rker of osteoclast number was followed weekly, and blood ionized calcium was measured at sacrifice. Bone and tumor area, apoptosis and proliferation of tumor cells were analyzed from histological sections. Results: ZOL prevented hypercalcemia and osteolytic lesion progression, whereas DOX induced apoptosis in the mDA-mB-231(sa)GFP cells. However, neither of the treatments alone nor in sequential combination were able to reduce tumor burden in bone. Furthermore, no additive effects on tumor cell apoptosis were observed in the ;combination group. Conclusion: No additive effects in combination of DOX and ZOL were observed in this aggressive model of breast cancer bone metastasis.

关键词： Combination treatment breast cancer bone metastasis mDA-mB-231(sa) doxorubicin zoledronic acid

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