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Combining the age-male-albumin-bilirubin-platelets score and shear wave elastography stratifies carcinogenic risk in hepatitis C patients after viral clearance

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World Journal of Clinical Cases 2023年第22期11卷 5204-5214页

作者： rion masaoka Yoshinori Gyotoku Ryosaku Shirahashi Toshikuni Suda masaya Tamano Department of Gastroenterology Dokkyo Medical University Saitama Medical CenterKoshigaya 343-8555SaitamaJapan

BACKGROUND The treatment of hepatitis C with direct-acting antiviral agents(DAAs)produces a high rate of sustained virological response(SVR)with fewer adverse events than interferon(IFN)therapy with a similar effect in inhibiting carcinogenesis as IFN *** age-male-albumin-bilirubin-platelets(amAP)score is useful for stratifying the risk of hepatocellular carcinoma in chronic hepatitis patients,and the velocity of shear waves(Vs)measured by shear wave elastography has also been shown to be useful for diagnosing the level of fibrotic progression in hepatitis C and predicting carcinogenic *** these two may improve the prediction of carcinogenic *** To determine whether combining the amAP score with Vs improves carcinogenic risk stratification in medium-to-high-risk hepatitis C *** This retrospective,observational study involved hepatitis C patients treated with DAAs who achieved *** was measured before treatment(baseline),at the end of treatment(EOT),and 12 wk(follow-up 12)and 24 wk(follow-up 24)after *** patients were followed for at least six months after EOT to determine whether cancer *** regression analysis was used to identify factors contributing to hepatic *** diagnostic performances of clinical parameters for predicting the presence of hepatocellular carcinoma were evaluated using receiver-operating characteristic(ROC)curve *** A total of 279 patients(mean age 65.9 years,118 males,161 females)were included in the *** regression analysis was performed with carcinogenesis as the target variable and alanine aminotransferase,platelets,α-fetoprotein,Vs,and the Fib-4 index as explanatory variables;only Vs was found to be significant(P=0.0296).The cut-off value for Vs for liver carcinogenesis calculated using the ROC curve was 1.53 m/*** developed in 2.0%(3/151)of those with Vsm/s and in 10.5%(9/86)of those with Vs≥1.53 m/*** In hepatitis

关键词： Hepatitis C Hepatocellular carcinoma Direct-acting antiviral therapy Shear wave elastography Sustained virological response Age-male-albumin-bilirubin-platelets score

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Differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review

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World Journal of Gastroenterology 2020年第30期26卷 4537-4556页

作者： mohid S Khan Thomas Walter Amy Buchanan-Hughes Emma Worthington Lucie Keeber m.rion feuilly Enrique Grande Department of Gastroenterology and Neuroendocrine Tumours University Hospital of WalesCardiff CF144XWUnited Kingdom Department d'Oncologie médicale Hospices Civils de LyonLyon 69003France Evidence Development Costello MedicalCambridge CB12JHUnited Kingdom medical Affairs IpsenSlough SL13XEUnited Kingdom Health Economics and Outcomes Research IpsenBoulogne-Billancourt 92100France Oncology Department MD Anderson Cancer CenterMadrid 28033Spain

BACKGROUND Approximately 20%of patients with neuroendocrine tumours(NETs)develop carcinoid syndrome(CS),characterised by flushing and *** analogues or telotristat can be used to control symptoms of CS through inhibition of serotonin *** CS is often the cause of diarrhoea among patients with gastroenteropancreatic NETs(GEP-NETs),other causes to consider include pancreatic enzyme insufficiency(PEI),bile acid malabsorption and small intestinal bacterial *** other causes of diarrhoea unrelated to serotonin secretion are mistaken for CS diarrhoea,these treatments may be ineffective against the diarrhoea,risking detrimental effects to patient quality of *** To identify and synthesise qualitative and quantitative evidence relating to the differential diagnosis of diarrhoea in patients with *** Electronic databases(mEDLINE,Embase and the Cochrane Library)were searched from inception to September 12,2018 using terms for NETs and ***,systematic literature review bibliographies and included articles were also *** study designs and publication types were eligible for inclusion if relevant data on a cause(s)of diarrhoea in patients with GEP-NETs were *** were screened by two independent reviewers at abstract and full-text *** synthesis was adapted to synthesise quantitative and qualitative *** definition of qualitative data was expanded to include all textual data in any section of relevant *** Forty-seven publications(44 studies)were included,comprising a variety of publication types,including observational studies,reviews,guidelines,case reports,interventional studies,and opinion *** reported on PEI on/after treatment with somatostatin analogs;9.5%-84%of patients with GEP-NETs had experienced steatorrhoea or confirmed *** reported,14.3%–50.7%of patients received pancreatic enzyme replacement *** causes of diarrhoea

关键词： Carcinoid syndrome Diarrhea Differential diagnosis Neuroendocrine tumours Serotonin Systematic review

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Shear wave elastography in hepatitis C patients before and after antiviral therapy

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World Journal of Hepatology 2017年第1期9卷 64-68页

作者： Toshikuni Suda Osamu Okawa rion masaoka Yoshinori Gyotoku Naohiko Tokutomi Yasumi Katayama masaya Tamano Department of Gastroenterology Dokkyo Medical University Koshigaya HospitalSaitama 343-8555Japan

AImTo investigate shear wave (SW) propagation velocity in patients with untreated hepatitis C and patients with sustained virological response (SVR). mETHODSA total of 136 hepatitis C patients [85 patients who had not received antiviral therapy (naïve group) and 51 patients who had received antiviral therapy and subsequently achieved SVR of at least 24 wk (SVR group)] and 58 healthy volunteers and outpatients without liver disease (control group) underwent evaluation of liver stiffness by SW elastography (SWE). Various parameters were evaluated in the chronic hepatitis C patients at the time of SWE. RESULTSSW propagation velocity (Vs) was 1.23 ± 0.14 m/s in the control group, 1.56 ± 0.32 m/s in the SVR group, and 1.69 ± 0.31 m/s in the naïve group. Significant differences were seen between the control group and the SVR group (P = 0.0000) and between the SVR group and the naïve group (P = 0.01417). All four fibrosis markers were higher in the naïve group than in the SVR group. In the naïve group, Vs was positively correlated with alanine aminotransferase (ALT) (r = 0.5372), α feto protein (AFP) (r = 0.4389), type IV collagen (r = 0.5883), procollagen III peptide (P-III-P) (r = 0.4140), hyaluronic acid (r = 0.4551), and mac-2 binding protein glycosylation isomer (m2BPGi) (r = 0.6092) and negatively correlated with albumin (r = -0.4289), platelets (r = -0.5372), and prothrombin activity (r = -0.5235). On multiple regression analysis, Vs was the most strongly correlated with ALT (standard partial regression std β = 0.4039, P = 0.00000). In the SVR group, Vs was positively correlated with AFP (r = 0.6977), type IV collagen (r = 0.5228), P-III-P (r = 0.5812), hyaluronic acid (r = 0.5189), and m2BPGi (r = 0.6251) and negatively correlated with albumin (r = -0.4283), platelets (r = -0.4842), and prothrombin activity (r = -0.4771). On multiple regression analysis, Vs was strongly correlated with AFP (standard partial r

关键词： Hepatocarcinogenesis Sustained virological response Antiviral therapy Shear wave elastography Hepatitis C

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Validation of Hoek-Brown failure criterion charts for rock slopes

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International Journal of mining Science and Technology 2013年第6期23卷 805-808页

作者： A.m.Nekouei K.Ahangari Department of mining Engineering.Science and Research Branch Islamic Azad University

Although stability charts suggested by Hoek and Bray on the basis of mohr-Coulomb criterion are used for rock slopes,but complete and precise recognition is required for distinguishing cohesive strength and mohr-Coulomb equivalent internal friction angle for rock *** paper by Lia et al.[6]is the only one that introduced rock slope charts according to Hoek-Brown failure *** this paper,at first,this type of charts is ***,mohr-Coulomb failure criterion charts[2]are compared and validated with Hoek-Brown failure criterion ones[6].Next,Bishop method utilizing Slide software is compared with Hoek-Brown failure criterion stability *** standard deviation(ASD),root mean square error(RmSE)and variance account for(VAF)were used for the *** to the results,because of high distribution and very low correlation among the comparisons,Hoek-Brown failure criterion charts are not efficient.

关键词： Slope stability Stability charts mohr-Coulomb failure criterion Hoek-Brown failure criterion

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A Nonlinear Optimal Control method for Attitude Stabilization of micro-Satellites

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Guidance, Navigation and Control 2022年第3期2卷 30-67页

作者： G.Rigatos m.Abbaszadeh K.Busawon L.Dala Unit of Industrial Automation Industrial Systems Institute 26504 Rion PatrasGreece Department of ECSE Rensselaer Polytechnic Institute New York 12065 USA Nonlinear Control Group University of Northumbria Newcastle NE18ST UK Department of mechanical Engineering University of Northumbria Newcastle NE18ST UK

Attitude control and stabilization of micro-satellites is a nontrivial problem due to the highly nonlinear and multivariable structure of the satellites'state-space *** this paper,a novel nonlinear optimal(H-infinity)control approach is developed for this control *** dynamic model of the satellite's attitude dynamics undergoesfirst approximate linearization around a temporary operating point which is updated at each iteration of the control *** linearization process relies on first-order Taylor series expansion and on the computation of the Jacobian matrices of the state-space model of the satellite's attitude *** the approximately linearized description of the satellite's attitude a stabilizing H-infinity feedback controller is *** compute the controller's feedback gains,an algebraic Riccati equation is solved at each time-step of the control *** stability properties of the control scheme are proven through Lyapunov *** is also demonstrated that the control method retains the advantages of linear optimal control that is fast and accurate tracking of the reference setpoints under moderate variations of the control inputs.

关键词： micro-satellites attitude control nonlinear optimal control H-infinity control differentialfiatness properties Taylor series expansion Jacobian matrices Lyapunov analysis global asymptotic stability

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连续耕作和轮作对作物产量、残茬复盖及土壤水分的影响

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土壤学进展 1993年第5期21卷 25-28页

作者： m.G.Wagger H.P.Denton 赵炳梓

不同耕作和轮耕制对作物产量反应的信息对决定一个区域或地区特定生产系统的适应性是必要的。本试验旨在确定玉米单作和玉米－大豆轮作情况下，连续耕作和轮耕顺序对残茬复盖，土壤水分和籽粒产量的影响。在５年试验期间，对传统的连续... 详细信息

不同耕作和轮耕制对作物产量反应的信息对决定一个区域或地区特定生产系统的适应性是必要的。本试验旨在确定玉米单作和玉米－大豆轮作情况下，连续耕作和轮耕顺序对残茬复盖，土壤水分和籽粒产量的影响。在５年试验期间，对传统的连续耕作（简称ＣＴ），连续免耕（ＮＴ），或每隔一年的ＣＴ和ＮＴ轮耕效果进行了评估。试验地的土壤为：在Ｐｉｅｄｍｏｎｔ地区的为砂粘壤复区，其中的Ｒｉｏｎ的为细砂壤质。

关键词：连作轮作作物产量残茬土壤水分

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