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在纺织纤维中CorterraPPT的挑战和机会

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技术创新 2002年第7期 16-18页

作者： m.buscemi 骆为林等 Shell化学公司

Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection

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World Journal of Hepatology 2021年第1期13卷 109-119页

作者： Jóice Teixeira de Bitencorte Tássia Flores Rech Vagner Ricardo Lunge Deivid Cruz dos Santos m.rio ReisÁlvares-da-Silva Daniel Simon PPG Biologia Celular e molecular AplicadaàSaúde Universidade Luterana do BrasilCanoas 92425-900Rio Grande do SulBrazil Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil

BACKGROUND Hepatitis C virus(HCV)infection is a public health concern *** factors,including genetic polymorphisms,may be evolved in the progression of HCV infection to liver *** lambdas(IFNLs)modulate the immune response during viral *** induce antiviral activity,interfering in the viral replication by promoting the expression of several genes that regulate immunological *** interferon lambda-4(IFNL4)rs12979860 polymorphism,which is characterized by a C to T transition in intron 1,is associated with spontaneous and treatment-induced clearance of HCV infection and may play a role in the development of HCV-associated liver diseases,including hepatocellular carcinoma(HCC).AIm To investigate the association of IFNL4 rs12979860 polymorphism with fibrosis,cirrhosis,and HCC in patients with chronic HCV *** This study was comprised of 305 chronic HCV-infected patients(53 fibrosis,154 cirrhosis,and 98 HCC cases).The control group was comprised of 260 HCVnegative healthy *** IFNL4 rs12979860 polymorphism was genotyped using the Taqman *** was diagnosed based on liver biopsy findings,while cirrhosis was diagnosed through clinical,laboratory,anatomopathological,and/or imaging *** was diagnosed through imaging tests,tumor,and/or anatomopathological *** The T allele was observed in the three groups of patients(fibrosis,cirrhosis,and HCC)at a significantly higher frequency when compared with the control group(P=0.047,Pmed using the codominant and dominant T allele *** the codominant model,it was observed that the CT genotype showed an increased risk of developing cirrhosis in comparison with the CC genotype[odds ratio(OR)=2.53;95%confidence interval(CI):1.55-4.15;

关键词： Hepatitis C Hepatitis C virus Cirrhosis Hepatocellular carcinoma Genetic polymorphism Interferon-lambda

milroy Disease:A Case Report

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Case Reports in Clinical medicine 2015年第11期4卷 349-351页

作者： Goncalo Gomes Pereira Joana moreira Vaz de macedo m.rio Santos General Practice Departement USF Sem FronteirasSanta Maria da FeiraPortugal General Practice Departement USF CoveloPortoPortugal

Hereditary lymphoedema type I is a congenital onset primary lymphoedema with autosomal dominant inheritance, which is characterized by the swelling of the lower body. In this article, the authors report a case of a 32-year-old woman with repeating episodes of swollen limbs. Imaging studies and genetic study were carried out and a milroy’s syndrome diagnosis was established. The patient started sintomatic treatment of the edema, with fitting stockings and descompressive massage, with symptomatic benefit.

关键词： milroy Disease Lower Limbs Edema FLT4 Gene VEGFR-3

Pseudoathletic Appearance:A Case Report in a male

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Case Reports in Clinical medicine 2015年第12期4卷 361-363页

作者： Joana moreira Goncalo Gomes Pereira m.rio Santos Vaz de macedo General Practice Department USF CoveloPortoPortugal General Practice Department USF Sem FronteirasSanta Maria da FeiraPortugal

multiple Symmetric Lipomatosis (mSL) is a rare condition characterized by a symmetrical pattern of massive fatty deposits. This condition predominates in males, between 30 and 60 years. In this article, the authors present a case report of a 47-year-old man that resorted to consultation to perform routine medical exams, without any complaint associated. Physical examination shows multiple bilateral swellings in the proximal region of the upper limbs and analytically presents hyperuricemia, hypertriglyceridemia, hypercholesterolemia and changes in hepatic tests. CT revealed the presence of non-encapsulated homogeneous masses of adipose tissue in the proximal region of the limbs. Currently the patient is asymptomatic, being monitoring in consultation.

关键词： Symmetric multiple Lipomatosis Hyperuricemia Hypertriglyceridemia Hypercholesterolemia

How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician

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World Journal of Gastroenterology 2021年第11期27卷 1022-1042页

作者： Júlio maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar mourão Cintra Damião Liliana Andrade Chebli márcia Henriques de magalhães Costa Rogério Serafim Parra Division of Gastroenterology Department of MedicineInflammatory Bowel Disease CenterFederal University of Juiz de ForaJuiz de Fora 36036-900MGBrazil Department of Gastroenterology University of São Paulo School of MedicineSão Paulo 05403-000SPBrazil Department of Clinical medicine Fluminense Federal UniversityRio de Janeiro 24210-200RJBrazil Department of Surgery and Anatomy Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão Preto 14048-900SPBrazil

managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly *** particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with *** patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of *** this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic.

关键词： Inflammatory bowel disease SARS-CoV-2 COVID-19 Crohn disease Colitis ulcerative Biological therapy

3D Printing Technology for Tapered Optical Fiber Protection With Gas Sensing Possibilities

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Photonic Sensors 2020年第4期10卷 298-305页

作者： Kaleb Roncatti de SOUZA Jonas H.OSÓrio Juliana B.CARVALHO Beatriz mota LImA Cristiano m.B.CORDEIRO Gleb Wataghin Physics Institute State University of CampinasCampinas 13083-970Brazil

We present a new procedure for protecting micro-optical fibers(tapered fibers)by using the 3-dimensional(3D)printing technology.A standard single-mode optical fiber was tapered down to the diameter of 1mm and embedded in a polymeric matrix obtained by an additive manufacturing *** show that the proposed structure protects the fiber taper against environmental humidity while keeping permeability to gas flow and the possibility of the realization of gas detection *** our knowledge,this is the first time 3D printed casings were applied to protect fiber tapers from humidity *** envisage this new approach will allow the development of new fiber taper devices to better resist in humid environments.

关键词： 3D printing additive manufacturing optical fiber tapered fibers sensing

The Poorly Known Northeast Atlantic Regional management Unit for Loggerhead (Caretta caretta)

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Open Journal of Ecology 2022年第8期12卷 529-536页

作者： Inês m. Ferreira Ana Raquel de Sales m.rio J. Pereira Rita Anastácio Department of Biology University of Aveiro Aveiro Portugal Department of Biology & CESAm (Centre for Environmental and marine Studies) University of Aveiro Aveiro Portugal Independent Researcher Aveiro Portugal

Loggerheads are distributed by ten Regional management Units (RmUs) worldwide. The Atlantic Ocean houses three of these: the Northwest, Southwest and Northeast RmUs. The most studied is, so far, the Northwest RmU, but the other two have focused attention of researchers. In contrast, marine turtles from the African Atlantic region (Southeast) belong to a complex but little-known region. What is their role in the Atlantic? Are these RmUs connected? To understand these questions, research was made of reports and publications concerning the Northeast Atlantic (NEA) RmU. The asymmetry in information and available knowledge about NEA is high when compared to other RmUs. This demonstrates that there is still a lack of conservation programs besides Cape Verde, and that there is difficulty in transforming data (nesting ecology, molecular, telemetry, etc.) into publications. However, this issue is evident for other marine turtle species of East African Atlantic. There is a need for better scientific support, to enable local conservation programs to deliver data in reports, and even scientific publications. There are so many aspects of loggerhead’s life cycle that will only be unravelled by more and better supported studies. This is a paper that, by analysing the available information of the NEA loggerhead RmU, reflects the following steps to address in loggerhead conservation for the African Atlantic coast.

关键词： Loggerhead Caretta caretta Regional management Units African Atlantic Region

HVEm,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-mi Lee Tae-Jin Kim Jose-Antonio Perez-Simon maria-Luisa del rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

Uniform-velocity spacetime crystals

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Advanced Photonics 2019年第5期1卷 17-42页

作者： Zoé-Lise Deck-Léger Nima Chamanara maksim Skorobogatiy m.rio G.Silveirinha Christophe Caloz Polytechnique montréal Department of Electrical EngineeringMontréalQuebecCanada Polytechnique montréal Department of Engineering PhysicsMontréalQuebecCanada Universidade de Lisboa-Instituto Superior Técnico and Instituto de Telecomunicações Department of Electrical EngineeringLisbonPortugal

We perform a comprehensive analysis of uniform-velocity bilayer spacetime crystals,combining concepts of conventional photonic crystals and special *** that a spacetime crystal consists of a sequence of spacetime discontinuities,we do this by solving the following sequence of problems:(1)the spacetime interface,(2)the double spacetime interface,or spacetime slab,(3)the unbounded crystal,and(4)the truncated *** these problems,we present the following results:(1)an extension of the Stokes principle to spacetime interfaces,(2)an interference-based analysis of the interference phenomenology,(3)a quick linear approximation of the dispersion diagrams,a description of simultaneous wavenumber and frequency bandgaps,and(4)the explanation of the effects of different types of spacetime crystal truncations and the corresponding scattering *** work may constitute the foundation for a virtually unlimited number of novel canonical spacetime media and metamaterial problems.

关键词： crystals special relativity Lorentz transformations spacetime bandgap structures