检索结果-南通市图书馆

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell(cDC1)activation and tumor infiltration

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2804-2818页

作者： Fenglian He Zhongen Wu Chenglong Liu Yuanyuan Zhu Yan Zhou Enming Tian rina Rosin-Arbesfeld Dehua Yang ming-Wei Wang Di Zhu Department of Pharmacology Minhang Hospitaland Key Laboratory of Smart Drug DeliveryShanghai Engineering Research Center of Immune TherapySchool of PharmacyFudan UniversityShanghai 201203China The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai 201203China Department of microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources SanyaChina Department of Chemistry School of ScienceThe University of TokyoTokyoJapan Engineering Research Center of Tropical medicine Innovation and Transformation of ministry of Education School of PharmacyHainan Medical UniversityHaikouChina Shandong Academy of Pharmaceutical Science JinanChina

Conventional type 1 dendritic cells(cDC1)are the essential antigen-presenting DC subset in antitumor *** B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts immune responses against ***,whether oncogenic BCL9/BCL9L impairs antigen presentation in tumors is still not completely ***,we show that targeting BCL9/BCL9L enhanced antigen presentation by stimulating cDC1 activation and infiltration into *** inhibition of BCL9/BCL9L with a novel inhibitor hsBCL9z96 or Bcl9/Bcl9l knockout mice markedly delayed tumor growth and promoted antitumor CD8^(+)T cell ***,targeting BCL9/BCL9L promoted antigen presentation in *** is due to the increase of cDC1 activation and tumor infiltration by the XCL1-XCR1 ***,using single-cell transcriptomics analysis,we found that Bcl9/Bcl9l deficient cDC1 were superior to wild-type(WT)cDC1 at activation and antigen presentation via NF-κB/IRF1 ***,we demonstrate that targeting BCL9/BCL9L plays a crucial role in cDC1-modulated antigen presentation of tumor-derived antigens,as well as CD8^(+)T cell activation and tumor *** BCL9/BCL9L to regulate cDC1 function and directly orchestrate a positive feedback loop necessary for optimal antitumor immunity could serve as a potential strategy to counter immune suppression and enhance cancer immunotherapy.

关键词： immunity Targeting markedly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

激光散射特性的红外瞄准镜基线检测方法

引用

激光杂志 2024年第7期45卷 227-232页

作者：李波莎日娜内蒙古医科大学呼和浩特010110 中国人民解放军32302部队50分队北京101400

为提升武器射击精度,设计激光散射特性的红外瞄准镜基线检测方法。通过固定瞄准镜并利用黑体发射红外激光,在镜子反射后形成红外平行光束,并在瞄准镜视场内生成靶标的像。通过调整瞄准镜分划中心与靶标像中心重合,实现基线检测。采用双... 详细信息

为提升武器射击精度,设计激光散射特性的红外瞄准镜基线检测方法。通过固定瞄准镜并利用黑体发射红外激光,在镜子反射后形成红外平行光束,并在瞄准镜视场内生成靶标的像。通过调整瞄准镜分划中心与靶标像中心重合,实现基线检测。采用双向反射分布函数和基尔霍夫近似理论的驻留相位近似法,分析红外激光的散射特性及波长与散射角对成像精度的影响,从而提高基线检测的精度。实验证明:当入射波长在9.5μm左右时,射击目标粗糙度为8μm时,双站极化散射系数最低,在1.0左右;当散射角在29°左右时,射击目标粗糙度为8μm时,双站极化散射系数最低在0.146左右;校正后目标位置偏差平均为0.01 m。

关键词：激光散射特性红外瞄准镜基线检测反射分布函数基尔霍夫驻留相位近似法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

萝卜硫素通过调节ALOX5/NF-κB信号通路调控巨噬细胞糖酵解抑制糖尿病肾病进展

引用

安徽医科大学学报 2024年第3期59卷 390-397页

作者：乌日娜丁海东常宏孙娜娜张磊内蒙古民族大学附属医院内分泌科通辽028000

目的探讨萝卜硫素(SFN)调节花生四烯酸5-脂氧合酶基因(arachidonic acid 5-lipoxygenase,ALOX5)/核因子kappa B(NF-κB)信号通路调节巨噬细胞糖酵解对糖尿病肾病(DN)进展的影响。方法生物信息学分析SFN治疗DN的靶基因。使用30 mmol/L高... 详细信息

目的探讨萝卜硫素(SFN)调节花生四烯酸5-脂氧合酶基因(arachidonic acid 5-lipoxygenase,ALOX5)/核因子kappa B(NF-κB)信号通路调节巨噬细胞糖酵解对糖尿病肾病(DN)进展的影响。方法生物信息学分析SFN治疗DN的靶基因。使用30 mmol/L高葡萄糖(Hg)处理人近端肾小管上皮细胞系(HK-2细胞)诱导体外DN模型。将HK-2细胞分为如下组:正常糖(Ng)组、Hg组、Hg+SFN(3 mmol/L)组、Hg+ALOX5组、Hg+SFN(3 mmol/L)+ALOX5组、Hg处理的巨噬细胞+HK-2细胞组、Hg+SFN(3 mmol/L)处理的巨噬细胞+HK-2细胞组、Hg+ALOX5转染处理的巨噬细胞+HK-2细胞组、Hg+SFN(3 mmol/L)+ALOX5转染处理的巨噬细胞+HK-2细胞组。CCK-8检测细胞活力,原位末端脱氧核苷酸转移酶标记(TUNEL)法检测细胞凋亡;葡萄糖和乳酸试剂盒检测各组细胞中葡萄糖和乳酸水平;Western blot检测各组细胞中ALOX5、NF-κB以及糖酵解相关蛋白己糖激酶-2(HK2)、丙酮酸激酶m2(PKm2)、葡萄糖转运蛋白1(gLUT1)的表达;使用链脲佐菌素(STZ)构建DN小鼠模型,DN小鼠给与SFN(0.5 mg/kg)治疗;检测小鼠各项生化指标,HE染色检测肾组织病理变化;Western blot检测小鼠肾脏巨噬细胞中糖酵解相关蛋白己糖激酶-2(HK2)、丙酮酸激酶m2(PKm2)、葡萄糖转运蛋白1(gLUT1)的表达。结果生物信息学分析结果显示ALOX5是SFN治疗DN的靶基因。与Hg组相比,SFN处理增强HK-2细胞活力并抑制细胞凋亡(Pg诱导的巨噬细胞糖酵解相关蛋白的表达,减弱巨噬细胞介导的HK-2细胞损伤(P<0.05);Western blot结果表明SFN抑制ALOX5和NF-κB的表达(P<0.05);小鼠实验结果显示,SFN治疗改善DN小鼠肾功能和肾组织病理学改变,抑制肾组织中巨噬细胞糖酵解相关蛋白的表达(P<0.05)。结论SFN通过抑制ALOX5/NF-κB信号通路抑制巨噬细胞糖酵解从而改善DN进展。

关键词：萝卜硫素糖尿病肾病巨噬细胞糖酵解花生四烯酸5-脂氧合酶 NF-κB信号通路

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Encapsulation of docosahexaenoic acid (DHA) using self-assembling food-derived proteins for efficient biological functions

引用

Food Science and Human Wellness 2023年第5期12卷 1861-1871页

作者： Yumeng Liu Kaixin Cao Tong Li Delun mu Naiqi Zhang Ying Wang rina Wu Junrui Wu College of Food Science Shenyang Agricultural UniversityShenyang 110866China Liaoning Engineering Research Center of Food Fermentation Technology Shenyang 110161China Shenyang Key Laboratory of microbial Fermentation Technology Innovation Shenyang 110866China

Docosahexaenoic acid(DHA;22n-6)possesses multiple biological functions, including antioxidant activity and ameliorating hypertriglyceridemia. However, the application of DHA has been limited due to poor aqueous solubility and susceptible to oxidation. Here, ovalbumin(O), myosin(m), 7S soy globulin(S), and β-lactoglobulin(β), hydrolyzed by chymotrypsin, self-assembled into micelles, respectively. Adding incremental DHA to micelles caused endogenous fluorescence quenching of O, m, S, and β micelles, implying successful incorporation of DHA into hydrophobic cores of micelles(O(DHA), m(DHA), S(DHA), and β(DHA)). The results showed that micelles provided spatial stability and improved solubility, and stability against thermal and ultraviolet(UV)light for DHA. The uptake of DHA from m(DHA), β(DHA), O(DHA), and S(DHA)was 3.27-, 3.91-, 2.7-, and 3.95-fold higher, respectively, than that of DHA by Caco-2 cells. Encapsulation in micelles increased DHA aqueous solubility and uptake, which enhanced cellular endogenous antioxidant defense. meanwhile, increased uptake of DHA was verified by Hepg2 cells, and O, m, S, and β micelles were proven to increase DHA uptake to reduce lipid deposition. Our findings strongly support the possibility that O, m, S, and β micelles can be regarded as a carrier for loading DHA.

关键词： Docosahexaenoic acid micelle Solubility Stability Cellular uptake

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

向列相液晶器件光调制性能研究

引用

沈阳理工大学学报 2024年第1期43卷 91-96页

作者：王萧鲁小鑫张雪凤王浪乌日娜沈阳理工大学理学院沈阳110159

液晶的折射率易受外加电压和温度的影响,据此可获得电场和温度可调制器件。为改善液晶器件对光的调制性能,制备了向列相液晶器件,并对其调制性能进行理论模拟和实验研究。首先研究液晶器件的透过光强和相位延迟随电压变化关系,结果显示... 详细信息

液晶的折射率易受外加电压和温度的影响,据此可获得电场和温度可调制器件。为改善液晶器件对光的调制性能,制备了向列相液晶器件,并对其调制性能进行理论模拟和实验研究。首先研究液晶器件的透过光强和相位延迟随电压变化关系,结果显示,相同电压下,增大器件厚度,光强调制曲线的峰谷数增多,相位调制量增大,其中电压在0.8~3 V范围内,相位延迟曲线变化较明显,厚度为4、6和10μm的器件可分别获得约1.21π、1.87π和3.19πrad的相位调制量。其次对厚度为4μm的器件进行温度可调制性能的研究,结果显示,温度从20℃升至45℃时,获得的温度可调制量约为0.29πrad。改变电场或温度均能引起液晶的折射率变化,从而实现对光的调控,适当增加液晶器件厚度可获得较大的相位调制量。研究结果对液晶光调制器件的性能改善及应用具有重要参考意义。

关键词：液晶光调制器向列相液晶光强调制相位调制

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Effects of leaf age,elevation and light conditions on photosynthesis and leaf traits in saplings of two evergreen conifers,Abies veitchii and ***

引用

Journal of Plant Ecology 2020年第4期13卷 460-469页

作者： rina Suzuki Koichi Takahashi Department of Science Graduate School of Science and TechnologyShinshu UniversityAsahi 3-1-1Matsumoto 390-8621Japan Department of Biology Faculty of ScienceShinshu UniversityMatsumoto 390-8621Japan Department of mountain Ecosystem Institute for Mountain ScienceShinshu UniversityAsahi 3-1-1Matsumoto 390-8621Japan

亚高山的针叶树物种分布在广泛的海拔范围内,因此它们必须具备抵抗严酷自然条件(如高海拔和长期的黑暗)的能力。在日本中部的亚高山地带,两种常绿的针叶树冷杉(Abies veitchii)和马尾冷杉(Abies mariesii)分别在低海拔和高海拔地区占据... 详细信息

亚高山的针叶树物种分布在广泛的海拔范围内,因此它们必须具备抵抗严酷自然条件(如高海拔和长期的黑暗)的能力。在日本中部的亚高山地带,两种常绿的针叶树冷杉(Abies veitchii)和马尾冷杉(Abies mariesii)分别在低海拔和高海拔地区占据优势。本研究的目的是探讨叶龄、海拔和光照条件对两个物种叶片形态和生理性状的影响。我们以两种针叶树的幼树为样本,分别在两种针叶树下部(1600米)和上部(2300米)的林下层和冠层间隙中取样,并分析叶龄、海拔和光照条件对冷杉和马尾冷杉的光合作用和叶片性状的影响。研究结果表明,两种针叶树的光合作用和叶片性状对叶龄呈现相似的响应,但其对海拔和光照条件则表现出不同的响应。冷杉最大光合速率与单位叶面积质量和非结构性碳水化合物浓度呈负相关。两种树木的单位叶面积质量在高海拔处均增加,而非结构性碳水化合物浓度仅在冷杉中增加。因此,冷杉的最大光合速率在高海拔时降低。此外,两个物种的最大光合速率均与氮浓度呈正相关。在林下层,叶片氮浓度在冷杉中下降,而在马尾冷杉中上升。在林下条件下,只有马尾冷杉的单位叶面积质量下降、叶绿素-氮比增加,表明在黑暗条件下,马尾冷杉比冷杉有更高的捕光效率。本研究表明,与冷杉相比,马尾冷杉的光合和叶片特性具有更强的耐阴性,光合速率受海拔的影响较小,从而使马尾冷杉在林下植被中生存,并在高海拔地区占据优势。

关键词：叶片叶绿素单位叶面积质量叶氮非结构性碳水化合物浓度稳定碳同位素比率

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Statistical modelling for effect of mix-parameters on properties of high-flowing sand-concrete

引用

Journal of Central South University 2012年第10期19卷 2966-2975页

作者： T.BOUZIANI A.BENmOUNAH m.BDrina Rheology of Dispersed media Research Unit-MaterialsProcesses and Environment(UR/MPE) University of BoumerdesBoumerdes 35000Algeria Structures Rehabilitation and materials Laboratory(SREmL) University Ammar Telidji of LaghouatLaghouat 03000Algeria

The high-flowing sand-concrete(HFSC) containing natural sands as aggregate was carried *** high fluidity and stability of HFSC can be achieved by tailoring the mix design parameters,such as fine to coarse sand ratio,dosage of additions,water to binder ratio and dosage of ***-cone slump test,v-funnel time test and viscosity model parameters were used to characterize the behaviour of HFSC in fresh *** mechanical compressive strength in 28 d was also determined.A factorial design approach was used to establish models highlighting the effect of each mix-parameter on measured properties of *** derived models are valid for mixtures made with 0 to 0.3 of dune sand to total sand ratio,82 to 418 kg/m3 of marble powder,0.42 to 0.46 of water/binder ratio and 1.3% to 1.9% of superplasticizer high *** results show that the derived models constitute very efficient means for understanding the influence of key mix-parameters on HFSC properties and are useful in selecting the optimum mix proportions,by simulating their impact on fluidity,stability and compressive strength.

关键词：混合参数混凝土统计建模流砂性能高效减水剂模型参数抗压强度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stable carbon and oxygen isotopes of four planktonic foraminiferal species from core-top sediments of the Indonesian throughflow region and their significance

引用

Acta Oceanologica Sinica 2016年第10期35卷 63-75页

作者： ZHANg Peng ZURAIDA rina XU Jian YANg Ce State Key Laboratory of Continental Dynamics Northwest UniversityXi'an 710069China Institute of Cenozoic geology and Environment Department of GeologyNorthwest UniversityXi'an 710069China marine geology Institute Bandung 40174Indonesia

Horizontal and vertical distributions of δ^18 and δ^13 were investigated in shells of four planktonic foraminiferal species, globigerinoides ruber, globigerinoides sacculifer, Pulleniatina obliquiloculata and Neogloboquedrina dutertrei, from a total of 62 core-top sediment samples from the Indonesian throughflow region. Results were compared to modern hydrologic conditions in order to explore potential of proxies in reconstructing fluvial discharge and upper ocean water column characteristics in this region. Our results show that, in the makassar Strait, both of depleted δ^18 and δ^13 of these four species were linked to freshwater input. In the Bali Sea,however, depleted δ^18 and δ^13 for these species may be due to different reasons. Depleted δ^18 was a result of freshwater input and as well influenced by along-shore currents while depleted δ^13 was more likely due to the Java-Sumatra upwelling. Comparison of shell δ^18 records and hydrographic data of World Ocean Atlas 2005 suggests that g. ruber and g. sacculifer calcify within the mixed-layer, respectively at 0–50 m and 20–75 m water depth, and P. obliquiloculata and N. dutertrei within the upper thermocline, both at 75–125 m water depth. *** calcifies at slightly deeper water depth than P. obliquiloculata does. In general, δ^13 values of both *** and g. sacculifer are larger than those of P. obliquiloculata and N. dutertrei at all sites, possibly related to depth habitats of these species and vertical distribution of nutrients in the Indonesian throughflow region.

关键词： planktonic foraminiferal δ^18O and δ^13C calcification depth freshwater input Java-Sumatra upwelling Indonesian throughflow region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China

引用

Chinese medical Journal 2022年第6期135卷 665-671页

作者： Yumei Wei Juan Juan rina Su geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia meng Yan Cai Cuilin Zhang Huixia Yang Department of Obstetrics and gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics Tianjin Central Obstetrics and Gynecology HospitalTianjin 300199China Department of Obstetrics Jinan Maternal and Child Health HospitalJinanShandong 250000China Department of Obstetrics Dalian Maternity HospitalDalianLiaoning 116033China Department of Obstetrics and gynecology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Obstetrics Shenzhen Peking University HospitalShenzhenGuangdong 518036China Department of Obstetrics and gynecology Tongji Hospital Affiliated to Huazhong University of Science and TechnologyWuhanHubei 430030China Department of Obstetrics and gynecology Suzhou Jiulong Hospital Affiliated to Shanghai Jiaotong UniversitySuzhouJiangsu 320571China Department of Obstetrics Affiliated Hospital of Inner Mongolia Medical UniversityHuhhotInner Mongolia 010050China Department of Obstetrics and gynecology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Epidemiology Branch Division of Intramural Population Health ResearchEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMD 20817USA

Background:gestational diabetes mellitus(gDm)brings health issues for both mothers and offspring,and gDm prevention is as important as gDm *** was shown that a history of gDm was significantly associated with a higher maternal risk for gDm *** incidence of gDm recurrence was unclear because of the incidence of second-child was low before 2016 in *** aim to investigate the prevalence of gDm recurrence and its associated high-risk factors which may be useful for the prediction of gDm recurrence in ***:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research *** participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of gDm were analyzed *** participants enrolled in the study had an oral glucose tolerance test(OgTT)result at 24 to 28 weeks and were diagnosed as gDm in the first pregnancy according to the OgTT value(when any one of the following values is met or exceeded to the 75-g OgTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of gDm recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were ***:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of gDm and 5202 women(5202/6204,83.85%)without a history of *** are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,Pgnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BmI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),Pmacrosomia(22.7%vs.11.0%vs.6.2%,Pmong the development of diabetes mellitus(Dm),recurrence of gDm,and normal ***,it seems

关键词： gestational diabetes mellitus Recurrence Risk factors multipara Primipara

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

geochemical characteristics from tests of four modern planktonic foraminiferal species in the Indonesian Throughflow region and their implications

引用

geoscience Frontiers 2019年第2期10卷 505-516页

作者： Peng Zhang rina Zuraida Yair Rosenthal Ann Holbourn Wolfgang Kuhnt Jian Xu Institute of Cenozoic geology and Environment State Key Laboratory of Continental DynamicsDepartment of GeologyNorthwest University marine geology Institute Department of marine and Coastal Sciences RutgersThe State University of New Jersey Institute of geosciences Christian-Albrechts-University

Test geochemistry of planktonic foraminifera is an indispensable tool in reconstructing past ocean hydrological changes. It is essential to investigate region-specific implications of test geochemistry,although those established from other regions can be broadly applied. In this study, characteristics of6180 and mg/Ca from tests of four planktonic foraminiferal species, globigerinoides ruber sensu stricto(s.s.), globigerinoides sacculifer, Pulleniatina obliquiloculata and Neogloboquadrina dutertrei, from 60 coretop sediment samples retrieved from the Indonesian Throughflow(ITF) region were studied. These geochemical data were compared with modern hydrographic profiles in order to assess their relations and to investigate potential implications of test geochemical parameters in reconstructing past oceanographic change in the ITF region. Calcification depths of these four species were first estimated based on comparison between measured test δ180 and predicted calcite δ^(18)O that was calculated from modern temperature and salinity. The results indicate that g. ruber s.s. and g. sacculifer calcify within the mixedlayer at 0-50 m and 20-75 m, respectively, whereas P. obliquiloculata and N. dutertrei calcify within the thermocline at around 75 to 125 m. A combined study of excess mg/Ca(difference between measured and predicted mg/Ca) and salinity suggests that salinity exerts a negligible impact on test mg/Ca of these foraminiferal species in the ITF region. Comparison of test mg/Ca-derived temperatures with temperature profiles of the upper 200 m of the water column from the seas of the ITF region also indicate calcification depths of these species, which match well with the above estimations using test δ^(18)O. It further indicates that g. sacculifer may be more sensitive in reflecting changes in the depth of the mixedlayer, highlighting a potential use of mg/Ca temperature difference between g. ruber s.s. and g. sacculifer in reconstructing the depth of the mixed-lay

关键词： Test geochemistry multi-species Planktonic foraminifera Core-top sediments Indonesian Throughflow region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：