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Evaluation of the Radiological Characteristics of Patients with COVID-19 in a General Hospital of Tabasco

Journal of Biosciences and medicines 2022年第12期10卷 217-224页

作者： Ady G. Córdova-Álvarez José E. serrano-García Elías Hernández-Cornelio Humberto Azuara-Forcelledo Ana P. Ovando-Rodríguez Copany martínez-De la Cruz Jesús m. Granados-Villalpando Erick m. Cabrera-Pérez Eduardo Ávila-Guillen Crystell G. Guzmán-Priego Cardiometabolism Laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa México Cardiometabolism Laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa México Social Security Institute of the State of Tabasco Villahermosa Mexico

According to various studies, it has been found that due to the lack of reagents for the RT-PCR test for the accurate diagnosis of SARS-CoV-2 infection, tomography began to be used as a criterion to achieve diagnostic support in patients with lack of a definitive diagnosis. The objective of this work is to describe the tomographic findings in patients with COVID-19 and their relationship with the clinical presentation in each of the radiological patterns. According to the Feinstein Criteria, the analytical type of study, with quantifiable, non-experimental data, was cross-sectional from October 2020 to June 2021, obtaining a sample of 227 patients hospitalized in the UAER of the CmJPP. Statistical analysis was performed using microsoft Excel (2021) and SPSS. According to the radiological classifications, 6.17% (14) presented in the Initial (early) phase of the disease, 46.7% (106) were in progression and 47.14% (107) in the advanced phase of the latter with a higher percentage in the CORADS classification at level 3 with 74.5% in both;Similarly, in advanced onset, the extension with the greatest presentation was severe with 86.96% (93). Tomographic studies played an important role during the COVID-19 pandemic, together with the application of international classifications such as CO-RADS and the classification issued by INER, being considered diagnostic support tools for COVID-19 and patient evolution.

关键词： COVID-19 TAC CO-RADS Appearance/Attenuation Extension

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腹腔脓肿经皮引流:采用2种外科评分系统评价尿激酶或生理盐水在100例病人中的随机对比临床试验

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国际医学放射学杂志 2009年第5期32卷 510-511页

作者： A.Laborda m.A.De Gregorio J.m.miguelena J.medrano J.Gómez-Arrue C.serrano 郭雪梅 Departamento de Pediatría Radiología y Medicina FísicaGrupo de Investigación en Técnicas Mínimamente Invasivas(GITMI)DomingoMiralS/N50009ZaragozaSpain

本研究目的是评价脓肿引流时常规灌注尿激酶与仅用生理盐水灌洗相比能否改进治疗效果。100例需要影像引导下引流的腹部脓肿病人被随机分为2组，分别给予3次／d尿激酶灌注或仅生理盐水灌洗。

关键词：介入放射学经皮引流腹部脓肿纤维蛋白溶解

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Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： Patricia Prieto Rafael I Jaén Daniel Calle maría Gómez-serrano Estefanía Nú?ez maría Fernández-Velasco Paloma martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán miguel ángel Peinado Lisardo Boscá Department of metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Ciber-CV) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Instituto de Investigación Sanitaria del Hospital Universitario la Paz(IdiPaz) Programa de medicina Predictiva y Personalizada del Cáncer (PmPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic *** Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRmAS) analysis was performed using a Bruker AVIII 500 mHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-mS/mS) using a QExactive HF orbitrap *** Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PN

关键词： Colon Carcinoma Cyclooxygenase Prostaglandin Proteomics High resolution magic angle spinning

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Prognosis of Patients with Acute Coronary Syndromes and Bleeding—The Importance of Routine Use of a Bleeding Risk Score

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World Journal of Cardiovascular Diseases 2015年第12期5卷 327-334页

作者： Alexandre de matos Soeiro Ricardo Cesar Campos Devezae Silva Aline Siqueira Bossa Cindel Nogueira Zullino Tatiana de Carvalho Andreucci Torres Leal maria Carolina Feres de Almeida Soeiro Carlos V. serrano Jr. múcio Tavares Oliveira Jr. Emergency Unit-Heart Institute University of Sao Paulo Medical School Sao Paulo Brazil

Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without in-hospital major and/or minor bleedings. methods: This was a pro-spective data bank analysis study with 546 patients (39 with bleeding (group I) and 507 without bleeding (group II)) with acute coronary syndromes included between may 2010 and may 2013. Besides, mehran bleeding risk score was calculated to all patients. The primary endpoint was all causes of in-hospital death and combined events. Comparison between groups was made by Anova and Q-square. multivariate analysis was determined by logistic regression and was considered significant when p p = 0.005) and combined events (35.9% vs 11.4%, p me results were observed in multivariate and long-term analysis. Con-clusions: Almost half of patients with acute coronary syndromes had higher risk of bleeding, and that with major or minor bleedings had greater deaths and combined events.

关键词： Unstable Angina Bleeding Acute myocardial Infarction

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Superiority of Prothrombin Complex Concentrate versus Frozen Fresh Plasma in Cardiology Patients with Warfarin Intoxication–Observational Study

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Open Journal of Emergency medicine 2017年第2期5卷 75-84页

作者： Alexandre de matos Soeiro maria Cristina César Bruno Biselli Aline Siqueira Bossa T. de Carvalho Andreucci Torres Leal maria Carolina Feres de Almeida Soeiro Carlos V. serrano Ludhmila Abraã o Hajjar múcio Tavares Oliveira Emergency Unit–Heart Institute–University of Sã o Paulo medical School S&atilde o Paulo Brazil

Objective: The objective of this study was to analyse the reversibility of the anticoagulant effect of warfarin by comparing prothrombin complex concentrate (PCC) versus frozen fresh plasma (FFP) in cardiology patients with serious warfarin intoxication. methods: This was an observational and retrospective study comprising 67 patients (18 in group I [PCC] and 49 in group II [FFP]). The primary endpoint was the reversal of anticoagulant effect of warfarin after 2 and 24 hours of PCC or FFP administration. Comparisons between the groups were made using T-test and Q-square. multivariate analyses were conducted using logistic regression, and the results were considered significant when p Results: The medium dose used was 27.6 UI/kg of PCC and 14.5 ml/kg of FFP. Significant differences were observed between groups I and II in the INR reversibility measurements after 2 hours (33.3% vs. 6.1%, p = 0.001) and 24 hours (38.9% vs. 12.2%, p = 0.009) as well as in the occurrence of pulmonary edema (5.6% vs. 42.9%, OR = 11.10, p = 0.04). The AUC for PCC was 0.891 (CI 95% [0.72 - 1.0]), and for FFP, it was 0.291 (CI 95% [0.09 - 0.49]). Conclusions: PCC is better than FFP treatment in reversing the warfarin intoxication after 2 and 24 hours of administration. Furthermore, PCC showed lower pulmonary edema in cardiology patients.

关键词： Intoxication Warfarin Fresh Frozen Plasma Prothrombin Complex Concentrate

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中红外差分吸收激光雷达NO_2测量波长选择及探测能力模拟

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红外与激光工程 2018年第10期47卷 70-77页

作者：徐玲卜令兵蔡镐泽萨日娜杨彬周军南京信息工程大学大气物理学院江苏南京210044 南京先进激光技术研究院江苏南京210038

差分吸收激光雷达是高精度测量大范围二氧化氮浓度的有效途径。介绍了差分吸收激光雷达原理及系统结构,基于可调谐固体激光吸收技术,以0.01 nm为步长,测量了二氧化氮在3.410~3.435μm吸收光谱,实验结果表明,在1.0 atm(1 atm=1.013×105 ... 详细信息

差分吸收激光雷达是高精度测量大范围二氧化氮浓度的有效途径。介绍了差分吸收激光雷达原理及系统结构,基于可调谐固体激光吸收技术,以0.01 nm为步长,测量了二氧化氮在3.410~3.435μm吸收光谱,实验结果表明,在1.0 atm(1 atm=1.013×105 Pa)、25℃情况下,所测吸收光谱与模拟计算吸收光谱相关系数为92.01%,基于实测吸收光谱分析确定了二氧化氮测量激光波长对为online 3.424μm、off-line 3.414μm。并研究了差分吸收激光雷达二氧化氮测量信号预处理方法和去噪算法,仿真计算结果表明,采用信号预处理结合多重自相关检测法,可有效将1 km内模拟探测所得二氧化氮浓度反演结果误差降为±0.1 mg/m3。

关键词：吸收光谱差分吸收激光雷达激光波长对去噪方法

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基于HYDRUS模型渠道渗漏模拟及影响因素分析

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水土保持学报 2020年第1期34卷 141-148页

作者：张健魏占民张金丁苏日娜内蒙古农业大学水利与土木建筑工程学院呼和浩特010018 内蒙古自治区水利新闻宣传中心呼和浩特010000

为探明影响有压入渗渠道渗漏的主要因素,采用恒水位静水试验的方法开展渠道渗漏试验,试验设置8个入渗水头,探究不同水深情况下渠道的累积入渗量及入渗速率的变化规律,并选用HYDRUS-2D软件进行模拟分析。结果表明:实测值与模拟值的变化... 详细信息

为探明影响有压入渗渠道渗漏的主要因素,采用恒水位静水试验的方法开展渠道渗漏试验,试验设置8个入渗水头,探究不同水深情况下渠道的累积入渗量及入渗速率的变化规律,并选用HYDRUS-2D软件进行模拟分析。结果表明:实测值与模拟值的变化规律基本吻合,入渗速率的RmSE值为0.003 6~0.376 3 cm/h,累积入渗量的RmSE值为0.001 7~0.300 9 m^3,R^2的值均达到0.9以上,说明选定的土壤水分运动方程合理,选取的相关参数值合适,用于渠道渗漏评价是可行的。采用HYDRUS-2D模型野外拓展试验对渠道水深、底宽及边坡系数进行影响分析,渠道水深的变化对入渗速率的影响较大,而渠道底宽、边坡系数的变化对入渗速率的影响较小。渠道水深、底宽及边坡系数对累积入渗量的影响均呈现极显著相关(P渠道底宽>边坡系数。其中渠道底宽和边坡系数的交互作用对累积入渗量的影响并不显著(P>0.05),渠道水深和边坡系数的交互作用对累积入渗量的影响呈极显著相关(P<0.01),渠道水深和底宽的交互作用对累积入渗量的影响同样呈极显著相关(P<0.01)。研究结果为探明渠道水分入渗规律、改进渠道防渗技术及开发新的的渠道渗漏损失计算方法等提供参考。

关键词： HYDRUS-2D 渠道渗漏累积入渗量入渗速率数值分析

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妊娠期高血糖孕妇血糖控制水平对胎盘葡萄糖转运蛋白的影响

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中华围产医学杂志 2021年第9期24卷 651-657页

作者：何承融许芊芊苏日娜杨慧霞北京大学第一医院妇产科妊娠合并糖尿病母胎医学北京市重点实验室100034

目的探讨孕期高血糖孕妇胎盘葡萄糖转运蛋白(glucose transport protein,GLUT)1及4的表达变化以及孕妇血糖控制水平对其的影响。方法回顾性纳入2017年1月至2019年12月于北京大学第一医院行择期剖宫产的足月、单胎妊娠孕妇,其中孕前糖尿... 详细信息

目的探讨孕期高血糖孕妇胎盘葡萄糖转运蛋白(glucose transport protein,GLUT)1及4的表达变化以及孕妇血糖控制水平对其的影响。方法回顾性纳入2017年1月至2019年12月于北京大学第一医院行择期剖宫产的足月、单胎妊娠孕妇,其中孕前糖尿病(pregestational diabetes mellitus,PGDm)孕妇16例为PGDm组,妊娠期糖尿病(gestational diabetes mellitus,GDm)孕妇16例为GDm组,无血糖异常的孕妇16例为正常糖耐量(normal glucose tolerance,NGT)组。PGDm组和GDm组进一步根据孕期血糖控制水平是否良好分为PGDm-控制良好亚组(n=10)、PGDm-控制不良亚组(n=6)、GDm-控制良好亚组(n=10)和GDm-控制不良亚组(n=6)。采用蛋白质印迹技术检测各组孕妇胎盘中GLUT1和GLUT4的表达水平。比较组间GLUT1和GLUT4的表达水平,分析GLUT1和GLUT4表达水平与孕前体重指数、分娩前体重、孕期增重、新生儿出生体重的相关性。采用两独立样本t检验、单因素方差分析(两两比较采用LSD检验)、Kruskal-Wallis H检验、χ^(2)检验、Pearson相关分析进行统计学分析。结果(1)PGDm组孕妇孕前体重指数和胰岛素治疗比例高于GDm组及NGT组[27.0 kg/m^(2)(22.1~29.9 kg/m^(2))与22.9 kg/m^(2)(20.5~25.7 kg/m^(2))和21.7 kg/m^(2)(20.5~24.3 kg/m^(2));13/16与1/16和0/16],PGDm组孕妇中孕期空腹血糖、中孕期和晚孕期平均糖化血红蛋白高于GDm组[(6.1±1.2)与(5.0±0.4)mmol/L;(5.9±0.5)%与(5.2±0.3)%],P值均m组及GDm组高于NGT组(1.251±0.354、1.004±0.368与0.733±0.216),在PGDm组高于GDm组;在PGDm-控制良好亚组(1.270±0.417)及PGDm-控制不良亚组(1.218±0.245)、GDm-控制良好亚组(0.900±0.424)及GDm-控制不良亚组(1.177±0.158)也均高于NGT组(LSD检验,P值均m-控制不良亚组与PGDm-控制良好亚组比较,GDm-控制不良亚组与GDm-控制良好亚组比较,GLUT1和GLUT4表达水平差异均无统计学意义(P值均>0.05)。(3)PGDm-控制良好亚组GLUT1、GLUT4及GDm-控制不良亚组的GLUT1与孕期增重正相关(r值分別为0.635、0.810和0.833,P值均<0.05)。结论不同类型孕期高血糖及孕期增重与胎盘GLUT1和GLUT4表达水平有关,但血糖控制水平对胎盘GLUT的表达水平影响较小。

关键词：糖尿病,妊娠孕期增重血糖胎盘葡萄糖转运体1型葡萄糖转运体4型

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导管介入经门静脉注射内皮细胞致肝再生:大动物肝硬化模型的可行性研究

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国际医学放射学杂志 2017年第6期 722-723页

作者： K.S.Lee S.F.Santagostino D.Li A.Ramjit K.serrano m.D.Ginsberg 赵娓娓 Department of Radiology Weill Cornell Medicine

摘要目的论证影像引导下经导管内皮细胞治疗猪肝硬化模型致其肝再生的可行性。材料与方法本研究获动物管理和使用委员会批准,自体肝内皮细胞取自猪肝脏标本。

关键词：内皮细胞肝硬化静脉导管肝再生硬化模型

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Cost Optimisation for minimizing the Visual Impact of Ornamental Stone Quarrying. A Case Study in murcia Region

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Journal of Geoscience and Environment Protection 2018年第2期6卷 74-88页

作者： José molina-Ruiz maría José martínez-Sánchez Carmen Pérez-Sirvent mari Luz García-Lorenzo maría Luz Tudela-serrano Department of Geography Faculty of Geography University of Murcia Campus de la Merced Murcia Spain Department of Agricultural Chemistry Geology and Pedology Faculty of Chemistry University of Murcia Campus de Espinardo Murcia Spain Department of mineralogy and Petrology Faculty of Geology University Complutense of Madrid Madrid Spain

Quarrying of ornamental stone has adverse effects that are both visual and environmental. This paper aims to develop a methodology for minimising the costs associated with reducing the visual impact of ornamental stone quarrying. This study uses digital topographical maps of the study zone and a GPS and GIS application to calculate the extent of the area affected by quarrying activities for each altitude designated in the work plan and to calculate the extent of the potential visual impact. The results obtained applying the proposed methodology for the selected area suggested that the potential visual impact is minimal for an altitude of 520 metres, this being the optimal point for the observer. When altitude increases, the potential visual impact increases and the optimal point for the observer diminishes until the highest impact altitude (740 m) is readied. The optimal point that the exploitation should reach is that at which the values of the diagram generated by the (%) area of potential visual impact and area of exploitation (%) intersect. The methodology allows the optimal altitude to be determined for mining exploitations and helps assess the viability of a given exploitation from an environmental point of view.

关键词： Restoration Costs Ornamental Stone Visual Impact Limestone Quarrying

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