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Fast compression of computer-generated holographic images based on a GPU-accelerated skip-dimension vector quantization method

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Chinese Optics Letters 2013年第5期11卷 28-32页

作者： Y.K.lam W.C.Situ P.W.m.Tsang Department of Electronic Engineering City University of Hong Kong

A method for fast and low bit-rate compression of digital holograms based on a new vector quantization （VQ） method known as the skip-dimension VQ （SDVQ） is proposed. Briefly, a complex hologram is converted into a real off-axis hologram, and partitioned into a set of image vectors. The image vectors are passed into a graphic processing unit （GPU）, and compressed through SDVQ into a set of code indices considerably smaller in data size than the source hologram. Experimental evaluation reveals that our scheme is capable of compressing a digital hologram to a compression ratio of over 500 times, in approximately 20-22 ms.

关键词： GPU Fast compression of computer-generated holographic images based on a GPU-accelerated skip-dimension vector quantization method VQ

Performance evaluation of polyamide nanofiltration membranes for phosphorus removal process and their stability against strong acid/alkali solution

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Chinese Journal of Chemical Engineering 2019年第8期27卷 1789-1797页

作者： Yen Khai Chai How Chun lam Chai Hoon Koo Woei Jye Lau Soon Onn Lai Ahmad Fauzi Ismail Department of Civil Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanJalan Bandar Sg.LongBandar Sg.Long43000 KajangSelangorMalaysia Advanced membrane Technology Research Centre(AmTEC) Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia Department of Chemical Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanJalan Bandar Sg.LongBandar Sg.Long43000 KajangSelangorMalaysia

In this study,a quantitative performance of three commercial polyamide nanofiltration(NF) membranes(i.e.,NF,NF90,and NF270) for phosphorus removal under different feed conditions was *** experiments were conducted at different feed phosphorus concentrations(2.5,5,10,and 15 mg·L^-1) and elevated pHs(pH 1.5,5,10,and 13.5) at a constant feed pressure of 1 mPa using a dead-end filtration *** rejection against total phosphorus generally increased with increasing phosphorus concentration regardless of membrane *** contrast,the permeate flux for all the membranes only decreased slightly with increasing phosphorus *** results also showed that the phosphorus rejections improved while water flux remained almost unchanged with increasing feed solution *** the three membranes were exposed to strong pHs(pH 1.5 and 13.5) for a longer duration(up to 6 weeks)it was found that the rejection capability and water flux of the membranes remained very similar throughout the duration,except for NF membrane with marginal decrement in phosphorus *** study also revealed that more phosphorus was adsorbed onto the membrane structure at alkaline conditions(pH 10 and 13.5) compared to the same membranes tested at lower pHs(pH 1.5 and 5).In eonelusion,NF270 membrane outperformed Nf and NF90 membranes owing to its desirable performance of water flux and phosphorus rejection particularly under strong alkali *** NF270 membrane achieved 14.0 L·m^-2·h^-1 and 96.5% rejection against 10 mg·L^-1 phosphorus solution with a pH value of 13.5 at the applied pressure of 1 mPa.

关键词： membrane Nanofiltration Phosphorus removal pH Stability Humic acid

Unsupervised learning on scientific ocean drilling datasets from the South China Sea

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Frontiers of Earth Science 2019年第1期13卷 180-190页

作者： Kevin C.TSE Hon-Chim CHIU man-Yin TSANG Yiliang LI Edmund Y.lam Department of Earth Sciences The University of Hong KongPokfulamHong KongChina Department of Geography and Centre for Geo-computation Studies Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Earth Sciences University of TorontoTorontoON M5S 2M8Canada Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Unsupervised learning methods were applied to explore data patterns in multivariate geophysical datasets collected from ocean floor sediment core samples coming from scientific ocean drilling in the South China *** to studies on similar datasets,but using supervised learning methods which are designed to make predictions based on sample training data,unsupervised learning methods require no a priori information and focus only on the input *** this study,popular unsupervised learning methods including K-means,self-organizing maps,hierarchical clustering and random forest were coupled with different distance metrics to form exploratory data *** resulting data clusters were externally validated with lithologic units and geologic time scales assigned to the datasets by conventional methods. Compact and connected data clusters displayed varying degrees of correspondence with existing classification by lithologic units and geologic time scales.K-means and self-organizing maps were observed to perform better with lithologic units while random forest corresponded best with geologic time *** study sets a pioneering example of how unsupervised machine learning methods can be used as an automatic processing tool for the increasingly high volume of scientific ocean drilling data.

关键词： machine learning unsupervised learning ODP IODP clustering

Chinese Guqin music and Calligraphy for Treating Symptoms of Primary Insomnia

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Chinese medicine and Culture 2019年第1期2卷 48-52页

作者： miranda m.Y.Fung Henry S.R.Kao Stewart R W.lam Tin Tin Kao Department of Chinese medicine China Academy of Chinese Medical SciencesBeijing Departments of Psychology University of Hong KongHKSARChina Departments of Psychology and Geography University of Hong KongHKSARChina

Purpose:To investigate the intervention effiects of using traditional Chinese Guqin music and Chinese Calligraphy handwriting(CCH)for patients with Primary ***:A total of ninety patients were assigned to control group,Guqin group,and calligraphy group for 8 *** 5 days a week,patients’heart rate variability(HRV)and frontal midline(FZ)electroencephalographic signals were recorded in a clinic during interventional period while either listening to Guqin music or writing *** in the control group remained in rest ***:For the Guqin group,the higher low-frequency-range HRV of coherence was found with marginal significance(P=0.055),and heart rate was significantly reduced(Pmusic compared to the prerest *** listening to Guqin music or calligraphy intervention,FZδ,FZθ,and FZα waves in the 8^th week compared to the 0^th week(Pre Intervention)showed a significantly enhanced effect(.Pmusic;FZδ,FZθ,and FZα waves of Guqin music and calligraphy proved that Guqin music together with calligraphy training helping to promote physical and mental health,thereby it contributes to the clinical application of TCm Psychology for patients with insomnia syndrome.

关键词： Alpha calligraphy Chinese calligraphy handwriting delta EEG brainwave Guqin heart rate variability physical and mental health primary insomnia TCm Psychology theta

阿片类物质对猴免疫缺陷病毒感染的CEm×174细胞内p53合成的调节作用(英文)

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中国生物化学与分子生物学报 2000年第2期16卷 162-168页

作者：李刚 Kanneth m.lam 海南医学院蛋白质核酸研究室海口570102 Department of Population Health and Reproduction University of California

已经证明阿片类物质如吗啡能够刺激猴免疫缺陷病毒 ( SIV)的复制 ,并最终加速细胞死亡 ,但是其机理却研究很少 .为探讨吗啡和甲硫氨酸脑啡肽对细胞内 p53合成的作用 ,用 SIV感染CEm× 1 74细胞 ,同时分析 SIV感染时病理过程的机理 .在 ... 详细信息

已经证明阿片类物质如吗啡能够刺激猴免疫缺陷病毒 ( SIV)的复制 ,并最终加速细胞死亡 ,但是其机理却研究很少 .为探讨吗啡和甲硫氨酸脑啡肽对细胞内 p53合成的作用 ,用 SIV感染CEm× 1 74细胞 ,同时分析 SIV感染时病理过程的机理 .在 CEm× 1 74细胞感染 SIV后不同时间 ,p53含量逐渐增加 ,但 1 0 -7mol/L的吗啡仅在起始阶段对其有促进作用 .在 SIV感染组加入吗啡或甲硫氨酸脑啡肽进行时间曲线实验时 ,p53含量较低 .加入 1 0 -8～ 1 0 -6mol/L吗啡 8h,正常细胞 p53含量仅有轻微改变 .但在 SIV感染情况下 ,则呈现剂量依赖性的大量增加 .相反 ,1 0 -8- 1 0 -6mol/L甲硫氨酸脑啡肽在 8h时能增加正常细胞 p53合成达 60 % .在 SIV感染时 ,SIV本身能够促进 p53的含量 .尽管各组 p53仍然高于对照组 ,但甲硫氨酸脑啡肽对其不再起作用 .结果提示甲硫氨酸脑啡肽对正常细胞 p53含量有明显影响 ,而吗啡 8h增加 SIV感染细胞的 p53含量可能是其加速爱滋病病理过程的机理之一 .

关键词：免疫缺陷病毒 p53 生物合成调节阿片类物质

mTBSTFA derivatization-LC-mS/mS approach for the quantitative analysis of endogenous nucleotides in human colorectal carcinoma cells

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Journal of Pharmaceutical Analysis 2022年第1期12卷 77-86页

作者： Huixia Zhang Yan Li Zheng Li Christopher Wai-Kei lam Peng Zhu Caiyun Wang Hua Zhou Wei Zhang State Key Laboratory of Quality Research in Chinese medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacaoChina

Endogenous ribonucleotides(RNs)and deoxyribonucleotides(dRNs)are important metabolites related to the pathogenesis of many *** light of their physiological and pathological significances,a novel and sensitive pre-column derivatization method with N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide(mTBSTFA)was developed to determine RNs and dRNs in human cells using high-performance liquid chromatography tandem mass spectrometry(HPLC-mS/mS).A one-step extraction of cells with 85%methanol followed by a simple derivatization reaction within 5 min at room temperature contributed to shortened analysis *** derivatives of 22 nucleoside mono-,di-and tri-phosphates were retained on the typical C;column and eluted by ammonium acetate and acetonitrile in 9 *** these optimal conditions,good linearity was achieved in the tested calibration *** lower limit of quantitation(LLOQ)was determined to be 0.1-0.4μm for the tested RNs and 0.001-0.1μm for *** addition,the precision(CV)wasmore,this method was applied to quantify the endogenous nucleotides in human colorectal carcinoma cell lines HCT 116 exposed to *** conclusion,our method has proven to be simple,rapid,sensitive,and *** may be used for specific expanded studies on intracellular pharmacology in vitro.

关键词： Ribonucleotides Deoxyribonucleotides Derivatization N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide High-performance liquid chromatography tandem mass spectrometry

A cyanostilbene-based molecule with aggregation-induced emission properties: amplified spontaneous emission, protonation effect and electroluminescence

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Science China Chemistry 2019年第2期62卷 212-219页

作者： Yujie Dong Suqian ma Xiaoyu Zhang Jingyu Qian Nianyong Zhu Bin Xu Cheuk-lam Ho Wenjing Tian Wai-Yeung Wong Institute of molecular Functional materials and Department of Chemistry Hong Kong Baptist University State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology College of Chemical Engineering Zhejiang University of Technology State Key Laboratory of Supramolecular Structure and materials Jilin University Department of Applied Biology & Chemical Technology The Hong Kong Polytechnic University

A terpyridine-substituted cyanostilbene derivative(Z)-2-(4′-([2,2′:6′,2″-terpyridin]-4′-yl)-[1,1′-biphenyl]-4-yl)-3-phenylacrylonitrile(CNSTPy) was synthesized and characterized. The compound exhibits remarkable aggregation-induced emission phenomenon and its single crystal shows a blue emission with fluorescent efficiency as high as 45%. Based on its aggregation state behavior, multiple applications towards exploring its lasing, fluorescence switching and electroluminescence properties were realized. Amplified spontaneous emission(ASE) was observed from the crystal and verified by the variable pump strip method, with a threshold value of ～1.5 m J cm^(-2). The protonation/deprotonation processes accompanied by the formation of different molecular aggregation structure result in the distinct blue and yellow emissions. Additionally, the molecule also shows a moderate electroluminescence performance.

关键词： aggregation-induced emission cyanostilbene amplified spontaneous emission protonation effect

Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous visual field defects

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 577-581页

作者： Qi N.Cui Priyanka Gogt Jonathan m.lam Safa Siraj Lisa A.Hark Jonathan S.myers L.Jay Katz michael Waisbourd Glaucoma Research Center Wills Eye Hospital Scheie Eye Center University of Pennsylvania Department of Ophthalmology Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine Tel Aviv University

AIm: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous visual field(VF) defects compared to the Octopus Visual Field(OVF) Analyzer and to determine the test-retest repeatability of both ***: This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA. Glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP) Ⅲ 30-2 Adaptive Staircase Thresholding Algorithm(ASTA) FAST protocol and OVF G-TOP white-on-white strategy. Testing order was randomized. Pearson's correlation coefficient was calculated for both mean deviation(mD) and pattern standard deviation/square root of loss of variance(PSD/s LV). Receiver operating characteristic(ROC) curves were used to determine the diagnostic abilities of both modalities. Glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs) were calculated to assess test-retest repeatability. RESULTS: Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled. HEP and OVF were significantly correlated for both mD(r=-0.84; Pmparable between HEP and OVF for both mD(0.74 and 0.79, respectively; P=0.26) and PSD/sL V(0.74 and 0.82; P=0.08). ICC was high for both HEP (0.96 for mD, 0.95 for PSD/s LV) and OVF(0.82 and 0.88, respectively). mean test duration(min) was significantly shorter for OVF(2.63) compared to HEP(5.15; PmD and PSD/s LV, and have similar validity for detecting glaucoma. The test-retest repeatability is high for both HEP and OVF, however the average testing duration of HEP is significantly longer than that of OVF.

关键词： glaucoma Heidelberg Edge Perimeter standard automated perimetry Octopus Visual Field Analyzer visual field

molecular Characterization of Plant Prevacuolar and Endosomal Compartments

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Journal of Integrative Plant Biology 2007年第8期49卷 1119-1128页

作者： Sheung Kwan lam Yu Chung Tse Yansong miao Hong-Ye Li Junqi Wang Sze Wan Lo Liwen Jiang Department of Biology and molecular Biotechnology Program The Chinese University of Hong Kong Shatin New Territories Hong Kong China Institute of Plant molecular Biology & Agricultural Biotechnology The Chinese University of Hong Kong Shatin New Territories Hong Kong China

Prevacuolar compartments （PVCs） and endosomal compartments are membrane-bound organelles mediating protein traffic to vacuoles in the secretory and endocytic pathways of plant cells. Over the years, great progress has been made towards our understanding in these two compartments in plant cells. In this review, we will summarize our contributions toward the identification and characterization of plant prevacuolar and endosomal compartments. Our studies will serve as important steps in future molecular characterization of PVC biogenesis and PVC-mediated protein traffickinq in plant cells.

关键词： BY-2 cells endosomal compartment prevacuolar compartment organelle proteomic vacuolar sorting receptor