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钆布醇钠与钆膦维司在下肢mR静脉成像中的比较

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国际医学放射学杂志 2018年第1期 119-119页

作者： C.W.K.P.Arnoldussen Y.lam N.Ito B.Winkens m.E.Kooi C.H.A.Wittens 屈瑾 Department of Radiology Maastricht University Medical Center

摘要目的 mR静脉成像(mRV)方案一直采用血池对比剂和长扫描序列来术前挑选适合于治疗的病人。然而,血池对比剂的可变性、高成本以及缩短常规mR采集时间的需

关键词：钆布醇静脉成像 mR

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

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Frontiers of medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen maria Teresa Landi mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le marchand Olle melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew lambertus AKiemeney Shan Zienolddiny Kjell Grankvist mikael Johansson Neil Caporaso Penella Woll Philip Lazarus matthew BSchabath melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health Sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical Biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster Salzburg at PLUS Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of medicine Carmel Medical CenterHaifa 3448516Israel markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of molecular and Clinical Cancer medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

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职业接触或(和)吸烟对死亡的影响——广州165660名职工队列的前瞻性研究

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职业接触或(和)吸烟对死亡的影响——广州165660名职工队列的前瞻...

屋尘螨1类变应原促进外周血嗜酸性粒细胞释放细胞因子的探讨

中国科协2001年学术年会

作者：江朝强 lam TH 刘薇薇张维森 Ho SY AJ Hedley 何健民曹民朱昌淇香港大学医学院英国伯明翰大学

为了研究职业接触或(和)吸烟对死亡的影响,本研究用前瞻性队列研究方法,利用1989～1992年广州市实施职业健康监护系统建立的165660名年龄≥30岁的工厂职工和司机个体健康档案为基础资料,填入由香港明日电脑处理中心编制印刷的光学扫描...

为了研究职业接触或(和)吸烟对死亡的影响,本研究用前瞻性队列研究方法,利用1989～1992年广州市实施职业健康监护系统建立的165660名年龄≥30岁的工厂职工和司机个体健康档案为基础资料,填入由香港明日电脑处理中心编制印刷的光学扫描直读表(ICR),同时建立基线

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临床检验杂志 2007年第5期25卷 346-347页

作者：王成彬黄振国李洛谊叶伟基林伟基丛玉隆中国人民解放军总医院临床检验科北京100853 香港中文大学化学病理学系

目的探讨屋尘螨1类变应原(DerP1)对嗜酸性粒细胞(E)释放炎性细胞因子IL-1β、IL-6、IL-8、IL-10和TNF-α的影响。方法用CD16抗体磁珠法从新鲜人外周血分离E;5×105/mlE与5μg/mlDerP1共培养12h;用流式细胞小球微阵列(cytometricbeadarra... 详细信息

目的探讨屋尘螨1类变应原(DerP1)对嗜酸性粒细胞(E)释放炎性细胞因子IL-1β、IL-6、IL-8、IL-10和TNF-α的影响。方法用CD16抗体磁珠法从新鲜人外周血分离E;5×105/mlE与5μg/mlDerP1共培养12h;用流式细胞小球微阵列(cytometricbeadarray,CBA)法定量细胞培养上清液中细胞因子。结果外周血E单独培养过程中仅有极少量IL-1β、IL-6、IL-8、IL-10和TNF-α释放,但与5μg/mlDerP1共育时,培养上清液中上述5种细胞因子浓度显著增加(P均<0.001),IL-10增加约5倍,其他4种细胞因子均增加约100倍。结论DerP1对E释放炎性细胞因子具有很强的促进作用。

关键词：屋尘螨嗜酸性粒细胞细胞因子

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9例佩梅病与2例佩梅样病人的PLP1与GJA12基因突变分析

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9例佩梅病与2例佩梅样病人的PLP1与GJA12基因突变分析

Viral blips during long-term treatment with standard or double dose lamivudine in HBe antigen negative chronic hepatitis B

中华医学会第五次全国儿科中青年学术交流大会

作者：李涛云王静敏姜玉武王慧芳 Tony m.F.Tong Stephn T.S.lam 吴晔李新毅杨艳玲秦炯吴希如北京大学第一医院儿科

佩梅氏病(Pelizaeus-merzbacher disease,PmD)与佩梅样病(Pelizaeus-merzbacher-like disease,PmLD)是罕见的中枢神经系统髓鞘形成障碍性疾病,临床表现均以眼球振颤、进行性痉挛性截瘫、共济失调及精神运动发育迟缓为特征。头颅mRI具有... 详细信息

佩梅氏病(Pelizaeus-merzbacher disease,PmD)与佩梅样病(Pelizaeus-merzbacher-like disease,PmLD)是罕见的中枢神经系统髓鞘形成障碍性疾病,临床表现均以眼球振颤、进行性痉挛性截瘫、共济失调及精神运动发育迟缓为特征。头颅mRI具有脑白质髓鞘形成落后的异常信号改变。佩梅氏病的致病基因位于Xq22的蛋白脂蛋白(pmtcoupid protein 1,PLP1),佩梅样病的致病基因于2004年定位在Iq41-42的缝隙连接蛋白A12(junction protein alpha 12,GJA12),目前对这两种病均没有生化方法进行诊断,而且根据临床表现二者难以区分,因此,对它们的诊断只能依赖于基因突变分析。目的本文对9例佩梅氏病人与2例佩梅样病人分别进行了PLP1与GJA12的基因突变分析。方法收集临床资料及周围血提取基因组DNA,采用多重连接依赖的探针扩增(multiplex ligation-dependent probe amplification,mLPA)方法进行PLP1基因重复突变检测;DNA直接测序方法进行PLP1与GJA12突变检测;应用单核苷酸多态标记(single nuclcotidc polymorphic markers)进行1号染色体单倍体分析,确定基因突变类型,明确基因诊断。结果9例佩梅氏病人根据临床与mRI表现诊断为4例经典型、4例中间型及1例先天型,9例病人中有7例为PLPI基因重复突变,占77.7%,1例PLP1基因发现第4外显子的c.517C>T(p.P173S)突变,1例PLP1与GJA12基因分析均未发现异常。2例佩梅样病人中1例为GJA12基因c.216delGinsAA(p.P73fsX106)纯合移码突变,患儿之父为本位点的杂合突变,而其母亲为本位点的正常野生型,进一步应用单核苷酸多态对第1号染色体单体型分析结果显示:患儿的c.216delGinsAA(p.P73fsX106)为父源单亲二倍体所致;另一例患儿为GJA12基因c.138C>G(p.146m)纯合错义突变,其父母为本位点的杂合突变。结论本研究中佩梅氏病患儿PLP1基因突变国内首次报道,PLP1基因的突变类型以重复突变为主。佩梅样病患儿发现GJA12基因c.216delGinsAA (p.P73fsX106)与c.138C>G(p.146m)为国际上首次报道,并且前者是由于父源单亲二倍体所致。

关键词：佩梅氏病患儿佩梅样病致病基因基因突变分析蛋白脂蛋白

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World Journal of Gastroenterology 2007年第42期13卷 5642-5647页

作者： Gianfranca Stornaiuolo maria Stanzione Giuseppina Brancaccio Gianluca Cuomo Vincenza Precone Sebastiano Di Biase Francesca m Felaco Felice Piccinino Giovanni B Gaeta Viral Hepatitis Unit Department of Infectious Diseases Second University Naples Italy Infectious Disease Unit Department of Infectious Diseases Second University Naples Italy merigen Laboratory of Molecular Biology Naples Italy

AIm:To evaluate safety and effect on hepatitis B virus(HBV)suppression of a long-term treatment with lamivudine(lam)at standard(100 mg/d)or double(200 mg/d)dose in chronic hepatitis ***:This was a case study with matched controls(1:3)in patients with chronic hepatitis B with anti-HBe ***:Twelve patients received lam 200 mg/d and 35 lam 100 mg/d,for a median of 28 mo.A primary response(PR;*** HBV-DNA with Amplicor assay)was achieved in 100% of lam-200 patients and 83% of lam-100 patients.A virological breakthrough occurred in 16.7 and 24.7%,respectively,of the PR-patients,with the appearance of typical lam resistance mutations in all but one *** blips(*** HBV-DNA below 80 IU/mL in patients who tested negative at Amplicor assay)were detected using a real time polymerase chain reaction(PCR)and occurred in seven out of nine patients with subsequent BT and in four out of 32 patients with end-of-study response(77.7% vs 12.5%;P = 0.001)at chi-square test).At the end of the study,51.4% of lam-100 patients and 83.3% of lam-200 patients had remained stably HBV-DNA ***-dose lam was well ***:Long-term treatment of anti-HBe positive chronic hepatitis B with double dose lamivudine causes a more profound and stable viral suppression ascompared to conventional treatment.

关键词： lamivudine Hepatitis B Chronic Hepatitis Polymerase chain reaction

圈的推广mycielski图的圆色数(英文)

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南京大学学报（数学半年刊） 2006年第2期23卷 232-241页

作者：林文松林子波邵慰慈东南大学数学系南京210096 香港浸会大学数学系

mycielski图是1955年由mycielski提出来的．任给一个图G和一个非负整数m,G的推广mycielski图μm(G)是G的mycielski图的一个自然的推广．推广mycielski图的性质以及它们的点色数、圆色数和分数色数等已有许多研究．本文研究圈的推广mycie... 详细信息

mycielski图是1955年由mycielski提出来的．任给一个图G和一个非负整数m,G的推广mycielski图μm(G)是G的mycielski图的一个自然的推广．推广mycielski图的性质以及它们的点色数、圆色数和分数色数等已有许多研究．本文研究圈的推广mycielski图的圆色数．定义Cn为n个顶点的圈．对任意非负整数m和大于2的整数n,本文确定了图μm(Cn)的圆色数,同时还得到了图μm(Cn)-v的圆色数的一些结果．

关键词：圆色数推广mycielski图圈奇围长临界图

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Vegetation Biomass of Sargassum meadows in An Chan Coastal Waters,Phu Yen Province,Vietnam Derived from PlanetScope Image

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Journal of Environmental Science and Engineering(B) 2019年第3期8卷 81-92页

作者： Nguyen Thi Thu Hang Nguyen Thai Hoa Tong Phuoc Hoang Son lam Nguyen-Ngoc Graduate University of Science and Technology Vietnam Academy of Science and Technology Ha Noi 11355Viet Nam Center for Environmental monitoring Department of Natural Resources and EnvironmentPhu Yen Prov.56000Viet Nam Institute of Oceanography Vietnam Academy of Science and TechnologyKhanh Hoa Prov.57000Viet Nam

SW(Seaweed)is a valuable coastal resource for its use in food,cosmetics,medicine and other *** this study,PS(PlanetScope)imagery was combined with field sampling to demonstrate the capability of mapping of SAV(Submerge Aquatic Vegetation)(including both SW and SG(Seagrass)beds)and biomass mapping of Sargassum meadows in An Chan coastal waters,Tuy An district,Phu Yen province,*** term of SAV and Sargassum mapping,authors proposed an improved remote sensing technique based on Sagawa’s BRI(Bottom Reflectance Index)algorithm with attention to Tassan’s concept in discrimination of light attenuation coefficient Kd between shallow and deep ***’results showed high accuracy in mapping of SAV and Sargassum distribution with overall accuracy and Kappa coefficient of 92.52%and 0.8957,*** classified class of SW(*** sp.)then was separated absolutely from other classes in SAV map for estimation of Sargassum *** red and green spectral pre-processed BRI channels(***3 and BRI2)of PS were used to estimate the Sargassum biomass using a multiple 2nd order polynomial regression model with very high accuracy(R2=0.9707;RmSE=±109.21 g/m2).The average total Sargassum biomass was 897.8 g/m2 with total Sargassum yield in whole region reaching a value of 449.57 tons in cover area of 50.32 ha of Sargassum *** result opens the great potential of biomass and yield estimation of Sargassum and other SW meadows in coastal waters(including enough optically deep waters)by remote sensing techniques based on PS imagery.

关键词： PS satellite image Sargassum biomass SW BRI

LC–mS characterization, anti-kinetoplastide and cytotoxic activities of natural products from Eugenia jambolana lam. and Eugenia uniflora

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 836-841页

作者： Celestina Elba Sobral de Souza Ana Raquel Pereira da Silva Janaina Esmeraldo Rocha maria Celeste Vega Gomez míriam Rolóm Cathia Coronel José Galberto martins da Costa manoel L.C.Netto Larissa A.Rolim Henrique Douglas melo Coutinho Laboratório de microbiologia e Biologia molecular Universidade Regional do Cariri Center for the Development of Scientific Research Moisés Bertoni Foundation/Díaz Gill Laboratories Laboratório de Pesquisa de Produtos Naturais Universidade Regional do Cariri Centro Universitário Dr.Leao Sampaio–UNILEAO Universidade Federal do Vale do Sao Francisco–UNIVASF

Objective: To evaluate the trypanocidal, leishmanicidal and cytotoxic activity of Eugenia jambolana(E. jambolana) and Eugenia uniflora(E. uniflora) extracts and ***: The products were characterized by LC–mS. Antiparasitic assays were performed and cytotoxicity was evaluated in fibroblastos. In vitro assays were performed using spectrophotometric evaluation. All assays were performed in ***: The results showed that the extracts and the tannic fraction from E. jambolana inhibited 100% of the epimastigote lines. The ethanolic extract was the most efficient in all concentrations tested against the three parasite strains. In the cytotoxicity assay the flavonoid fraction showed low toxicity. All E. uniflora samples showed cytotoxicity at the highest concentration tested, but the extract showed no toxic effect on the fibroblasts at the lowest concentration. The flavonoid and tannic fractions were more efficient against Leishmania braziliensis promastigotes compared to the extract. However, the extracts and the tannic fraction were more effective against Leishmania infantum strains. The effect on epimastigote cells was observed at all concentrations tested, with all E. uniflora samples. However, the samples were more effective at the highest concentration, where there was inhibition in 100% of the Trypanosoma cruzi ***: The species E. jambolana and E. uniflora presented antiparasitic activity against all tested parasite strains, indicating that these species can serve as an alternative therapy as they were efficient in the tests performed. The E. uniflora extract and the E. jambolana flavonoid fraction presented a low cytotoxicity, opening the floor for new biological studies.

关键词： Antiparasitic effect Cytotoxicity Eugenia jambolana Eugenia uniflora