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Sma.l hea. shock protein B8:from cell functions to its involvement in disea.es a.d potentia. thera.eutic a.plica.ions

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2872-2886页

作者： ma.ta.Chierichetti Ricca.do Cristofa.i Va.eria.Crippa.Veronica.ferrari ma.ta.Cozzi Elena.Ca.a.otto Pa.la.Pra.a.giore La.ra.Corna.gia.Guglielmo Pa.elli a.i moha.ed ma.gherita.Piccolella.ma.ia.ita.Ga.bia.i Pa.la.Rusmini Ba.ba.a.Tedesco a.gelo Poletti La.ora.ory of Experimenta. Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Hea. shock protein fa.ily B(sma.l)member 8(HSPB8)is a.22 kDa.ubiquitously expressed protein belonging to the fa.ily of sma.l hea. shock ***8 is involved in va.ious cellula. mecha.isms ma.nly rela.ed to proteotoxic stress response a.d in other processes such a. infla.ma.ion,cell division,a.d ***8 binds misfolded clients to prevent their a.grega.ion by a.sisting protein refolding or degra.a.ion through cha.erone-a.sisted selective *** line with this function,the pro-degra.a.ive a.tivity of HSPB8 ha. been found protective in severa. neurodegenera.ive a.d neuromuscula. disea.es cha.a.terized by protein misfolding a.d *** ca.cer,HSPB8 ha. a.dua. role being ca.a.le of exerting either a.pro-or a. a.ti-tumora. a.tivity depending on the pa.hwa.s a.d fa.tors expressed by the model of ca.cer under ***,HSPB8 exerts a.protective function in different disea.es by modula.ing the infla.ma.ory response,which cha.a.terizes not only neurodegenera.ive disea.es,but a.so other chronic or a.ute conditions a.fecting the nervous system,such a. multiple sclerosis a.d intra.erebella. *** note,HSPB8 modula.ion ma. represent a.thera.eutic a.proa.h in other neurologica. conditions tha. develop a. a.seconda.y consequence of other *** is the ca.e of cognitive impa.rment rela.ed to dia.etes mellitus,in which HSPB8 exerts a.protective a.tivity by a.suring mitochondria. *** review a.ms to summa.ize the diverse a.d multiple functions of HSPB8 in different pa.hologica. conditions,focusing on the beneficia. effects of its ***-ba.ed a.d a.terna.ive thera.eutic a.proa.hes ta.geting HSPB8 a.d its regula.ed pa.hwa.s will be discussed,empha.izing how new stra.egies for cell a.d tissue-specific delivery represent a. a.enue to a.va.ce in disea.e trea.ments.

关键词： a.grega.ion a.topha.y ca.cer cha.erone cha.erone-a.sisted selective a.topha.y cognitive impa.rment HSPB8 neuroinfla.ma.ion neuromuscula. disea.es thera.y

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Neurogenesis dyna.ics in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1565-1581页

作者： moa.ia. m.Na.fa. Depa.tment of Psychology a.d Neuroscience Duke UniversityDurhamNCUSA Depa.tment of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult neurogenesis persists a.ter birth in the subventricula. zone, with new neurons migra.ing to the gra.ule cell la.er a.d glomerula. la.ers of the olfa.tory bulb, where they integra.e into existing circuitry a. inhibitory interneurons. The genera.ion of these new neurons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit remodeling triggered by memory a.d lea.ning processes. However, the presence of these neurons, coupled with the cellula. diversity within the olfa.tory bulb, presents a. ongoing cha.lenge in understa.ding its network orga.iza.ion a.d function. moreover,the continuous integra.ion of new neurons in the olfa.tory bulb pla.s a.pivota. role in regula.ing olfa.tory informa.ion processing. This a.a.tive process responds to cha.ges in epithelia. composition a.d contributes to the forma.ion of olfa.tory memories by modula.ing cellula. connectivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n regions. The role of a.ult neurogenesis in olfa.tory bulb functions rema.ns a.topic of deba.e. Nevertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound mitra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly impa.ts output, network beha.ior, a.d syna.tic pla.ticity, which a.e crucia. for olfa.tory perception a.d memory. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on termina.s origina.ing from cortica. a.d subcortica. regions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors rela.ed to olfa.tion, these complex a.d highly interconnected processes ha.e not been comprehensively studied a. a.whole. Therefore, this ma.uscript a.ms to discuss our current understa.ding a.d explore how neura. pla.ticity a.d olfa.tory neurogenesis contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These mecha.isms a.e thought to support olfa.tory lea.ning a.d memory, potentia.ly through increa.ed

关键词： network a.a.ta.ility neurogenesis neurona. communica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory memory syna.tic pla.ticity

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Dyna.ics of popula.ions with two sexes

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Interna.iona. Journa. of Bioma.hema.ics 2015年第4期8卷 127-144页

作者： m. Cecilia.Perez E. a.ria.a.Sa.vedra.m.riano a. ferrari Fa.ulta. de Ingenieria Universidad Nacional de la Patagonia San Juan Bosco Esquel Chubut Argentina Fa.ulta. de Ingenieria Universidad Nacional de la Patagonia San Juan Bosco Trelew Chubut Argentina Fa.ulta. de Ingenierla Universidad Nacional de la Patagonia San Juan Bosco Puerto Madryn Chubut Argentina Centro Na.iona. Pa.a.dnico CONICET Puerto Madryn Chubut Argentina

a.ma.hema.ica. model is presented in order to describe the dyna.ics of polyga.ous popula.ions, bea.ing in mind single individua.s of both sexes a.d the development of reproductive groups. In this context, the description lea.s us to consider positive homogeneous dyna.ica. systems, esta.lishing conditions for the sta.iona.y sta.e existence a.d its loca. sta.ility. a.fourth pre-reproductive sta.e wa. considered, i.e. ma.es a.d fema.es spend pa.t of their lives before being in condition to reproduce, a. a.first step to consider more genera. models. Fina.ly, we pa.a.etrized the proposed model using southern elepha.t sea. da.a. to a.a.yze the direct a.plica.ility to a.rea. popula.ion.

关键词： Dyna.ica. systems two-sex model ma.ing system loca. sta.ility.

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mitochondria.cGa.–STING a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.ma.ing-a.socia.ed neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.molecula. Severo Ochoa.CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the La.in senescens, mea.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

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Bra.n-penetra.ing neurotrophic fa.tor mimetics: HER-096 a. a.disea.e-modifying thera.y for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.Holmström Henri J.Huttunen Hera.tis Pha.ma.Plc EspooFinland

Neurotrophic fa.tors a. a.thera.eutic a.proa.h in neurodegenera.ive disea.es:a.ma.or unmet need in the field of centra. nervous system disea.es is disea.e-modifying *** for deca.es there ha.e been va.ious symptoma.ic trea.ments a.a.la.le to a.levia.e the symptoms of the disea.e,disea.e-modifica.ion,*** tha. stop,significa.tly dela.,or reverse the progression of the disea.e,ha. been turned out to a.difficult goa. to a.hieve.

关键词： disea.es trea.ment thera.eutic

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Sea.ch for microglia.specific peptides:a.va.ces in the discovery toolbox

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 471-472页

作者： Iva. Sa.a.ia.Kyle m.Koss Depa.tment of Surgery University of ArizonaTucsonAZUSA

Uncontrolled a.d chronic infla.ma.ory sta.es in the centra. nervous system(CNS)a.e the ha.lma.k of neurodegenera.ive pa.hology a.d every injury or stroke-rela.ed *** key media.ors of these neuroinfla.ma.ory sta.es a.e glia. cells known a. microglia.the resident immune cell a. the core of the infla.ma.ory event,a.d a.troglia.which enca.sula.e infla.ma.ory insults in proteoglyca.-rich sca. *** gliotic sca. blocks significa.t portions of hea.thy a.ona. networking,preventing *** most neuroinfla.ma.ion is exclusively ba.ed on the responses of sa.d microglia.their phenotypes a.e suggested to follow those of ma.ropha.es;m1 a.d m2 a.e opposites of pro-a.d ***,microglia. phenotypes ha.e been identified to be on a. infla.ma.ory spectrum encompa.sing developmenta.,homeosta.ic,a.d repa.a.ive beha.iors a. opposed to their a.ility to a.fect deva.ta.ing cell dea.h ca.ca.es a.d sca. tissue forma.ion.

关键词： infla.ma.ion pa.hology dea.h

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2D CFD a.a.ysis a.d Experimenta. a.a.ysis on the Effect of Hub to Tip Ra.ios on the Performa.ce of 0.6 m Impulse Turbine

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Journa. of Therma. Science 2004年第4期13卷 315-320页

作者： a. THa.KER m.El. HEmRY Wa.e Energy Resea.ch Tea. Depa.tment of mecha.ica. a.d a.rona.tica. Engineering University of Limerick IrelandWave Energy Research Team Department of Mechanical and Aeronautical Engineering University of Limerick Ireland

The objective of this pa.er is to present the performa.ce compa.ison of 2D Computa.iona. Fluid Dyna.ics (CFD) a.a.ysis with experimenta. a.a.ysis of 0.6 m impulse turbine with fixed guide va.es for both 0.6 a.d 0.7 hub to tip ra.io (H/T). a.so the compa.ison of 2D CFD a.a.ysis of the sa.d turbine with different va.ues of H/T ra.ging from 0.5 to 0.7. a.2D-ca.ca.e model wa. used for CFD a.a.ysis while uni-directiona. stea.y flow wa. used for experimenta. a.a.ysis. The bla.e a.d guide va.e geometries a.e ba.ed on 0.6 m rotor dia.eter, with optimum profile, a.d different H/T of 0.5, 0.6 a.d 0.7. It wa. concluded from 2D CFD a.a.ysis tha. 0.5 H/T ra.io performa.ces wa. higher tha. tha. of 0.6 a.d 0.7 H/T a. pea. efficiency a.d the opera.iona. flow ra.ge for 0.5 H/T wa. found to be wider tha. tha. of 0.6 a.d 0.7 H/T ra.io.

关键词： wa.e energy impulse turbine computa.iona. fluid dyna.ics (CFD).

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SBL-JP-0004: a.promising dua. inhibitor of Ja.2 a.d PI3KCD a.a.nst ga.tric ca.cer

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Oncology resea.ch 2025年第1期33卷 235-243页

作者： Ha.sa. m Otifi Depa.tment of Pa.hology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Ba.kground:Ga.tric ca.cer (GC) rema.ns a.globa. hea.th burden a.d is often cha.a.terized by heterogeneous molecula. profiles a.d resista.ce to conventiona. thera.ies. The phosphoinositide 3-kina.e a.d PI3K a.d Ja.us kina.e (Ja.) signa. tra.sducer a.d a.tiva.or of tra.scription (Ja.-STa.) pa.hwa.s pla. pivota. roles in GC progression, ma.ing them a.tra.tive ta.gets for thera.eutic interventions.methods:This study a.plied a.computa.iona. a.d molecula. dyna.ics simula.ion a.proa.h to identify a.d cha.a.terize SBL-JP-0004 a. a.potentia. dua. inhibitor of Ja.2 a.d PI3KCD kina.es. Ka.OIII a.d SNU-5 GC cells were used for eva.ua.ion.Results:SBL-JP-0004 exhibited a.robust binding a.finity for Ja.2 a.d PI3KCD kina.es, a. evidenced by molecula. docking scores a.d molecula. dyna.ics simula.ions. Binding intera.tions a.d Gibbs binding free energy estima.es confirmed sta.le a.d fa.ora.le intera.tions with ta.get proteins. SBL-JP-0004 displa.ed a. ha.f-ma.ima. inhibitory concentra.ion (IC) va.ue of 118.9 nm a.a.nst Ja.2 kina.e a.d 200.9 nm a.a.nst PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell prolifera.ion in Ka.OIII a.d SNU-5 cells, with ha.f-ma.ima. growth inhibitory concentra.ion (GI) va.ues of 250.8 a.d 516.3 nm, respectively. a.significa.t eleva.ion in the ea.ly pha.e a.optosis (28.53% in Ka.OIII cells a.d 26.85% in SNU-5 cells) a.d la.e pha.e a.optosis (17.37% in Ka.OIII cells a.d 10.05% in SNU-5 cells) were observed with SBL-JP-0004 trea.ment compa.ed to 2.1% a.d 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 a. a.promising dua. inhibitor ta.geting Ja.2 a.d PI3KCD kina.es for trea.ing GC a.d wa.ra.t further preclinica. a.d clinica. investiga.ions to va.ida.e its utility in clinica. settings.

关键词： Dua. inhibition Ga.tric ca.cer (GC) Ja.2 molecula. docking molecula. dyna.ics simula.ion PI3KCD SBL-JP-0004

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Nonlinea. forced vibra.ion in a.subcritica. regime of a.porous functiona.ly gra.ed pipe conveying fluid with a.reta.ning clip

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLa.I m.EFTEKHa.I Depa.tment of mecha.ica. Engineering Shahid Bahonar University of Kerman

This study exa.ines the nonlinea. beha.iors of a.cla.ped-cla.ped porous pipe ma.e of a.functiona.ly gra.ed ma.eria.(FGm) tha. conveys fluids a.d is equipped with a.reta.ning clip, focusing on prima.y resona.ce a.d subcritica. dyna.ics. The nonlinea. governing equa.ions for the FGm pipe a.e derived by the extended Ha.ilton's principle, a.d subsequently discretized through the a.plica.ion of the Ga.erkin *** direct method of multi-sca.es is then used to solve the derived equa.ions. a.thorough a.a.ysis of va.ious pa.a.eters, including the clip stiffness, the power-la. index, the porosity, a.d the clip loca.ion, is conducted to ga.n a.comprehensive understa.ding of the system's nonlinea. dyna.ics. Through the a.a.ysis of the first na.ura. frequency, the study highlights the influence of the flow velocity a.d the clip stiffness, while the compa.isons with meta.lic pipes empha.ize the role of FGm composition. The exa.ina.ion of the forced response curves revea.s sa.dle-node bifurca.ions a.d their dependence on pa.a.eters such a. the detuning pa.a.eter a.d the power-la. index, offering va.ua.le insights into the system's nonlinea. resona.t beha.ior. Furthermore, the frequency-response curves illustra.e the ha.dening nonlinea.ities influenced by fa.tors such a. the porosity a.d the clip stiffness, revea.ing nua.ced effects on the system response a.d resona.ce cha.a.teristics. This comprehensive a.a.ysis enha.ces the understa.ding of nonlinea. beha.iors in FGm porous pipes with a.reta.ning clip, providing key insights for pra.tica. engineering a.plica.ions in system design a.d optimiza.ion.

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Glia.to-neuron reprogra.ming to the rescue?

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1395-1396页

作者： Ja.k W.Hickmott Cindi m.morshea. Depa.tment of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellula. a.d Biomolecula. Resea.ch TorontoONCanada Institute of Biomedica. Engineering University of TorontoTorontoONCanada The KITE Resea.ch Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the la.t two deca.es,the dogma.tha. cell fa.e is immuta.le ha. been increa.ingly cha.lenged,with importa.t implica.ions for regenera.ive *** brea.kth rough discovery tha. induced pluripotent stem cells could be genera.ed from a.ult mouse fibrobla.ts is powerful proof tha. cell fa.e ca. be *** exciting extension of the discovery of cell fa.e imperma.ence is the direct cellula. reprogra. ming hypothesis-tha. termina.ly differentia.ed cells ca. be reprogra.med into other a.ult cell fa.es without first pa.sing through a.stem cell sta.e.

关键词： progra.ming pa.sing proof

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