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免疫放射分析法测定人促甲状腺激素及其临床应用

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中华内分泌代谢杂志 1987年第3期03卷 5-7+62页

作者：苏天水,欧阳安,李凤良,J.m.Hershman 河南省医学科学研究所内分泌研究室河南省医学科学研究所内分泌研究室河南省医学科学研究所内分泌研究室美国加州大学洛杉矶医学院内分泌科主任

本文应用免疫放射分析法（IRmA）测定52名正常人和44例地甲肿流行区健康人血清TSH、FT4和FT3。并对28例甲亢患者、11例甲低患者、13例甲亢治疗后患者及51例地方性克汀病患者和96例地方性甲状腺肿大病人的血清TSH,FT4和FT3结果进行分析... 详细信息

本文应用免疫放射分析法（IRmA）测定52名正常人和44例地甲肿流行区健康人血清TSH、FT4和FT3。并对28例甲亢患者、11例甲低患者、13例甲亢治疗后患者及51例地方性克汀病患者和96例地方性甲状腺肿大病人的血清TSH,FT4和FT3结果进行分析。甲亢患者血清TSH水平显著低于正常组（P<0.001）;甲低患者显著高于正常组（P<0.001）。血清甲状腺激素及TSH实验室测定值能较好地符合上述各试验组的临床诊断,表明本法是一种较灵敏、准确的血清TSH分析方法。

关键词：地方性甲状腺肿血清地方病克汀病呆小症促甲状腺激素促甲状腺素免疫放射分析法甲亢甲状腺机能亢进 TSH 补碘流行区

External versus Internal Loads of Nutrients of an Urban Eutrophic Tropical Reservoir （Southeastern Brazil）

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Journal of Environmental Science and Engineering(A) 2012年第5期1卷 598-610页

作者： Antonio A. mozeto marcelomontini Simone A. Braz Felipe G. martins Aloisio Soares marcos Roberto L.do Nascimento Francisco Antonio R. Barbosd Pedro S. Fadini Bias m. de Faria Environmental Biogeochemistry Laboratory (LBGqA) Chemistry Department Federal University of S6o Carlos (UFSCar) S~oCarlos SP13565-905 Brazil Biological Sciences Institute (1CB) Federal University of Minas Gerais (UFMG) Belo Horizonte MG30161-970 Brazil Povos de Caldas Laboratory (LAPOC) Brazilian National Commission for Nuclear Energy (CNEN) Pogos de CaldasMG37701-970 Brazil Research and Development Center (CENPES)-Petrobras Cidade Universit6ria Rio de Janeiro RJ21941-915 Brazil

mycobacterium bovis BCG as a Delivery System for the dtb Gene Antigen from Diphtheria Toxin

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American Journal of molecular Biology 2017年第4期7卷 176-189页

作者： Dilzamar V.Nascimento Odir A.Dellagostin Denise C.S.matos Douglas mcIntosh Raphael Hirata Jr. Geraldo m.B.Pereira Ana Luíza mattos-Guaraldi Geraldo R.G.Armoa Faculdade de Ciências médicas Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Núcleo de Biotecnologia Universidade Federal de PelotasCampus UniversitárioPelotasBrazil Instituto de Tecnologia em Imunobiológicos Fundacao Oswaldo CruzRio de JaneiroBrazil Instituto Oswaldo Cruz Fundacao Oswaldo CruzRio de JaneiroBrazil Instituto de Veterinária Universidade Federal Rural do Rio de JaneiroSeropedicaRio de JaneiroBrazil

Diphtheria is a fulminant bacterial disease caused by toxigenic strains of Corynebacterium diphtheriae whose local and systemic manifestations are due to the action of the diphtheria toxin (DT). The vaccine which is used to prevent diphtheria worldwide is a toxoid obtained by detoxifying DT. Although associated with high efficacy in the prevention of disease, the current anti-diphtheria vaccine, one of the components of DTP (diphtheria, tetanus and pertussis triple vaccine), may present post vaccination effects such as toxicity and reactogenicity resulting from the presence of contaminants in the vaccine that originated during the process of production and/or detoxification. Therefore, strategies to develop a less toxic and at the same time economically viable vaccine alternatives are needed to improve existing vaccines in use worldwide. In this study, the moreau substrain of BCG which is used in Brazil as a live vaccine against human tuberculosis was genetically modified to carry and express the gene encoding for the diphtheria toxin fragment B (DTB). As such, the DNA sequence encoding the dtb gene was cloned into the pUS977 shuttle vector for cytoplasmic expression and successfully introduced into BCG cells by electroporation. mice immunized with recombinant BCG expressing DTB showed seroconversion with the detection of specific antibodies against DTB. Also, rBCGs stably expressing DTB persisted up to 60 days in the absence of selective pressure in mice and cell viability did not change significantly during the period tested. Finally, immune sera from BALB/c mice vaccinated with rBCGpUS977dtbPW8 were preliminarily tested for their capacity of neutralizing the diphtheria toxin in the Vero Cells assay.

关键词： Recombinant BCG Diphtheria Toxin dtb Gene Park Williams 8(PW8) Corynebacterium diphtheriae rDTBPW8 pUS977 Vector

Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Hanna Santos marques Ronaldo Teixeira da Silva Júnior Lorena Sousa de Carvalho Samuel de Sousa Cruz Gabriel Reis Rocha Gabriel Lima Correa Santos Kathlen Coutinho de Souza Rebeca Gabrielle Almeida maciel Daiana Silva Lopes Natália Oliveira e Silva márcio Vasconcelos Oliveira Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

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浴光疗同步治疗对不同类型银屑病均有效

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 14-15页

作者： Holló P. Gonzalez R. Kása m. Horváth A. 崔荣 Department of Dermatovenereology and Dermatooncology Semmelweis UniversityMária u. 42 1085 Budapest Hungary

Background: The efficacy of synchronous balneophototherapy in clearing psoriasis is based on the multiple-targeted effects of UVB light and Dead Sea salt. Their synchronous application produces a synergic effect. Objective: The purpose of this retrospective study is: 1 ) to evaluate the efficacy of synchronous balneophototherapy for treating different clinical types of psoriasis; 2) to determine whether there is any difference between response to treatment, and 3) to gain more data in order to predict the effect of treatment in different clinical types, and thus to support the selection of patients for treatment. methods: Patients received a basic course of synchronous balneophototherapy according to the Regensburg scheme, consisting of 35 treatment sessions, followed by a maintenance course of a further 25 treatments. The patients skin status was monitored by weekly assessment using the PASI score throughout the course. The efficacy of the treatment was evaluated through the results of 373 patients treated according to protocol during the basic course, and the results of 78 of these patients during the maintenance course. One hundred and eighty-six patients were enrolled into the study comparing the efficacy of the basic course for the different clinical types of psoriasis: data of patients with large plaques, small plaques, guttate and confluating type of skin signs were summarized and compared. Results: During the basic course of treatment 70.7% improvement of the average PASI index was observed; the average PASI index decreased from 16.14 to 4.73. A further improvement from 4.58 to 4.27 of the average PASI was found during the maintenance therapy. Small plaque-type skin signs showed the best response with a PASI decrease of 76.1% ; Guttate type had a PASI decrease of 73.7% , large plaque type, 67.1 % and confluating type, 62% . Comparing data with the average PASI decrease, a statistically significant lower decrease was found in confluating type cases. Conclusi

关键词：同步治疗银屑病同类型光疗 PASI评分治疗效果多靶点作用临床类型治疗反应类型选择

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海马异常和停用抗癫痫药后复发痫性发作

世界核心医学期刊文摘(神经病学分册) 2006年第12期 19-20页

作者： Cardoso T.A.m. Coan A.C. Kobayashi E. F.Cendes 郭俊 Dr.Departamento de Neurologia Faculdade de Ciências Médicas-UNICAMPCidade Universitária Zeferino VazCampinas SPCEP 13083-970Brazil

The authors performed hippocampal volumetry and T2 relaxometry in 84 consecutive patients with partial epilepsy from a protocol for antiepileptic drug(AED)withdrawal after at least 2 years of seizure *** recurrence af... 详细信息

关键词：痫性发作海马边缘系统停用

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克汀病患者垂体甲状腺轴功能的研究

中华地方病学杂志 1987年第4期 18-21+65页

作者：苏天水,欧阳安,Hershman J.m,张保田,郝康太河南省医学科学研究所内分泌研究室河南省医学科学研究所内分泌研究室美国加州大学洛杉矶分校医学院内分泌科洛阳地方病防治研究所方城县卫生防疫站主任

本文测定了两个病区共53名克汀病患者的血清中促甲状腺激素、甲状腺激素及甲状腺球蛋白浓度。同时选非病区53名正常人做对照。两病区患者所测指标水平大部分在正常范围内。表明缺碘原因所致的克汀病经补碘后,缺碘状态可以改善,垂体甲状... 详细信息

本文测定了两个病区共53名克汀病患者的血清中促甲状腺激素、甲状腺激素及甲状腺球蛋白浓度。同时选非病区53名正常人做对照。两病区患者所测指标水平大部分在正常范围内。表明缺碘原因所致的克汀病经补碘后,缺碘状态可以改善,垂体甲状腺激素可恢复正常水平。

关键词：克汀病垂体甲状腺轴

Cardiopulmonary changes in patients with sickle cell anemia:A systematic review

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World Journal of Hematology 2022年第3期9卷 20-29页

作者： Jamile Silva Lopes Ícaro Garcia Viana maria Luísa Cordeiro Santos Fabrício Freire de melo márcio Vasconcelos Oliveira Cláudio Lima Souza Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Given the high prevalence of cardiovascular and pulmonary abnormalities associated with sickle cell anemia(SCA),the clinical impact caused in addition to compromising the quality of life of patients and the overcharge that it represents to the public health system,this study systematized and evaluated scientific publications on pulmonary complications and cardiovascular diseases in sickle cell patients from 1920 to *** compilation aims to provide knowledge for health professionals and managers in order to draw attention to the importance of chronic diseases in SCA patients and in addition to providing elements that provide improvements in management of useful resources that contribute to improve the quality and increase the life expectancy of these *** To systematically compile information about cardiopulmonary changes in patients with *** A systematic literature review was performed based on the PRISmA recommendation including scientific articles indexed in the Scientific Electronic Library Online databases of the United States National Library of medicine and Biblioteca Virtual de Saú*** search period was delimited between 1990 and 2020 and selected in Portuguese,English and *** sets of descriptors were used for each database including research carried out with human *** reading the articles,those useful for this review were extracted using a collection instrument designed for this *** The final selection included 27 *** year with the highest number of publications was 2016 with 5 studies(18.51%),followed by 2017 with 4(14.81%).The type of study most carried out in the period was cohort 10(37.03%)followed by cross-sectional and case-control with 8 studies in each(29.62%).Regarding the language of publication,the distribution was as follows:25(92.59%)in English,1(3.70%)in Spanish and 1(3.70%)in *** The findings of the present study suggest that cardiopulmonary alterations

关键词： Sickle cell anemia Cardiopulmonary alterations Clinical profile Systematic review

The Biogeographic Network of Birds in the Brazilian Cerrado may Guide Conservation Efforts

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Research in Ecology 2022年第3期4卷 42-53页

作者： Lívia P.De Sordi Rochely S.morandini Vânia R.Pivello mariana m.Vidal JoséC.motta-Junior Department of Ecology Instituto de BiociênciasUniversidade de São PauloRua do MatãoTravessa 14Cidade UniversitáriaSão PauloSP05508-090Brazil

The Brazilian Cerrado,characterized by grasslands,savannahs and riverine forests,is a biodiversity hotspot,threatened by the expansion of the agricultural frontier,and therefore,needs effective conservation *** the national level,the Cerrado core-region has received more conservation efforts than the marginal(non-core)areas,being considered more ***,many marginal areas are also home to high species richness and *** represent a highly diverse and widely distributed biological group,whose variety of functions gives them important roles in the maintenance of ecosystem *** this study the authors analysed the distribution patterns of bird biodiversity in the Brazilian Cerrado and verified whether a separation into core and marginal Cerrado zones would make sense for birds’distribution,as this is an important issue concerning resources allocation for biodiversity *** authors developed a biogeographic network analysis considering 42 sites with savannah vegetation distributed throughout the country and built two presence-absence matrices for birds-with and without species typical of the woodland Cerrado and forest physiognomies-and generated two biogeographic *** network without woodland/forest bird species showed no modularity,whereas the complete network produced three modules:Northwest,Centre-South and *** modularity was mainly determined by forest/woodland bird *** Northwest region was richer and had a greater number of regional species compared to the other two modules;lower richness of bird species was found in the Centre-South region,which had more widespread *** biogeographic pattern for the Cerrado birds perceived in this study did not evidence a clear dichotomy between core versus marginal ***,the same conservation effort should be implemented throughout the Cerrado.

关键词： Bird assembly Bird species distribution Conservation effort Savannah