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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-time Administration

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Chinese Journal of Integrative medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI Chan CHEN Zhi-jie CHEN Yi-fei LUO chao-hua mO Zhi-xian LIN Ying-bo School of traditional Chinese medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research team of tCm Prevention and treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: to study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. methods: B16F10 and 4t1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. the cell viability was detected by cell counting kit-8. the expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRt-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNt group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). the pathological changes of tumor tissues were observed by hematoxylin-eosin staining. the cell apoptosis of tumor tissues was detected by tUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRt-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P tion of Caspase-3 protein(PmRNA(Pthe above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4t1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

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mantle contributions to granitoids associated with Sn mineralization:Geochemical and isotopic evidence from the giant Dachang deposit,South China

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Geoscience Frontiers 2024年第1期15卷 187-208页

作者： tingyi Wang Qihai Shu Xiaoping Xia chao Li Yanning Wang Jiahao Chen Xiang Sun m.Santosh Qingfei Wang State Key Laboratory of Geological Processes and mineral Resources China University of GeosciencesBeijing 100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China Department of Earth Science University of AdelaideAdelaideSouth Australia 5005Australia State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China

major Sn deposits are commonly linked to crust-derived and highly evolved granites,with magma generation aided by mantle ***,whether and how the mantle components contribute to Sn polymetallic mineralization remains *** this study,in combination with a compilation of equivalent data in the region,we provide new constraints on this issue based on detailed investigations on the petrogenesis and metallogenic significance of granitoids including the causative batholith and later granodiorite porphyry dike in the giant Dachang Sn deposit from South *** former has zircon U-Pb ages of 93-91 ma and belongs to highly evolved S-type biotite granite,which experienced fractionation of massive *** latter shows zircon U-Pb ages of 90 ma and displays I-type granite *** batholith was mainly derived from the dehydration melting of biotite in the metasedimentary sources,as revealed by the relatively low whole-rock Pb contents(m)and high Ba/Pb ratios(2.71-17.1)and initial t(ti-zr)of 790℃.Compared with the adjacent crust-derived S-type granites(-24.8--5.1)and I-type granites(-11.0 to-5.2),the Dachang S-type biotite granites present higher zirconεHf(t)values(-9.1 to-2.1).Furthermore,the low magmatic zirconδ18O values(6.2‰)and higher apatite LREE(3277-4114 ppm)and Sr(1137-1357 ppm)contents than of arc-type basic rocks were *** characteristics jointly hint the contributions of mantle *** higher initial t(ti-zr)(>850℃),whole-rock mg#(52 to 58),apatiteεNd(t)(-9.2 to-6.5)and zirconεHf(t)(-7.6 to 2.5)values but lower zirconδ18O values(6.33 to 8.30‰)of the later granodiorite porphyry dike than those of the batholith also suggest that mantle material was involved in the generation of the dikes,which is evident by the variational features of zircon and apatite trace *** addition,at the zircon Hfm and Eu/Eu*>0.05,the higher zirconΔFmQ values(mostly from-1.8 to 2.0)and H2O contents(100-1100 ppm)of the Dachang

关键词： Highly evolved S-type biotite granite I-type granodiorite porphyry dike Crust-mantle mixing mantle contributions Dachang Sn mineralization

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Fairness in machine learning: definition, testing,debugging, and application

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Science China(Information Sciences) 2024年第9期67卷 41-61页

作者： Xuanqi GAO chao SHEN Weipeng JIANG Chenhao LIN Qian LI Qian WANG Qi LI Xiaohong GUAN Faculty of Electronic and Information Engineering Xi'an Jiaotong University School of Cyber Science and Engineering Wuhan University Institute for Network Sciences and Cyberspace Tsinghua University

In recent years, artificial intelligence technology has been widely used in many fields, such as computer vision, natural language processing and autonomous driving. machine learning algorithms, as the core technique of AI, have significantly facilitated people's lives. However, underlying fairness issues in machine learning systems can pose risks to individual fairness and social security. Studying fairness definitions, sources of problems, and testing and debugging methods of fairness can help ensure the fairness of machine learning systems and promote the wide application of artificial intelligence technology in various fields. this paper introduces relevant definitions of machine learning fairness and analyzes the sources of fairness problems. Besides, it provides guidance on fairness testing and debugging methods and summarizes popular datasets. this paper also discusses the technical advancements in machine learning fairness and highlights future challenges in this area.

关键词： artificial intelligence security machine learning security machine learning fairness model testing model debugging

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Enrichment characteristics of normal-pressure marine shale gas in the complex tectonic zone: a case study of the Lower Cam.rian Niutitang Formation in northern Guizhou

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Journal of Earth Science 2024年

作者： Wenjibin Sun Zhonghu Wu Yujun Zuo chao Pan Hao Liu Baofeng Lan Jianyun Lin Bin Chen Qinggang Chen Guizhou Energy Industry Research Institute Co. Ltd mining College Guizhou University College of Resource and Environmental Engineering Guizhou University College of Civil Engineering Guizhou University

the Lower Cam.rian Niutitang Formation is a crucial stratum for the exploration of normal-pressure marine shale gas in southern China， with great development potential. to research the normal-pressure shale gas accumulation of the Niutitang Formation in the complex tectonic zone， the shale cores in northern Guizhou were subjected to X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEm) observation， and tests were conducted to determine total organic content (tOC)， bitumen reflectance， and nitrogen isotopes. the results indicate that the equivalent vitrinite reflectance of cores varies from 2.30% to 3.73%， and the tOC content of cores varies from 3.8% to 7.8%. the total gas content of three wells in northern Guizhou is 0.5 m3/t， 0.3 m3/t， and 1.4 m3/t， respectively. the tOC content of the shale in the syncline structure is higher than that of the shale in the anticline structure. Nitrogen in shale gas originates primarily from the thermal ammoniation of organic matter， the atmosphere， and the deep crust. Shale gas preservation is favourable in regions with a large range of lifting， and small lifting differences. the syncline is broad and gentle with few faults have better gas accumulation conditions. the Niutitang Formation in the residual syncline of the study area has better gas content than that of other structures. Exploration of shale gas accumulation sweet spots in northern Guizhou should focus on the broad-gentle synclines with minimal changes in stratigraphic lifting， few faults， and no hydrothermal activity at the edges of paleo-uplifts.

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Camrelizumab,apatinib and hepatic artery infusion chemotherapy combined with microwave ablation for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3481-3495页

作者： meng-Xuan Zuo chao An Yu-Zhe Cao Jia-Yu Pan Lu-Ping Xie Xin-Jing Yang Wang Li Pei-Hong Wu Department of minimally Invasive Interventional therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Interventional Ultrasound Chinese General PLA HospitalBeijing 100853China Department of medical Imaging and Interventional Radiology Sun Yatsen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy and camrelizumab plus apatinib(tRIPLEt protocol)is promising for advanced hepatocellular carcinoma(Ad-HCC).However,the usefulness of microwave ablation(mWA)after tRIPLEt is still *** to compare the efficacy and safety of tRIPLEt alone(t-A)vs tRIPLEt-mWA(tm)for *** From January 2018 to march 2022,217 Ad-HCC patients were retrospectively *** them,122 were included in the t-A group,and 95 were included in the t-m group.A propensity score matching(PSm)was applied to balance *** survival(OS)was compared using the Kaplan-meier curve with the log-rank *** overall objective response rate(ORR)and major complications were also *** After PSm,82 patients were included both the t-A group and the t-m *** ORR(85.4%)in the t-m group was significantly higher than that(65.9%)in the t-A group(Pthe cumulative 1-,2-,and 3-year OS rates were 98.7%,93.4%,and 82.0%in the t-m group and 85.1%,63.1%,and 55.0%in the t-A group(hazard ratio=0.22;95%confidence interval:0.10-0.49;Pthe incidence of major complications was 4.9%(6/122)in the t-A group and 5.3%(5/95)in the t-m group,which were not significantly different(P=1.000).CONCLUSION t-m can provide better survival outcomes and comparable safety for Ad-HCC than t-A.

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma molecular targeting agent Programmed cell death protein 1 inhibitors microwave ablation

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2023: Weather and Climate Extremes Hitting the Globe with Emerging Features

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Advances in Atmospheric Sciences 2024年第6期41卷 1001-1016页

作者： Wenxia ZHANG Robin CLARK tianjun ZHOU Laurent LI chao LI Juan RIVERA Lixia ZHANG Kexin GUI tingyu ZHANG Lan LI Rongyun PAN Yongjun CHEN Shijie tANG Xin HUANG Shuai HU State Key Laboratory of Numerical modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China met Office Hadley Centre Exeter EX13PBUK University of Chinese Academy of Sciences Beijing 100049China Laboratoire de météorologie Dynamique CNRSSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75230France max Planck Institute for meteorology Hamburg 20146Germany Instituto Argentino de Nivología Glaciología Y Ciencias Ambientales(IANIGLA)CCT CONICETMendoza CP 5500Argentina Shanghai typhoon Institute China Meteorological AdministrationShanghai 200030China Asia-Pacific typhoon Collaborative Research Center Shanghai 201306China

Globally,2023 was the warmest observed year on record since at least 1850 and,according to proxy evidence,possibly of the past 100000 *** in recent years,the record warmth has again been accompanied with yet more extreme weather and climate events throughout the ***,we provide an overview of those of 2023,with details and key background causes to help build upon our understanding of the roles of internal climate variability and anthropogenic climate *** also highlight emerging features associated with some of these extreme *** extremes are occurring earlier in the year,and increasingly simultaneously in differing parts of the world(e.g.,the concurrent hot extremes in the Northern Hemisphere in July 2023).Intense cyclones are exacerbating precipitation extremes(e.g.,the North China flooding in July and the Libya flooding in September).Droughts in some regions(e.g.,California and the Horn of Africa)have transitioned into flood *** extremes also show increasing interactions with ecosystems via wildfires(e.g.,those in Hawaii in August and in Canada from spring to autumn 2023)and sandstorms(e.g.,those in mongolia in April 2023).Finally,we also consider the challenges to research that these emerging characteristics present for the strategy and practice of adaptation.

关键词： weather and climate extremes temperature extremes extreme precipitation drought wildfires

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Functional characterization,structural basis,and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3746-3759页

作者： Zilong Wang Xueqing Du Guo Ye Haotian Wang Yizhan Liu Chenrui Liu Fudong Li HansÅgren Yang Zhou Junhao Li chao He De-An Guo min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Anhui Key Laboratory of modern Biomanufacturing and School of Life Sciences Anhui UniversityHefei 230601China National Science Center for Physical Sciences at microscale Division of molecular&Cell Biophysics and School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Physics and Astronomy Uppsala UniversityUppsala SE-75120Sweden School of Pharmacy Jinan UniversityGuangzhou 510632China Shanghai Research Center for modernization of traditional Chinese medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Glycosylation is an important post-modification reaction in plant secondary metabolism,and contributes to structural diversity of bioactive natural *** plants,glycosylation is usually catalyzed by *** 2′-O-glycosides are rare ***,no UGts have been reported,thus far,to specifically catalyze 2′-O-glycosylation of *** this work,UGt71AP2 was identified from the medicinal plant Scutellaria baicalensis as the first flavonoid 2′-*** could preferentially transfer a glycosyl moiety to 2′-hydroxy of at least nine flavonoids to yield six new *** of the 2′-O-glycosides showed noticeable inhibitory activities against cyclooxygenase *** crystal structure of UGt71AP2(2.15Å)was solved,and mechanisms of its regio-selectivity was interpreted by pKa calculations,molecular docking,mD simulation,mm/GBSA binding free energy,Qm/mm,and hydrogen‒deuterium exchange mass spectrometry *** structure-guided rational design,we obtained the L138t/V179D/m180t mutant with remarkably enhanced regio-selectivity(the ratio of 7-O-glycosylation byproducts decreased from 48%to 4%)and catalytic efficiency of 2′-O-glycosylation(kcat/Km,0.23 L/(s·μmol),12-fold higher than the native).moreover,UGt71AP2 also possesses moderate UDP-dependent de-glycosylation activity,and is a dual function *** work provides an efficient biocatalyst and sets a good example for protein engineering to optimize enzyme catalytic features through rational design.

关键词： Glycosyltransferase Regio-selectivity Crystal structure De-glycosylation Catalytic mechanisms

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Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?

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Genes & Diseases 2023年第4期10卷 1263-1278页

作者： Klára Prajzlerová Ladislav Senolt m.ria Filková Institute of Rheumatology Prague 12800Czech Republic Department of Rheumatology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t microRNAs(miRNAs)are small non-coding single-stranded RNAs of about 22 nucle-otides in length that act as post-transcriptional regulators of gene *** on the complementarity between miRNA and target mRNA,cleavage,destabilization,or transla-tional suppression of mRNA occurs within the RISC(RNA-induced silencing complex).As gene expression regulators,miRNAs are involved in a variety of biological *** of miRNAs and their target genes contribute to the pathophysiology of many diseases,including autoimmune and inflammatory *** are also present extracellularly in their sta-ble form in body *** incorporation into membrane vesicles or protein complexes with Ago2,HDL,or nucleophosmin 1 protects them against ***-free miRNAs can be deliv-ered to another cell in vitro and maintain their functional ***,miRNAs can be considered mediators of intercellular *** remarkable stability of cell-free miRNAs and their accessibility in body fluid makes them potential diagnostic or prognostic bio-markers and potential therapeutic *** we provide an overview of the potential role of circulating miRNAs as biomarkers of disease activity,therapeutic response,or diagnosis in rheumatic *** circulating miRNAs reflect their involvement in the pathogenesis,while for plenty,their pathogenetic mechanisms remain to be *** miRNAs described as biomarkers were also shown to be of therapeutic potential,and some miRNAs arealready tested in clinical trials.

关键词： Biomarker Diagnosis miRNA Rheumatic diseases therapy

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the marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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military medical Research 2024年第3期11卷 323-344页

作者： Ping Wu Lin Shen Hui-Fan Liu Xiang-Hui Zou Juan Zhao Yu Huang Yu-Fan Zhu Zhao-Yu Li chao Xu Li-Hua Luo Zhi-Qiang Luo min-Hao Wu Lin Cai Xiao-Kun Li Zhou-Guang Wang Key Laboratory of Imaging Diagnosis and minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and musculoskeletal tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABatiO_(3),PBt)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBt were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:the incorporation of BatiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBt hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to m2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECm)mineralization of mC3t3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBt hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage m2 ***:the piezoelectric Cs/Gel/PHA/PBt hy

关键词： Piezoelectric hydrogel tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

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多功能mXene-CCNt/聚酰亚胺电磁屏蔽薄膜的制备与性能

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复合材料学报 2024年第8期41卷 4146-4159页

作者：储娜骆春佳晁敏杨雪雪颜录科长安大学材料科学与工程学院

导电聚合物复合材料(CPC)因其耐腐蚀性好、比强度高、成本低和易加工等良好的综合性能，被广泛用于制备电磁屏蔽材料。本文采用简单的刮膜法和热酰亚胺化法制备了综合性能良好的mXene-羧基化碳纳米管/聚酰亚胺(mXene-CCNt/PI)复合薄膜。... 详细信息

导电聚合物复合材料(CPC)因其耐腐蚀性好、比强度高、成本低和易加工等良好的综合性能，被广泛用于制备电磁屏蔽材料。本文采用简单的刮膜法和热酰亚胺化法制备了综合性能良好的mXene-羧基化碳纳米管/聚酰亚胺(mXene-CCNt/PI)复合薄膜。mXene和CCNt协同作用构筑了良好的导电网络，赋予薄膜高效的电磁屏蔽效能(EmI SE)，当mXene和CCNt含量均为12.5wt%，膜厚度为80μm时，电导率和EmI SE分别为5.88 S/cm和26.49 dB，电磁屏蔽效能与厚度的比值(EmI SE/t)为331.13 dB/mm。并且在极端恶劣环境下(酸-碱处理、高低温处理和重复弯曲)显示出持久而稳定的EmI SE。与此同时，mXene-CCNt/PI薄膜仍具有53.17 mPa的拉伸强度、优异的热稳定性(>500℃)和阻燃性能。实现了聚合物基电磁屏蔽复合材料的便捷、高效制备，同时兼顾其优异的力学性能和耐热性能。

关键词：聚酰亚胺 mXene 羧基化碳纳米管电磁屏蔽薄膜

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