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Characterization of the High-Strength mg–3Nd–0.5Zn Alloy Prepared by Thermomechanical Processing

Acta metallurgica Sinica(English Letters) 2019年第3期32卷 321-331页

作者： Ji■í Kub■sek Drahomír Dvorsk■ Jozef Vesel■ Peter min■rik m.ria Zemkov■ Dalibor Vojtěch Department of metals and Corrosion Engineering Faculty of Chemical Technology University of Chemistry and Technology Prague Department of Physics of materials Charles University

magnesium alloys based on Nd and Zn are promising materials for both aviation industry and medical *** mechanical properties of these materials can be achieved by thermomechanical processing such as extrusion or rolling and by aging treatment, which can significantly strengthen the alloy. The question remains especially about the connection of texture strength created in the alloys based on the specific conditions of preparation. This work focuses on the mg–3 Nd–0.5 Zn magnesium alloy prepared by hot extrusion of the as-cast state at two different temperatures combined with heat pre-treatment. Extrusion ratio of 16 and rate of 0.2 mm/s at 350 and 400 °C were selected for material preparation. The structures of prepared materials were studied by scanning electron microscopy and transmission electron microscopy. The effect of microstructure on mechanical properties was evaluated. Obtained results revealed the strong effect of thermal pre-treatment on final microstructure and mechanical properties of extruded materials. The Hall–Petch relation between grain size and tensile yield strength has been suggested in this paper based on the literature review and presented data. The observed behavior strongly supports the fact that the Hall–Petch of extruded mg–3Nd–0.5 Zn alloys with different texture intensities cannot be clearly estimated and predicted. In addition, Hall–Petch relations presented in literature can be sufficiently obtained only for fraction of the mg–3Nd–0.5 Zn alloys.

关键词： mg–Nd–Zn alloys Extrusion Thermal treatment microstructure mechanical properties

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An update on the molecular biology of glioblastoma,with clinical implications and progress in its treatment

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Cancer Communications 2022年第11期42卷 1083-1111页

作者： elena Verdugo Iker Puerto miguelÁngel medina Department of molecular Biology and Biochemistry University of MálagaMálagaMálaga E-29071Spain Biomedical Research Institute of málaga(IBImA-Plataforma Bionand) MálagaMálaga E-29071Spain Spanish Biomedical Research Network Center for Rare Diseases(CIBERER) Spanish Health Institute Carlos III(ISCIII)MálagaMálaga E-29071Spain

Glioblastoma multiforme(GBm)is the most aggressive and common malig-nant primary brain *** with GBm often have poor prognoses,with a median survival of∼15 *** understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications,the most recent of which classified these tumors into new categories and made some changes in their nomenclature and grading *** review aims to give a panoramic view of the last 3 years’findings in glioblastoma characterization,its heterogeneity,and current advances in its *** molecular parameters have been used to achieve an accurate and personalized characterization of glioblastoma in patients,including epigenetic,genetic,transcriptomic and metabolic features,as well as age-and sex-related patterns and the involvement of several noncoding RNAs in glioblastoma ***-like neural stem cells and outer radial glial-like cells from the subven-tricular zone have been proposed as agents involved in GBm of IDH-wildtype origin,but this remains *** metabolism is characterized by upregulation of the PI3K/Akt/mTOR signaling pathway,promotion of the gly-colytic flux,maintenance of lipid storage,and other *** metabolism also contributes to glioblastoma’s resistance to conventional *** heterogeneity,a hallmark of GBm,has been shown to affect the genetic expresion,modulation of metabolic pathways,and immune system ***’s aggressive invasion potential is modulated by cell-to-cell crosstalk within the tumor microenvironment and altered expressions of specific genes,such as ANXA2,GBP2,FN1,PHIP,and ***,the rising number of active clinical trials illustrates the efforts to identify new targets and drugs to treat this *** is still relevant for research purposes,given the amount of ongoing clinical trials based on this strategy to treat GBm,and neoantigen and nuclei

关键词： cancer molecular biology diagnosis glioblastoma multiforme ongoing clinical trials targeted therapy tumor heterogeneity tumor metabolism

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Application of Vortex Generators to Remove Heat Trapped in Closed Channels

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Fluid Dynamics & materials Processing 2023年第1期19卷 15-24页

作者： Alim Al Ayub Ahmed Salim Oudah mezan Binyamin murtadha Doghiam Abdullah elena Tesleva Linar G.Akhmetov Rustem Zalilov mustafa m.Kadhim Abduladheem Turki Jalil School of Accounting Jiujiang UniversityJiujiang332000China General Directorate of Education in Al-muthanna Governorate Ministry of EducationSamawah66001Iraq Department of mechanical Engineering Faculty of Science and TechnologyUniversitas Muhammadiyah Kalimantan TimurSamarinda75124Indonesia College of Petroleum Engineering Al-Ayen UniversityThi-Qar64001Iraq National Research Tomsk Polytechnic University Tomsk634050Russia Kazan Federal University Kazan420008Russian Nosov magnitogorsk State Technical University Magnitogorsk455000Russia Department of Dentistry Kut University CollegeKutWasit52001Iraq College of Technical Engineering The Islamic UniversityNajaf7003Iraq Department of Pharmacy OsolAldeen University CollegeBaghdad993P+PWXIraq Faculty of Biology and Ecology Yanka Kupala State University of GrodnoGrodno230023Belarus

The utilization of vortex generators to increase heat transfer from cylinders installed inside a duct is *** particular,a channel containing eight cylinders with volumetric heat sources is considered for different values of the Reynolds *** effective possibility to use vortex generators with different sizes to increase heat transfer and,consequently,reduce the surface temperature of the cylinders is ***,the amount of pressure drop inside the channel due to the presence of vortex generators is considered and compared with the cases without vortex *** results show that although the addition of generators increases the pressure drop,it strongly contributes to increase the heat transfer coefficient inside the duct(up to 80–90%).

关键词： Vortex generators heat trapped temperature of hot surfaces heat transfer

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Influence of Pt/Pd state on ceria-based support in CO oxidation

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Journal of Rare Earths 2023年第12期41卷 1963-1968,I0005页

作者： Igor V.Zagaynov elena Yu.Liberman Alexander V.Naumkin A.A.Baikov Institute of metallurgy and materials Science MoscowRussia D.I.mendeleev University of Chemical Technology of Russia MoscowRussia A.N.Nesmeyanov Institute of Organoelement Compounds MoscowRussia

Noble metal(m:Pt,Pd,PtPd) supported on ceria system catalysts were *** oxidized and reduced forms of the active component were examined in CO *** catalysts become more active after a reduction pretreatment,which shifts the temperature of CO *** of the data obtained from characterization techniques indicates that the strong interaction of metal ions with the support prevent the reduction of the initial mO_(x)to metallic *** formation of m-ceria interfaces efficiently boosts the oxygen activation during CO oxidation,leading to the formation of chemisorbed O on m and the regeneration of the ceria lattice oxygen,thus greatly improving the catalytic performance.

关键词： Ceria Platinum Palladium CO oxidation Rare earths

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m6A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes

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Genes & Diseases 2023年第5期10卷 1751-1754页

作者： Tamara Kleinbielen Felix Olasagasti elena Beristain Amparo Viguri-Díaz Isabel Guerra-merino Africa García-Orad m.rian mde Pancorbo BIOmICs Research Group Lascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-GasteizAraba 01006Spain Bioaraba Health Research Institute Vitoria-GasteizAraba 01009Spain Department of Biochemistry and molecular Biology University of the Basque CountryUPV/EHUVitoria-GasteizAraba 01006Spain molecular Genetics Laboratory Araba University HospitalOsakidetza Basque Health ServiceVitoria-GasteizAraba 01009Spain Pathology Department Araba University HospitalVitoria-GasteizAraba 01009Spain Department of Genetics Physical Anthropology and Animal PhysiologyUniversity of the Basque Country(UPV/EHU)LeioaBizkaia 48940Spain BioCruces Bizkaia Health Research Institute BarakaldoBizkaia 48903Spain Department of Zoology and Animal Biology.University of the Basque Country(UPV/EHU) LeioaBizkaia 48940Spain

N6-methyladenosine(m6A)is the most abundant modification in eukaryotic messenger RNA.1 This modification is dynamic,reversible,and mediated by proteins characterized as methyltransferases and *** investigations have found that aberrant expression of methyltransferases and demethylases results in m6A dysregulation and,in consequence,affects the biological functions in which this modification is ***,m6A dysregulation affects the development and maintenance of various diseases,including cancer.2 For this reason,we explored the potential role that m6A modification has in invasive breast cancer of no special type(IBC-NST)and its molecular subtypes luminal A,luminal B HER2-,luminal B HER2+,HER2+,and triple-negative breast cancer(TNBC)whose degree of global m6A methylation has not yet been studied.

关键词： breast cancer HER2

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Role of Electromagnetic Fluctuations in Organic Electronics

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Journal of Electronic Science and Technology 2020年第1期18卷 52-58页

作者： Vladimir m.mostepanenko elena N.Velichko maksim Aleksandrovich Baranov Institute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Central Astronomical Observatory at Pulkovo of Russian Academy of Sciences St.Petersburg 196140

Thin organic films find expanding applications in electronic and optoelectronic devices, biotechnology,food packing, and for many other purposes. Among other factors, the stability of films with a thickness below a micrometer is determined by the zero-point and thermal fluctuations of the electromagnetic field. These fluctuations result in the van der Waals and Casimir free energy and forces between a film and a substrate. The fluctuationinduced force may be both attractive and repulsive making the film either more or less stable, respectively. Here, we review recently obtained results for the Casimir free energy of both freestanding and deposited on the metallic and dielectric substrates peptide films. We also perform computations for the free energy of the peptide films deposited on a silica glass substrate in the region of parameters where this free energy vanishes. Possible applications of the obtained results are discussed.

关键词： Casimir free energy organic electronics peptide film

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The potential application of red mud and soil mixture as additive to the surface layer of a landfill cover system

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Journal of Environmental Sciences 2016年第6期28卷 189-196页

作者： Eva Ujaczki Viktória Feigl mónika molnár Emese Vaszita Nikolett Uzinger Attila Erdélyi Katalin Gruiz Department of Applied Biotechnology and Food Science Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics H-1111 Budapest Muegyetem rkp. 3 Hungar Institute for Soil Sciences and Agricultural Chemistry Centre for Agricultural Research Hungarian Academy of Sciences H-1022 Budapest Herman Otto Street 15 Hungary A.S.A. Hungary Ltd. H-2360 Gydl Karosi Street 53 Hungary

Red mud, the by-product of aluminum production, has been regarded as a problematic residue all over the world. Its storage involves risks as evidenced by the Ajka red mud spill,an accident in Hungary where the slurry broke free, flooding the surrounding areas. As an immediate remediation measure more than 5 cm thick red mud layer was removed from the flooded soil surface. The removed red mud and soil mixture（RmSm） was transferred into the reservoirs for storage. In this paper the application of RmSm is evaluated in a field study aiming at re-utilizing waste, decreasing cost of waste disposal and providing a value-added product. The purpose was to investigate the applicability of RmSm as surface layer component of landfill cover systems. The field study was carried out in two steps： in lysimeters and in field plots. The RmSm was mixed at ratios ranging between 0 and 50% w/w with low quality subsoil（LQS） originally used as surface layer of an interim landfill cover. The characteristics of the LQS ＋ RmSm mixtures compared to the subsoil（LQS） and the RmSm were determined by physical–chemical, biological and ecotoxicological methods. The addition of RmSm to the subsoil（LQS） at up to 20% did not result any ecotoxic effect, but it increased the water holding capacity. In addition, the microbial substrate utilization became about triple of subsoil（LQS） after 10 months. According to our results the RmSm mixed into subsoil（LQS） at20% w/w dose may be applied as surface layer of landfill cover systems.

关键词： Red mud Soil amelioration Environmental toxicology Landfill cover constituent Field-study Lysimeter

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Preliminary analysis on roles of metal–organic compounds in the formation of invisible gold

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Acta Geochimica 2021年第6期40卷 1050-1072页

作者： medet Junussov mádai Ferenc Kristály Ferenc Tòth Tivadar Fintor Krisztián muránszky Gábor Prekob Ádám Hámor-Vidóm.ria Department of mineralogy and Petrography Institute of Mineralogy and GeologyFaculty of Earth Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Institute of mineralogy and Geology Faculty of Earth Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Department of mineralogy and Geochemistry Faculty of Science and InformaticsUniversity of SzegedAradi vértank tere 1Szeged 6720Hungary Institute of Chemistry Faculty of Material Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Department of Geology and meteorology Institute of Geography and Earth SciencesFaculty of SciencesUniversity of PécsVasvári pál utcaPecs 7622Hungary

The paper comprises new analytical data on the nature and occurrence of gold in solid pyrobitumen,closely associated with the main gold-bearing sulfide arsenic ores of the Bakyrchik gold deposit(Kazakhstan),related to post-collisional magmatic-hydrothermal *** mineralization of the deposit occurs mainly in the form of an“invisible”type of gold in the structures of arsenian pyrite and arsenopyrite,and the form of gold-organic compounds of pyrobitumen in carbonaceous-terrigenous sequences of Carboniferous *** and electron microscopic analysis,Raman and FT-Infrared analysis,mineralogical and three-step sequential extraction analysis(NH2OHHCl,H2O2,HNO3?HCl)has been carried out using 9 ore samples(from 3 different types of ores)for a comprehensive study of pyrobitumen and sulfide arsenic ores focusing mainly on organic *** sequentially extracted precious metal content of pyrobitumen reaches up to 7 ppm gold and other metals like Ag 4 ppm,Pt 31 ppb,and Pd 26 ppb,forming metal–organic compounds,while arsenic sulfide minerals incorporate 11 ppm gold,39 ppm Ag,0.49 ppm *** enrichment of gold associating with organic matter and sulfide ore minerals was confirmed in this *** matter was active in the migration of gold and the capture of gold by ***,the reductive organic matter agent released gold,most likely for the sulfide arsenic ore *** was a decisive factor in the concentration,transportation,and preservation of gold in the deposit.

关键词： Gold Pyrobitumen Bakyrchik Vitrinite metal-organic compounds

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Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BmPR1A depletion and brown fat activation

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Journal of molecular Cell Biology 2022年第9期14卷 54-67页

作者： Zhaofei Wu m.elena m.rtinez Victoria Demambro marie Francois Arturo Hernandez maineHealth Institute for Research Center for Molecular MedicineMaineHealthScarboroughME 04074USA Graduate School of Biomedical Science and Engineering University of MaineOronoME 04469USA Naomi Berrie Diabetes Center Division of Molecular GeneticsColumbia University Irving Medical CenterNew YorkNY10032USA Department of medicine Tufts University School of MedicineBostonMA 02111USA

Thyroid hormone excess secondary to global type 3 deiodinase(DIO3)deficiency leads to increased locomotor activity and reduced adiposity,but also to concurrent alterations in parameters of the leptin-melanocortin system that would predict *** distinguish the underlying contributions to the energy balance phenotype of Dlo3 deficiency,we generated mice with thyroid hormone excess targeted to pro-opiomelanocortin(POmC)-expressing cells via cell-specific DIO3 *** mice exhibit a male-specific phenotype of reduced hypothalamic Pomc expression,hyperphagia,and increased activity in brown adipose tissue,with adiposity and serum levels of leptin and thyroid hormones remained *** male mice also manifest a marked and widespread hypothalamic reduction in the expression of bone morphogenetic receptor 1a(BmPR1A),which has been shown to cause similar phenotypes when inactivated in PomC-expressing *** results indicate that developmental overexposure to thyroid hormone in PomC-expressing cells programs energy balance mechanisms in a sexually dimorphic manner by suppressing adult hypothalamic BmPR1A expression.

关键词： thyroid hormone type 3 deiodinase(DIO3) bone morphogenetic receptor 1a(BmPR1A) pro-opiomelanocortin(POmC) hyperphagia brown adipose tissue corticosterone

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ImEX Large Time Step Finite Volume methods for Low Froude Number Shallow Water Flows

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Communications in Computational Physics 2014年第7期16卷 307-347页

作者： Georgij Bispen K.R.Arun m.ria Lukácová-medvid’ová Sebastian Noelle Institute of mathematics University of MainzGermany School of mathematics Indian Institute of Science Education and Research ThiruvananthapuramIndia IGPm RWTH AachenGermany.

We present new large time step methods for the shallow water flows in the lowFroude number *** order to take into accountmultiscale phenomena that typically appear in geophysical flows nonlinear fluxes are split into a linear part governing the gravitational waves and the nonlinear *** propose to approximate fast linear waves implicitly in time and in space bymeans of a genuinely multidimensional evolution *** the other hand,we approximate nonlinear advection part explicitly in time and in space bymeans of themethod of characteristics or some standard numerical flux *** integration is realized by the implicit-explicit(ImEX)*** apply the ImEX Euler scheme,two step Runge Kutta Cranck Nicolson scheme,as well as the semi-implicit BDF scheme and prove their asymptotic preserving property in the low Froude number *** experiments demonstrate stability,accuracy and robustness of these new large time step finite volume schemes with respect to small Froude number.

关键词： LowFroude number flows asymptotic preserving schemes shallowwater equations large time step semi-implicit approximation evolution Galerkin schemes

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