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Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers

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Cancer Biology & medicine 2019年第2期16卷 319-330页

作者： Andreas m. Luebke Ali Attarchi-Tehrani Jan meiners Claudia Hube-magg Dagmar S. Lang martina Kluth m.ria christina tsourlakis Sarah minner Ronald Simon Guido Sauter Franziska Buscheck Frank Jacobsen Andrea Hinsch Stefan Steurer Thorsten Schlomm Hartwig Huland markus Graefen Alexander Haese Hans Heinzer Till S. Clauditz Eike Burandt Waldemar Wilczak Doris Hoflmayer Institute of Pathology University Medical Center Hamburg-Eppendorf Hamburg 20246 Germany General Visceral and Thoracic Surgery Department and Clinic University Medical Center Hamburg-Eppendorf Hamburg 20246 Germany Department of Urology Charite-Universitatsmedizin Berlin Berlin 10117 Germany martini-Clinic Prostate Cancer Center University Medical Center Hamburg-Eppendorf Hamburg 20246 Germany

Objective: Prostate secretory protein of 94 amino acids(PSP94) is a target gene of the EZH2 transcriptional repressor and is often downregulated in prostate cancer;however, its prognostic value is ***: Immunohistochemical analysis of a tissue microarray of 12, 432 prostate cancer specimens was performed to evaluate PSP94 expression. Correlation of PSP94 expression with tumor phenotype, patient prognosis, TmPRSS2:ERG fusion status, EZH2 expression and PTEN deletion was ***: PSP94 expression was increased in benign prostatic hyperplasia;however, it was downregulated in 48% and negative in42% of the 9, 881 interpretable prostate cancer specimens. The loss of PSP94 expression was inversely correlated to EZH2 expression(P mor stage, and nodal metastasis(P mens increased from 40% in pT2 to 52%in pT3 b-pT4(P m 40% in Gleason 3+3 = 6 to 46% in Gleason 4+3 = 7 and 60% in Gleason ≥4+4 = 8(P mpact in cancer specimens with PTEN deletion. Loss of PSP94 deteriorated prognosis of cancer patients with PTEN deletion by more than 10%(P mbination of PTEN deletion and PSP94 loss provided independent prognostic information that was observed in several subgroups defined by classical and quantitative Gleason ***: The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer.

关键词： mSmB PSP94 PTEN prostate cancer tissue microarray

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