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Compa.a.ive effica.y a.d sa.ety between endoscopic submucosa. dissection,surgery a.d definitive chemora.iothera.y in pa.ients with cT1N0m0 esopha.ea. ca.cer

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World Journa. of Ga.trointestina. Endoscopy 2024年第2期16卷 72-82页

作者： Shu-a. Luo Yu-Ying Sun Ya.Ting Zeng Chun-Yu Hua.g Sta.e Key La.ora.ory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

Ba.KGROUND Endoscopic submucosa. dissection(ESD)a.d surgica. resection a.e the sta.da.d of ca.e for cT1N0m0 esopha.ea. ca.cer(EC),wherea. definitive chemora.iothera.y(d-CRT)is a.trea.ment ***,the compa.a.ive efficiency a.d sa.ety of ESD,surgery a.d d-CRT for cT1N0m0 EC rema.n *** To compa.e the efficiency a.d sa.ety of ESD,surgery a.d d-CRT for cT1N0m0 *** We retrospectively a.a.yzed the hospita.ized da.a.of a.tota. of 472 consecutive pa.ients with cT1N0m0 EC trea.ed a. Sun Ya.-sen University Ca.cer center between 2017-2019 a.d followed up until October 30th,*** a.a.yzed demogra.hic,medica. recorded,histopa.hologic cha.a.teristics,ima.ing a.d endoscopic,a.d follow-up *** Ka.la.-meier method a.d Cox proportiona. ha.a.ds modeling were used to a.a.yze the difference of surviva. outcome by *** proba.ility of trea.ment weighting(IPTW)wa. used to minimize potentia. confounding *** We retrospectively a.a.yzed pa.ients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)a. the Sun Ya.-sen University Ca.cer Center from 2017 to *** media. follow-up time for the ESD group,the surgery group,a.d the d-CRT group wa. 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)a.d 32.5 mo(95%CI:28.3-40.0),*** a.justing for ba.kground fa.tors using IPTW,the highest 3-yea. overa.l surviva.(OS)ra.e a.d 3-yea. recurrence-free surviva.(RFS)ra.e were observed in the ESD group(3-yea. OS:99.7% a.d 94.7% a.d 79.1%;a.d 3-yea. RFS:98.3%,87.4% a.d 79.1%,in the ESD,surgica.,a.d d-CRT groups,respectively).There wa. no difference of severe complica.ions occurring between the three groups(P≥0.05).multiva.0}te a.a.ysis showed tha. trea.ment method,histology a.d depth of infiltra.ion were independently a.socia.ed with OS a.d *** For cT1N0m0 EC,ESD ha. better long-term surviva. a.d lower hospita.iza.ion costs tha. those who underwent d-CRT a.d surgery,with a.simila. ra.e of severe complica.ions occurring.

关键词： Retrospective study cT1N0m0 Esopha.ea. squa.ous cell ca.cinoma Endoscopic submucosa. dissection Surgery Definitive chemora.iothera.y

Highly Therma.ly Conductive a.d Structura.ly Ultra.Sta.le Gra.hitic Films with Sea.less Heterointerfa.es for Extreme Therma. ma.a.ement

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Na.o-micro Letters 2024年第3期16卷 383-397页

作者： Peijua. Zha.g Yua.yua. Ha. Ha.g Shi Jia.a. Lu Yingjun Liu Xin ming Ya.Wa.g Wenzha.g Fa.g Yuxing Xia.Ya.ce Chen Peng Li Ziqiu Wa.g Qingyun Su Weidong Lv Ji Zhou Ying Zha.g Ha.wen La. Weiwei Ga. Zhen Xu Cha. Ga. mOE Key La.ora.ory of ma.romolecula. Synthesis a.d Functiona.iza.ion Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Sha.xi-Zheda.Institute of a.va.ced ma.erials a.d Chemica. Engineering Taiyuan 030032People’s Republic of China Beijing Spa.ecra.ts ma.ufa.turing Co. LtdBeijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China Beijing Institute of Spa.e mecha.ics a.d Electricity Beijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China China.a.a.emy of a.rospa.e a.rodyna.ics Beijing 100074People’s Republic of China Ha.gzhou Ga.xi Technol Co. LtdHangzhou 311113People’s Republic of China Interna.iona. Resea.ch Center for X Polymers International CampusZhejiang UniversityHaining 314400People’s Republic of China

Highly therma.ly conductive gra.hitic film(GF)ma.erials ha.e become a.competitive solution for the therma. ma.a.ement of high-power electronic ***,their ca.a.trophic structura. fa.lure under extreme a.terna.ing therma./cold shock poses a.significa.t cha.lenge to relia.ility a.d ***,we present the first investiga.ion into the structura. fa.lure mecha.ism of GF during cyclic liquid nitrogen shocks(LNS),which revea.s a.bubbling process cha.a.terized by“permea.ion-diffusion-deforma.ion”*** overcome this long-sta.ding structura. wea.ness,a.novel meta.-na.oa.mor stra.egy is proposed to construct a.Cu-modified gra.hitic film(GF@Cu)with sea.less *** well-designed interfa.e ensures superior structura. sta.ility for GF@Cu a.ter hundreds of LNS cycles from 77 to 300 ***,GF@Cu ma.nta.ns high therma. conductivity up to 1088 W m^(−1)K^(−1)with degra.a.ion of less tha. 5%even a.ter 150 LNS cycles,superior to tha. of pure GF(50%degra.a.ion).Our work not only offers a. opportunity to improve the robustness of gra.hitic films by the ra.iona. structura. design but a.so fa.ilita.es the a.plica.ions of therma.ly conductive ca.bon-ba.ed ma.erials for future extreme therma. ma.a.ement in complex a.rospa.e electronics.

关键词： Highly therma.ly conductive Structura.ly ultra.sta.le Gra.hitic film Extreme therma. ma.a.ement Liquid nitrogen bubbling

QuEChERS/超高效液相色谱-串联质谱法同时测定大米中16种香豆素和香兰素及其衍生物

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分析测试学报 2024年第2期43卷 254-260页

作者：邓楠尹芳平刘川汪辉向芬陈娅娅长沙市食品药品检验所湖南长沙410036 国家酒类产品质量检验检测中心(湖南) 湖南长沙410036 张家界市高级技工学校湖南张家界427000

建立了大米中16种香豆素和香兰素及其衍生物的超高效液相色谱-串联质谱(UPLC-mS/mS)检测方法。大米样品采用1%甲酸乙腈提取,150 mg C_(18)与450 mg无水mgSO_(4)吸附剂净化,采用a.ilent SB-C_(18)色谱柱(2.1 mm×50 mm,1.8μm)分离,0.2%... 详细信息

建立了大米中16种香豆素和香兰素及其衍生物的超高效液相色谱-串联质谱(UPLC-mS/mS)检测方法。大米样品采用1%甲酸乙腈提取,150 mg C_(18)与450 mg无水mgSO_(4)吸附剂净化,采用a.ilent SB-C_(18)色谱柱(2.1 mm×50 mm,1.8μm)分离,0.2%甲酸水溶液(含5 mmol/L甲酸铵)和乙腈为流动相梯度洗脱,在电喷雾离子源正负离子模式下采用多反应监测模式(mRm)进行测定,以基质匹配标准溶液内标法定量。结果显示,16种待测组分在各自质量浓度范围内线性关系良好(r≥0.998),方法检出限为0.001~0.400 mg/kg,定量下限为0.004~0.600 mg/kg,平均回收率为71.3%~120%,相对标准偏差(RSD,n=6)为1.6%~6.5%,日内RSD(n=6)为1.0%~8.8%,日间RSD(n=3)为0.60%~14%。该法前处理简单易操作、灵敏度高、准确性好,适用于大米中香豆素与香兰素及其衍生物的同时检测。

关键词： QuEChERS 超高效液相色谱-串联质谱大米香豆素香兰素衍生物同位素内标

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ma.e genitourina.y schistosomia.is-rela.ed symptoms a.ong long-term Western a.rica. migra.ts in Spa.n: a.prospective popula.ion-ba.ed screening study

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贫困所致传染病(英文) 2024年第2期13卷 29-38页

作者： Roure Sílvia.Va.lès Xa.ier Pérez-Quílez Olga.López-mu?oz Isra.l Cha.orro a.na.a.a. Elena.Va.erio Lluís Soldevila.La.ra.Espa.a.Sergio Hega.y a.a. H. a. Fernández-Riva. Gema.Gorriz Ester Herena.Dolores Oliveira.mário mira.les m.ria Ca.me Conde Ca.men montero-a.ia.Jua. José Fernández-Pedrega. Elia.mira.da.Sánchez Jose Llibre Josep m. Isna.d ma. Bonet Josep m.ria Estra.a.Oriol Pra. Núria Clotet Bona.entura.The Schisto-Stop study group Interna.iona. Hea.th Progra. (PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Funda.ió Lluita.contra.les Infeccions c/Can Ruti s/n Badalona Spain Infectious Disea.es Depa.tment Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germa.s Trias i Pujol Resea.ch Institute c/Can Ruti s/n Badalona Spain microbiology Depa.tment Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Depa.tment of Genetics a.d microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Fa.ulty of medicine University of Asyut El Fateh Assiut Governorate Egypt Depa.tment of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Ca.ovelles Prima.y Hea.th Ca.e Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain Prima.y Hea.th Ca.e Unit ma.a.ó-(Roca.onda.Pa.a.) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Ba.celona.North metropolita. Prima.y Ca.e Directora.e Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directora.e for Innova.ion a.d Interdisciplina.y Coopera.ion Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain IrsiCa.xa.a.DS Resea.ch Institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious Disea.es Directora.e Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Ba.kground Schistosomia.is is highly endemic in sub-Sa.a.a. a.rica.a.d frequently imported to Europe. ma.e urogenita. ma.ifesta.ions a.e often neglected. We a.med to a.certa.n the preva.ence of genitourina.y clinica. signs a.d symptoms a.ong long-term a.rica. migra.ts in a.non-endemic Europea. country using a.serology *** We ca.ried out a.prospective, community-ba.ed cross-sectiona. study of a.ult ma.e migra.ts from sub-Sa.a.a. a.rica.living in *** serology tests a.d microscopic urine exa.ina.ions were ca.ried out, a.d clinica. da.a.were obta.ned from a. electronic medica. record sea.ch a.d a.structured *** We included 388 a.ult ma.es, mea. a.e 43.5 yea.s [Sta.da.d Devia.ion (SD) = 12.0, ra.ge: 18–76]. The media. time since migra.ion to the Europea. Union wa. 17 [Interqua.tile ra.ge (IQR): 11–21] yea.s. The most frequent country of origin wa. Senega. (N = 179, 46.1%). Of the 338, 147 (37.6%) tested positive forSchistosoma. Pa.a.ite eggs were present in the urine of only 1.3%. Nine genitourina.y clinica. items were significa.tly a.socia.ed with positiveSchistosoma.serology results: pelvic pa.n (45.2%;OR = 1.57, 95%CI: 1.0–2.4), pa.n on eja.ula.ion (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dyspa.eunia.(12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), self-reported episodes of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), ha.ma.uria (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undia.nosed syndromic STIs (5.4%), a.d orchitis (20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinica. signs tended to *** Urogenita. clinica. signs a.d symptoms a.e preva.ent a.ong ma.e a.rica. long-term migra.ts with a.positiveSchistosoma.serology results. Genita. involvement ca. be frequent even a.ong those with long periods of non-residence in their sub-Sa.a.a. a.rica. countries of origin. Further resea.ch is needed to develop dia.nostic tools a.d va.ida.e thera.eutic a.proa.hes to

关键词： Schistosomia.is Chronic schistosomia.is Urogenita. schistosomia.is ma.e genita. schistosomia.is Longterm migra.t

Is there a.potentia. of circula.ing miRNa. a. bioma.kers in rheuma.ic disea.es?

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Genes & Disea.es 2023年第4期10卷 1263-1278页

作者： Klára.Pra.zlerová La.isla. Senolt m.ria Filková Institute of Rheuma.ology Prague 12800Czech Republic Depa.tment of Rheuma.ology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t microRNa.(miRNa.)a.e sma.l non-coding single-stra.ded RNa. of a.out 22 nucle-otides in length tha. a.t a. post-tra.scriptiona. regula.ors of gene *** on the complementa.ity between miRNa.a.d ta.get mRNa.clea.a.e,desta.iliza.ion,or tra.sla.tiona. suppression of mRNa.occurs within the RISC(RNa.induced silencing complex).a. gene expression regula.ors,miRNa. a.e involved in a.va.iety of biologica. *** of miRNa. a.d their ta.get genes contribute to the pa.hophysiology of ma.y disea.es,including a.toimmune a.d infla.ma.ory *** a.e a.so present extra.ellula.ly in their sta.ble form in body *** incorpora.ion into membra.e vesicles or protein complexes with a.o2,HDL,or nucleophosmin 1 protects them a.a.nst ***-free miRNa. ca. be deliv-ered to a.other cell in vitro a.d ma.nta.n their functiona. ***,miRNa. ca. be considered media.ors of intercellula. *** rema.ka.le sta.ility of cell-free miRNa. a.d their a.cessibility in body fluid ma.es them potentia. dia.nostic or prognostic bio-ma.kers a.d potentia. thera.eutic *** we provide a. overview of the potentia. role of circula.ing miRNa. a. bioma.kers of disea.e a.tivity,thera.eutic response,or dia.nosis in rheuma.ic *** circula.ing miRNa. reflect their involvement in the pa.hogenesis,while for plenty,their pa.hogenetic mecha.isms rema.n to be *** miRNa. described a. bioma.kers were a.so shown to be of thera.eutic potentia.,a.d some miRNa. a.ea.rea.y tested in clinica. trials.

关键词： Bioma.ker Dia.nosis miRNA Rheuma.ic disea.es Thera.y

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一种无偏差的多通道多尺度样本熵算法

物理学报 2024年第11期73卷 46-55页

作者：李惟嘉申晓红李亚安西北工业大学航海学院西安710072 西北工业大学海洋声学信息感知工业和信息化部重点实验室西安710072

多通道数据采集技术的发展为复杂系统非线性动力学特性研究提供了更加丰富的先验信息.然而传统的非线性特征量只能处理单通道数据,无法直接提取多通道数据的非线性特征.近年来,有学者对多尺度样本熵算法进行了一般化处理,提出了多通道... 详细信息

多通道数据采集技术的发展为复杂系统非线性动力学特性研究提供了更加丰富的先验信息.然而传统的非线性特征量只能处理单通道数据,无法直接提取多通道数据的非线性特征.近年来,有学者对多尺度样本熵算法进行了一般化处理,提出了多通道多尺度样本熵算法.该算法不仅可以对多通道数据整体的复杂度进行表征,还可以有效提取通道内和通道间隐含的相关性信息.但是,该算法缺乏相应的理论支撑,在实际应用中无法兼顾性能和稳定性.针对以上问题,本文提出了一种无偏差的多通道多尺度样本熵算法,并利用概率论从理论上分析了多通道多尺度样本熵算法不稳定以及性能差的原因.后续的仿真实验证明改进后的算法不但可以有效地提取通道内和通道间的相关性信息,同时在处理复杂数据时表现出了良好的稳定性.该算法为诸如模糊熵、排列熵等非线性特征量的算法一般化提供了思路和理论依据.

关键词：非线性动力学多通道数据多通道多尺度样本熵

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郁闭果园图传遥控式割草机的设计与性能试验

吉林大学学报（工学版） 2024年第1期54卷 281-293页

作者：杨福增孙景彬李亚男张亚洲刘志杰西北农林科技大学机械与电子工程学院陕西杨凌712100 农业农村部苹果全程机械化科研基地陕西杨凌712100 农业农村部北方农业装备科学观测实验站陕西杨凌712100

针对传统郁闭果园内部空间狭窄密闭,现有割草机难以进入作业,面临无机可用的生产难题,设计了一种适用于郁闭果园环境、割茬高度可调且株间避障灵活便捷的小型图传遥控式割草机。在分析郁闭果园种植模式和割草农艺要求的基础上,确定了割... 详细信息

针对传统郁闭果园内部空间狭窄密闭,现有割草机难以进入作业,面临无机可用的生产难题,设计了一种适用于郁闭果园环境、割茬高度可调且株间避障灵活便捷的小型图传遥控式割草机。在分析郁闭果园种植模式和割草农艺要求的基础上,确定了割草机的总体设计方案,然后对割草机关键部件(刀盘高度调节机构、株间避障切割机构、遥控及图传系统等)进行了设计与匹配选型,最后完成了整机集成与性能试验。基本性能试验结果表明:割草机整机尺寸(长×宽×高)为1.9 m×1.7 m×0.7 m,割茬高度调节范围为30~110 mm,株间避障通过率为100%,遥控和图传距离均大于110 m。同时以前进速度、刀盘转速和割茬高度为试验因素,割茬稳定系数、割幅利用率和漏割率为试验性能指标开展正交试验,并对试验结果进行显著性分析。结果表明,各因素对割茬稳定系数、割幅利用率和漏割率性能指标影响的主次顺序均为前进速度、刀盘转速和割茬高度;确定的较优方案为前进速度0.6 m/s、刀盘转速3000 r/min、割茬高度70 mm,并对该较优方案进行了验证试验,结果表明:设计的新型割草机在该方案下割茬稳定系数为93.2%,割幅利用率为99.3%,漏割率为0.5%,能满足郁闭果园实际作业要求。

关键词：割草机郁闭果园割茬高度调节株间避障遥控图传

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面向磁约束聚变装置在强磁环境下磁性元件的失效分析及屏蔽效能研究

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南方能源建设 2024年第3期11卷 87-95页

作者：黄亚黄正义安徽微伏特电源科技有限公司安徽合肥230088 中国科学院合肥物质科学研究院等离子体物理研究所安徽合肥230031 中国科学技术大学安徽合肥230026

[目的]文章旨在探究核聚变装置产生的空间磁场对磁性器件的影响,并深入了解复杂电磁环境下的磁场屏蔽特性。[方法]研究过程中,以核聚变内电源系统中的开关电源和电子变压器为具体研究对象,通过详细分析磁场对损耗的影响以及不同方向磁... 详细信息

[目的]文章旨在探究核聚变装置产生的空间磁场对磁性器件的影响,并深入了解复杂电磁环境下的磁场屏蔽特性。[方法]研究过程中,以核聚变内电源系统中的开关电源和电子变压器为具体研究对象,通过详细分析磁场对损耗的影响以及不同方向磁场下的特性变化,同时深入探讨影响磁场屏蔽效能的关键因素以及不同材料的应用情况,来实现研究目的。[结果]结果表明,强磁场环境下磁性元件的损耗明显增加,且不同方向磁场对元件特性的影响程度不同。通过对比分析不同材料的屏蔽效果,发现具有高导电性和磁导率的材料在屏蔽设计中具有更好的应用前景。此外,优化屏蔽结构能够进一步提高屏蔽效能,降低磁场对磁性元件的影响。[结论]通过系统分析核聚变装置强磁场对磁性元件的影响及屏蔽效能,为设备磁场耐受能力的测试和屏蔽设计的验证提供了关键参考。未来工作将聚焦于进一步优化屏蔽材料和结构设计,以提高磁性元件在强磁场环境下的稳定性和可靠性。

关键词：空间磁场磁场屏蔽磁性元件屏蔽效能聚变

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载铜纳米粒鼻用原位凝胶体外释放度研究

科学技术与工程 2024年第22期24卷 9302-9308页

作者：曹雅仇丽颖西南民族大学药学院成都610225

为研究载铜纳米粒鼻用原位凝胶(TETa.Cu-NPs-gel)中三乙烯四胺铜(TETa.Cu)的体外释放规律,通过透析法研究TETa.Cu的体外释放度,以0.1 mol/mL磷酸盐缓冲液(PBS,pH=7.4)为释放介质,并用Origin软件对释药数据进行模型拟合。采用高效液相色... 详细信息

为研究载铜纳米粒鼻用原位凝胶(TETa.Cu-NPs-gel)中三乙烯四胺铜(TETa.Cu)的体外释放规律,通过透析法研究TETa.Cu的体外释放度,以0.1 mol/mL磷酸盐缓冲液(PBS,pH=7.4)为释放介质,并用Origin软件对释药数据进行模型拟合。采用高效液相色谱法检测TETa.Cu在溶出介质中的释放水平,以Swell Chromplus^(Tm)C_(18)(4.6 mm×150 mm,5μm)为色谱柱,流动相a.pH=3.0磷酸盐缓冲液,流动相B为甲醇(a.B=90∶10),流速1.0 mL/min,检测波长为260 nm。结果表明,TETa.Cu在0.05~1 mg/mL范围内线性关系良好,高、中、低三个浓度的回收率在99.9%~101.0%,RSD均小于2%;与TETa.Cu溶液相比,TETa.Cu-NPs-gel释药速率缓慢,符合一级释药动力学方程。可见,本文研究所建立的TETa.Cu-NPs-gel体外释放度测定方法准确、简便可行。TETa.Cu-NPs-gel具有缓释的作用。

关键词：三乙烯四胺铜铜补充剂高效液相色谱体外释放度离子型凝胶