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Selenoprotein W cDNAs From Five Species of Animals

Biomedical and Environmental Sciences 1997年第2期10卷 190-197页

作者： P. D. WHANGER S. C. VENDELAND Q-P GU m. A. BEILSTEIN AND L. W. ream.Department of Agricultural Chemistry, Oregon State University,Corvallis, Oregon 97331, USA) Department of Agricultural Chemistry Oregon State University Corvallis 97331 USA.

The nucleotide sequences of the open reading frames of cDNAs for selenoprotein W from skeletal muscle of rat, mouse, sheep, rhesus monkey and human are reported. Theoretical translation of the coding sequences indicated highly similar proteins of 88 (mouse and rat) or 87 (human, monkey and sheep) amino acids. In 73 of 88 positions the specified amino acids are identical for all five proteins. TGA encoding selenocysteine is the 13th codon of all the cDNAs. The rnouse, rat and sheep open reading frames terminate with TGA but the human and rhesus monkey coding regions terminate with TAA. The encoded amino acid sequences are identical for the rat and mouse proteins, and for the human and monkey proteins. The similarity of the cDNAs continues in the 3' noncoding regions through the putative selenocysteine insertion sequence (SEClS) elements which are required for correct interpretation of the selenocysteine codon. The region between the SECIS elements and the polyadenylation signals showed much lower similarity. The cloned rat gene for selenoprotein W is 5000 bases long,with the 663 bases of the cDNA in six exons. The transcription start site was identified by nuclease protection assay to be 16 bases upstream.of the longest cDNA clone. A canonical TATA box occurs 150 bases upstream. but the assay did not indicate the presence of longer mRNAs

关键词： cDNA RNA Selenoprotein W cDNAs From Five Species of Animals Beilstein

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Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-membered 1,3-Disubstituted Cyclic Amidinium Salts

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Open Journal of medicinal Chemistry 2020年第4期10卷 139-152页

作者： maría m. Blanco maría A. ream.rez maría C. Caterina Isabel A. Perillo Guido A. Oppezzo maría S. Shmidt Gabriel O. Gutkind José Di Conza Alejandra Salerno Departamento de Química Orgánica Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Buenos Aires Argentina Departamento de microbiología Inmunología y Biotecnología Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Buenos Aires Argentina

Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently synthesized in excellent yields by dehydrogenation of the corresponding N,N'-dibenzyl aminals employing N-bromosuccinimide (NBS) as dehydrogenating agent under ultrasound irradiation. The present methodology has proven to be simple, efficient and environmentally benign. All novel compounds were identified and characterized by 1H and 13C NMR spectra. The synthesized compounds were screened for their antimicrobial activities.

关键词： medium Ring Amidinium Salts Ultrasonic Assisted Synthesis Antimicrobial Green Chemistry

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