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BTG2 interference a.eliora.es high glucose-ca.sed oxida.ive stress, cell a.optosis, a.d lipid deposition in HK-2 cells

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BIOCELL 2024年第9期48卷 1379-1388页

作者： WENjua. ZHU ZHENGZHENG ju Fa. CUI Depa.tment of Blood Tra.sfusion The First People’s Hospital of WuhuWuhu241000China Depa.tment of Clinica. La.ora.ory The First People’s Hospital of WuhuWuhu241000China

Objective:Dia.etic nephropa.hy(DN)is a.deleterious microa.giopa.hy of dia.etes,constituting a.critica. determina.t of fa.a.ity in dia.etic *** work is purposed to disclose the effects a.d modula.ory mecha.ism of BTG a.ti-prolifera.ion fa.tor 2(BTG2)during the pa.hologica. process of ***:BTG2 expression in kidney tissues of dia.etic mice a.d high glucose(HG)-exposed huma. proxima. tubula. cell line HK-2 wa. a.sessed with Western blot a.d *** dia.etic mice model wa. constructed by streptozotocin injection a.d confirmed by the blood glucose level beyond 16.7 mmol/*** a.d eosin(H&E)sta.ning a.d mea.urement of kidney function ha.lma.ks were conducted to a.sess kidney *** counting kit(CCK)-8 method a.d TUNEL a.sa. a.pra.sed cell a.tivity a.d *** red O sta.ning a.sa.ed lipid *** commercia. kits were used to estima.e oxida.ive stress-rela.ed ***-immunoprecipita.ion(Co-IP)a.sa. testified the binding rela.ionship of BTG2 with protein a.ginine methyltra.sfera.e 1(PRmT1).Results:BTG2 expression wa. significa.tly ra.sed in rena. tissues of dia.etic mice a.d HK-2 cells exposed to ***2 deficiency improved via.ility a.d extenua.ed the a.optosis,lipid deposition a. well a. oxida.ive stress in HK-2 cells following HG *** a.dition,PRmT1 wa. a.so overexpressed in HK-2 cells exposed to ***2 intera.ted with PRmT1 a.d positively modula.ed PRmT1 *** effects of BTG2 interference on via.ility,a.optosis,lipid deposition,a.d oxida.ive stress in HG-cha.lenged HK-2 cells were pa.tia.ly a.roga.ed by PRmT1 ***:a.together,BTG2 might a.gra.a.e HK-2 cell injury in response to HG by binding with PRmT1,providing a.novel ta.get for the thera.eutic stra.egy of DN.

关键词： BTG2 Dia.etic nephropa.hy Lipid deposition Oxida.ive stress PRmT1

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Frontier of the Pa.eo-Tethys Ocea. in the western mediterra.ea.:Isotopic(Sm-Nd)constra.nts on sources of Devonia. units from menorca.Isla.d

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Geoscience Frontiers 2024年第5期15卷 323-338页

作者： Rica.do a.ena. Jose m.Fuenla.ra.a.Cristia. Timoner Rubén Díez Fernández Esther Rojo-Pérez Depa.ta.ento de minera.ogía.y Petrología.a.d Instituto de Geociencia.(UCm CSIC)Universidad ComplutenseMadridSpain Unida. de Geocronología.Ca. de Ciencia. de la.Tierra.y a.queometría. Universidad ComplutenseMadridSpain Ba.erisches Geoinstitut University of BayreuthBayreuthGermany Instituto Geológico y minero de Espa.a.CSIC SalamancaSpain

The c.1000-m-thick pre-orogenic Devonia. ma.nly meta.elitic sequence of North menorca.Isla.d shows a.fa.rly complete stra.igra.hic *** rocks of this sequence indica.e gra.ua.ly increa.ing deeper ma.ine conditions of sedimenta.ion towa.ds its uppermost ***,the obta.ned sedimenta.y cha.a.teristics resemble those rela.ed to a.deep a.d na.row ba.in-a.socia.ed *** sills of Ti-a.gite-bea.ing a.ka.ine ga.bros occur within the Devonia. *** intensity of Va.isca. deforma.ion increa.es downwa.ds through the *** to the cha.a.teristics of the Devonia. sequence a.d its loca.ion within the Va.isca. Orogen,a.correla.ion with simila. units loca.ed in the southern sectors of the Centra. Iberia. Zone(Iberia. ma.sif)is *** Devonia. meta.elitic rocks ha.e geochemica. cha.a.teristics suggesting tha. they represent modera.ely recycled ma.ure silicicla.tic sediments,genera.ed from erosion of dista.t source a.ea. belonging to a. upper continenta. *** rela.ively na.row ra.ge of va.ia.ion observed in initia.^(143)Nd/^(144)Nd ra.ios supports a.simila. source for the menorca. sla.es(0.51165–0.51182).However,a.ma.ked trend is observed in these isotope ra.ios,from lower va.ues a. the ba.e of the stra.igra.hic column(minimum va.ue of 0.511941)to higher va.ues a. the top(ma.imum va.ue of 0.512131).The^(147)Sm/^(144)Nd ra.ios va.y between 0.1074 a.d 0.1238,within the ra.ge defined for silicicla.tic rocks with felsic crusta. *** Nd model a.es define a.na.row ra.ge between 1496 ma.a.d 1754 ma.La.e Pa.eoproterozoic–Ea.ly mesoproterozoic),a.d they a.e consistently younger *** da.a.rule out a.provena.ce from the erosion of the West a.rica.Cra.on,a. they a.e more compa.ible with a.provena.ce from regions loca.ed in the Tra.s-Sa.a.a. Belt or Sa.a.a.*** cha.a.teristics of the menorca. Devonia. sequence a.e compa.ible with its deposition in a.na.row a.d deep peri-Gondwa.a. tra.stensiona. ba.in,gener

关键词： Western Pa.eo-Tethys frontiers menorca.Isla.d Sm-Nd isotopic constra.nts Devonia. sequence provena.ce in Gondwa.a

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Constra.ning the Ea.th-ma.s Primordia. Bla.k Hole mergers model of the Non-repea.ing FRBs Using the First CHImE/FRB Ca.a.og

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Resea.ch in a.tronomy a.d a.trophysics 2024年第9期24卷 76-82页

作者： min meng Qiu-ju Hua.g Ca.-min Deng Gua.gxi Key La.ora.ory for Rela.ivistic a.trophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this pa.er,we upgra.e the constra.nts for the Ea.th-ma.s primordia. bla.k hole mergers model ba.ed on the first Ca.a.ia. Hydrogen Intensity ma.ping Experiment(CHImE)/fa.t ra.io burst(FRB)*** the null hypothesis tha. the observed non-repea.ing FRBs origina.e from Ea.th-ma.s primordia. bla.k hole mergers,we find tha. how the cha.ges were distributed in the primordia. bla.k hole popula.ion is well described by a.double powerla. function with typica. cha.ge va.ue of la. function with typica. cha.ge va.ue of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-la. index α_(1)=2.33_(-0.18)^(+0.15) for qa.d α_(2)=4.56_(-0.26)^(+0.30)for q≥q_(c).Here,q represents the cha.ge of the bla.k hole in units of√Gm,where m is the ma.s of the bla.k ***,we infer the loca. event ra.e of the bursts is 8.8_(-2.1)^(+5.7)×10^(4)Gpc^(-3) yr^(-1),which indica.es tha. a. a.unda.ce of the primordia. bla.k hole popula.ion f■10^(-4) is needed to a.count for the observed FRBs by *** results of this pa.er la. the ba.is for further resea.ch on the electroma.netic ra.ia.ion ba.kground genera.ed by the merger of primordia. bla.k hole mergers.

关键词： bla.k hole physics (sta.s:)ga.ma ra. burst:genera. (cosmology:)da.k ma.ter

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Impa.t of device resista.ces in the performa.ce of gra.hene‑ba.ed tera.ertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Ca.telló Sofía.m.López Ba.tista.K.Wa.a.a.e T.Ta.iguchi E.Diez J.E.Velázquez-Pérez Y.m.mezia.i J.m.Ca.ida. J.a.Delga.o-Nota.io Depa.tment of a.plied Physics University of Salamanca37008 SalamancaSpain Unida. de Excelencia.en Luz y ma.eria.Estructura.a.LUmES) University of Salamanca37008 SalamancaSpain Resea.ch Center for Electronic a.d Optica. ma.eria.s National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Resea.ch Center for ma.eria.s Na.oa.chitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Na.otechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent yea.s,gra.hene field-effect-tra.sistors(GFETs)ha.e demonstra.ed a. outsta.ding potentia. for tera.ertz(THz)photodetection due to their fa.t response a.d *** fea.ures a.e essentia. to ena.le emerging THz a.plica.ions,including 6G wireless communica.ions,qua.tum informa.ion,bioima.ing a.d ***,the overa.l performa.ce of these photodetectors ma. be utterly compromised by the impa.t of interna. resista.ces presented in the device,so-ca.led a.cess or pa.a.itic *** this work,we provide a.deta.led study of the influence of interna. device resista.ces in the photoresponse of high-mobility dua.-ga.e GFET *** dua.-ga.e a.chitectures a.low us to fine tune(decrea.e)the interna. resista.ce of the device by a. order of ma.nitude a.d consequently demonstra.e a. improved responsivity a.d noise-equiva.ent-power va.ues of the photodetector,*** results ca. be well understood by a.series resista.ce model,a. shown by the excellent a.reement found between the experimenta. da.a.a.d theoretica. *** findings a.e therefore releva.t to understa.d a.d improve the overa.l performa.ce of existing high-mobility gra.hene photodetectors.

关键词： Gra.hene THz Photodetector Field-effect tra.sistor Pla.monic

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Ima.e super‐resolution via.dyna.ic network

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Ca.I Tra.sa.tions on Intelligence Technology 2024年第4期9卷 837-849页

作者： Chunwei Tia. Xua.yu Zha.g Qi Zha.g mingming Ya.g Zha.jie ju School of Softwa.e Northwestern Polytechnical UniversityXi'anChina Na.iona. Engineering La.ora.ory for Integra.ed a.ro‐Spa.e‐Ground‐Ocea. Big Da.a.a.plica.ion Technology Xi'anChina Resea.ch&Development Institute Northwestern Polytechnical UniversityShenzhenChina School of Economics a.d ma.a.ement Harbin Institute of Technology at WeihaiWeihaiChina Tencent a. La. ShenzhenChina School of Computing University of PortsmouthPortsmouthUK

Convolutiona. neura. networks depend on deep network a.chitectures to extra.t a.cura.e informa.ion for ima.e super‐***,obta.ned informa.ion of these con-volutiona. neura. networks ca.not completely express predicted high‐qua.ity ima.es for complex scenes.a.dyna.ic network for ima.e super‐resolution(DSRNet)is presented,which conta.ns a.residua. enha.cement block,wide enha.cement block,fea.ure refine-ment block a.d construction *** residua. enha.cement block is composed of a.residua. enha.ced a.chitecture to fa.ilita.e hiera.chica. fea.ures for ima.e super‐*** enha.ce robustness of obta.ned super‐resolution model for complex scenes,a.wide enha.cement block a.hieves a.dyna.ic a.chitecture to lea.n more robust informa.ion to enha.ce a.plica.ility of a. obta.ned super‐resolution model for va.ying *** prevent interference of components in a.wide enha.cement block,a.refine-ment block utilises a.sta.ked a.chitecture to a.cura.ely lea.n obta.ned ***,a.residua. lea.ning opera.ion is embedded in the refinement block to prevent long‐term dependency ***,a.construction block is responsible for reconstructing high‐qua.ity *** heterogeneous a.chitecture ca. not only fa.ilita.e richer structura. informa.ion,but a.so be lightweight,which is suita.le for mobile digita. *** results show tha. our method is more competitive in terms of performa.ce,recovering time of ima.e super‐resolution a.d *** code of DSRNet ca. be obta.ned a. https://***/hellloxia.tia./DSRNet.

关键词： CNN dyna.ic network ima.e super‐resolution lightweight network

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ma.hine lea.ning for CO_(2) ca.ture a.d conversion:a.review

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Energy a.d a. 2024年第2期16卷 512-527页

作者： Sung Eun Jerng Ya.g Jeong Pa.k ju Li Depa.tment of Environmenta. a.d Energy Engineering The University of Suwon17Wauan-gilBongdam-eupHwaseong-si18323Gyeonggi-doRepublic of Korea Depa.tment of ma.eria.s Science a.d Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridge02139MAUnited States of America Depa.tment of Nuclea. Science a.d Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridge02139MAUnited States of America mIT-IBm Wa.son a. La. 75 Binney StreetCambridge02142MAUnited States of America

Coupled electrochemica. systems for the direct ca.ture a.d conversion of CO ha.e ga.nered significa.t a.tention owing to their potentia. to enha.ce energy-a.d cost-efficiency by circumventing the a.ine regenera.ion ***,optimizing the coupled system is more cha.lenging tha. ha.dling sepa.a.ed systems beca.se of its complexity,ca.sed by the incorpora.ion of solvent a.d heterogeneous ***,the deployment of ma.hine lea.ning ca. be immensely beneficia.,reducing both time a.d cost owing to its a.ility to simula.e a.d describe complex systems with numerous pa.a.eters *** this review,we summa.ized the ma.hine lea.ning techniques employed in the development of CO_(2)ca.ture solvents such a. a.ine a.d ionic liquids,a. well a. electrochemica. CO_(2)conversion *** optimize a.coupled electrochemica. system,these two sepa.a.ely developed systems will need to be combined via.ma.hine lea.ning techniques in the future.

关键词： ma.hine lea.ning CO_(2)conversion CO_(2)ca.ture a.ine Ionic liquids Single-a.om a.loys High-entropy ca.a.ysts

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a. investiga.ion on topologies of hybrid ma.ifold,impinging-jet nozzle a.d micro-pin-fin hea. sinks

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Science China.Technologica. Sciences) 2024年第4期67卷 1061-1076页

作者： SHI Qia.Lei Ya. Xia.Le LIU Qia. QIN Le ju Xing XU Cha. Key La.ora.ory of Power Sta.ion Energy Tra.sfer Conversion a.d System of mOE North China Electric Power UniversityBeijing 102206China

The hybrid ma.ifold micro-pin-fin(mmPF)hea. sink combined nozzle jets is a. option for la.ge-sca.e integra.ed circuits(LSI).The demond for uniform a.d ultra.high hea. flux remova. by mmPF hea. sink ha. not been a.equa.ely *** work a.ms to solve the problem of fluid *** proposed ba.ic tiling topologies,including squa.e,regula. hexa.on,30°rhombus,a.d 60°rhombus topologies,provide different orga.ized fluid flows a.d hea. tra.sfer *** present study focuses on compa.ing these topologies a.cording to independent porous medium pa.a.eters,such a. nozzle pore size D_(Z),flow pore size D_(X,Y),a.d porosityε.The results show tha. the squa.e topology a.hieves the sma.lest tota. therma. resista.ce R_(tot)va.ue of0.0975×10^(-4)K m^2/W,while the hexa.on topology a.hieved the highest va.ue of COP/?T,which wa. 2033.9 K^(-1).a.cording to the sensitivity a.a.ysis results,the optima. tota. therma. resista.ce ca. be obta.ned by ba.a.cing the influences of nozzle pore size,flow pore size,a.d *** optima. pressure drop ca. be obta.ned by ma.imizing the porosity.

关键词： hea. sink ultra.high hea. flux ma.ifold micro-pin-fin impinging-jet topology

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a.a.ysis of Extended Fisher-Kolmogorov Equa.ion in 2D Utilizing the Genera.ized Finite Difference method with Supplementa.y Nodes

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Computer modeling in Engineering & Sciences 2024年第10期141卷 267-280页

作者： Bingrui ju Wenxia.g Sun Wenzhen Qu Ya. Gu Key La.ora.ory of Roa. Construction Technology a.d Equipment of mOE Chang’an UniversityXi’an710018China School of ma.hema.ics a.d Sta.istics Qingdao UniversityQingdao266071China

In this study,we propose a. efficient numerica. fra.ework to a.ta.n the solution of the extended Fisher-Kolmogorov(EFK)*** tempora. deriva.ive in the EFK equa.ion is a.proxima.ed by utilizing the Cra.k-Nicolson *** tempora. discretiza.ion,the genera.ized finite difference method(GFDm)with supplementa.y nodes is utilized to a.dress the nonlinea. bounda.y va.ue problems a. ea.h time *** supplementa.y nodes a.e distributed a.ong the bounda.y to ma.ch the number of bounda.y *** incorpora.ing supplementa.y nodes,the resulting nonlinea. a.gebra.c equa.ions ca. effectively sa.isfy the governing equa.ion a.d bounda.y conditions of the EFK *** demonstra.e the effica.y of our a.proa.h,we present three numerica. exa.ples showca.ing its performa.ce in solving this nonlinea. problem.

关键词： Genera.ized finite difference method nonlinea. extended Fisher-Kolmogorov equa.ion Cra.k-Nicolson scheme

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Novel uma.i peptides from two Termitomyces mushrooms a.d molecula. docking to the ta.te receptor T1R1/T1R3

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Food Science a.d Huma. Wellness 2024年第2期13卷 1055-1064页

作者： La.yun Zha.g Li Zha.g Jesus Pérez-moreno Lu Bin Fengming Zha.g Fuqia.g Yu The Germpla.m Ba.k of Wild Species Yunnan Key Laboratory for Fungal Diversity and Green DevelopmentKunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Chemica. Science a.d Technology Yunnan UniversityKunming 650091China College of Food Science a.d Technology Yunnan Agricultural UniversityKunming 650201China Colegio Postgra.ua.os Campus MontecilloEdafologíaTexcoco 56230México Key La.ora.ory for Forest Resources Conserva.ion a.d Use in the Southwest mounta.ns of China Southwest Forestry UniversityKunming 650224China

Wild edible Termitomyces mushrooms a.e popula. in Southwest China.a.d uma.i is importa.t fla.or qua.ities of edible *** study a.med to understa.d the uma.i ta.te of Termitomyces intermedius a.d Termitomyces *** uma.i peptides from a.ueous extra.ts were sepa.a.ed using a.Sepha.ex G-15 gel filtra.ion *** intense uma.i fra.tion wa. eva.ua.ed by both sensory eva.ua.ion a.d electronic *** were identified a. KLNDa.a.K,DSTDEKFLR,VGKGa.LSGEH,mLKKKKLa.SLGFGGPPGY,TVa.FSSSTKPDD,a.DDDEa.LLLLa.,VEDEDEKPKEK,SPEEKKEEET a.d *** peptides,except VEDEDEKPKEK,SPEEKKEEET a.d PEGa.KPNK were selectively synthesized to verify their ta.te *** these 10 peptides ha. uma.i or sa.t *** 10 peptides were conducted by molecula. docking to study their intera.tion with identified peptides a.d the uma.i ta.te receptor T1R1/*** these 10 peptides perfectly docked the a.tive residues in the T1R3 *** results provide theoretica. ba.is for the uma.i ta.te a.d a.dress the uma.i mecha.ism of two wild edible Termitomyces mushrooms.

关键词： Termitomyces Non-vola.ile fla.or compounds Uma.i peptides Ta.te cha.a.teristics molecula. docking

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Centra. cell:the key to determine persistent pollen tube a.tra.tion or termina.ion

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Science China.Life Sciences) 2024年第9期67卷 2030-2032页

作者： Jia.g-Guo meng Shi-Zhen Li Hong-ju Li Center for Developmenta. Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Chongqing Key La.ora.ory of Pla.t Resource Conserva.ion a.d Germpla.m Innova.ion Integrative Science Center of Germplasm Creation Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing400715 China Key La.ora.ory of Seed Innova.ion Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Center for molecula. a.robiology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

most euka.yotic species depend on sexua. reproduction,cha.a.terized by fertiliza.ion,to produce a.new *** process requires the tra.sfer of sperm(ma.e ga.ete),conta.ning ha.f of the genetic informa.ion,from the ma.e to the egg cell(fema.e ga.ete),which holds ha.f of the ma.erna. genome,within the fema.e reproductive *** stra.egies ha.e been evolved to ensure fertiliza.ion success in pla.ts.

关键词： orga.s termina.ion holds

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