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Correlative light-electron microscopy using small gold nanoparticles as single probes

Light(Science & Applications) 2023年第4期12卷 657-670页

作者： Iestyn Pope Hugh Tanner Francesco masia Lukas Payne Kenton Paul Arkilll Judith mantell Wolfgang Langbein Paola borri Paul Verkade School of Biosciences Cardiff UniversityMuseum AvenueCardiff CF103AXUK School of Biochemistry University of BristolUniversity WalkBristolUK Department of Chemistry Umea UniversityUmea 90187Sweden School of Physics and Astronomy Cardiff UniversityThe ParadeCardiff CF243AAUK School of medicine University of NottinghamNottinghamNG72RDUK

Correlative light-electron microscopy(CLEm)requires the availability of robust probes which are visible both in light and electron *** we demonstrate a CLEm approach using small gold nanoparticles as a single *** gold nanoparticles bound to the epidermal growth factor protein were located with nanometric precision background-free in human cancer cells by light microscopy using resonant four-wave mixing(FWm),and were correlatively mapped with high accuracy to the corresponding transmission electron microscopy *** used nanoparticles of 10 nm and 5 nm radius,and show a correlation accuracy below 60 nm over an area larger than 10 pm size,without the need for additional fiducial *** accuracy was improved to below 40 nm by reducing systematic errors,while the localisation precision is below 10 ***-resolved FWm correlates with nanoparticle shapes,promising for multiplexing by shape recognition in future *** to the photostability of gold nanoparticles and the applicability of FWm microscopy to living cells,FWm-CLEm opens up a powerful alternative to fluorescence-based methods.

关键词： light radius resonant

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乳腺抑脂动态增强检查:磁场的不均匀性是否会影响对比剂摄取曲线

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国际医学放射学杂志 2013年第4期 401-401页

作者： m.A. Schmidt m. borri E. Scurr G. Ertas G. Payne E. O 'Flynn 张晓丹 Royal marsden NHS Foundation Trust and Institute of Cancer Research MRI UnitDowns Rd Sutton SM2 5 PT UK

目的研究磁场的不均匀性对乳腺脂肪抑制动态增强扫描(DCE-FS)的影响。材料与方法对10例病人的乳腺进行检查。使用1.5TmR设备,行DCE-FS,采用快速扰相梯度回波及频谱选择性脂肪抑制序列。在共振和去共振时,计算T1值为25～1200ms的信号强度... 详细信息

目的研究磁场的不均匀性对乳腺脂肪抑制动态增强扫描(DCE-FS)的影响。材料与方法对10例病人的乳腺进行检查。使用1.5TmR设备,行DCE-FS,采用快速扰相梯度回波及频谱选择性脂肪抑制序列。在共振和去共振时,计算T1值为25～1200ms的信号强度,结果经测试实验证实。评价场不均匀性对临床检查的预期影响。结果位于中心横断面的乳腺磁场变化为(3.6±1.2)ppm,乳腺整体的磁场变化为(5.1±1.5)ppm。当由于磁场不均匀引起意外的水抑制时,或由于脂肪抑制失败导致对比剂(CA)摄取曲线变形时(因为像素内包含脂肪),计算机模块即会预测到动态变化范围的缩小。需要同时兼顾动态变化范围和脂肪饱和效果两方面的需求。全部临床检查中均存在脂肪抑制失败并产生了意外的水抑制。结论磁场不均匀可能通过两种机制降低DCE-FS的敏感性。其一,磁场不均匀可使脂肪抑制失败(由于像素包含脂肪)导致CA摄取曲线变形。其二,引起意外的水抑制,导致动态变化范围缩小。要点①磁场不均匀对乳腺mR检查有显著影响。②磁场不均匀会导致对比剂摄取曲线变形。③放射学专家必须清楚变形的可能,正确解释对比剂摄取曲线。④需同时兼顾对脂肪抑制效果和动态变化范围两方面的需求。

关键词： mRI 乳腺诊断技术及程序肿瘤钆复合物

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CEPC Technical Design Report

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Radiation Detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp m.rcello borri Angelo Bosotti Vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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