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Non-Protein-Coding RNAs and their Interacting RNA-Binding Proteins in the Plant Cell Nucleus

molecular Plant 2010年第4期3卷 729-739页

作者： Celine Charon Ana Beatriz moreno Florian bardou martin Crespi University Paris-Sud Institut de Biologie des Plantes UMR8618 Orsay Cedex F-91405 France CNRS Orsay Cedex F-91405 France Institut des Sciences du Vegetal CNRS F-91198 Gif-sur-Yvette Cedex France

The complex responses of eukaryotic cells to external factors are governed by several transcriptional and post-transcriptional processes. Several of them occur in the nucleus and have been linked to the action of non-proteincoding RNAs （or npcRNAs）, both long and small npcRNAs, that recently emerged as major regulators of gene expression. Regulatory npcRNAs acting in the nucleus include silencing-related RNAs, intergenic npcRNAs, natural antisense RNAs, and other aberrant RNAs resulting from the interplay between global transcription and RNA processing activities （such as Dicers and RNA-dependent polymerases）. Generally, the resulting npcRNAs exert their regulatory effects through interactions with RNA-binding proteins （or RBPs） within ribonucleoprotein particles （or RNPs）. A large group of RBPs are implicated in the silencing machinery through small interfering RNAs （siRNAs） and their localization suggests that several act in the nucleus to trigger epigenetic and chromatin changes at a whole-genome scale. Other nuclear RBPs interact with npcRNAs and change their localization. In the fission yeast, the RNA-binding mei2p protein, playing pivotal roles in meiosis, interact with a meiotic npcRNA involved in its nuclear re-localization. Related processes have been identified in plants and the ENOD40 npcRNA was shown to re-localize a nuclear-speckle RBP from the nucleus to the cytoplasm in medicago truncatula. Plant RBPs have been also implicated in RNA-mediated chromatin silencing in the FLC locus through interaction with specific antisense transcripts. In this review, we discuss the interactions between RBPs and npcRNAs in the context of nuclear-related processes and their implication in plant development and stress responses. We propose that these interactions may add a regulatory layer that modulates the interactions between the nuclear genome and the environment and, consequently, control plant developmental plasticity.

关键词： Abiotic/environmental stress gene silencing Arabidopsis RNA-binding proteins non-protein-coding RNAs nucleus.

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Effect of alcohol consumption on liver stiffness measured by transient elastography

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World Journal of Gastroenterology 2013年第4期19卷 516-522页

作者： Edouard bardou-Jacquet Ludivine Legros Draman Soro marianne Latournerie Anne Guillygom.rc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain moirand Hepatology and Addictology Department University Hospital PontchaillouF35000 RennesFrance Institut National de la Santé et de la Recherche médicale U991 Institut Fédératif de Recherche 140University of Rennes 1F35000 RennesFrance

AIm:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or ***:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver *** was performed at least one week apart by senior *** examinations with less than ten successful measures or with an interquartile range above 30% were *** retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was *** biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were *** fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis *** and final putative fibrosis score were compared according to alcohol consumption during ***:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two ***-seven patients met our criteria with a median follow-up of 32.5 *** the end of the study,13(35%) were abstinent,and 24(65%) *** patients had liver biopsy during *** decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off *** relapsers TE increased in 45% and decreased in 54% of *** was no statistical difference between initial and final TE in *** the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final ***

关键词： Alcohol Transient elastography Cirrhosis Fibrosis Liver biopsy Liver stiffness

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Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

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World Journal of Gastroenterology 2016年第20期22卷 4926-4935页

作者： Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff m.rcet Sophie michalak Antonia Le Gruyer Ludivine Legros Edouard bardou-Jacquet Yves Gandon Romain moirand Department of Abdominal Imaging Rennes University Hospital Clinical Inverstigation Center CIC INSERM 1414 Rennes University Hospital Department of Hepatology Rennes University Hospital Department of Pathology Rennes University Hospital Rennes Department of Pathology Angers University Hospital Department of Addictology Rennes University Hospital Department of Research INSERm UmR 991 Rennes 1 Medicine University

AIm: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to ***: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the mETAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each ***: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/***: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

关键词： Alcoholic liver disease Elastography Noninvasive Acoustic radiation force impulse Fibrosis

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Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation

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World Journal of Gastroenterology 2020年第16期26卷 1938-1949页

作者： Elodie Fallet michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard bardou-Jacquet Service des maladies du Foie CHU RennesUniversity RennesRennes 35033France Service de Chirurgie Hepatobilaire CHU RennesUniversity RennesRennes 35033France Service de Réanimation médicale CHU RennesUniversity RennesRennes 35033France Laboratoire de biochimie CHU RennesUniversity RennesRennes 35033France

BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant *** identifying factors associated with mortality could help improve patient *** impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this *** studies suggest that increased serum ferritin is associated with higher *** iron deficiency which is a well described risk factor in critically ill patients has not been *** To assess the impact of pre-transplant iron metabolism parameters on posttransplant *** From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were *** were prospectively recorded at the time of evaluation and at the time of LT regarding donor and *** ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical *** regression analysis was used to determine mortality risks ***-up data were obtained from the local and national database regarding causes of *** At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of *** multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SFrcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan meier curves show that patients with low SF(400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron m

关键词： Iron deficiency Overload Cirrhosis Infection Death Ferritin Transferrin saturation

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Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 1-12页

作者： Jean marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard bardou-Jacquet Christophe Camus mohamed Lakehal Veronique Desfourneaux Aude merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard meunier michel Rayar CHU Rennes Service de Chirurgie Hépatobiliaire et DigestiveRennesFrance UniversitéRennes 1 Facultéde MédecineRennesFrance CHU Rennes Service des Maladies du FoieRennesFrance INSERm CIC 1414RennesFrance CHU Rennes Service de Maladies Infectieuses et Réanimation MédicaleRennesFrance

Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not ***:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to ***:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were *** groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as *** median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,Pmplications(P=0.26)was not statistically *** of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA *** difference was observed regarding graft(P=0.18)and patient(P=0.16)***:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta.

关键词： Liver transplantation(LT) hepatic artery(HA) arterial anastomosis splenic artery(SA)

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Pharmacological manipulation of cannabinoid neurotransmission reduces neuroinflammation associated with normal aging

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Health 2012年第9期4卷 679-684页

作者： Isabelle bardou Nicholas DiPatrizio Holly m. Brothers Roxanne m. Kaercher Kevin Baranger mollie mitchem Sarah C. Hopp Gary L. Wenk Yannick m.rchalant Department of Pharmacology University of California Irvine USA Department of Psychology Ohio State University Columbus USA NICN Aix-Marseille University Marseille France NICN CNRS UMR 7259 Marseille France

We have previously demonstrated that antagonism of glutamate NmDA receptors or activation of endocannabinoid receptors could reduce experimentally induced neuroinflammation within the hippocampus of young rats. In the current study, we investigated whether pharmacological manipulation of glutamate or endocannabinoid neurotransmission could reduce naturally-occurring neuroinflammation within the hippocampus of aged rats. We investigated whether UCm707, an inhibitor of endocannabinoid re-uptake, WIN- 55,212-2, an endocannabinoid receptor agonist, and URB597, an inhibitor of endocannabinoid catabolism, or memantine, a non-competitive, low-affinity, inhibitor of the open NmDA receptor channel, could reduce the number of mHC II-IR microglia within the hippocampus. All of the drugs, except URB597, reduced the number of reactive microglia, as compared to vehicle treated rats. The current results suggest potential pharmacological approaches that may mitigate the pathological consequences of chronic brain inflammation associated with numerous neurodegenerative diseases.

关键词： Rats memantine UCm707 microglia WIN-55 212-2 URB597

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3.0T mR无创性检测肝脏铁含量:活检验证

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国际医学放射学杂志 2018年第4期 489-490页

作者： G.d'Assignies A.Paisant E.bardou-Jacquet A.Boulic E.Bannier F.Lainé 陈圣妮 Department of Radiology Rennes University Hospital

目的采用3 T mRI评估R2*值和信号强度比（SIR）方法定量检测肝脏铁含量（LIC）的效能及局限性。方法这项前瞻性研究共纳入105例病人,行肝脏活检测量组织生化铁含量（LICb）。所有病人均进行3 T mRI屏气多回波梯度回波（mGRE）序列扫描... 详细信息

目的采用3 T mRI评估R2*值和信号强度比（SIR）方法定量检测肝脏铁含量（LIC）的效能及局限性。方法这项前瞻性研究共纳入105例病人,行肝脏活检测量组织生化铁含量（LICb）。所有病人均进行3 T mRI屏气多回波梯度回波（mGRE）序列扫描。通过3 T SIR算法(LICSIR)和R2*（LICR2*）计算出LIC,并与LICb行相关分析。将数据等分为连续多组对2种方法的比较。结果LICb与R2*（r=0.95,Pmol/g和（14.8±37.6）μmol/g。LICbmol/g时,LICR2*差异性最低,LICb>130μmol/g时,LICSIR差异性最低。结论 3 T mRI R2*在铁过载水平较低时可精确定量LIC,但铁过载水平较高时建议使用SIR方法克服R2*的局限性。该软件发布在***网站,可综合应用2种方法 ,并择优使用。

关键词： mRI 铁含量 mR LIC

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霍尼韦尔为城市空中交通提供混合动力推进系统解决方案

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航空动力 2019年第5期 10-10页

作者：羅迪霍尼韦尔中国

尽管电动推进是未来的方向,但在电池技术、基础设施、适航规章及其他障碍被克服之前,混合动力推进是一种较为可行的解决方案。按照美国国家航空航天局(NASA)的定义,混合动力推进是一种用飞机燃油和电力共同驱动推进系统的方式,目的是减... 详细信息

尽管电动推进是未来的方向,但在电池技术、基础设施、适航规章及其他障碍被克服之前,混合动力推进是一种较为可行的解决方案。按照美国国家航空航天局(NASA)的定义,混合动力推进是一种用飞机燃油和电力共同驱动推进系统的方式,目的是减少燃油消耗、降低运营成本,减少CO2和NOx的排放。

关键词：混合动力空中交通霍尼韦尔系统解决方案

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Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

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World Journal of Hepatology 2020年第12期12卷 1326-1340页

作者： Anais Brayette marie Essig Paul Carrier marilyne Debette-Gratien Anais Labrunie Sophie Alain marianne maynard Nathalie Ganne-Carrie Eric Nguyen-Khac Pauline Pinet Victor De Ledinghen Christophe Renou Philippe mathurin Claire Vanlemmens Vincent Di martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard m.rc bardou Armand Abergel manh-Thong Dao Thierry Thevenot Jean-Baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti U1248 INSERm Department of Hepatology and GastroenterologyUniv.LimogesCHU LimogesLimoges F-87000France U1248 INSERm Department of Nephrology and TransplantationCHU LimogesLimoges F-87000France Department of Center of Epidemiology Biostatistics and Research MethodologyCHU LimogesLimoges F-87000France U1092 INSERm Department of VirologyCHU LimogesLimoges F-87000France Department of Hepatology Croix-Rousse University Hospital of LyonLyon 69004France Department of Hepatology Jean Verdier University Hospital of BondyBondy 93140France Department of Hepato-Gastroenterology Amiens University HospitalAmiens 80054France Department of Infectious Diseases CHU LimogesLimoges F-87000France Department of Hepatology Haut Leveque HospitalBordeaux University HospitalPessac 33604France Department of Gastroenterology Hyeres HospitalHyeres 83407France Department of Hepato-Gastroenterology Claude Huriez University HospitalLille 59037France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Infectious Diseases Bichat University HospitalParis 75018France Department of Hepatology University Hospital of AngersAngers 49933France Department of Hepato-Gastroenterology and Nutrition University Hospital of CaenCaen 14033France Department of General medecine University Hospital of CaenCaen 14000France Department of Hepatology La Pitié-Salpêtrière University HospitalParis 75651France Department of Hepatology and Gastroenterology Dijon University HospitalDijon 21079France Department of Hepatology and Gastroenterology Estaing University HospitalClermont Ferrand 63003France Department of Hepatology Beaujon University HospitalClichy 92110France Department of Hepatology Saint-AndréUniversity HospitalBordeaux 33000France Department of Hepatology and Gastroenterology La Roche-Sur-Yon Hospital CenterLa Roche-Sur-Yon 85000France Department of Hepatology and Gastroenterology University Hospital of MontpellierMontpellier 34295France Department of Addictology Hospita

BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal *** early markers are available,but no consensus exists on their *** To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected *** A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was *** patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)*** on the early markers of SPT,the eGFR and phosphatemia,were collected *** was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(m24)were *** data were analyzed using analyses of variance or Kruskal-Wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative *** analyses were used to adjust for any potential confounding *** Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at *** m24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,PmL/min/1.73 m²or phosphatemia less than 0.48 mmoL/*** the multivariate analysis,no explanatory variables were identified after *** cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at m24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TD

关键词： Hepatitis B virus Proximal tubulopathy Biomarkers Renal insufficiency Nucleoside analogues

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