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3.0Tmr的外周血管CE-mrA提高空间分辨率和降低对比剂剂量的初步临床经验

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国际医学放射学杂志 2009年第1期32卷 101-101页

作者： K. Nael m. Krishnam A. Nael A. Ton S.G. ruehm J.P. Finn 王高峰 department of radiological Sciences David Geffen School of Medicine at University of California Los Angeles 10945 Le Conte Avenue Suite # 3371 Los Angeles CA 90095-7206 USA

为了研究高空间分辨率的外周血管对比增强磁共振血管成像（CE-mrA）的序列，在3．0Tmr中应用一个专用的多通道阵列线圈和加速并行采集来评价患外周血管疾病的病人。对20例患外周血管疾病的病人进行了3．0Tmr多站式高空间分辨率外周血管C... 详细信息

为了研究高空间分辨率的外周血管对比增强磁共振血管成像（CE-mrA）的序列，在3．0Tmr中应用一个专用的多通道阵列线圈和加速并行采集来评价患外周血管疾病的病人。对20例患外周血管疾病的病人进行了3．0Tmr多站式高空间分辨率外周血管CE-mrA检查。2名放射科医师独立地对影像质量，有无静脉污染、影像噪声和伪影进行了评估。

关键词：外周血管mrI 3.0T或高场强多线圈技术低剂量对比剂动脉粥样硬化

急性脊髓损伤患者治疗的临床操作指南:关于mrI基线在临床治疗决策与结果预测中作用的几点建议（英文）

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中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Fehlings mG martin Ar Tetreault LA Aarabi B Anderson P Arnold Pm Brodke D Burns AS Chiba K dettori Jr Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-ryan S Kotter m Kurpad S Kwon BK marino rJ massicotte E merli G middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson Jr Yee A Harrop JS Toronto Western Hospital University Health Network University of Toronto University College Cork University of maryland University of Wisconsin University of Kansas medical Center The University of Kansas University of Utah Toronto rehabilitation Institute University Health Network National defense medical College Spectrum research Inc University of California at los Angeles Christopher & Dana reeve Foundation Ontario Neurotrauma Foundation University of Cambridge medical College of Wisconsin University of British Columbia Thomas Jefferson University Hospital University of Sydney Nagoya University Keio University The University of Kansas Ottawa Hospital research Institute Thomas Jefferson University Li Ka Shing Knowledge Institute St. Michael's Hospital Sunnybrook Health Sciences Centre

The objective of this guideline is to outline the role of magnetic resonance imaging(mrI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).methods A systematic review of the literature was conducted to address key questions related to the use of mrI in patients with traumatic *** review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of mrI for SCI *** on GrAde(Grading of recommendation,Assessment,development and Evaluation),a strong recommendation is worded as " we recommend," whereas a weaker recommendation is indicated by "we suggest." results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) "We suggest that mrI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making"(quality of evidence,very low) and(2) "We suggest that mrI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome "(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI.

关键词：神经外科疾病医学研究患者

αKLOTHO and sTGFβr2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma martinez-redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion rodriguez Esteban Kensaku Shojima Ling Huang maxim Shokhirev Estrella Nunez-delicado Josep mCampistol Isabel Guillen-Vicente Elena rodriguez-Inigo Juan manuel Lopez-Alcorocho m.r.a Guillen-Vicente George Church Pradeep reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de murcia(UCAm) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain department of Traumatology and research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and regeneration Chinese Academy of SciencesBeijing 100101China Translational medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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皮质下小血管病诊断的共识声明

国际脑血管病杂志 2016年第6期24卷 481-496页

作者： Gary A rosenberg Anders Wallin Joanna m Wardlaw Hugh S markus Joan montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel martin Dichgans marco Duering reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师张劼陈涵丰俞娅美徐子奇罗本燕 department of Neurology University of New Mexico Albuquerque New Mexico USA Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK department of Clinical Neurosciences University of Cambridge Cambridge UK Neurovascular research Laboratory Vail d'Hebron Research Institute Universitat Auto'noma de Barcelona Barcelona Spain department of Neurology University of Connecticut Health Center Farmington Connecticut USA Feil Family Brain and mind research Institute Weill Cornell Medical College New York New York USA department of Physiology and Biophysics Zilkha Neurogenetic Institute Keck School of Medicine University of Southern Califomia Los Angeles California USA INSErm U1161 Paris France Institute for Stroke and dementia research Klinikum der Universitat Mtinchen Munich Germany department of Neurology Medical University of Graz Graz Austria Tel-Aviv University medical School Ramat Aviv Israel department of Neurology Memory and Aging Center and Department of Pathology University of Califomia San Francisco California USA University of Sao Paulo medical School Sao Paulo Brazil department of Neurology University of Southern California Medical School Los Angeles California USA department of Clinical Neurological Sciences University Hospital University of Western Ontario London Ontario Canada 浙江大学医学院附属第一医院杭州310003

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性... 详细信息

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组，存在缺氧缺血、腔隙性梗死和炎症，它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物，这将有助于诊断以及将来协作性治疗试验的患者选择。

关键词：宾斯旺格病血脑屏障通透性脑脊液炎症白质疏松