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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-ram.r.z mónica G mendoza-rodríguez Om.r.r Alemán Fernando A Candanedo-González m.r.am.r.dríguez-Sosa Juan Josémontesinos-montesinos mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CrC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(Dr)that has been inversely associated with poor prognosis;less Dr is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tum.r.*** are directly involved in tum.r.genesis through different ***,their role in immunosuppression in CrC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CrC remains *** the m.r.ad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tum.r.growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

A novel diurnal and seasonal variation analysis of BTEX in Bengaluru urban area

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research in Cold and Arid regions 2024年第1期16卷 14-19页

作者： H.n.Sowmya m.Dinamani G.P.Shivashankara H.K.ram.r.ju B.S.Surendra Vijaya V.Shanbhag r.Prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemistry Dayananda Sagar College of EngineeringBangalore 560078India Department of Physics GFGCVijayanagarBengaluru 560040India

In the urban atmosphere of Bengaluru, various volatile organic compounds(VOCs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have shown an increasing trend in concentration. The present research was conducted during summ.r.and monsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru metropolitan City. Hourly sample data was collected using a BTEX analyzer(model GC955-600) and subsequently transformed into daily, monthly, and seasonal values. The study revealed distinct patterns in benzene concentrations. Benzene levels were lowest during the early m.r.ing hours, specifically from 1:00 *** 7:00 a.m.. Concentrations then increased from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corresponding to the m.r.ing and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic levels. These diurnal variations in benzene concentration are influenced by meteorological parameters. Comparing the two seasons, higher concentrations of Benzene, EthylBenzene, and mP-xylene were observed during the summ.r.season. This increase is attributed to the elevated temperatures during summ.r. which promote the vaporization of BTEX compounds. Conversely, lower BTEX concentrations were recorded during the monsoon season due to the wet deposition process. The observed positive correlation(r > 0.5) among BTEX parameters strongly suggests a common source, most likely originating from vehicular emissions.

关键词： BTEX Summ.r.variation meteorological parameters Correlation

DFT investigation of half-metallic ferromagnetic rare earth based spinels mgHo_(2)Z_(4)(Z=S,Se)

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Journal of rare Earths 2024年第1期42卷 121-128,I0005页

作者： maiza Zanib mumtaz manzoor n.A.noor m.Waqas Iqbal mazia Asghar H.H.Hegazy A.Laref Department of Physics Riphah International UniversityLahore CampusPakistan research Centre for Advanced materials Science King Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Department of Physics and Astronomy College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Half-metallic ferromagnetism,mechanical as well as thermoelectric properties for rare earth-based spinels mgHo_(2)Z_(4)(Z=S,Se)were investigated using density functional theory(DFT).Structural optimization was done with Perdew-Burke-Ehrenzorf(PBE)sol-generalized gradient approximation(GGA)to calculate the lattice constant of both spinels comparable to experimental *** addition,Born stability criteria and negative formation energy show that our studied spinels are also structurally and dynamically stable in the cubic *** ferromagnetic(Fm)state stability,we also calculated the energy differences among Fm,antiferromagnetic(AFm),and non-magnetic(nm)***,Curie temperatures of ferromagnetic phases were also *** used Trans-Blaha im.r.ved BeckeJohnson(TB-mBJ)potential functional for electronics as well as magnetic characteristics,which lead to the consistent explanation of half-metallic ferromagnetism.r.presenting the whole band-occupancy in material with exact detail of density of states(DOS).The stable Fm state was examined in spinels due to the exchange splitting of Ho cation consisting of p-d hybridizations compatible with the result achieved for electronics band structure and ***,spin magnetic moment was explained in terms of anion,cation,and sharing charge on studied *** addition,the calculated thermoelectric properties clearly show that operation range of these systems may be utilized by future experimental works for identifying the potential applications of these systems.

关键词： Ho-based spinels DFT simulations mechanical parameters Electronic properties Hm ferromagnetism Figure of m.r.t

Beyond dentistry:could prevention and screening for neurodegenerative diseases start in the dental office?

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neural regeneration research 2024年第1期19卷 156-157页

作者： Francesca r.Buccellato Daniela Galimberti Gianluca m.Tartaglia Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItalyFondazione IRCCS Ca’GrandaOspedale Maggiore PoliclinicoMilanItaly

The differential diagnosis of neurodegenerative diseases is complex and relies on clinical assessment,biom.r.er levels in cerebrospinal fluid,neuroimaging and neuropsychological *** efforts of the scientific community are focused on two aspects:a)the discovery of minimally invasive biom.r.ers;b)the discovery of early biom.r.ers that can predict the progression to clinical disease in the presymptomatic stage of a *** the impact of the number of patients affected by chronic neurodegenerative diseases on public health expenditures,early diagnosis seems to be a prim.r. need of our society.

关键词： diagnosis diseases prevention

Sodium nitroprusside as a signal molecule for up-regulating mem.r.ne characteristics, antioxidant defense system to im.r.ve flax productivity under water stress

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Oil Crop Science 2024年第3期9卷 160-169页

作者： Al-Ashkar n.m. Bakry B.A. El-Bassiouny H.m.S. Abdallah m.m.S. Sadak m.S. Botany Department Agricultural and Biological Research Institute National Research Centre 33 El Bohouth Street P.O. 12622 Dokki Giza Egypt Field Crops research Department Agricultural and Biological Research Institute National Research Centre 33 El Bohouth Street P.O. 12622 Dokki Giza Egypt

Water stress is a critical environmental adversity that significantly impacts the growth, development, and yield of flax plants. In this study, flax seeds were cultivated under different water irrigation requirements (WIr) (100%, 75%, and 50%) to investigate the effects of exogenously supplied nitric oxide (nO) donor sodium nitroprusside (SnP) as foliar treatments at concentrations of 0.0 mmol/L, 0.5 mmol/L, 1.0 mmol/L, and 2.0 mmol/L. Drought stress led to a significant decrease in plant growth, photosynthetic pigments, yield components such as oil and total carbohydrate percentage. It also resulted in an increase in leaf H2O2 production, lipid peroxidation levels and activities of enzymatic antioxidants including polyphenol oxidase, superoxide dismutase, and nitrate reductase enzymes. However, foliar application of SnP im.r.ved photosynthetic pigments and antioxidant defense system which mitigated the negative impact of water stress on growth and yield productivity by reducing oxidative damage caused by reactive oxygen species accumulation. The use of SnP also decreased H2O2 accumulation levels, lipid peroxidation levels, and im.r.ved mem.r.ne stability. SnP treatment at concentration of 2 mmol/L showed superior results compared to other concentrations with extremely significant increases observed in yield characteristics such as oil content, total carbohydrate percentages, and unsaturated fatty acids to saturated fatty acids ratio. © 2024 the Oil Crop research Institute, Chinese Academy of Agriculture Sciences

关键词： Antioxidant enzymes Fatty acid Flax Sodium nitroprusside Yield

Extended Deep Learning Algorithm for Im.r.ved Brain Tum.r.Diagnosis System

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Intelligent Automation & Soft Computing 2024年第1期39卷 33-55页

作者： m.Adimoolam K.maithili n.m.Balam.r.gan r.rajkum.r.S.Leelavathy raju Kannadasan mohd Anul Haq Ilyas Khan ElSayed m.Tag El Din Arfat Ahmad Khan Department of Computer Engineering Government Polytechnic CollegeSevvapetTiruvallurTamil Nadu602025India Department of Computer Science and Engineering KG Reddy College of Engineering and TechnologyHyderabadTelangana500075India Department of Computer Science and Engineering Sri Venkateswara College of EngineeringSriperumbudurChennai602117India Department of Computer Science and Engineering Annamalai UniversityChidambaramTamil Nadu608002India Department of Computer Science and Engineering Aarupadai Veedu Institute of TechnologyVinayaka Mission Research FoundationPaiyanurTamil Nadu603104India Department of Electrical and Electronics Engineering Sri Venkateswara College of EngineeringSriperumbudur602117India Department of Computer Science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia Electrical Engineering Department Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer Science College of ComputingKhon Kaen UniversityKhon Kaen40002Thailand

At present,the prediction of brain tum.r. is performed using machine Learning(mL)and Deep Learning(DL)*** various mL and DL algorithms are adapted to predict brain tum.r. to some range,some concerns still need enhancement,particularly accuracy,sensitivity,false positive and false negative,to im.r.ve the brain tum.r.prediction system ***,this work proposed an Extended Deep Learning Algorithm(EDLA)to measure performance parameters such as accuracy,sensitivity,and false positive and false negative *** addition,these iterated measures were analyzed by comparing the EDLA method with the Convolutional neural network(Cnn)way further using the SPSS tool,and respective graphical illustrations were *** results were that the mean performance measures for the proposed EDLA algorithm were calculated,and those measured were accuracy(97.665%),sensitivity(97.939%),false positive(3.012%),and false negative(3.182%)for ten *** in the case of the Cnn,the algorithm means accuracy gained was 94.287%,mean sensitivity 95.612%,mean false positive 5.328%,and mean false negative 4.756%.These results show that the proposed EDLA method has outperformed existing algorithms,including Cnn,and ensures symmetrically im.r.ved *** EDLA algorithm introduces novelty concerning its performance and particular activation *** proposed method will be utilized effectively in brain tum.r.detection in a precise and accurate *** algorithm would apply to brain tum.r.diagnosis and be involved in various medical diagnoses *** the quantity of dataset records is enormous,then themethod’s computation power has to be updated.

关键词： Brain tumor extended deep learning algorithm convolution neural network tum.r.detection deep learning

Prompt neutron emission in ^(250)no spontaneous fission associated with ground and isom.r.c state decays

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Chinese Physics C 2024年第6期48卷 112-117页

作者： r.S.mukhin A.V.Isaev A.V.Andreev m.L.Chelnokov V.I.Chepigin H.m.Devaraja I.n.Izosimov A.A.Kuznetsova O.n.malyshev A.G.Popeko Yu.A.Popov A.rahmatinejad B.Sailaubekov T.m.Shneidman E.A.Sokol A.I.Svirikhin m.S.Tezekbayeva m.A.Bychkov A.V.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-m.r.ens Joint Institute for nuclear research Dubna141980Russia Dubna State University Dubna141982Russia Institute of nuclear Physics Almaty050032Kazakhstan L.n.Gumilyov Eurasian national University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasbourg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)Pb(^(48)Ca,2n)^(250)no was used to study two activities of^(250)no with distinct half-lives.A total of 1357 events were observed in the SFinx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)no was determined to be(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isom.r.state decays.

关键词： spontaneous fission prompt neutrons actinide

Freeze-thaw cycles and associated geom.r.hology in a post-glacial environment:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,mexico

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Journal of mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor SOTO Carlos m.WELSH r. Kenji YOSHIKAWA Hugo DELGADO GrAnADOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environmental research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Department of Earth and Environmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m *** retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geom.r.hological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geom.r.hological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction *** geom.r.hological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.

关键词： Freeze-Thaw Gelifraction mountain mechanical erosion Periglacial geom.r.hology Postglacial scenarios

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders:preclinical models and clinical studies

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neural regeneration research 2024年第4期19卷 788-799页

作者： r.Scott Duncan Sean m.r.ordan matthew C.Gernon Peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human *** have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human *** of these include central nervous system(CnS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric *** addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CnS function,and if controlled or modified,may represent an additional therapeutic avenue for CnS *** review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CnS *** addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CnS *** and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol