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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition mem.ry deficits in aging and Alzheim.r's disease rodents

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Neural regeneration research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato m.riam masmudi-m.rtín manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-rom.ro m.rta Carretero-rey Sinforiano Posadas m.ría e.quiros-ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en red de enfermedades Neurodegenerativas(CIBerNeD) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

mem.ry deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the rGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition mem.ry(Orm),can induce enhancement of *** this study,we demonstrated that the same treatment with rGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheim.r s disease,produced longlasting enhancement of Orm in young animals and prevent Orm deficits in rodent models of aging and Alzheim.r’s ***,we found that the prevention of mem.ry deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in rGS14414-treated aging rats and Alzheim.r s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of Orm *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of mem.ry deficits in rGS14414-treated rodent models of aging and Alzheim.r’s ***,our findings of rGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of mem.ry deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic mem.ry mem.ry circuit activation mem.ry deficits mem.ry enhancement object recognition mem.ry prevention of mem.ry loss regulator of G protein signaling

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Kaoline-based catalyst for a high stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan m.Hmood Saba A.Gheni Safaa m.r.Ahmed mudheher m.Ali Hamid Yonis Saleh mohammed H.mohammed Awad e.mohammed m.rwan A.mahomood Hiba r.mohammed Ahmed A.Hassan Adam Harvey North refineries Company Ministry of OilIraq Chemical engineering Department Tikrit UniversityIraq ministry of Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of engineering Newcastle UniversityUK

To meet the rapidly increasing demand for energy and the dramatic depletion of conventional crude oil,it is imperative to utilize sour *** no coke being produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and average molecular *** this article,we outline a method for heavy naphtha non-extractive ODS using a very stable *** technique involves the use of a solid catalyst with oxygen gas as the *** necessitated relatively high mixing intensities;hence a three-phase Oscillatory Baffled reactor(OBr)was *** catalyst was based on the zeolite ZSm-5,prepared from natural kaolin by a series of delamination and activation steps and im.regnated with Fe.A TiO2 nanolayer was applied,using the sol-gel method,to prevent rapid *** reactor performance was evaluated to minimize the sulfur content in the naphtha *** to the protective coating,the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term *** also showed that modest ODS can be achieved using an environmentally friendly oxidant,at mild operating conditions,whilst maintaining stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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enhanced quantum.resources via two distant atom-cavity systems under the influence of atomic dissipation

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Communications in Theoretical Physics 2024年第2期76卷 62-73页

作者： m Setodeh Kheirabady m K Tavassoly m.rafeie e Ghasemian Laser and Optics Group Faculty of PhysicsYazd UniversityYazd 89195-741Iran Department of electrical engineering Faculty of Intelligent Systems Engineering and Data SciencePersian Gulf UniversityBushehrIran

Quantum.resources such as entanglement and coherence are the holy grail for modern quantum technologies. Although the unwanted environmental effects tackle quantum information processing tasks, suprisingly these key quantum.resources may be protected and even enhanced by the implementation of some special hybrid open quantum systems. Here, we aim to show how a dissipative atom-cavity-system can be accomplished to generate enhanced quantum *** do so, we consider a couple of dissipative cavities, where each one contains two effective two-level atoms interacting with a single-mode cavity field. In practical applications, a classical laser field may be applied to drive each atomic subsystem. After driving the system, a Bell-state measurement is performed on the output of the system to quantify the entanglement and coherence. The obtained results reveal that the remote entanglement and coherence between the atoms existing inside the two distant cavities are not only enhanced, but can be stabilized, even under the action of dissipation. In contrast, the local entanglement between two atoms inside each dissipative cavity attenuates due to the presence of unwanted environmental ***, the local coherence may show the same behavior as the remote ***, the system provides the steady state entanglement in various interaction regimes,particularly in the strong atom-cavity coupling and with relatively large detuning. m.re interestingly, our num.rical analyses demonstrate that the system may show a mem.ry effect due to the fact that the death and revival of the entanglement take place during the interaction. Our proposed model may find potential applications for the implementation of long distance quantum networks. In particular, it facilitates the distribution of quantum.resources between the nodes of large-scale quantum networks for secure communication.

关键词： remote entanglement and coherence atomic dissipation steady state entanglement Bell-statemeasurement

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Nanomotion of bacteria to determine metabolic profile

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Nanotechnology and Precision engineering 2024年第1期7卷 1-9页

作者： S.N.Pleskova e.V.Lazarenko N.A.Bezrukov r.N.Kriukov A.V.Boryakov m.e.Dokukin S.I.Surodin research Laboratory of Scanning Probe microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Department of Nanotechnology and Biotechnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Technology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to their visible motion such as swimming(e.g.,with the help ofﬂagella),bacteria can also exhibit nanomotion that is detectable only with highly sensitive instruments,and this study shows that it is possible to detect bacterial nanomotion using an AFm detection *** results show that the nanomotion characteristics depend on the bacterial strain,and that nanomotion can be used to sense the metabolic activity of bacteria because the oscillations are sensitive to the food preferences of the bacteria and the type of surrounding medium.

关键词： Nanomotion Bacteria Cantilever Oscillation Atomic force microscopy metabolism

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Converting Trex-rGB green-channel data to 557.7 nm auroral intensity:methodology and initial results

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earth and Planetary Physics 2024年第1期8卷 258-274页

作者： Jun Liang D.m.Gillies e.Spanswick e.F.Donovan University of Calgary CalgaryT2N 1N4Canada

The recently deployed Transition region explorer(Trex)-rGB(red-green-blue)all-sky imager(ASI)is designed to capture“true color”images of the aurora and *** the 557.7 nm green line is usually the brightest emission line in visible auroras,the green channel of a Trex-rGB cam.ra is usually dominated by the 557.7 nm *** this rationale,the Trex mission does not include a specific 557.7 nm imager and is designed to use the rGB green-channel data as a proxy for the 557.7 nm *** this study,we present an initial effort to establish the conversion ratio or formula linking the rGB green-channel data to the absolute intensity of 557.7 nm auroras,which is crucial for quantitative uses of the rGB *** illustrate two approaches:(1)through a comparison with the collocated measurement of green-line auroras from the Trex spectrograph,and(2)through a comparison with the modeled green-line intensity according to realistic electron precipitation flux measurements from low-earth-orbit satellites,with the aid of an auroral transport *** demonstrate the procedures and provide initial results for the Trex-rGB ASIs at the rabbit Lake and Lucky Lake *** rGB response is found to be *** conversion ratios or formulas between rGB green-channel data and the green-line auroral intensity are given and can be applied immediately by Trex-rGB data *** methodology established in this study will also be applicable to the upcoming SmILe ASI mission,which will adopt a similar rGB cam.ra system in its deployment.

关键词： Trex rGB green-line aurora auroral transport model

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enhancing the clinical relevance of haem.rrhage prediction models in trauma

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military medical research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared m.Wohlgemut max e.r.m.rsden erhan Pisirir evangelia Kyrimi rebecca S.Stoner William m.rsh Zane B.Perkins Nigel r.m.Tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The royal London Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of electronic engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

We read with interest the recent systematic reviewaArtificial intelligence and machine learning for hem.rrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(mL)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion massive transfusion Prediction Artificial intelligence machine learning

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The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： D A Baghdasaryan V A Harutynyan e m Kazaryan H A Sarkisyan russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

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Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： melissa A.Stephen Chris r.Burke Jennie e.Pryce Nicole m.Steele Peter r.Am.r Susanne meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL rae Centre for Genetics and Breeding-massey University RuakuraHamilton 3214New Zealand Agriculture Victoria research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGeP4),which generally coincides with onset of puberty,as an example *** We produced AGeP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(eBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler m.rkov-chain monte Carlo(mCmC) Puberty

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mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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Neural regeneration research 2024年第7期19卷 1401-1402页

作者： Jean-David m.Gothié Timothy e.Kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma mem.rane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological mem.ranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

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New insights into the role of the endoplasmic reticulum in microglia

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Neural regeneration research 2024年第7期19卷 1397-1398页

作者： Veronika e.Neubrand m.rosario Sepúlveda Department of Cell Biology Faculty of SciencesUniversity of GranadaGranadaSpain

microglial cells are the only resident immune cells in the central nervous system and constitute its frontline *** are extremely reactive against infections,trauma,or toxins,but are also responsible for mediating inflammation,taking part in the pathogenic course of many neuropathologies(Sierra et al.,2019).Cell-specific staining,ultrastructural analysis by transmission electron microscopy(Tem),or two-photonmicroscopy imaging have been relevant for the characterization of microglia as well as their cell-cell interactions。

关键词： inflammation reticulum

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