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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 51-51页

作者： Nogales Asensio J.m. m.reno Snchez N. Doncel Vecino L.J. 马超 Department of Cardiology Hospital Universitario Infanta Cristina Badajoz Ctra. de Portugal s/n 06080Badajoz Spain

对于无结构病变的心脏病患者,氟卡尼被认为是一种安全的抗心律失常药物,且常被用于预防房颤。然而,对于有梗死病史和(或)重度传导障碍的患者,其致心律失常的作用则可能致死。扭转型室性心动过速不在其所

关键词：心动过速心搏过速扭转型室性心律失常氟卡尼氟卡胺抗心律失常药患者

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治疗前γ干扰素IP-10水平与聚乙二醇干扰素联合利巴韦林治疗慢性HCV-1型感染的持续病毒学应答之间的关系

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 39-39页

作者： Diago m. Castellano G. Garca-Samaniego J. C. Garca-monzó n 王顺涛 Liver research Unit University Hospital Santa Cristina Maestro Vives 2 28009- Madrid SpainDr.

Background: Increased serum and intrahepatic interferon γ inducible protein 10 (IP- 10) levels in patients with chronic hepatitis C (CHC) have been described. Aim: To analyse the possible association of serum IP- 10 levels with different outcomes to antiviral therapy. Patients: A total of 137 CHC patients treated with peginterferon plus ribavirin. methods: Serum IP- 10 levels were determined by enzyme linked immunosorbent assay before therapy, after 12 weeks of treatment, and 24 weeks after cessation of therapy. Variables significantly associated with a sustained virological response (SVr) on univariate analysis were included in a multivariate logistic regression model. results: Pretreatment serum IP- 10 levels in patients with SVr were significantly lower than in non-responders (Nr) (332.4 (222.1) v 476.8 (305.3) pg/ml, respectively; p=0.004). Serum IP- 10 concentrations significantly decreased in patients with SVr (pretreatment: 332.4 (222.1) pg/ml; post-treatment: 170.2 (140.1) pg/ml; pr (pretreatment: 476.8 (305.3) pg/ml; post treatment: 387.3 (268.1) pg/ml; p=0.06). By multivariate analysis, non-1 genotype (odds ratio (Or) 3.5 (95% confidence interval (CI) 1.1- 10.4); p=0.003) and low viral load at baseline (Or 0.34 (95% CI 0.14- 0.79); p=0.01) were independent predictors of SVr in all patients. When multivariate analysis was restricted to patients with genotype 1, only baseline viral load (Or 0.38 (95% CI 0.155- 0.96); p=0.04) and pretreatment serum IP- 10 levels (Or 0.99 (95% CI 0.996- 0.999); p=0.03) were identified as predictive factors of SVr. Conclusion: Pretreatment serum IP- 10 behaves as a predictive factor of SVr to peginterferon plus ribavirin therapy in genotype 1 infected patients.

关键词：持续病毒学应答聚乙二醇干扰素 IP-10 慢性丙型肝炎治疗前后利巴韦林 γ干扰素 logistic回归模型联合酶联免疫吸附检测

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad rizwan Ahmed Sebastiano Aiello muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde m.rcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan m.rco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti riccardo Brugnera riccardo Bruno Antonio Budano m.rio Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering m.rco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich m.rcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini m.rtin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 m.rco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov m.rco Giamm.rchi Agnese Giaz Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel m.rco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone m.ria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear research DubnaRussia INFN Sezione di milano and Dipartimento di Fisica dell Universitàdi milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN milano Bicocca and University of milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of roma Tre and INFN Sezione roma Tre RomaItaly Aix m.rseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN milano Bicocca and Politecnico of milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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