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Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard reynolds Anna m.Barron Chih Hung Lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

现代小麦品种的产量潜力与低竞争性株型的关系

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麦类文摘 1995年第4期 8-14页

作者： m.p.reynolds E.Dcereds K.D.Sayre R.A.Fischer 高家明孙建伟李世林 CImmYT

1 引言关于多种作物是否已达到其产量潜力,或产量是否随着对产量限制机理的深入了解而提高这一阐题,依然受到有关研究者的关注(Evans,1993)。要了解田间作物的生长,就必须参考其与所处微观、宏观环境的互作。微观环境是通过个体株间互... 详细信息

1 引言关于多种作物是否已达到其产量潜力,或产量是否随着对产量限制机理的深入了解而提高这一阐题,依然受到有关研究者的关注(Evans,1993)。要了解田间作物的生长,就必须参考其与所处微观、宏观环境的互作。微观环境是通过个体株间互作形成的,包括主要资源可用性的变化,例如,株冠结构影响光照的空间分布(Hawkins,1982),同样,

关键词：产量潜力光处理小麦品种品系竞争性基因型籽粒产量田间试验理想型收获指数

自1965以来发展中国家现代春小麦的多样性

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国外作物育种 2003年第2期22卷 22-22页

作者： m.Smale m.p.reynolds 邱敦莲

Oxidative Stress in Collegiate Cross Country Skiers in mid- and post-Seasons

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Journal of Biosciences and medicines 2024年第5期12卷 99-110页

作者： Scott p. Jerome Kriya L. Dunlap Ava m. parrish matthew L. Lowman Emily m. Shipman Lawrence K. Duffy Arleigh J. reynolds Department of Chemistry & Biochemistry University of Alaska Fairbanks Fairbanks AK USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK USA Department of Biology & Wildlife University of Alaska Fairbanks Fairbanks AK USA Department of Veterinary medicine University of Alaska Fairbanks Fairbanks AK USA

purpose: The oxidative stress (OS) hypothesis of overtraining syndrome argues that increased production of free radicals through exercise cause muscle fatigue and damage resulting in lower athletic performance. Several studies have investigated OS immediately before and after exercise bouts in a training macrocycle. Our study aimed to compare OS of endurance athletes between a competition macrocycle and the immediate post-season recovery macrocycle. In addition, we aimed to identify athletes who experienced an unexplainable drop in athletic performance during the competition season in order to compare their OS to those who experienced no drop in performance. methods: Fifteen members of the University of Alaska Fairbanks cross country ski team volunteered for this study. Blood samples were taken in early February (“mid-season”) and late April (“post-season”). participants completed questionnaires regarding physical activity and athletic performance at the time of the blood draws. plasma was analyzed for 4-hydroxynonenalp> p>(HNE), nitrotyrosine,p> p>nitric oxide (NOX), and superoxide dismutase (SOD). Significance was determined by Wilcoxon and mann-Whitney tests. Results: participants displayed significantly higher (p Conclusion: Signs of oxidative stress and mitigation during the post-season recovery macrocycle were higher in athletes who reported experiencing a drop in athletic performance during the competition season macrocycle.

关键词： Oxidative Stress 4-Hydroxynonenal Superoxide Dismutase Athletic performance Training macrocycle

EmDS 3.0:A modeling framework for coping with complexity in environmental assessment and planning

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Science China(Technological Sciences) 2006年第z1期49卷 63-75页

作者： Keith m.reynolds U.S.Dept.Agriculture Forest ServicePacific Northwest Research Station3200 SW Jefferson WayCorvallisOR 97331USA

The Ecosystem management Decision Support (EmDS) system is an application framework for knowledge-based decision support of ecological assessments at any geographic scale. The system integrates state-of-the-art geographic information system (GIS) as well as knowledge-based reasoning and decision modeling technologies to provide decision support for a substantial portion of the adaptive management process of ecosystem management. EmDS 3.0 is implemented as an Arcmap extension and integrates the logic engine of NetWeaver to perform landscape evaluations, and the decision modeling engine of Criterium Decisionplus for evaluating management priorities. Key features of the system's evaluation component include abilities to (1) reason about large, abstract, multi-faceted ecosystem management problems, (2) perform useful evaluations with incomplete information, (3) evaluate the influence of missing information, and (4) determine priorities for missing information. A key feature of the planning component is the ability to determine priorities for management activities, taking into account not only ecosystem condition, but also criteria that account for the feasibility and efficacy of potential management actions. Both components include powerful and intuitive diagnostic features that facilitate communicating the explanation of modeling results to a broad audience.

关键词： natural resources, modeling, assessment, analysis, planning, software, ecosystem management.

Chemical exposures and suspected impacton Gulf War Veterans

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military medical Research 2023年第5期10卷 577-586页

作者： Rami Elhaj Joseph m.reynolds Center for Cancer Biology Immunology and InfectionChicago Medical SchoolRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

Gulf War Illness(GWI) encompass a spectrum of maladies specific to troops deployed during the persian Gulf War(1990–1991). There are several hypothesized factors believed to contribute to GWI, including(but not limited to)exposures to chemical agents and a foreign environment(e.g., dust, pollens, insects, and microbes). moreover, the inherent stress associated with deployment and combat has been associated with GWI. While the etiology of GWI remains uncertain, several studies have provided strong evidence that chemical exposures, especially neurotoxicants,may be underlying factors for the development of GWI. This mini style perspective article will focus on some of the major evidence linking chemical exposures to GWI development and persistence decades after exposure.

关键词： Gulf War Illness(GWI) Sarin Neuroinfammation Organophosphate(Op)

Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics-population balance coupled compartment model

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particuology 2018年第1期16卷 1-12页

作者： p.J. Abrahamsson p. Kvist G. reynolds X. Yu I. Niklasson Bjorn m.J. Hounslow A. Rasmuson Department of Chemical and Biological Engineering Chalmers University of Technology SE-412 96 Gothenburg Sweden pharmaceutical Development AstraZeneca Macclesfield SK10 2NA UK European Bioenergy Research Institute (EBRI) School of Engineering and Applied Science Aston University Birmingham B4 7ET UK AstraZeneca pharmaceutical and Analytical R&D Molndal SE-431 83 Moldnal Sweden Department of Chemical and Biological Engineering University of Sheffield Sheffield SI 3JD UK

There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that com- partmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent pow- der mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.

关键词： High-shear wet granulation population-balance model Compartment model Computational fluid dynamics

Glutaminase inhibition in renal cell carcinoma therapy

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Cancer Drug Resistance 2019年第2期2卷 356-364页

作者： Aleksandra m.Raczka paul A.reynolds School of medicine University of St AndrewsSt Andrews KY169TFUK Biomedical Sciences Research Complex University of St AndrewsSt AndrewsUK.

Receptor tyrosine kinase inhibitors have been a standard first-line therapy for renal cell carcinoma(RCC)for over a *** they stabilize the disease,they are unable to remove all tumor cells,leading to ***,both intrinsic and acquired resistance to therapy are a significant health *** order to overcome resistance,several combination therapies have been recently approved by the *** approach takes advantage of altered metabolism in tumor cells,which switch to alternative metabolic pathways to sustain their rapid growth and ***-839 is a small molecule inhibitor of kidney type glutaminase(GLS).GLS is often upregulated in glutamine addicted cancers,enhancing glutamine metabolism for the production of energy and the biosynthesis of various cellular building ***-839 is currently in clinical trials for several tumors,including clear cell(cc)RCC,both as monotherapy and in combination with the approved therapeutic agents everolimus,cabozantinib and *** results of phase 1/2 clinical trials look promising,especially for CB-839 plus cabozantinib,and all combinations seem to be well ***,cancer cells can activate compensatory pathways to overcome glutaminolysis ***,genetic and metabolomic studies are crucial for the successful implementation of CB-839 alone or in combination in subgroups of ccRCC patients.

关键词： Glutamine addiction renal cell carcinoma combination therapy metabolism

mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation

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Journal of Animal Science and Biotechnology 2013年第4期4卷 287-293页

作者： Tammi L Neville Allison m meyer Arshi Reyaz pawel B Borowicz Dale A Redmer Lawrence p reynolds Joel S Caton Kimberly A Vonnahme Center for Nutrition and pregnancy Department of Animal Sciences North Dakota State University

Background： Objectives were to examine the effects of selenium （Se） supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes （n = 84） were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se （adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BVV]） and nutritional plane （60% IRES], 100% [CON], or 140% [EXC]）. At parturition, lambs were removed and 42 ewes （7/treatment） were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present （p 〈 0.05）, least squares means from the highest-order interaction are presented. Results： Final body weight of ewes was least （p 〈 0.002） in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy （parturition or d 20 of lactation）. In ewes necropsied at parturition, mammary glands were heavier （p = 0.02） in EXC compared to RES, with CON intermediate. Concentration of RNA （rag/g） was decreased （p= 0.01） in EXC compared to CON at parturition. There was a tendency （p= 0.07） for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater （p_〈 0.02） number of proliferating cells then all other treatments. mammary vascular area tended （p = 0.08） to be affected by a Se by nutrition interaction where ASe-CON had less （p= 0.007） vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased （p 〈- 0.05） in RES compared to CON and EXC-fed ewes. Conclusions： Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland develo

关键词： mammary gland Nutrition proliferation Selenium Vascularity