检索结果-南通市图书馆

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-contained Capsubot Propulsion mechanism

引用

International Journal of Automation and computing 2011年第3期8卷 348-356页

作者： m.Nazmul huda Samuel Oliver Wane Faculty of Computing Engineering and Technology Staffordshire University

In this paper, a self contained capsubot （capsule robot） propulsion mechanism is investigated. The proposed capsubot works on the principle of internal force-static friction. A modified linear DC motor is used to drive the capsubot. A novel acceleration profile is proposed for the moving part （linear cylinder） based on the principle. A significant feature of the proposed capsubot is that it is legless, wheelless, and trackless. The developed capsubot with a proposed propulsion mechanism demonstrates a very good average velocity. The propulsion mechanism has the potential to be used for the propulsion of a wireless-controlled self-propelling capsule endoscope. Simulation and experimental results demonstrate the performance of the self-contained capsubot with the proposed acceleration profile.

关键词： Capsubot internal force and static friction linear DC motor propulsion capsule endoscopy.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

引用

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Use of biopolymers in wastewater treatment:A brief review of current trends and prospects

引用

Chinese Journal of Chemical Engineering 2023年第12期64卷 292-320页

作者： Ahmed m.Elgarahy m.G.Eloffy Eric Guibal huda m.Alghamdi Khalid Z.Elwakeel Egyptian Propylene and Polypropylene Company(EPPC) Port-SaidEgypt Environmental Chemistry Division Environmental Science DepartmentFaculty of SciencePort Said UniversityPort SaidEgypt National Institute of Oceanography and Fisheries(NIOF) CairoEgypt Polymers Composites and Hybrids(PCH) C2MAIMT Mines AlesAlèsFrance University of Jeddah College of ScienceDepartment of ChemistryJeddahSaudi Arabia

Indeed,polymeric materials have thrived in worldwide sectors over the last five decades due to their versatility and durability,to the point that we can no longer envisage a product that does not contain ***,many synthetic polymers that have been produced are mostly sourced from petroleum and coal as raw materials,making them environmentally incompatible because they cannot be integrated with what is a natural recycling *** of the most important aspects of the transition to a circular bioeconomy(CBE)is the provision of more sustainable strategies for resource and waste *** the environmental consequences associated with petroleum-based polymers(PBPs),natural biopolymers,originating from biomass,can be conceived as a promising solution to gradually replace the PBPs,and address,and resolve the potential challenges and prevailing research gaps in the *** biopolymers have significant advantages over PBPs in terms of low-cost/zero-cost precursors,environmental friendliness,and *** present review dissects the sources,synthesis pathways,structures,characterization,and employment of biopolymers and their composites in water and wastew-ater treatment applications via different ***,the CBE model framework proposes potential approaches to applying CBE principles in the wastewater management sector,with a heavy emphasis on not only technology but also organizational and societal *** sum up,the reliance on biopolymers can be considered a crucial tool for assessing the global progress toward CBE,as well as future environmental management and planning.

关键词： Biopolymers Biomass Bioseparation Coagulation Photocatalysis Sustainability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kinematic Analysis and Rock mass Classifications for Rock Slope Failure at USAID Highways

引用

Structural Durability & Health monitoring 2019年第4期13卷 379-398页

作者： Ibnu Rusydy Nafisah Al-huda m.Fahmi Naufal Effendi Department of Geological Engineering Faculty of EngineeringUniversitas Syiah KualaBanda AcehIndonesia Department of Civil Engineering Faculty of EngineeringUniversitas Syiah KualaBanda AcehIndonesia Tsunami and Disaster mitigation Research Center(TDmRC) Universitas Syiah KualaBanda AcehIndonesia Department of mining Engineering Faculty of EngineeringUniversitas Syiah KualaBanda AcehIndonesia

Rock slope kinematic analysis and rock mass classifications has been conducted at the 17^(th) km to 26^(th) km of USAID(United States Agency for International Development)highway in *** research aimed to examine the type of rock slope failures and the quality of rock mass as *** scan-line method was performed in six slopes by using a geological compass to determine rock mass structure on the rock slope,and the condition of joints such as persistence,aperture,roughness,infilling material,weathering and groundwater *** kinematic analysis was performed employing a stereographic *** rock slope quality and stability were investigated based on RmR(rock mass rating)and SmR(slope mass rating)*** rock slope kinematic analysis revealed that planar failure was likely to occur in Slope 1,3,and 4,the wedge failure in Slope 1 and 6,and toppling failure in Slope 2,5,and *** RmR rating is ranging from 57 to 64 and can be categorized as Fair to Good *** SmR rating revealed that the failure probability of Slope 3 was 90%,while it was from 40%to 60%for *** the uniform RmR for all slopes,the SmR was significantly *** detailed quantitative consideration of orientation of joint sets and geometry of the slope contributed to such differences in outcomes.

关键词： Engineering geology kinematic analysis rock mass classifications rock slope stability Aceh Indonesia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Search for microglia-specific peptides:advances in the discovery toolbox

引用

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

引用

Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mechanical and thermodynamical stability of BiVO4 polymorphs using first-principles study

引用

Chinese Physics B 2017年第3期26卷 395-403页

作者： A K m Farid UI Islam md Nurul huda Liton H m Tariqul Islam md Al Helal md Kamruzzaman Department of Computer Science and Engineering Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Physics Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Chemistry Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Physics and materials Science and Center of Super-Diamond and Advanced Films (COSDAF) City University of Hong Kong Hong Kong SAR China

First principles calculations of structural, electronic, mechanical, and thermodynamic properties of different poly- morphs of BiVO4 are performed using Bender-type plane/wave ultrasoft pseudopotentials within the generalized gradient approximation （GGA） in the flame of density functional theory （DFT）. The calculated structural and electronic properties are consistent with the previous theoretical and experimental results. The electronic structures reveal that m-BiVO4, op- BiVO4, and st-BiVO4 have indirect band gaps, on the other hand, zt-BiVO4 has a direct band gap. From the DOS and mulliken＇s charge analysis, it is observed that only m-BiVO4 has 6s2 Bi lone pair. Bond population analysis indicates that st-BiVO4 shows a more ionic nature and a similar result is obtained from the elastic properties. From the elastic prop- erties, it is observed that st-BiVO4 is more mechanically stable than the others, st-BiVO4 is more ductile and useful for high electro-optical and electro-mechanical coupling devices. Our calculated thermodynamic properties confirm the similar characteristics found from electronic and elastic properties, m-BiVO4 is useful as photocatalysts, solid state electrolyte, and electrode and other polymorphs are applicable in electronic device fabrications.

关键词： BiVO4 crystal structure lone pair mechanical stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

引用

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：