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microRNAs: New players in endometriosis

World Journal of Obstetrics and Gynecology 2016年第1期5卷 28-38页

作者： Josep marí-Alexandre moisés Barceló-molina maría olcina-Guillem Javier García-Oms Aitana Braza-Bo?ls Juan Gilabert-Estellés Grupo de Hemostasia TrombosisAterosclerosisy Biología Vascular Instituto de Investigación Sanitaria La Fe área maternoinfantil Hospital General Universitario University of Valencia

Endometriosis is an estrogen-dependent inflammatory disorder that limits the quality of life of affected women. This pathology affects 10% of reproductive-age women, although the prevalence in those patients experiencing pain, infertility or both is as high as 35%-50%. Endo-metriosis is characterized by endometrial-like tissue outside the uterus, primarily on the pelvic peritoneum, ovaries and the pouch of Douglas. Despite extensive research endeavours, a unifying theory regarding the exact etiopathogenic mechanism of this high prevalent and incapacitating condition is still lacking, although it has been suggested that epigenetics could be involved. microRNAs （miRNAs）, one of the epigenetic players, are small non-coding RNAs that can act as post-trans-criptional regulators of gene expression, reducing the expression of their target mRNAs either inhibiting its translation or promoting its degradation. miRNA expression profles are specifc of tissue and cell type. Abnormal miRNA expression has been described in different pathological conditions, such as a myriad of oncological, cardiovascular and inflammatory diseases and gynecological pathologies. In endometriosis, miRNA expression patterns of eutopic endometrium from patients and control women and from different endometriotic lesions have been described. These small non-coding molecules have become attractive candidates as novel biomarkers for an early non-invasive diagnosis of the disease, which could suppose a valuable beneft to the patients in terms of improvement of prognosis and reduction of the ratio of recurrence. In this systematic review we will focus on the role of miRNAs in the patho-phisiology of endometriosis.

关键词： microRNAs Endometriosis Epigenetics Angiogenesis Biomarkers

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Colorectal Cancer Surgery in Extreme Elderly Population

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Journal of Cancer Therapy 2015年第1期6卷 12-20页

作者： Javier Gallego Plazas Elena Asensio Juan C. Navalon Inmaculada Lozano Jose m. Navarro Guillermo Ricote m.ntse olcina Almudena Cotes Henry m. Ore Alejandra magdaleno maria C. Ors maria J. Escudero miguel A. morcillo Servicio de Oncología médica Hospital General Universitario de Elche-Hospital Vega Baja Alicante Espana Servicio de Cirugía General Hospital Vega Baja Alicante Espana

Background: Colorectal cancer surgery in extreme elderly population (380 years) is a growing problem and a subject in question. Experiences and results in this scenario are limited. methods: medical records of patients?380 years old hospitalized in General Surgery Department in Vega Baja Hospital between January 1st 2008 and December 31st 2012 were retrospectively reviewed. Patients diagnosed with colorectal cancer (CRC) were selected. Data regarding comorbidities, treatment performed, complications and survival were collected. Results: 95 patients (74 colon, 21 rectum) were identified: median age 83.0 years (80 - 93), 64.2% males. 93.7% of patients were operated on: median hospital and post-operative stay of 11 and 9 days, respectively;curative intention surgery 82.1%. 4.2% of patients were treated with interventionist procedures, and 2.1% of patients in a conservative way. 17.9% and 4.2% of patients came up with early and late complications, respectively. Early and late mortality occurred in 9.5% and 3.2% of patients, respectively. By march 2014, with a median follow up of 43.8 months, median overall survival for colorectal cancer patients was 2.7 years (95%IC, 2.0 - 3.2). Univariaye Cox Regresion analysis revealed the presence of cardiomyopathy (p = 0.024), the presence of chornic kidney disease (p = 0.025), the presence of comorbidities (vs absence) (0.026), the number of comorbidities (0.034), type of admission (p = 0.001), treatment with surgery (p = 0.001) and the incidence of early (p = 0.004) or late complications (p = 0.023) associated to overall survival with statically significance. multivariate Cox Regression analysis showed number of comorbidities (HR = 1.104;95%CI: 0.851 - 1.431;p = 0.456), treatment with surgery (HR = 4.928;95%CI: 1.815 - 13.385;p = 0.002), programmed admission into hospital (HR = 2.316;95%CI: 1.298 - 4.133;p = 0.004), and the incidence of late complications (HR = 4.629;95%CI: 1.279 - 16.750;p = 0.020) independently associated with o

关键词： Colorectal Cancer Surgery Elderly

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