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Speed and surface steepness affect internal tibial loading during running

Journal of Sport and Health Science 2024年第1期13卷 118-124页

作者： Hannah Rice markus Kurz Patrick mai leon Robertz Kevin Bill Timothy R.Derrick Steffen Willwacher Department of Physical Performance Norwegian School of Sport SciencesOslo 0806Norway Sports Tech Research Centre Mid Sweden UniversityÖstersund SE-83125Sweden Department of mechanical and Process Engineering Offenburg University of Applied SciencesOffenburg 77652Germany Institute of Biomechanics and Orthopaedics German Sport University CologneCologne 50933Germany Department of Kinesiology Iowa State UniversityAmesIA 50011USA

Background:Internal tibial loading is influenced by modifiable factors with implications for the risk of stress *** encounter varied surface steepness(gradients)when running outdoors and may adapt their speed according to the *** study aimed to quantify tibial bending moments and stress at the anterior and posterior peripheries when running at different speeds on surfaces of different ***:Twenty recreational runners ran on a treadmill at 3 different speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gradients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).Force and marker data were collected synchronously *** moments were estimated at the distal third centroid of the tibia about the medial-lateral axis by ensuring static equilibrium at each 1%of *** was derived from bending moments at the anterior and posterior peripheries by modeling the tibia as a hollow ***-way repeated-measures analysis of variance were conducted using both functional and discrete statistical ***:There were significant main effects for running speed and gradient on peak bending moments and peak anterior and posterior *** running speeds resulted in greater tibial *** uphill at+10%and+15%resulted in greater tibial loading than level *** downhill at-10%and-15%resulted in reduced tibial loading compared to level *** was no difference between+5%or-5%and level ***:Running at faster speeds and uphill on gradients≥+10%increased internal tibial loading,whereas slower running and downhill running on gradients≥-10%reduced internal *** running speed according to the gradient could be a protective mechanism,providing runners with a strategy to minimize the risk of tibial stress injuries.

关键词： Bending moments Gradient musculoskeletal modeling Overuse injury Tibial stress Training factors

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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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military medical Research 2024年第2期11卷 228-267页

作者： miguel A.Ortega Oscar Fraile-martinez Cielo García-montero Sergio Haro miguel Ángel Álvarez-mon Diego De leon-Oliva Ana m.Gomez-Lahoz Jorge monserrat mar Atienza-Pérez David Díaz Elisa Lopez-Dolado melchor Álvarez-mon Department of medicine and medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Sodium-glucose cotransporter-2 inhibitors protect tissues via cellular and mitochondrial pathways:Experimental and clinical evidence

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World Journal of Experimental medicine 2024年第2期14卷 46-52页

作者： Raúl Lelio Sanz Sebastián García menéndez Felipe Inserra leon Ferder Walter manucha Department of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina Department of Pharmacology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina Department of Nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina Department of Cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

mitochondrial dysfunction is a key driver of cardiovascular disease(CVD)in metabolic syndrome and *** dysfunction promotes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the main mediator of the renin-angiotensin-aldosterone system,also contributes to CVD by promoting ROS *** activity of sirtuins(SIRTs),a family of proteins that regulate cellular metabolism,also worsens oxidative *** of energy production by mitochondria is a common feature of all metabolic *** SIRT levels and 5’adenosine monophosphate-activated protein kinase signaling stimulate hypoxia-inducible factor 1 beta,which promotes ***,in turn,increases autophagy and mitophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGLT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGLT2i improves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase mitochondrial efficiency,reduce oxidative stress and inflammation,and strengthen *** findings suggest that SGLT2i hold great potential for the treatment of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these preliminary findings.

关键词： Sodium-glucose cotransporter-2 inhibitors Cardiovascular diseases Sirtuins Oxidative stress Inflammation mitochondrial dysfunction

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía m.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.m.meziani J.m.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y materia Estructurada(LUmES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless comm.nications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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modeling and Control of Parallel Hybrid Electric Vehicle Using Sea-Lion Optimization

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Intelligent Automation & Soft Computing 2023年第2期35卷 1441-1454页

作者： J.leon Bosco Raj m.marsaline Beno Department of EEE St.Xavier’s Catholic College of EngineeringChunkankadaiAnna UniversityChennaiIndia St.Xavier’s Catholic College of Engineering ChunkankadaiAnna UniversityChennaiIndia

This paper develops a parallel hybrid electric vehicle(PHEV)propor-tional integral controller with driving *** improve fuel efﬁciency and reduce hazardous emissions in hybrid electric vehicles(HEVs)combine an electric motor(Em),a battery and an internal combustion engine(ICE).The electric motor assists the engine when accelerating,driving longer highways or climbing *** enables the use of a smaller,more efﬁcient *** also makes use of the concept of regenerative braking to maximize energy efﬁ*** a Hybrid Electric Vehicle(HEV),energy dissipated while braking is utilized to charge the *** proportional integral controller was used in this paper to analyze engine,motor performance and the New European Driving Cycle(NEDC)was used in the vehicle driving test using matlab/*** proportional integral controllers were designed to track the desired vehicle speed and manage the vehi-cle’s energyﬂ*** Sea Lion Optimization(SLnO)methods were created to reduce fuel consumption in a parallel hybrid electric vehicle and the results were obtained for the New European Driving Cycle.

关键词： Hybrid electric vehicle(HEV) proportional integral controller parallel HEV fuel efﬁciency new European driving cycle(NEDC) sea lion optimization(SLnO)

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Preventing surgical site infection using operating room bundle of care in patients undergoing elective exploratory laparotomy cholecystectomy surgery

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Frontiers of Nursing 2023年第3期10卷 335-345页

作者： Erika Leslie R magat Josephine m De leon Graduate School Centro Escolar UniversityManila 1005Philippines School of Nursing Centro Escolar UniversityManila 1005Philippines

Objective:Surgical procedures manifest immense risks to *** of the adverse events that healthcare professionals see as a threat to the patient’s health is the development of complications known as surgical site infection(SSI).Although several effor ts are being under taken to determine the proper means to reduce such complications,there is still a high incidence of SSI *** requires knowledge in infection control and high precision in maintaining a clean surgical *** study tested the effectiveness of an operating room(OR)bundle of care in preventing SSI in patients undergoing elective exploratory laparotomy cholecystectomy ***:A quasi-experimental pretest and posttest design was utilized to determine its *** study was composed of 60 par ticipants divided into two groups:30 subjects were selected to receive the OR bundle of care,while the other 30 subjects received the usual *** groupings were determined through a systematic random sampling *** OR bundle of care had three interventions,namely:(1)maintaining perioperative normothermia,(2)no pre-operative surgical site hair removal,and(3)changing gloves before abdominal wall *** patients were evaluated using the standard instrument,Bates–Jensen Wound Assessment Tool(BWAT)in the post-intervention phases of the wound healing process,which are as follows:hemostasis,inflammatory,and proliferative *** describe the difference in the patients’wound status after implementation of the OR bundle of care in each post-intervention phase,Friedman’s test was *** describe the difference in the patients’wound status in both groups after implementation of the OR bundle of care,the mann–Whitney U test was ***:The patient’s wound status was lower,indicating a more healing *** between the wound status of the control and the experimental group were observed on the third postoperative *** indicates that the experimental gro

关键词： bundle of care exploratory laparotomy operating room bundle of care preventing surgical site infection surgery

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Vascular complications of pancreatitis

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World Journal of Clinical Cases 2022年第22期10卷 7665-7673页

作者： m Ammar Kalas m.nica leon Luis Omar Chavez Eduardo Canalizo Salim Surani Department of medicine Texas Tech University Health CenterEl PasoTX 79905United States Department of General Surgery Centro Medico ABCCiudad de Mexico 01120Mexico Department of medicine Texas A&M UniversityBryanTX 77807United States

more than 200000 hospital admissions happen per year for acute pancreatitis and more than 50000 for chronic pancreatitis in the United States of *** pancreatitis accounts for 20%-30%of the ***-quarter of the patients with pancreatitis develop vascular complications,which carries a high *** mini-review will address these complications that can help primary care physicians and hospitalists in managing their patients effectively.

关键词： Acute pancreatitis Vascular complications Gastrointestinal bleeding Pseudoaneurysm Hemosuccus pancreaticus Pancreas

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Numerical simulations of smoke spread during solar roof fires

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Building Simulation 2022年第4期15卷 561-570页

作者： Xin Zhang monireh Aram Dahai Qi Liangzhu(leon)Wang Department of Civil and Building Engineering Universite de Sherbrooke2500boul.de I'UniversiteSherbrooke(Quebec)J1K2R1Canada Centre for Zero Energy Building Studies Deportment of BuildingCivil and Environmental EngineeringConcordia University1455 de Maisonneuve Blvd.WestMontreal(Quebec)H3G 1M8Canada

As the installation of solar roofs increases,so has the concern over *** from a solar roof fire could spread into a building through roof openings and presents a challenge for existing fire protection *** date,there have been insufficient studies on solar roof fire-induced smoke *** this study,we conducted computational fluid dynamics(CDF)simulations using Fire Dynamics Simulator(FDS)to better understand the mechanisms of solar roof fire-induced smoke spread and help with solar roof ***,the photovoltaic(PV)combustion model was created in FDS and validated by experimental data.A parametric study was then simulated to investigate the impacts of roof slopes and vent sizes on the smoke spread of the solar *** was found that the roof slope has a significant effect on the fire smoke *** the roof slope increases,the region of separation,where the smoke and air are mixed,can extend from the leeward side of the building to the roof *** a result,smoke could fill the attic and room more slowly,leading to a lower soot density and lower indoor *** design a solar roof,both fire smoke protection and PV energy performance should be considered,especially for the low latitude regions where the PV optimal title angle regarding energy performance is small and leads to a higher risk of smoke infiltration.

关键词： solar roof fire CFD smoke infiltration

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De leon Xitlaly J González-Leal Raúl del Toro-mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor mingura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRm).Statistical analyses employed appropriate tests,Kaplan-meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRm,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

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An exploratory study on road tunnel with semi-transparent photovoltaic canopy-From energy saving and fire safety perspectives

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Building Simulation 2022年第4期15卷 537-548页

作者： Dahai Qi Senwen Yang Chang Shu Xin Zhang Liangzhu(leon)Wang Andreas Athienitis Department of Civil and Building Engineering Universite de Sherbrooke2500boul.de I'UniversiteSherbrookeQuebec J1K2R1Canada Centre for Zero Energy Building Studies Department of BuildingCivil and Environmental EngineeringConcordia University1455 de Maisonneuve Blvd.WestMontrealQuebec H3G 1M8Canada

Road tunnels consume a large amount of energy,especially in the Canadian cold climate,where the roads are heated electrically or deicing during the *** a more sustainable and resilient road tunnel energy system,we conducted an exploratory study on installing a semi-transparent photovoltaic(STPV)canopy at the entrances and exits of a tunnel under a *** proposed system generates solar-powered electricity,improves thermal and visual conditions,and reduces energy *** this study,field measurements of road surface temperature and air temperature were conducted,and numerical simulations with and without STPV were performed to study air and road surface temperatures under different traffic *** field measurements show the road surface temperatures are higher than the air temperature on *** interior air and road surface temperature were measured to be above 0°C,even though the outdoor temperature is far below 0°C,thus significantly reducing the need for deicing in winter using *** simulations show that the air and surface temperatures elevate due to the solar transmission heat through the STPV canopy,thus reducing deicing energy consumption *** fire safety analysis also showed that the proposed system's top opening should be located near the tunnel entrance instead of the canopy entrance for better smoke exhaust during a fire.

关键词： STPV road tunnel fire safety energy efficiency cold climate

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