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An Energy Trading method Based on Alliance Blockchain and multi-Signature

Computers, materials & Continua 2024年第2期78卷 1611-1629页

作者： Hongliang tian Jiam.ng Wang College of Electrical Engineering Northeast Electric Power UniversityJilin132012China

Blockchain,known for its secure encrypted ledger,has garnered attention in financial and data transfer realms,including the field of energy ***,the decentralized nature and identity anonymity of user nodes raise uncertainties in energy *** broadcast consensus authentication slows transaction speeds,and frequent single-point transactions in multi-node settings pose key exposure risks without protective measures during user *** address these,an alliance blockchain scheme is proposed,reducing the resource-intensive identity verification am.ng *** integrates multi-signature functionality to fortify user resources and transac-tion security.A novel multi-signature process within this framework involves neutral nodes established through central *** neutral nodes participate in multi-signature’s signing and verification,ensuring user identity and transaction content *** interactions am.ng user nodes enhances transaction efficiency by minimizing communication overhead during verification and consensus *** assessments on reliability and operational speed highlight superior security performance,resilient against conventional attack *** shows that compared to traditional solutions,this scheme has advantages in terms of running *** conclusion,the alliance blockchain framework introduces a novel approach to tackle blockchain’s limitations in energy *** integrated multi-signature process,involving neutral nodes,significantly enhances security and *** scheme’s efficiency,validated through analytical assessments and simulations,indicates robustness against security threats and improved transactional *** research underscores the potential for improved security and efficiency in blockchain-enabled energy trading systems.

关键词： Alliance blockchain multi-signature energy trading security performance transaction efficiency

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Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1564-1577页

作者： Sai-Nan Li Shan Yang Hao-Qi Wang tian-Li hui m.ng Cheng Xi Zhang Bao-Kun Li Gui-Ying Wang The First Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Second Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of General Surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and a significant cause of cancer-related mortality *** to chemotherapy,especially during CRC treatment,leads to reduced effectiveness of drugs and poor patient *** noncoding RNAs(lncRNAs)have been implicated in various pathophysiological processes of tumor cells,including chemotherapy resistance,yet the roles of many lncRNAs in CRC remain *** To identify and analyze the lncRNAs involved in oxaliplatin resistance in CRC and to understand the underlying molecular mechanisms influencing this *** Gene Expression Omnibus datasets GSE42387 and GSE30011 were reanalyzed to identify lncRNAs and mRNAs associated with oxaliplatin *** bioinformatics tools were employed to elucidate molecular *** expression levels of lncRNAs and mRNAs were assessed via quantitative reverse transcription-polymerase chain *** assays,including mTT,wound healing,and Transwell,were conducted to investigate the functional implications of lncRNA *** between lncRNAs and trans-cription factors were examined using RIP and luciferase reporter assays,while Western blotting was used to confirm downstream ***,a xenograft mouse model was utilized to study the in vivo effects of lncRNAs on chemotherapy *** LncRNA prion protein testis specific(PRNT)was found to be upregulated in oxaliplatin-resistant CRC cell lines and negatively correlated with homeodomain interacting protein kinase 2(HIPK2)*** was demonstrated to sponge transcription factor zinc finger protein 184(ZNF184),which in turn could regulate HIPK2 *** expression of PRNT influenced CRC cell sensitivity to oxaliplatin,with overexpression leading to decreased sensitivity and decreased expression reducing *** RIP and luciferase reporter assays indicated that ZNF184 and HIPK2 are targets of *** PRNT/ZNF184

关键词： Colorectal cancer Oxaliplatin resistance Prion protein testis specific Zinc finger protein 184 Homeodomain interacting protein kinase 2

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Revisiting East Asian monsoon change during the Last Glacial maximum using PmIP4 simulations

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 47-52页

作者： Zhiping tian Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina

利用PmIP4多模式试验数据,本文重新检查了末次冰盛期(距今约21000年)东亚季风变化.结果表明:相对于工业革命前期,所有5个模式一致模拟显示末次冰盛期东亚季风减弱,冬季和夏季减幅分别为1%-18%和2-32%;不同模式中东亚季风环流变化的空间... 详细信息

利用PmIP4多模式试验数据,本文重新检查了末次冰盛期(距今约21000年)东亚季风变化.结果表明:相对于工业革命前期,所有5个模式一致模拟显示末次冰盛期东亚季风减弱,冬季和夏季减幅分别为1%-18%和2-32%;不同模式中东亚季风环流变化的空间分布存在差异,这主要源于该时期大尺度变冷和海平面气压梯度变化的空间分布不同;由于模式之间的差异和重建记录之间的不确定性,未来有待开展更多模拟和重建工作以更好地理解冰期东亚季风变化.

关键词：末次冰盛期东亚冬季风东亚夏季风 PmIP4试验

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Glymphatic function and its influencing factors in different glucose metabolism states

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World Journal of Diabetes 2024年第7期15卷 1537-1550页

作者： Bin tian Chen Zhao Jia-Li Liang hui-Ting Zhang Yi-Fan Xu hui-Lei Zheng Jia Zhou Jiang-Nian Gong Shu-Ting Lu Zi-San Zeng Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina magnetic Resonance Research Collaboration Siemens HealthineersGuangzhou 510620Guangdong ProvinceChina magnetic Resonance Research Collaboration Siemens Healthineers Ltd.Wuhan 430071Hubei ProvinceChina Department of Health management The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well *** To investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states,the present study employed diffusion tensor imaging along the perivascular space(DTI-ALPS)*** Sample size was calculated using the pwr package in R *** crosssectional study enrolled 22 patients with normal glucose metabolism.ngm),20 patients with prediabetes,and 22 patients with type 2 diabetes mellitus(T2Dm).A 3.0T magnetic resonance imaging was used to evaluate the function of the glymphatic *** mini-mental state examination(mmSE)was used to assess general cognitive *** DTI-ALPS index of bilateral basal ganglia and the mean DTI-ALPS index was ***,the correlation between DTI-ALPS and clinical features was *** The left-side,right-side,and mean DTI-ALPS index in the T2Dm group were significantly lower than that in the ngm *** right-side DTI-ALPS and mean DTI-ALPS index in the T2Dm group were significantly lower than those in the prediabetes ***-ALPS index lateralization was not *** mmSE score in the T2Dm group was significantly lower than that in the ngm and prediabetes *** controlling for sex,the left-side DTI-ALPS and mean DTI-ALPS index in the prediabetes group were positively correlated with 2-hour postprandial blood glucose level;the left-side DTI-ALPS index was negatively correlated with total cholesterol and low-density lipoprotein *** right-side DTI-ALPS and mean DTI-ALPS index were negatively correlated with the glycosylated hemoglobin level and waist-to-hip ratio in the prediabetes *** left-side,right-side,and mean DTI-ALPS index in the T2Dm group were positively correlated with *** left-side and mean DTIALPS index in the T2Dm group were negatively

关键词： Glymphatic system Prediabetes Type 2 diabetes mellitus magnetic resonance imaging Diffusion tensor imaging along the perivascular space

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A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

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China CDC weekly 2024年第27期6卷 677-680页

作者： Qingqing Xu Cuiping Wu hui Liu Chao Geng Jinhui Zhang Dongri Piao Hongyan Zhao Yu Fan Guozhong tian Hai Jiang National Key Laboratory of Intelligent Tracing and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Infectious Diseases Yidu Central Hospital of WeifangWeifang CityShandong ProvinceChina Institute of Bacterial Disease Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina Tongliao Center for Disease Control and Prevention Tongliao CityInner Mongolia Autonomous RegionChina

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain *** is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

关键词： neglected instance Shandong

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First Passage Density of Brownian motion with Two-sided Piecewise Linear Boundaries

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Acta mathematica Sinica,English Series 2024年第6期40卷 1505-1520页

作者： Zhen YU mao Zai tian Center for Applied Statistics School of StatisticsRenmin University of ChinaBeijing 100872P.R.China School of mathematics and Data Science Changji UniversityChangji 831100P.R.China

The first passage time has many applications in fields like finance,econometrics,statistics,and ***,explicit formulas for the first passage density have only been obtained for a few *** paper derives an explicit formula for the first passage density of Brownian motion with twosided piecewise continuous boundaries which may have some points of *** are used to obtain a simplified formula for estimating the first passage ***,the results are also generalized to the case of two-sided general nonlinear *** can be easily carried out with monte Carlo method and it is demonstrated for several typical two-sided boundaries that the proposed approximation method offers a highly accurate approximation of first passage density.

关键词： Boundary non-crossing probability first density passage density two-sided piecewise continuous boundaries Brownian motion

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Recent progress in side chain engineering of Y-series non-fullerene molecule and polymer acceptors

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Science China Chemistry 2024年第3期67卷 788-805页

作者： Li tian Chunchen Liu Fei Huang School of materials Science and Engineering Henan University of TechnologyZhengzhou 450001China Institute of Polymer Optoelectronic materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Organic solar cells(OSCs) have drawn considerable attention in the last decade due to the great potential of light weight,flexibility, and low-cost solution processing. Particularly, Y-series non-fullerene acceptors(NFAs) including small molecular acceptors(SmAs) and polymerized small molecular acceptors(PSmAs) have become research hot spots due to their excellent power conversion efficiency. Side chain engineering is crucial to adjust the solubility and crystallinity of NFAs, which will significantly affect the morphology of active layers and the efficiency of OSCs. However, the understanding of side chain engineering on NFAs is still limited and lacks a systematic review. This review aims to provide a brief summary of the recent developments in side chain engineering of NFAs, with a special focus on the design and application of Y-series SmAs and PSmAs for high-efficiency non-fullerene organic solar cells(NF-OSCs). In addition, the review also points out challenges and provides useful guidance regarding side chain regulation for Y-series NFAs.

关键词： organic solar cell Y-series non-fullerene acceptors side chain engineering

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All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1131-1144页

作者： Junning Pu Daiwen Chen Gang tian Jun He Ping Zheng Zhiqing Huang Xiangbing mao Jie Yu Yuheng Luo Junqiu Luo hui Yan Aimin Wu Bing Yu Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanPeople’s Republic of China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan Province611130 ChengduSichuanPeople’s Republic of China

Background Transmissible gastroenteritis virus(TGEV)is one of the main pathogens causing severe diarrhea of *** pathogenesis of TGEV is closely related to intestinal ***-trans retinoic acid(ATRA)is the main active metabolite of vitamin A,which has immunomodulatory and anti-inflammatory ***,it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation and barrier dysfunction in *** study aimed to investigate the effects of ATRA on growth performance,diarrhea,intestinal inflammation and intesti-nal barrier integrity of TGEV-challenged *** In a 19-d study,32 weaned piglets were randomly divided into 4 treatments:Control group(basal diet),TGEV group(basal diet+TGEV challenge),TGEV+ATRA5 group(basal diet+5 mg/d ATRA+TGEV challenge)and TGEV+ATRA15 group(basal diet+15 mg/d ATRA+TGEV challenge).On d 14,piglets were orally administered TGEV or the sterile *** Feeding piglets with 5 and 15 mg/d ATRA alleviated the growth inhibition and diarrhea induced by TGEV(Png piglets with 5 and 15 mg/d ATRA also inhibited the increase of serum diamine oxidase(DAO)activ-ity and the decrease of occludin and claudin-1 protein levels in jejunal mucosa induced by TGEV,and maintained intestinal barrier integrity(Pmeanwhile,5 mg/d ATRA feeding increased the sucrase activity and the expres-sions of nutrient transporter related genes(GLUT2 and SLC7A1)in jejunal mucosa of TGEV-challenged piglets(Pmore,5 mg/d ATRA feeding attenuated TGEV-induced intestinal inflammatory response by inhibit-ing the release of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α),and promoting the secretion of IL-10 and secretory immunoglobulin A(sIgA)(Png 5 mg/d ATRA also down-regulated the expressions of Toll-like receptors and RIG-I like receptors signaling pathway related genes(TLR3,TLR4,RIG-I,myD88,TRIF and mAVS)and the phosphorylation level of nuclear factor-κB-p65(NF-κB p65),and

关键词： All-trans retinoic acid Inflammation Intestinal barrier Piglets Transmissible gastroenteritis virus

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Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide

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Chinese Journal of Polymer Science 2024年第9期42卷 1333-1340,I0007页

作者： tian-Hao Ren De-Hai Liang Beijing National Laboratory for molecular Sciences Department of Polymer Science and Engineering and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

The liquid-liquid phase separation of biopolymers in living cells contains multiple interactions and occurs in a dynamic *** the regulation mechanism is still a *** this work,we designed a series of peptides(XXLY)_(6)SSSGSS and studied their complexation and coacervation behavior with single-stranded ***“X”and“Y”are varied to combine known amounts of charged and non-charged amino acids,together with the introduction of secondary structures and pH *** show that the electrostatic interaction,which is described as charge density,controls both the strength of complexation and the degree of chain relaxation,and thus determines the growth and size of the *** hydrophobic interaction is prominent when the charges are ***,the secondary structures of peptides exhibit profound effect on the morphology of the phases,such as solid phase to liquid phase *** study gains insight into the phase separation under physiological *** is also helpful to create coacervates with desirable structures and functions.

关键词： Polyelectrolyte complex Coacervate Peptides Secondary structure Electrostatic interaction

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GmAP1d regulates flowering time under long-day photoperiods in soybean

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The Crop Journal 2024年第3期12卷 845-855页

作者： Shiyu Guo Yanfei Li Hongmei Qiu Guoyu Hu Chaosen Zhao Ruizhen Wang Hao Zhang Yu tian Xiaoyu Li Bin Liu Ying-hui Li Li-juan Qiu College of Agriculture Northeast Agricultural UniversityHarbin 150030HeilongjiangChina State Key Laboratory of Crop Gene Resources and Breeding/The National Key Facility for Crop Gene Resources and Genetic Improvement(NFCRI)/Key Laboratory of Grain Crop Genetic Resources Evaluation and Utilization(mARA) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Jilin Academy of Agricultural Sciences/National Engineering Research Center for Soybean Changchun 130033JilinChina Crop Research Institute Anhui Academy of Agricultural SciencesHefei 230031AnhuiChina Crops Research Institute of Jiangxi Academy of Agricultural Sciences/Jiangxi Province Key Laboratory of Oilcrops Biology Nanchang 330200JiangxiChina Key Lab of Chinese medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Flowering time is important for adaptation of soybean(Glycine max)to different ***,we conducted a genome-wide association study of flowering time using a panel of 1490 cultivated soybean *** identified three strong signals at the qFT02-2 locus(Chr02:12037319–12238569),which were associated with flowering time in three environments:Gongzhuling,m.ngcheng,and *** analyzing linkage disequilibrium,gene expression patterns,gene annotation,and the diversity of variants,we identified an AP1 homolog as the candidate gene for the qFT02-2 locus,which we named *** one nonsynonymous polymorphism existed am.ng 1490 soybean accessions at position Chr02:*** carrying the Chr02:12087053-T allele flowered significantly earlier than those carrying the Chr02:12087053-A ***,we developed a cleaved amplified polymorphic sequence(CAPS)marker for the SNP at Chr02:12087053,which is suitable for marker-assisted breeding of flowering *** of GmAP1d in the‘Williams 82’background by gene editing promoted flowering under long-day conditions,confirm.ng that GmAP1d is the causal gene for *** analysis of the region surrounding GmAP1d revealed that GmAP1d was artificially selected during the genetic improvement of *** stepwise selection,the proportion of modern cultivars carrying the Chr02:12087053-T allele has increased,and this allele has become nearly fixed(95%)in northern *** findings provide a theoretical basis for better understanding the molecular regulatory mechanism of flowering time in soybean and a target gene that can be used for breeding modern soybean cultivars adapted to different latitudes.

关键词： Soybean Flowering time GWAS GmAP1d Long-day conditions

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