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microbiological assessment of indoor air of a teaching hospital in Nigeria

Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 465-468页

作者： Awosika sa Olajubu fa Amusa na Department of microbiology Olabisi Onabanjo University Department of medical microbiology & Parasitology Olabisi Onabanjo University Teaching Hospital Department of Plant Science & Applied Zoology Olabisi Onabanjo University

Objective:To investigate the quality of indoor air of different wards and units of Olabisi Onabanjo University Teaching Hospital, sagamu, to ascertain their contribution to infection rate in the ***:The microbial quality of indoor air of nine wards/units of Olabisi Onabanjo University Teaching Hospital, sagamu, Nigeria was conducted. Sedimentation technique using open Petri-dishes containing different culture media was employed and samplings were done twice daily, one in the morning shortly after cleaning and before influx of people/patients into the wards/units and the other in the evening when a lot of activities would have taken place in these wards. Isolates were identified according to standard ***:Results showed that there was a statistically significant difference(氈2= 6.0167) in the bacteria population of the different sampling time whereas it was not so for fungi population(氈2= 0.2857). male medical ward(mmW) and male surgical general(mSG) recorded the highest bacterial and fungal growth while the operating theatre(OT) was almost free of microbial burden. The bacteria isolates were Staphylococcus aureus, Klebsiellasp., Bacillus cereus, Bacillus subtilis, Streptococcus pyogenes andSerratia marscenceswhile the fungi isolates includedAspergillus flavus, Penicilliumsp.,Fusariumsp.,Candida *** aureuswas the predominantly isolated bacterium whilePenicilliumsp. was the most isolated ***:Though most of the microbial isolates were potential and or opportunistic pathogens, there was no correlation between the isolates in this study and the surveillance report of nosocomial infection during the period of study, hence the contribution of the indoor air cannot be established. From the reduction noticed in the morning samples, stringent measures such as proper disinfection and regular cleaning, restriction of patient relatives' movement in and out of the wards/units need to be enforced so as to imp

关键词： Indoor air OOUTH Open-plate technique Nosocomial infections Staphylococcus aureus microbiological assessment microbial quality Bacterial isolate Fungal isolate Opportunistic pathogen Nosocomial infection Infection rate microbial isolate Penicilliumsp Sedimentation technique

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人类精子代谢和表观遗传调控通过影响精子活力导致男性不育的研究进展

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中华生殖与避孕杂志 2024年第5期44卷 548-555页

作者：孙非凡张茂翔姜昱王纳任发乔鹏云潍坊医学院附属医院(临床医学院) 潍坊261042 潍坊医学院附属医院生殖医学中心潍坊261041

精子作为男性体内高度分化的单倍体生殖细胞,是生命遗传信息传递的重要载体,其结构完整是正常受精的条件,也是正常代谢产生能量和完成表观遗传的基础。精子代谢被认为是精子运动的“供能站”,保证精子发生、成熟、过活化和精卵结合等生... 详细信息

精子作为男性体内高度分化的单倍体生殖细胞,是生命遗传信息传递的重要载体,其结构完整是正常受精的条件,也是正常代谢产生能量和完成表观遗传的基础。精子代谢被认为是精子运动的“供能站”,保证精子发生、成熟、过活化和精卵结合等生命活动正常进行,代谢异常会直接影响精子活力造成男性不育。而精子表观遗传是一种通过父系遗传来影响后代胚胎发育和繁殖的过程,包括Dna甲基化、染色质重塑和精子携带的小Rna等多种调控方式,它们可在一定程度上影响能量产生,进而导致精子活力和男性生育力下降。因此,精子代谢和表观遗传在维持精子活力方面有着不可分割的联系,本文就人类精子结构、代谢和表观遗传调控方面进行综述,以期为与它们相关的精子活力异常导致的男性不育症相关研究提供理论参考。

关键词：氧化磷酸化活性氧组蛋白 Dna甲基化精子代谢

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An Analysis of the Low moving Speed of Landfalling Typhoon In-fa in 2021

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Journal of Tropical meteorology 2024年第1期30卷 51-60页

作者：郑丽娜吕新刚李瑞 Jinan meteorological Bureau of Shandong Province Jinan 250102 China

The movement speed of Typhoon In-fa(2021)was notably slow,at 10 km h-1or less,for over 20 hours following its landfall in Zhejiang,China,in contrast to other typhoons that have made *** study examines the factors contributing to the slow movement of Typhoon In-fa,including the steering flow,diabatic heating,vertical wind shear(VWS),and surface synoptic situation,by comparing it with Typhoons Yagi(2018)and Rumbia(2018)which followed similar *** findings reveal that the movement speed of Typhoons Yagi and Rumbia is most closely associated with their respective 500 h Pa environmental winds,with a steering flow of 10^(-12)m s^(-1).In contrast,Typhoon Infa’s movement speed is most strongly correlated with the 850 h Pa environmental wind field,with a steering flow speed of only 2 m s^(-1).Furthermore,as Typhoon In-fa moves northwest after landfall,its intensity is slightly greater than that of Typhoons Yagi and Rumbia,and the pressure gradient in front of Typhoon In-fa is notably smaller,leading to its slow ***,the precipitation distribution of Typhoon In-fa differs from that of the other two typhoons,resulting in a weak asymmetry of wavenumber-1 diabatic heating,which indirectly affects its movement *** analysis indicates that VWS can alter the typhoon’s structure,weaken its intensity,and ultimately impact its movement.

关键词： landfalling typhoon steering flow diabatic heating VWS

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基于无人机和地面调查的典型草原“种-面积”关系

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中国环境科学 2024年第9期44卷 5169-5179页

作者：朱萨宁高吉喜万华伟尤春赫杨雪郭雨桐祝晨佳吕娜中国环境科学研究院生态研究所北京100012 生态环境部卫星环境应用中心北京100094 北京林业大学草业与草原学院北京100091

本研究以呼伦贝尔市典型草原为研究对象,通过传统地面样方调查和无人机调查,系统研究了“种-面积”关系,确定了典型草原地面与无人机调查的最小调查面积.调查结果表明:1)典型草原的物种数量与调查面积呈非线性关系,“种-面积”关系呈现... 详细信息

本研究以呼伦贝尔市典型草原为研究对象,通过传统地面样方调查和无人机调查,系统研究了“种-面积”关系,确定了典型草原地面与无人机调查的最小调查面积.调查结果表明:1)典型草原的物种数量与调查面积呈非线性关系,“种-面积”关系呈现为S=aln(bA+1).基于组合样方法,至少要包括8个1m^(2)小样方,才能达到涵盖80%物种的目标,基于巢式样法,需要的最小调查面积为8.63m^(2);2)针对典型草原,无人机调查的平均物种发现率为传统地面调查方法的81.7%,无人机可作为地面调查的辅助手段,提高调查的效率;3)在典型草原物种监测中,可选取1个或2个组合样方,并使用无人机进行4~5次随机拍摄作为补充,此时可发现典型草原物种总数的84.7%~88.3%.该方法相对传统的3~5次重复样方调查,代表性更高,调查效率更高.

关键词： “种-面积”关系无人机地面调查典型草原

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Establishment of a multiplex Detection method for Common Bacteria in Blood Based on Human mannan-Binding Lectin Protein-Conjugated magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO Zi Jin CHEN Xiao Ping HUA Shao Wei LI Feng Yu ZHAO meng XING Chen Hao WANG Jie TIAN Feng Yu ZHANG Rui Qing LYU Xiao na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin mA Xue Jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China national Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic Center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification *** study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(sa),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(m1 protein)-conjugated magnetic bead(m1 bead)enrichment of pathogens combined with *** Recombinant plasmids were used to evaluate the assay *** blood influenza bacteria were used for the specific *** and clinical plasma samples were enriched with m1 beads and then subjected to multiple recombinase-aided PCR(m-RAP)and quantitative PCR(qPCR)*** analysis was used to evaluate the consistency between the two *** The m-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of sa,PA,and AB plasmids,respectively,without cross-reaction to other bacterial *** m-RAP assay obtained results formL pathogens in the blood within 4 h,with higher sensitivity than qPCR.m-RAP and qPCR for sa,PA,and AB yielded Kappa values of 0.839,0.815,and 0.856,respectively(Pm-RAP assay for sa,PA,and AB in blood samples utilizing m1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay multiple detection

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía m.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.m.meziani J.m.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y materia Estructurada(LUmES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for materials nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín michalŠmíd Pablo Perez-martin marion Kühlman Juan Pintor Jakub Cikhardt matthias Dreimann Dennis Eckermann Felix Rosenthal sam m.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston mikako makita motoaki nakatsutsumi Xiayun Pan Alexander Köhler marion Harmand Sven Toleikis Katerina falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore national Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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考虑水土互馈关系的区域水土资源联合优化配置

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水科学进展 2024年第2期35卷 208-219页

作者：卢娜张佳明苏承国胡政磊吴泽宁严登华郑州大学水利与交通学院河南郑州450001 黄河实验室(郑州大学) 河南郑州450001 中国水利水电科学研究院北京100038

针对水土资源空间不匹配、水资源总量不足及土地资源利用程度不高等问题,以二元水循环理论为基础,构建考虑水土互馈关系的区域水土资源联合优化配置模型。该模型包括产水模块、水土联合配置模块和土地模拟模块,以GDP最大和基于生态绿当... 详细信息

针对水土资源空间不匹配、水资源总量不足及土地资源利用程度不高等问题,以二元水循环理论为基础,构建考虑水土互馈关系的区域水土资源联合优化配置模型。该模型包括产水模块、水土联合配置模块和土地模拟模块,以GDP最大和基于生态绿当量的区域植被覆盖率(EGE-RVC)最高为目标函数,并提出了一种耦合约束法、逐次逼近法和非线性规划的三层嵌套算法进行求解。以河南省洛阳市为例对模型和方法进行验证,结果表明,洛阳市可利用水量增加了4463万m^(3),GDP提高了12.5%,EGE-RVC增加了2.6%,各用地类型缺水率不同程度下降。研究成果能够为区域水土资源优化配置研究提供新的思路和技术参考。

关键词：水土资源联合优化配置相互作用二元水循环三层嵌套算法

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Isolation and characterization of a new candidate human inactivated rotavirus vaccine strain from hospitalized children in Yunnan,China:2010-2013

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World Journal of Clinical Cases 2018年第11期6卷 426-440页

作者： Jin-Yuan Wu Yan Zhou Guang-ming Zhang Guo-fa mu Shan Yi na Yin Yu-Ping Xie Xiao-Chen Lin Hong-Jun Li mao-Sheng Sun Department of molecular Biology Institute of Medical BiologyChinese Academy of Medical Science and Peking Union Medical College Pediatrics Department the First People's Hospital of Zhaotong City

AIm To determine the distribution of rotavirus VP7 gene in hospitalized children in Yunnan, China. mETHODS A total of 366 stool specimens were collected from hospitalized children in hospitals in Yunnan Province from September 2010 to December 2013. The genomic Rna electropherotypes and the G genotypes of the rotaviruses were determined. A phylogenetic analysis of the VP7 gene was performed. Rotavirus isolation was performed, and characterized by plaque, minimum essential medium, and all genes sequence analysis. Quantification of antibodies for inactivated vaccine prepared with ZTR-68 was examined by enzyme-linked immunosorbent assay and microneutralization *** Group A human rotavirus was detected in 177 of 366(48.4%) stool samples using a colloidal gold device assay. The temporal distribution of rotavirus cases showed significant correlation with the mean air temperature. Rotaviruses were isolated from 13% of the rotavirus-positive samples. The predominant genotype was G1(43.5%), followed by G3(21.7%), G9(17.4%), G2(4.3%), G4(8.7%), and mixed(4.3%) among a total of 23 rotavirus isolates. A rotavirus strain was isolated from a rotavirus-positive stool sample of a 4-month-old child in The First People's Hospital of Zhaotong(2010) for use as a candidate human inactivated rotavirus vaccine strain and for further research, and was designated ZTR-68. The genotype of 11 gene segments of strain ZTR-68(RVA/Human-wt/CHN/ZTR-68/2010/G1P[8]) was characterized. The genotype constellation of strain ZTR-68 was identified as G1-P[8]-I1-R1-C1-m1-A1-N1-T1-E1-H1. The VP7 and VP4 genotypes of strain ZTR-68 were similar to Wa-like *** A high prevalence of the G1, G2, and G3 genotypes was detected from 2010 to 2012. However, a dominant prevalence of the G9 genotype was identified as the cause of gastroenteritis in children in Yunnan, China, in 2013. A candidate human inactivated rotavirus vaccine strain, designated ZTR-68 was isolated, characterized, and showed

关键词： Rotavirus Genotype G G1P Inactivated rotavirus vaccine Genotype characterization Rapid antigen detection kit Phylogenetic analysis

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Epidermal growth factor receptor double mutations in non-small cell cancer patients

Epidermal growth factor receptor double mutations in non-sma...

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浙江省免疫学会第十次学术大会

作者： Jing Qin Jun-fa Xie na Han Department of medical Oncology Zhejiang Cancer Hospital

Background:Epidermal growth factor receptor(EGFR) mutations occur in >70%of patients with non-small-cell cancer(NSCLC).These mutations are concentrated in exons 18-21,common mutations enhances clinical sensitivity to tyrosine kinase inhibitors(TKIs).However,the relation between EGFR double activating mutations with the therapeutic efficacy of EGFR-TKIs is still not well ***:In our study,we detected EGFR mutations in NSCLC with pyrosequencing asssy and mutant-enriched PCR,and further analyzed the correlation between EGFR mutation type and clinicopathologic features of ***:In this study,7 patients with double EGFR mutation,including L858 R +DelE746-A750,L858 R+S768 I,L858 R+T790 m.85.7%were *** median age was 62 years old.L858 R + DelE746-A750 double mutations had a higher sensitivity to TKI and a substantially longer overall survival than the other two single-activating *** L858 R+T790 m mutations confer EGFR-TKI resistance in NSCLC ***:These data might inform therapeutic options for patients with non-small-cell lung cancer harbouring EGFR double *** propose that positive EGFR double-activating somatic mutation may be a good prognostic factor.

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