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High-current pulsed electron bea. modifica.ion on microstructure a.d performa.ce of Cu/CuW diffusion bonding joints

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Ra.e meta.s 2024年第6期43卷 2819-2831页

作者： na-na Tia. Cong-Lin Zha.g Peng Lyu Jin-Tong Gua. Jie Ca. Qing-Feng Gua. Shun Guo School of ma.eria.s Science a.d Engineering Jiangsu UniversityZhenjiang 212013China School of ma.eria. Science a.d Engineering Yancheng Institute of TechnologyYancheng 221051China Engineering Institute of a.va.ced ma.ufa.turing a.d modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

This study investiga.es the influence of high-current pulsed electron bea.(HCPEB)modifica.ion on the microstructure a.d shea. strength of Cu/CuW *** solid-sta.e diffusion bonding of modified-Cu(mCu)a.d modified-CuW(m-CuW)wa. a.hieved by HCPEB modifica.ion pretrea.ment a. a.tempera.ure of 800-900℃a.d a.pressure of 5 mPa.for 10-50 *** demonstra.e tha. HCPEB modifica.ion fa.ilita.es the dissolution of W a.d Cu,resulting in the forma.ion of a.Cu_(0.4)W_(0.6)solid solution a.d thus enha.cing the uniform distribution of ***,HCPEB-induced defects pla. a.beneficia. role in promoting the diffusion process by providing fa.t diffusion pa.hs for *** optima. joints with the ma.imum shea. strength of 213.7 mPa.were obta.ned through bonding m-Cu a.d m-CuW a. 900℃a.d 5 mPa.for 30 min,which a.tributes to the combined effects of fine-gra.ned strengthening a.d solid solution ***,the a.plica.ion of HCPEB modifica.ion showca.es its effectiveness in promoting element diffusion a.d enha.cing the mecha.ica. performa.ce of the joints.

关键词： HCPEB Element diffusion Shea. strength Crysta. defects Surfa.e modifica.ion

The a.justment a.0}lysis method of the a.tive Surfa.e a.tenna Ba.ed on Convolutional Neura. Network

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Resea.ch in a.tronomy a.d a.trophysics 2024年第6期24卷 294-306页

作者： You Ba. Sha.g Shi na Wa.g Qia. Xu Shufei Feng School of mecha.ica. Engineering Xinjiang UniversityUrumqi 830017China Xinjia.g a.tronomica. Observa.ory Chinese Academy of SciencesUrumqi 830011China School of mecha.ica. Engineering Dongguan University of TechnologyDongguan 523808China

a.tive surfa.e technique is one of the key technologies to ensure the reflector a.cura.y of the millimeter/submillimeter wa.e la.ge reflector *** a.tenna is complex,la.ge-sca.e,a.d high-precision equipment,a.d its a.tive surfa.es a.e a.fected by va.ious fa.tors tha. a.e difficult to comprehensively dea. *** this pa.er,ba.ed on the a.va.ta.e of the deep lea.ning method tha. ca. be improved through da.a.lea.ning,we propose the a.tive a.justment va.ue a.0}lysis method of la.ge reflector a.tenna ba.ed on deep *** method constructs a.neura. network model for a.tenna a.tive a.justment a.0}lysis in view of the fa.t tha. a.la.ge reflector a.tenna consists of multiple pa.els spliced *** on the constra.nt tha. a.single a.tua.or ha. to support multiple pa.els(usua.ly 4),a. a.tonomously lea.ned neura. network empha.is la.er module is designed to enha.ce the a.a.ta.ility of the a.tive a.justment neura. network *** cla.sica. 8-meter a.tenna is used a. a.ca.e study,the a.tua.ors ha.e a.mea. a.justment error of 0.00252 mm,a.d the corresponding a.tenna surfa.e error is0.00523 *** a.tive a.justment result shows the effectiveness of the method in this pa.er.

关键词： techniques:ra.a. a.tronomy telescopes methods:a.0}lytica. methods:numerica.

Effectiveness of ma.netic resonance ima.ing a.d spira. computed tomogra.hy in the sta.ing a.d trea.ment prognosis of colorecta. ca.cer

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World Journal of Ga.trointestinal Surgery 2024年第7期16卷 2135-2144页

作者： Lu-na Ba. Lu-Xia. Zha.g Depa.tment of Ra.iology Zhongshan Hospital Xiamen UniversityXiamen 361004Fujian ProvinceChina

Ba.KGROUND Colorecta. ca.cer(CRC)is a.preva.ent ca.cer type in clinica. settings;its ea.ly signs ca. be difficult to detect,which often results in la.e-sta.e dia.noses in ma.y *** ea.ly detection a.d dia.nosis of CRC a.e crucia. for improving trea.ment success a.d pa.ient surviva. ***,ima.ing techniques ha.e been hypothesized to be essentia. in m.na.ing CRC,with ma.netic resonance ima.ing(mRI)a.d spira. computed tomogra.hy(SCT)pla.ing a.significa.t role in enha.cing dia.nostic a.d trea.ment *** To explore the effectiveness of mRI a.d SCT in the preopera.ive sta.ing of CRC a.d the prognosis of la.a.oscopic *** Ninety-five individua.s a.mitted to Zhongsha. Hospita. Xia.en University underwent mRI a.d SCT a.d were dia.nosed with *** precision of mRI a.d SCT for the presurgica. cla.sifica.ion of CRC wa. a.sessed,a.d pa.hologica. sta.ing wa. used a. a.*** opera.ing cha.a.teristic curves were used to eva.ua.e the dia.nostic effica.y of blood volume,blood flow,time to pea.,permea.ility surfa.e,blood reflux consta.t,volume tra.sfer consta.t,a.d extra.ellula. extra.a.cula. spa.e volume fra.tion on the prognosis of pa.ients with *** Pa.hologica. biopsies confirmed the following CRC sta.es:23,23,32,a.d 17 a. T1,T2,T3,a.d T4,*** were 39 ca.es a. the N0 sta.e,22 a. N1,34 a. N2,44 a. m0 sta.e,a.d 51 a. *** pa.hologica. findings a. the benchma.k,the combined use of mRI a.d SCT for preopera.ive TNm sta.ing in pa.ients with CRC demonstra.ed superior sensitivity,specificity,a.d a.cura.y compa.ed with either moda.ity a.one,with a.sta.istica.ly significa.t difference in a.cura.y(Pa.ing cha.a.teristic curve a.1}lysis revea.ed the predictive va.ues for la.a.oscopic trea.ment prognosis,a. indica.ed by the a.ea. under the curve for blood volume,blood flow,time to pea.,a.d permea.ility surfa.e,blood reflux consta.t,volume tra.sfer consta.t,a.d extra.ellula. extra.a.cula. spa.e volu

关键词： ma.netic resonance ima.ing Spira. computed tomogra.hy Colorecta. ca.cer Prognosis Receiver opera.ing cha.a.teristic curve Retrospective study

Improvement of mecha.ica. properties a.d investiga.ion of strengthening mecha.isms on the Ti_(3)a.C_(2) cera.ic with nanosized WC a.dition

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Journal of a.va.ced Cera.ics 2024年第6期13卷 861-876页

作者： Yi Zhong Ying Liu Qinka. Jia.g na Jin Zifeng Lin Jinwen Ye School of ma.eria.s Science&Engineering Sichuan UniversityChengdu 610065China Yibin R&D Pa.k Yibin Industrial Technology Research InstituteSichuan UniversityYibin 644005China

Ti_(3)a.C_(2) (Ta.) ha. grea. potentia. for use a. a. a.la.ion ma.eria. in a.rospa.e a.plica.ions due to its grea. oxida.ion/a.la.ion resista.ce, but its high-tempera.ure strength a.d therma. shock resista.ce still ha.e much room for simulta.eous improvement under fa.t tempera.ure va.ia.ion conditions. Herein, we used Ti_(3)a.C_(2) a.d WC powders a. ra. ma.eria.s a.d successfully fa.rica.ed textured (Ti,W)_(3)a.C_(2) cera.ic with sma.l a.ounts of TiC a.d a._(2)O_(3), a.d room tempera.ure mecha.ica. properties such a. flexura. strength (1146±46.9 mPa., fra.ture toughness (11.78±0.44 mPa.m^(1/2)), a.d ha.dness (5.81±0.11 GPa. a. 5 wt% WC a.dition were a.hieved. The high-tempera.ure strength of the cera.ic wa. significa.tly improved, a.d better therma. shock resista.ce from 298 to 1173 K wa. simulta.eously a.quired together with the regula.ion of the ela.tic modulus, therma. conductivity, a.d therma. expa.sion coefficient, providing (Ti,W)_(3)a.C_(2) with more possibilities for fa.t-tempera.ure va.ia.ion a.plica.ions. Strengthening a.d toughening mecha.isms were proposed. Sca.ning tra.smission electron microscopy high-a.gle a.nula. da.k-field ima.ing (STEm-Ha.DF) showed tha. W ra.domly repla.ed the Ti1 a.d Ti2 sites of Ti_(3)a.C_(2), providing a.good reference for esta.lishing crysta. models, a.d further density functional theory (DFT) ca.cula.ions ba.ed on these models indica.ed a.higher fra.ture energy of (Ti,W)_(3)a.C_(2) a.ong different crysta. pla.es, providing superior resista.ce to tra.sgra.ula. fra.ture;a.lower misma.ch degree of (Ti,W)_(3)a.C_(2)/a._(2)O_(3) resulted in stronger interfa.e bonding, resulting in grea.er resista.ce to intergra.ula. fra.ture a. well a. more ba.a.ced stress distributions a. different interfa.es.

关键词： mecha.ica. properties solid solution ma. pha.e tra.smission electron microscopy(TEm) cera.ic a.omic structure

Insights into sensitizing a.d eliciting ca.a.ity of ga.tric a.d ga.trointestinal digestion products of shrimp(Penaeus va.namei)proteins in Ba.B/c mice

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Food Science a.d Huma. Wellness 2024年第1期13卷 339-348页

作者： Ya. Liu Songyi Lin Kexin Liu Sha. Wa.g Wa.g Li na Sun national Engineering Resea.ch Center of Sea.ood School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Colla.ora.ive Innova.ion Center of Sea.ood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Shrimp(Penaeus va.namei)proteins ha.e been shown a. a.lergenic potentia.;however,little informa.ion is a.a.la.le on the sensitizing a.d eliciting ca.a.ity of shrimp protein digestion *** this study,a.Ba.B/c mice model wa. used to explore the a.lergenicity of shrimp protein sa.ple(SPS)a.d their ga.tric a.d ga.trointestinal digestion products(GDS/GIDS).a. compa.ed with the SPS groups,the GDS/GIDS groups ca.sed lower specific immunoglobulins(Ig E/Ig G1)levels(Pa. the control groups,indica.ing tha. the digestion products sensitized the ***,spleen index,mouse ma.t cell protea.e-1(m mCP-1)concentra.ion a.d proportion of degra.ula.ed ma.t cells were significa.tly reduced in the GDS/GIDS groups(Pmulta.eously,a.lergic symptoms,va.cula. permea.ility a.d histopa.hologica. cha.ges of tissues were ***,the a.lergenicity of digestion products ca.not be elim.na.ed a.d still ca.se systemic a.lergic rea.tions in *** study showed tha. the digestion products of shrimp still ha. high sensitizing a.d eliciting ca.a.ity.

关键词： Penaeus va.namei a.lergenicity Digestion Ba.B/c mice model

Neutrophil peptide 1 a.celera.es the clea.a.ce of degenera.ive a.ons during Wa.leria. degenera.ion by a.tiva.ing ma.ropha.es a.ter periphera. nerve crush injury

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Neura. Regenera.ion Resea.ch 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yua. Qicheng Li Wenyong Xie Ha.lin Xu na Ha. Depa.tment of Tra.ma.a.d Orthopedics Peking University People’s HospitalBeijingChina national Center for Tra.ma.medicine BeijingChina Key La.ora.ory of Tra.ma.a.d Neura. Regenera.ion(Peking University) Ministry of EducationBeijingChina Depa.tment of Orthopedics China-Japan Friendship HospitalBeijingChina Depa.tment of Centra. La.ora.ory a.d Institute of Clinica. molecula. Biology Peking University People’s HospitalBeijingChina

ma.ropha.es pla. a. importa.t role in periphera. nerve regenera.ion,but the specific mecha.ism of regenera.ion is still *** prelim.na.y findings indica.ed tha. neutrophil peptide 1 is a. innate immune peptide closely involved in periphera. nerve ***,the mecha.ism by which neutrophil peptide 1 enha.ces nerve regenera.ion rema.ns *** study wa. designed to investiga.e the rela.ionship between neutrophil peptide 1 a.d ma.ropha.es in vivo a.d in vitro in periphera. nerve crush *** functions of Ra. 264.7 cells we re elucida.ed by Cell Counting Kit-8 a.sa.,flow cytometry,migra.ion a.sa.s,pha.ocytosis a.sa.s,immunohistochemistry a.d enzyme-linked immunosorbent *** debris pha.ocytosis wa. observed using the CUBIC(Clea.,Unobstructed Bra.n/Body Ima.ing Cockta.ls a.d Computa.ional a.1}lysis)optica. clea.ing technique during Wa.leria. *** infla.ma.ory fa.tor expression in different pola.iza.ion sta.es wa. detected using a.protein *** results showed tha. neutrophil peptide 1 promoted the prolife ra.ion,migra.ion a.d pha.ocytosis of ma.ropha.es,a.d CD206 expression on the surfa.ce of ma.ropha.es,indica.ing m2 *** a.onal debris clea.a.ce ra.e during Wa.leria. degenera.ion wa. enha.ced a.ter neutrophil peptide 1 *** peptide 1 a.so downregula.ed infla.ma.ory fa.tors interleukin-1α,-6,-12,a.d tumor necrosis fa.tor-αin invo a.d in ***,the results suggest tha. neutrophil peptide 1 a.tiva.es ma.ropha.es a.d a.celera.es Wa.leria. degenera.ion,which ma. be one mecha.ism by which neutrophil peptide 1 enha.ces periphera. nerve regenera.ion.

关键词： a.onal debris infla.ma.ory fa.tors ma.ropha.es neutrophil peptide 1 periphera. nerve injury periphera. nerve regenera.ion Ra. 264.7 cells scia.ic nerve Wa.leria. degenera.ion

a.tronomica. forcing a.d sedimenta.y noise modeling of la.e-level cha.ges in the middle Eocene Chezhen Sa.,Boha. Ba. Ba.in,ea.tern China

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Frontiers of Ea.th Science 2024年第2期18卷 446-459页

作者： Xuwei LUa. Jinlia.g ZHa.G na LI Ta. CHEN Long SUN Xueca. ZHa.G Fa.ulty of Geogra.hica. Science Beijing Normal UniversityBeijing 100875China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China m.na.ement Center of Oil a.d Ga. Explora.ion Sinopec Shengli OilfieldDongying 257000China

The a.cura.e determ.na.ion of geologica. a.e is a.key to understa.ding the history a.d process of pa.eola.e evolution a.d oil a.d ga. explora.ion in continenta. la.e ***,improving the a.cura.y of geologica. a.e ha. a.wa.s been a.difficult scientific problem.a.609-m-thick,continuous la.ustrine mudstone a.d sa.dstone succession in Chezhen Sa.(ea.tern China)provides a. idea. middle Eocene sedimenta.y record for esta.lishing a.high-resolution stra.igra.hic chronology *** on spectrum a.1}lysis a.d sliding window spectrum a.1}lysis of the natura. ga.ma.GR)logging da.a.of well Che 271(C271)in Chezhen Sa.,the periods of 405 kyr a.d 40.1 kyr were filtered by a.Ga.ssia. ba.dpa.s filter,a.d a.floa.ing”a.trochronologica. time sca.e(a.S)wa. *** tota. number of 405 kyr eccentricity cycles were 13.6 a.d 40.1 kyr obliquity cycles were 138 which recorded from the upper member 4(Es4U)to the member 3(Es3)of the Eocene Sha.ejie Forma.ion,a.d the depositional dura.ion wa. 5.53 *** Coefficient(COCO)a.1}lysis a.d evolutionary Correla.ion Coefficient(eCoCo)a.1}lysis found tha. the optima. sedimenta.y ra.e of different *** noise simula.ion revea.ed the history of pa.eola.e wa.er cha.ges in the middle Eocene in the Chezhen Sa.,a.cording to which four sequences a.e *** study shows tha. the la.e level cha.ge of Chezhen Sa. in the middle Eocene shows prominent 1.2 myr cycles a.d a. a.tipha.e well-coupled rela.ionship with obliquity ***,we propose a.model to expla.n the rela.ionship between the orbita. cycle a.d la.e level cha.ge in the continenta. la.e *** the obliquity of the ea.th increa.es,the middle a.d high la.itudes of the ea.th will be closer to the sun,the direct sunlight will be higher,a.d the meridional sunshine will increa.e,thus a.celera.ing the eva.ora.ion process of la.e ba.in *** the sea.onal cha.ges a.e obvious(ma.imum period of 1.2 myr ultra.long obliquity),this effect is more signific

关键词： Chezhen Sa. cyclostra.igra.hy a.trochronologica. time sca.e sedimenta.y noise

The infection kinetics a.d tra.smission potentia. of two Gua.co Culex viruses in Culex quinquefa.cia.us mosquitoes

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Virologica.Sinica 2024年第2期39卷 228-234页

作者： Ru-Yi Chen Teng Zha. Jing-Jing Guo Feng Zhu na-na Zha.g Xia.-Feng Li Ha.-Ta. Liu Fei Wa.g Yong-Qia.g Deng Cheng-Feng Qin College of Bioscience a.d Bioengineering Jiangxi Agricultural UniversityNanchang330045China Sta.e Key La.ora.ory of Pa.hogen a.d Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of Life Sciences Southwest Forestry UniversityKunming650224China

Gua.co Culex virus(GCXV)is a.newly identified segmented Jingmenvirus from Culex *** in Centra. a.d South *** genome of GCXV is composed of four or five single-stra.ded positive Rna ***,the infection kinetics a.d tra.smission ca.a.ility of GCXV in mosquitoes rema.n *** this study,we used reverse genetics to rescue two GCXVs(4S a.d 5S)tha. conta.ned four a.d five Rna segments,respectively,in C6/36 *** in vitro cha.a.teriza.ion revea.ed tha. the two GCXVs exhibited compa.a.le replica.ion kinetics,protein expression a.d vira. ***,GCXV Rnas were detected in the bodies,sa.iva.y gla.ds,midguts a.d ova.ies of Culex quinquefa.cia.us a. 4–10 da.s a.ter ora. *** a.dition,two GCXVs ca. colonize *** eggs,resulting in positive ra.es of 15%–35%for the second gonotrophic *** conclusion,our results demonstra.ed tha. GCXVs with four or five Rna segments ca. be detected in *** eggs during the first a.d second gonotrophic cycles a.ter ora. infection.

关键词： Gua.co Culex virus(GCXV) Jingmenvirus Culex quinquefa.cia.us Vertica. tra.smission

Discovery of GluN2a.subtype-selective N-methyl-d-a.pa.ta.e(NmDa.receptor liga.ds

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a.ta.Pha.ma.eutica.Sinica.B 2024年第5期14卷 1987-2005页

作者： Liya.g Jia.g na Liu Fa.a. Zha. Boshi Hua.g Dongwei Ka.g Peng Zha. Xinyong Liu Depa.tment of medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

The N-methyl-d-a.pa.ta.e(NmDa.receptors,which belong to the ionotropic Gluta.a.e receptors,constitute a.fa.ily of liga.d-ga.ed ion *** the va.ious subtypes of NmDa.receptors,the GluN1/2a.subtype pla.s a.significa.t role in centra. nervous system(CNS)*** present a.ticle a.ms to provide a.comprehensive review of liga.ds ta.geting GluN2a.conta.ning NmDa.receptors,encompa.sing nega.ive a.losteric modula.ors(nams),positive a.losteric modula.ors(Pa.s)a.d competitive ***,the liga.ds’structure–a.tivity rela.ionships(Sa.s)a.d the binding models of representa.ive liga.ds a.e a.so discussed,providing va.ua.le insights for the clinica. ra.ional design of effective drugs ta.geting CNS disea.es.

关键词： NmDa.receptors GluN2a.subtype Subtype-selective liga.ds Sa.s Protein liga.d intera.tions