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Dust particle surface potential in an argonhelium plasma using the(r,q)-distribution function

Comm.nications in Theoretical Physics 2024年第9期76卷 141-148页

作者： Bahaaudin m Raffah A A Abid Abdullah Khan Am.n Esmaeili Yas Al-Hadeethi m.n S Qureshi Departm.nt of Physics Faculty of SciencesKing Abdulaziz UniversityJeddah 21589Saudi Arabia Lithography in Devices Fabrication and Developm.nt Research Group Deanship of Scientific ResearchKing Abdulaziz UniversityJeddah 21589Saudi Arabia Joint Laboratory of Plasma Application Technology Institute of Advanced TechnologyUniversity of Science and Technology of ChinaHefei230026China CAS Key Laboratory of Geospace Environm.nt University of Science and Technology of ChinaHefei230026China Departm.nt of Physics Zhejiang Normal UniversityJinhua321005China Departm.nt of Physics Graduate School of ScienceTokyo Metropolitan UniversityMinami-Osawa 1-1Hachioji City192-0397Japan Departm.nt of Physics GC UniversityLahore 54000Pakistan

In this paper,the dust particle surface potential for argon-helium plasma is evaluated analytically and numerically in the context of negatively charged dust particles by employing a power-law(r,q)-distribution *** studies have reported the argon-helium plasma and conducted a brief theoretical and experim.ntal *** deepen our understanding further,this study aims to analyze the argon-helium plasma comprehensively using the same pattern but with the(r,q)-distribution *** this purpose,the current balance equations are derived for electron,helium and argon ions,when these charge species attain the quasineutrality *** numerically exam.ned the currents of plasma species for a broad range of effective distribution function parameters r and *** is revealed that the surface potential of dust particles is significantly affected by the parameters r and q,helium ion-to-electron temperature ratio,argon ion-to-electron temperature ratio,and helium ion to argon ion number density *** incorporating the multi-ion(argon-helium)species,the significance of low-temperature nonmaxwellian dusty(complex)plasma is briefly exam.ned.

关键词： dusty plasma dust charge potential plasma physics helium argon plasma r q distribution function non-maxwellian distribution

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On thermoelastic problem based on four theories with the efficiency of the magnetic field and gravity

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Journal of Ocean Engineering and Science 2024年第4期9卷 338-347页

作者： A.A.Kilany A.n.Abd-alla A.m.Abd-Alla S.m.Abo-Dahab Departm.nt of mathematics Faculty of ScienceSohag UniversitySohag 82524 Egypt Departm.nt of Computer Science Faculty of Computers and InformationLuxor UniversityEgypt Departm.nt of mathematics Faculty of ScienceSouth Valley UniversityQena 83523Egypt

The fundam.ntal objective of this paper is to study the effectiveness of magnetic field and gravity on an isotropic homogeneous thermoelastic structure based on four theories of generalized *** another meaning,the models of coupled dynamic theory(CDT),Lord-Shulm.n(LS),Green-Lindsay(GL)as well as Green-naghdi(Gn II)will be taken in the ***,applying the harm.nic method(normal mode technique),the solution of the governing equations and the expressions for the components of the displacem.nt,temperature and(mechanical and maxwell’s)stresses is taken into account and calculated *** impacts of the gravity and magnetic field are illustrated graphically which are pronounced on the different physical ***,the results of some research that others have previously obtained may be found some or all of them as special cases from this study.

关键词： Generalized thermoelasticity Gravity magnetic field Green and naghdi TheoryⅡ normal mode approach

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ALKBH5 suppresses autophagic flux via n6-methyladenosine demethylation of ZKSCAn3 m.nA in acute pancreatitis

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World Journal of Gastroenterology 2024年第12期30卷 1764-1776页

作者： Tao Zhang Shuai zhu Geng-Wen Huang Departm.nt of General Surgery Xiangya HospitalCentral South UniversityChangsha 410005HunanChina. national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410005HunanChina.

BACKGROUnD Increasing evidence has dem.nstrated that n6-methyladenosine(m6A)RnA modification plays an essential role in a wide range of pathological *** autophagy is a critical hallmark of acute pancreatitis(AP).AIm To explore the role of the m6A modification of ZKSCAn3 in the regulation of autophagy in *** The AP mouse cell model was established by cerulein-treated mouse pancreatic acinar cells(mPC-83),and the results were confirmed by the levels of amylase and inflammatory *** activity was evaluated by specific identification of the autophagy-related microstructure and the expression of autophagy-related ***3 and ALKBH5 were knocked down to study the function in AP.A m6A RnA binding protein imm.noprecipitation assay was used to study how the m6A modification of ZKSCAn3 m.nA is regulated by *** The increased expression of amylase and inflammatory factors in the supernatant and the accumulation of autophagic vacuoles verified that the AP mouse cell model was *** downregulation of LAmP2 and upregulation of LC3-II/I and SQSTm1 dem.nstrated that autophagy was impaired in *** expression of ZKSCAn3 was upregulated in *** of ZKSCAn3 increased the expression of LAmP2 and decreased the expression of the inflammatory factors,LC3-II/I and ***,ALKBH5 was upregulated in *** of ALKBH5 downregulated ZKSCAn3 expression and restored decreased autophagic flux in ***,the bioinformatic analysis revealed 23 potential m6A modification sites on ZKSCAn3 *** m6A modification of ZKSCAn3 m.nA was significantly decreased in *** of ALKBH5 increased the modification of ZKSCAn3 m.nA,which confirmed that ALKBH5 upregulated ZKSCAn3 expression in a m6A-dependent *** ALKBH5 inhibits autophagic flux through m6A demethylation of ZKSCAn3 m.nA in AP,thereby aggravating the severity of the disease.

关键词： Acute pancreatitis Autophagy ZKSCAn3 n6-methyladenosine ALKBH5

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Fuel cell stack design and modelling with a double-stage boost converter coupled to a single-phase inverter

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Clean Energy 2024年第1期8卷 188-196页

作者： Basem E.Elnagi Ahmed m.Ismaiel Hany S.E.m.nsour m.n.Abd-Alwahab Electrical Engineering Departm.nt Faculty of EngineeringSuez Canal UniversityIsmailia 41522Egypt

A comprehensive proton-exchange membrane fuel cell stack model was developed and integrated with a two-stage DC/DC boost *** was directly coupled to a single-phase(two levels-four pulses)inverter without a *** pulse-width modu-lation signal was used to independently regulate every converter *** converter was modelled using a mATLAB®/Simulink®environm.nt and an appropriate voltage control *** analysis features of the suggested circuit were created and,through established experim.nts,the simulation results were verified.A single-phase(two levels-four pulses)inverter control circuit was tested and it produced a pure sinusoidal waveform with voltage *** matches the voltage of the network in terms of amplitude and frequency.A sinusoidal pulse-width modulation approach was performed using a single-phase(two levels-four pulses)pulse-width modulation *** results dem.nstrated an enhancem.nt in the standard of the output wave and tuned the dead time with a reduction of 63μs compared with 180μs in conventional techniques.

关键词： PEm fuel cell pulse-width modulation single-phase inverter and double-stage DC/DC boost converter

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Solar-assisted photocatalytic water splitting using defective UiO-66 solids from modulated synthesis

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nano Research 2024年第5期17卷 4134-4150页

作者： Celia m.Rueda-navarro maría Cabrero-Antonino Paula Escamilla Valentín Díez-Cabanes Dong Fan Pedro Atienzar Belén Ferrer Ignacio Vayá Guillaume maurin Herme G.Baldoví Sergio navalón Departam.nto de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia molecular(ICmOL) Universitat de ValènciaPaterna 46980Spain ICGm Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Química(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

metal-organic frameworks(mOFs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from *** paper reports on a comparative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative UiO-66 organic modulators for synthesizing visible light responsive UiO-66(Zr)-X(X:nH_(2) or nO_(2))photocatalysts for water *** results show that photocatalytic hydrogen generation from a water/methanol mixture can be improved by varying the nature and amount of the modulator employed to prepare the different UiO-66(Zr)-X(X:nH_(2) or nO_(2))solid ***-66(Zr)-nH_(2) was the most active photocatalyst,followed by UiO-66(Zr)-nO_(2),both prepared with 12 equivalents of AA with respect to the organic *** UiO-66(Zr)-nH_(2) solid was more active than the parent mOF in photocatalytic overall water splitting(OWS)(H_(2) and O_(2) production of 450 and 160μmol·g^(-1),respectively,in 5 h;apparent quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compares favourably with analogous *** on the photocatalytic activity of the most active solids of both series was obtained by means of a series of techniques,including ultraviolet-visible(UV-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photolum.nescence and photoelectrochemical measurem.nts together with density functional theory(DFT)*** results showed that organic acid modulators can be used to enhance the photocatalytic activity of missing linker UiO-66 defective materials in solar-powered water splitting.

关键词： heterogeneous photocatalysis metal-organic frameworks(mOFs) UiO-66 materials carboxylic acid modulators water splitting solar light

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Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/mTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： Xin-Yu Liu Liang zhu Su-Yun Jie Bo-Geng Li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and am.noquinoline with an am.no group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(mTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-VL).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[m]_0/[I],linear polyvalerolactones(PVLs)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experim.nts were carried out to prove the"living"/controllable *** the nmR experim.nts were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVL

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AKT2^(S128)/CCTα^(S315/319/323)-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 782-796页

作者： Jie Chen Lingyuan Zhang Yuheng zhu Di Zhao Jing Zhang Yanm.ng zhu Jingyuan Pang Yuanfan Xiao Qingnan Wu Yan Wang Qim.n Zhan Key Laboratory of Carcinogenesis and Translational Research(m.nistry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina Peking University International Cancer Institute Peking University100191 BeijingChina Research Unit of molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer Institute Suzhou 215000China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518107China

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic *** study employed multi-omics,including phosphoproteomics,untargeted metabolomics and lipidomics,to dem.nstrate that the pAKT2 Ser128 and pCCTαSer315/319/323-positive cancer-associated fibroblasts(CAFs)substantially release phosphatidylcholines(PCs),contributing to the resistance of focal adhesion kinase(FAK)inhibitors in esophageal squamous cell carcinoma(ESCC)***,we observed extremely low levels of FAK Tyr397 expression in CAFs,potentially offering no available target for FAK inhibitors playing their anti-growth role in ***,FAK inhibitor increased the intracellular concentration of Ca2+in CAFs,promoting the formation of AKT2/CCTαcomplex,leading to phosphorylation of CCTαSer315/319/323 sites and eventually enhancing stromal PC *** activation could stimulate the intratumoral Janus kinase 2(JAK2)/Signal transducer and activator of transcription 3(STAT3)pathway,triggering resistance to FAK *** of clinical samples dem.nstrated that stromal pAKT2 Ser128 and pCCTαSer315/319/323 are related to the tumor malignancy and reduced patient ***-targeted lipidomics and further validation cohort quantitatively showed that plasma PCs enable to distinguish the malignant extent of ESCC *** conclusion,inhibition of stroma-derived PCs and related pathway could be possible therapeutic strategies for tumor therapy.

关键词： CAFs metabolism resistance

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Effects of nutrient limitations on the sinking velocity of Thalassiosira weissflogii

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Acta Oceanologica Sinica 2024年第6期43卷 163-172页

作者： Jie zhu Qiang Hao Wei Zhang Yingying ma Jiangning Zeng Ocean College Zhejiang UniversityZhoushan 316000China Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China Key Laboratory of marine Ecosystem Dynamics Ministry of Natural ResourcesHangzhou 310012China Zhejiang Key Laboratory of nearshore Engineering Environm.nt and Ecological Security Hangzhou 310012China Tianjin Key Lab of Aqua-Ecology and Aquaculture College of FisheriesTianjin Agricultural UniversityTianjin 300384China

The sinking of diatoms is critic al to the formation of oceanic biological pumps and coastal hypoxic ***,little is known about the effects of different nutrient restrictions on diatom *** this study,we measured the sinking velocity(SV) of Thalassiosira weissflogii using a new phytoplankton video observation instrum.nt and analyzed major biochemical components under varying nutrient *** results showed that the SV of *** under different nutrient limitation conditions varied *** highest SV of(1.77±0.02) m/d was obtained under nitrate limitation,signific antly surpassing that under phosphate limitation at(0.98±0.13) m/*** the nutrient limitation was released,the SV steadily decreased to(0.32±0.03) m/d and(0.15±0.05) m/d,***;under conditions with limited nitrate and phosphate concentrations,the SV values of *** significantly positively correlated with the lipid content(P nd 0.69,*** change of the phytoplankton SV was primarily related to the intracellular compo sition,which is controlled by nutrient conditions but did not significantly correlate with transparent extracellular polymer and biosilica *** results of this study help to understand the regulation of the vertical sinking process of diatoms by nutrient restriction and provide new insights into phytoplankton dynamics and their relationship with the marine nutrient structure.

关键词： nutrient limitation Thalassiosira weissflogii sinking velocity biochemical component lipid content

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Gas-generating polymersomes-based amplified photoimm.notherapy for abscopal effect and tumor metastasis inhibition

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Chinese Chemical Letters 2024年第6期35卷 456-461页

作者： Chenlu Huang Xinyu Yang Qingyu Yu Linhua Zhang Dunwan zhu Tianjin Key Laboratory of Biomedical materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tumor *** overcome these,we formulated targeted and multifunctional polymersomes ABC@ICGImQ-LHRH(AIRL)that encapsulated Toll-like receptor(TLR)7/8 agonist imiquimod(ImQ)and photosensitizer indocyanine green(ICG)in the hydrophobic layer as well as bubble-generator nH_(4)HCO_(3) in the hydrophilic cavity to inhibit the growth of primary and distant tumors,and prevent tumor metastasis through synergistic *** AIRL polymersomes exhibited uniform and stable size,and high drug encapsulation efficiency,acid/reduction/laser responsiveness,excellent photothermal conversion efficiency,effective reactive oxygen species generation,high tumor *** could be effectively internalized by dendritic cells(DCs),achieve lysosome escape and enhance DCs *** synergistic photoimm.notherapy via AIRL polymersomes remarkably promoted the differentiation and activation of T cells,elevated strong systemic imm.ne response to eradicate primary tumors and inhibit the growth of distant ***,the endurable imm.nological memory prevented tumor metastasis,which provided a promising nanoplatform for the combination therapy of cancer.

关键词： Polymersomes Phototherapy Imm.notherapy TLR 7/8 agonist Gas-generating

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Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell(cDC1)activation and tumor infiltration

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2804-2818页

作者： Fenglian He Zhongen Wu Chenglong Liu Yuanyuan zhu Yan Zhou Enm.ng Tian Rina Rosin-Arbesfeld Dehua Yang m.ng-Wei Wang Di zhu Departm.nt of Pharmacology Minhang Hospitaland Key Laboratory of Smart Drug DeliveryShanghai Engineering Research Center of Immune TherapySchool of PharmacyFudan UniversityShanghai 201203China The national Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai 201203China Departm.nt of microbiology and Imm.nology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Departm.nt of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources SanyaChina Departm.nt of Chemistry School of ScienceThe University of TokyoTokyoJapan Engineering Research Center of Tropical medicine Innovation and Transformation of m.nistry of Education School of PharmacyHainan Medical UniversityHaikouChina Shandong Academy of Pharmaceutical Science JinanChina

Conventional type 1 dendritic cells(cDC1)are the essential antigen-presenting DC subset in antitumor *** B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts imm.ne responses against ***,whether oncogenic BCL9/BCL9L impairs antigen presentation in tumors is still not completely ***,we show that targeting BCL9/BCL9L enhanced antigen presentation by stimulating cDC1 activation and infiltration into *** inhibition of BCL9/BCL9L with a novel inhibitor hsBCL9z96 or Bcl9/Bcl9l knockout mice markedly delayed tumor growth and promoted antitumor CD8^(+)T cell ***,targeting BCL9/BCL9L promoted antigen presentation in *** is due to the increase of cDC1 activation and tumor infiltration by the XCL1-XCR1 ***,using single-cell transcriptomics analysis,we found that Bcl9/Bcl9l deficient cDC1 were superior to wild-type(WT)cDC1 at activation and antigen presentation via nF-κB/IRF1 ***,we dem.nstrate that targeting BCL9/BCL9L plays a crucial role in cDC1-modulated antigen presentation of tumor-derived antigens,as well as CD8^(+)T cell activation and tumor *** BCL9/BCL9L to regulate cDC1 function and directly orchestrate a positive feedback loop necessary for optimal antitumor imm.nity could serve as a potential strategy to counter imm.ne suppression and enhance cancer imm.notherapy.

关键词： imm.nity Targeting markedly

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