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Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor Siew-Keah Lee Dharm.ni Devi m wei Chih Ling Departm.nt of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Departm.nt of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHR).methods:Wistar-Kyoto(WKY)rats and SHR were divided into four groups;WKY control,SHR control and SHR treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatm.nt was given daily for 4 weeks by oral gavage and the blood pressure was m.nitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine m.nophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in SHR treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine m.nophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine m.nophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

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Effect of chloride ion on corrosion behavior of low carbon steel in 0.1 m.naHCO_3 solution with different dissolved oxygen concentrations

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Journal of materials Science & Technology 2019年第4期35卷 596-603页

作者： Fang Xue Xin wei Junhua Dong Changgang Wang wei Ke Institute of metal Research Chinese Academy of Sciences University of Science and Technology of China

The corrosion behavior of low carbon steel in 0.1 m.naHCO_3+ 0.1 m.naCl solution with different dissolved oxygen concentrations was investigated with gravimetric tests and electrochemical *** show that the corrosion mass loss of steel is remarkably increased with the addition of chloride ion. In the initial stage, the carbon steel tends to active dissolution due to the dissolution effect of chloride ion on the oxide film; as a result, the corrosion potential maintains as low values. With the immersion time going by, the corrosion potential of the steel is promoted as a result of the accumulation of the corrosion products. However, the rust layer is loose and porous due to the deteriorating effect of chloride ion, which decreases the reduction resistance of oxygen. meanwhile, the porous rust layer could be repaired by the depolarization of oxygen. Under the synergistic effect of chloride ion and oxygen, the corrosion of the steel is accelerated during the repeated process of dissolution and reparation of the oxide film.

关键词： Carbon steel Chloride ion Electrochemical measurem.nts Rust characterization Localized corrosion

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RECOVERY BASED FInITE ELEm.nT mETHOD FOR BIHARm.nIC EQUATIOn In 2D

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Journal of Computational mathematics 2020年第1期38卷 84-102页

作者： Yunqing Huang Huayi wei wei Yang nianyu Yi Key Laboratory of Intelligent Computing&Information Processing of m.nistry of Education School of Mathematics and Computational ScienceXiangtan UniversityXiangtan 411105China Hunan Key Laboratory for Computation and Simulation in Science and Engineering School of Mathematics and Computational ScienceXiangtan UniversityXiangtan 411105China

We design and numerically validate a recovery based linear finite elem.nt method for solving the biharm.nic *** main idea is to replace the gradient operator▽on linear finite elem.nt space by G(▽)in the weak formulation of the biharm.nic equation,where G is the recovery operator which recovers the piecewise constant function into the linear finite elem.nt *** operator G,Laplace operator△is replaced by▽·G(▽).Furthermore,the boundary condition on normal derivative▽u-n is treated by the boundary penalty *** explicit matrix expression of the proposed method is also *** examples on the uniform and adaptive meshes are presented to illustrate the correctness and effectiveness of the proposed method.

关键词： Biharm.nic equation Linear finite elem.nt Recovery Adaptive

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A m.nitoring-modeling approach to SO_4^(2-) and nO_3^- secondary conversion ratio estimation during haze periods in Beijing, China

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Journal of Environm.ntal Sciences 2019年第4期31卷 293-302页

作者： Xiaoqi Wang wei wei Shuiyuan Cheng Chong Zhang Wenjiao Duan Key Laboratory of Beijing on Regional Air Pollution Control Beijing University of Technology Collaborative Innovation Center of Beijing City Traffic Beijing University of Technology

SO_4^(2-) and nO_3^- are important chemical components of fine particulate matter(Pm_(2.5)),especially during haze *** study selected two haze episodes in Beijing,China with similar meteorological conditions.A m.nitoring-modeling approach was developed to estimate the secondary conversion ratios of sulfur and nitrogen based on m.nitored and simulated *** showed that in Episode 1(24th–25th October,2014),the concentrations(proportions)of SO_4^(2-) and nO_3^- reached 35.1μg/m^3(14.9%) and 55.0μg/m^3(22.9%),while they reached 14.4μg/m^3(9.3%) and 59.1μg/m^3(38.1%)in Episode 2(26th–27th October,2017).A modeling system was applied to apportion Beijing's SO_4^(2-) and nO_3^- in primary and secondary SO_4^(2-)/nO_3^- emitted from local and regional ***,secondary conversion contributions considering the local and regional level were *** former primarily focused on Beijing atmospheric oxidation ability and the latter mainly considered the existence form of Beijing SO_4^(2-)/nO_3^- under the regional transport ***,secondary oxidation ratios were estimated through combining secondary conversion contribution coefficients for simulated and m.nitored *** regional level,sulfur oxidation ratios in polluted(clean)days during two sampling periods were0.57–0.72(0.07–0.52)and 0.74–0.80(0.08–0.61),nitrogen oxidation ratios were 0.20–0.29(0.05–0.15)and 0.34–0.38(0.02–0.29),indicating that atmospheric oxidation was enhanced when considering regional transport through 2014–*** the local level,sulfur oxidation ratios were 0.66–0.71(0.04–0.48)in haze(clean)days,while nitrogen oxidation ratios were0.16–0.29(0.02–0.16).The atmospheric oxidation ability markedly increased in Pm_(2.5)pollution days,but changed only slightly between the two periods.

关键词： Haze periods SO42- and nO3- Secondary conversion Secondary oxidation ratio

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Anaerobic co-digestion of m.nicipal biomass wastes and waste activated sludge: Dynamic model and material balances

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Journal of Environm.ntal Sciences 2013年第10期25卷 2112-2122页

作者： Yifei Sun Dian Wang wei Qiao wei Wang Tianle Zhu School of Chemistry and Environm.nt Beihang University College of Chemical Science and Engineering China University of Petroleum School of Environm.nt Tsinghua University

The organic matter degradation process during anaerobic co-digestion of m.nicipal biomass waste （mBW） and waste-activated sludge （WAS） under different organic loading rates （OLRs） was investigated in bench-scale and pilot-scale semi-continuous stirred tank reactors. To better understand the degradation process of mBW and WAS co-digestion and provide theoretical guidance for engineering application, anaerobic digestion model no. 1 was revised for the co-digestion of mBW and WAS. The results showed that the degradation of organic matter could be characterized into three different fractions, including readily hydrolyzable organics, easily degradable particulate organics, and recalcitrant particle organics. Hydrolysis was the rate-limiting step under lower OLRs, and methanogenesisis was the rate-limiting step for an OLR of 8.0 kg volatile solid （VS）/（m^3·day）. The hydrolytic parameters of carbohydrate, protein, and lipids were 0.104, 0.083, and 0.084 kg chemical oxygen dem.nd （COD）/（kg COD·hr）, respectively, and the reaction rate parameters of lipid ferm.ntation were 1 and 1.25 kg COD/（kg ***） for OLRs of 4.0 and 6.0 kg VS/（m^3·day）. A revised model was used to simulate methane yield, and the results fit well with the experim.ntal data. material balance data were acquired based on the revised model, which showed that 58.50% of total COD was converted to methane.

关键词： anaerobic digestion material balances kinetic parameters modelling m.nicipal biomass waste

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Preoperative biliary drainage in patients with hilar cholangiocarcinoma undergoing major hepatectomy

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World Journal of Gastroenterology 2013年第46期19卷 8731-8739页

作者： Jun-Jie Xiong Quentin m.nunes wei Huang Samir Pathak Ai-Lin wei Chun-Lu Tan Xu-Bao Liu Departm.nt of Hepato-Biliary-Pancreatic Surgery West China HospitalSichuan University nIHR Liverpool Pancreas Biomedical Research Unit Department of Molecular and Clinical Cancer MedicineRoyal Liverpool University HospitalUniversity of Liverpool Sichuan Provincial Pancreatitis Center Department of Integrated Traditional Chinese and Western MedicineWest China HospitalSichuan University

AIm:To investigate the effect of preoperative biliary drainage(PBD)in jaundiced patients with hilar cholangiocarcinoma(HCCA)undergoing major liver ***:An observational study was carried out by reviewing a prospectively maintained database of HCCA patients who underwent major liver resection for curative therapy from January 2002 to December *** were divided into two groups based on whether PBD was performed:a drained group and an undrained *** baseline characteristics,preoperative factors,perioperative and short-term postoperative outcomes were compared between the two *** factors for postoperative complications were also analyzed by logistic regression test with calculating OR and 95%***:In total,78 jaundiced patients with HCCA underwent major liver resection:32 had PBD prior to operation while 46 did not have *** two groups were comparable with respect to age,sex,body mass index and ***,there was no significant difference in the total bilirubin(TBIL)levels between the drained group and the undrained group at admission(294.2±135.7 vs 254.0±63.5,P=0.126).PBD significantly improved liver function,reducing not only the bilirubin levels but also other liver *** preoperative TBIL level was significantly lower in the drained group as compared to the undrained group(108.1±60.6 vs 265.7±69.1,P=0.000).The rate of overall postoperative complications(53.1%vs 58.7%,P=0.626),reoperation rate(6.3%vs 6.5%,P=1.000),postoperative hospital stay(16.5 vs 15.0,P=0.221)and mortality(9.4%vs 4.3%,P=0.673)were similar between the two *** addition,there was no significant difference in infectious complications(40.6%vs 23.9%,P=0.116)and noninfectious complications(31.3%vs 47.8%,P=0.143)between the two *** and multivariate analyses revealed that preoperative TBIL>170μmol/L(OR=13.690,95%CI:1.275-147.028,P=0.031),Bismuth-Corlette classification(OR=0.013,95%CI:0.001-0.166,P=0.001)and extended

关键词： Obstructive jaundice Hilar cholangiocar-cinoma Preoperative biliary drainage major hepatec-tomy Surgical outcome

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A short review on natural gas hydrate, kinetic hydrate inhibitors and inhibitor synergists

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Chinese Journal of Chemical Engineering 2019年第9期27卷 2049-2061页

作者： wei Ke Daoyi Chen Division of Ocean Science and Technology Graduate School at Shenzhen Tsinghua University

Gas hydrate-caused pipeline plugging is an industrial nuisance for petroleum flow assurance that calls for technological *** thermodynamic inhibitors such as glycols and inorganic salts suffer from high dosing,environm.ntal unfriendliness,corrosiveness,and economical *** developm.nt and use of kinetic hydrate inhibitors(KHIs),mostly polymeric compounds,with their inhibiting effects on hydrate nucleation and growth are considered an effective and economically viable chemical treatm.nt for hydrate ***,the actual perform.nce of a KHI candidate is dependent on various factors including its chemical structure,molecular weight,spatial configuration,effective concentration,pressure and temperature,evaluation methods,use of other additives,*** review provides a short but systematic overview of the fundam.ntals of natural gas hydrates,the prevailing categories of polymeric kinetic hydrate inhibitors with proposed inhibition mechanisms,and the various synergists studied for boosting the KHI *** research endeavors are in need to unveil the KHI working modes under different *** conjunctive use of KHIs and synergists may facilitate the commercial application of effective KHIs to tackle the hydrate plugging problem in the oil and gas flow assurance practices.

关键词： Hydrate nucleation Kinetics Hydrate inhibitors Inhibition mechanism Inhibitor synergist

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DnA-PK inhibition by m3814 enhances chemosensitivity in non-small cell lung cancer

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3935-3949页

作者： m.nni Wang Siyuan Chen Yuquan wei Xiawei wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610000China

A significant proportion of non-small cell lung cancer(nSCLC) patients experience accumulating chemotherapy-related adverse events,motivating the design of chemosensitizating *** main cytotoxic damage induced by chemotherapeutic agents is DnA double-strand breaks(DSB).It is thus conceivable that DnA-dependent protein kinase(DnA-PK) inhibitors which attenuate DnA repair would enhance the anti-tumor effect of *** present study aims to systematically evaluate the efficacy and safety of a novel DnA-PK inhibitor m3814 in synergy with chemotherapies on *** identified increased expression of DnA-PK in hum.n nSCLC tissues which was associated with poor prognosis.m3814 potentiated the anti-tumor effect of paclitaxel and etoposide in A549,H460 and H1703 nSCLC cell *** the four combinations based on two nSCLC xenograft models and two chemotherapy,we also observed tumor regression at tolerated doses in ***,we identified a P53-dependent accelerated senescence response by m3814 following treatm.nt with paclitaxel/*** present study provides a theoretical basis for the use of m3814 in combination with paclitaxel and etoposide in clinical practice,with hope to aid the optimization of nSCLC treatm.nt.

关键词： m3814 Paclitaxel Etoposide DnA-dependent protein kinase non-small cell lung cancer DnA repair Cell senescence Chemosensitization

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Recyclable polythioesters and polydisulfides with near-equilibrium thermodynamics and dynamic covalent bonds

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Science China Chemistry 2023年第3期66卷 725-738页

作者： wei Xiong Hua Lu Beijing national Laboratory for molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The accumulation of discarded petroleum-based plastics causes serious environm.ntal ***,recyclable polymers with neutrality in thermodynamics,such as polyesters,polycarbonates,and polyolefins,have been developed as promising alternatives to traditional petroleum-based ***,the chemical recycle of these polymers usually requires high energy input and expensive *** covalent bonds,such as thioester and disulfide bonds,have emerged as building blocks for constructing recyclable polymers that can be rapidly degraded/recycled under mild *** this review,we introduce representative studies on recyclable polythioesters and polydisulfides with respect to their synthetic strategies,thermodynamic m.nipulation,physicochemical properties,and prelim.nary *** also highlight the important role of kinetic factors played in the design of recyclable ***,major challenges,perspectives,and future opportunities in the synthesis and applications of polythioesters/polydisulfides are discussed.

关键词： polythioesters polydisulfides recyclable near-equilibrium thermodynamics dynamic covalent bond

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microstructure observation and mechanical behavior modeling for limnetic nacre

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Acta mechanica Sinica 2008年第1期24卷 83-89页

作者： Shuchun Zuo Yueguang wei Lnm Institute of mechanics Chinese Academy of Sciences 100080 Beijing China

In the present research, microstructure of akind of limnetic shell （Hyriopsis cum.ngii） is observed and measured by using the scanning electron microscopy, and mechanical behavior experim.nts of the shell nacre are carried out by using bending and tensile tests. The dependence of mechanical properties of the shell nacre on its microstructure is analyzed by using a modified shear-lag model, and the overall stress-strain relation is obtained. The experim.ntal results reveal that the mechanical properties of shell nacre strongly depend on the water contents of the limnetic shell. Dry nacre shows a brittle behavior, whereas wetting nacre displays a strong ductility. Compared to the tensile test, the bending test overestimates the strength and underestimates the Young＇s modulus. The modified shear-lag model can characterize the deformation features of nacre effectively.

关键词： nacre. microstructure Shear-lag model .mechanical property

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