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Obstetric Outcomes in Advanced maternal Age among Women at King Abdulaziz University Hospital

Open Journal of Obstetrics and Gynecology 2023年第1期13卷 108-120页

作者： Rawan A. gari Ghaday m. Alrefaei Shatha A. Alsuwaida Zahra m. Alalwan Zahraa H. Aljeshi Amenah H. Al Jumah Department of Obstetrics and Gynecology King Abdulaziz University Hospital Jeddah Saudi Arabia Faculty of medicine King Abdulaziz University Jeddah Saudi Arabia

Background: Advanced maternal age, over 35 years, is a well-known risk factor for poor pregnancy outcomes. It is commonly associated with various pregnancy complications, such as spontaneous miscarriage, preeclampsia/ toxemia, gestational diabetes mellitus, preterm labor, stillbirth, chromosomal abnormalities, and cesarean delivery. Objectives: This study assessed obstetric and neonatal complications associated with advanced maternal age. methods: We reviewed the medical records of 199 pregnant women over 35 years old at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, from January to June 2022. We gathered data on age, nationality, number of antenatal visits, results of ultrasound scans for dating and viability, nuchal translucency and anatomy surveys, medications and multivitamins taken during pregnancy, smoking status, pregnancy, and fetal complications, and mode of delivery. Results: The prevalence of obstetric complications was 71.4% (preeclampsia/toxemia, 4.5%;antepartum hemorrhage, 4%;postpartum hemorrhage, 1%;and gestational diabetes, 23.1%). The most frequent complication was preterm labor between 34 and 36 weeks (48%), and only 12.6% of all deliveries were associated with fetal and neonatal complications such as congenital anomalies and neonatal jaundice. The prevalence of anemia during pregnancy was 10.1%, 21.1%, and 28.6% in the first, second, and third trimesters, respectively, and pregnancies complicated with antepartum or postpartum hemorrhage were associated with higher rates of anemia in the second trimester. A significant relationship was found between mean maternal age (38.84 ± 2.75 years) and the development of maternal complications (p mplications were much more likely to be born to mothers with a history of antepartum hemorrhage and anemia in the second trimester. Conclusion: Our findings confirm that pregnancy at an advanced maternal age is associated with increased overall maternal complications. T

关键词： Advanced maternal Age Preeclampsia/Toxemia Pregnancy Outcomes Com-plications KAUH Jeddah

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Sunitinib Reduces Acute myeloid Leukemia Clonogenic Cells in Vitro and Has Potent Inhibitory Effect on Sorted AmL ALDH+ Cells

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Open Journal of Blood Diseases 2016年第1期6卷 9-16页

作者： Asad m. Ilyas Youssri Ahmed m.m.ooh gari mohammed H. Alqahtani Taha A. Kumosani Abdulrahman L. Al-malki Khalid O. Abualnaja Saad H. S. Albohairi Adeel G. A. Chaudhary Farid Ahmed Centre of Excellence in Genomic medicine Research King Abdulaziz University Jeddah Saudi Arabia Department of Biochemistry Faculty of Science King Abdulaziz University Jeddah Saudi Arabia Production of Bioproducts for Industrial Applications Research Group Experimental Biochemistry Unit King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia microbial Biotechnology Department National Research Center Cairo Egypt Bioactive Natural Products Research Group Experimental Biochemistry Unit King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia King Abdulaziz University Hospital Jeddah Saudi Arabia

Sunitinib is an orally administered, multi-target tyrosine kinase inhibitor that has been approved by the FDA for the treatment of renal cell carcinoma and imatinib resistant gastro-intestinal tumors. Anti-leukemic activity of sunitinib has been examined in early clinical trials with limited success. However, recent trials on acute myeloid leukemia (AmL) patients carrying FLT3 mutations have shown promising results. Effects of sunitinib on leukemic clonogenic cells and potential leukemic stem cells have not been examined so far. We analyzed the anti-proliferative and apoptotic properties of sunitinib on AmL-derived cell lines. We also tested the effect of sunitinib on AmL patient derived clonogenic cells (AmL-CFC), as well as flow-sorted potential leukemic progenitors. Peripheral blood or bone marrow samples were obtained from newly diagnosed AmL patients and flow sorted for CD34+ CD133+ or ALDH+ cells. Umbilical cord blood derived CD34+ cells were used as normal controls. Sunitinib induced growth arrest and apoptosis in AmL derived cell lines. In addition, 7 μm sunitinib induced 75% reduction of AmL-CFC as compared to DmSO treated control (±6.79%;n = 4). In contrast, 7 μm sunitinib treatment of umbilical cord blood derived normal CD34+ cells showed 29% reduction in AmL-CFC (±6.77%;n = 5). Treatment of ALDH+ cells sorted from 2 AmL cases and CD34+ CD133+ cells from one patient showed reduction of AmL-CFC on treatment with sunitinib. Our study highlighted a potent anti-proliferative and proapoptotic effect of sunitinib on AmL cell lines, AmL patient derived clonogenic cells and potential leukemic stem cells.

关键词： Acute myeloid Leukemia Sunitinib Tyrosine Kinase Inhibitor AmL-CFC Leukemic Stem Cells

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基于机载LiDAR数据估测林分平均高

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林业科学研究 2020年第4期33卷 59-66页

作者：赵勋岳彩荣李春干张丽梅谷雷西南林业大学林学院云南昆明650224 广西大学林学院广西南宁530004 西南林业大学园林园艺学院云南昆明650224

[目的]以2016年9月广西壮族自治区高峰林场实验区获取的机载LiDAR点云数据为基础,通过提取30 m×30 m空间林分尺度下的LiDAR点云特征变量实现对林分平均高的估测。[方法]首先将105块实测林分平均高度的样地数据按照3:1的比例随机划分为... 详细信息

[目的]以2016年9月广西壮族自治区高峰林场实验区获取的机载LiDAR点云数据为基础,通过提取30 m×30 m空间林分尺度下的LiDAR点云特征变量实现对林分平均高的估测。[方法]首先将105块实测林分平均高度的样地数据按照3:1的比例随机划分为训练样本(79)和检验样本(26),采用随机森林回归(RFR)和支持向量回归(SVR)两种机器学习算法对79个训练样本与对应的林分LiDAR点云特征变量回归建模。建模方案包括随机森林模型、支持向量机模型及随机森林+支持向量机组合模型。其次利用26个检验样本数据评价模型预测精度。最后统计3个模型中训练样本和检验样本对应的精度评价指标,以一个预测精度高、泛化能力强的模型作为最终模型进行林分平均高制图。[结果]表明:随机森林模型的训练样本和检验样本的决定系数(R2)分别为0.8861和0.8375,均方根误差(RmSE)分别为1.22和1.56;支持向量机模型的训练样本和检验样本的决定系数(R2)分别为0.8864和0.8409,均方根误差(RmSE)分别为1.21和1.54;组合模型的训练样本和检验样本的决定系数(R2)分别为0.8598和0.8532,均方根误差(RmSE)分别为1.35和1.48;[结论]组合模型的泛化能力及预测精度最好,支持向量机次之,最后为随机森林。利用组合模型可有效完成研究区林分平均高制图。

关键词：机载LiDAR点云数据随机森林回归支持向量回归林分平均高高峰林场

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一种可能的制革体系:三元溶剂(水-乙醇-乙酸乙酯)在制革中的应用

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中国皮革 2019年第2期48卷 43-44,45-50,52页

作者： Solomon Fessehaye Bhargavi Narayana Reddy gari Rathinam Aravindhan Kalarical Janardhanan Sreeram Jonnalagadda Raghava Rao1 Balachandran Unni Nair 王玉增(译) 中央皮革研究所科学与工业研究中心化学实验室钦奈安达亚印度皮革技术局皮革行业发展研究所24692代码1000 四川大学

报道了一种尝试利用三元混合溶剂代替水(7～10 m^3/t)在制革中的应用,该混合溶剂具有比水更低的沸点(便于通过蒸发回收),对传统染料、合成鞣剂及加脂剂具有较大溶解度。该三元混合溶剂(水-乙醇-乙酸乙酯)对制革试剂具有较好的溶解分散能... 详细信息

报道了一种尝试利用三元混合溶剂代替水(7～10 m^3/t)在制革中的应用,该混合溶剂具有比水更低的沸点(便于通过蒸发回收),对传统染料、合成鞣剂及加脂剂具有较大溶解度。该三元混合溶剂(水-乙醇-乙酸乙酯)对制革试剂具有较好的溶解分散能力,合成鞣剂及染料在混合溶剂和水中的平均分散粒子大小是一样的,但是混合溶剂对染料及合成鞣剂粒子的分散更有利,即在混合溶剂中分散性更好。试验发现,与传统方法相比,鞣制后的中和过程在混合溶剂中使用中和合成鞣剂更容易获得性能优异的皮革。在水和混合溶剂中进行的染料吸附试验符合弗罗德利克吸附理论,说明染料的吸附是多分子层吸附。试验组的皮革的物理性能与对照组非常相似,说明该混合溶剂不会对胶原产生不利影响,并且对制革试剂具有较好的分散和固定作用。因此,该方法可以通过对制革生产工序中小的改变,提供有效的节水方案。

关键词：三元混合溶剂弗罗德利希吸附模型扩散

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