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mETA-R:A software to analyze data from multi-environment plant breeding trials

The Crop Journal 2020年第5期8卷 745-756页

作者： Gregorio Alvarado Francisco m.rodríguez Angela Pacheco Juan Burgueño JoséCrossa mateo Vargas Paulino Pérez-rodríguez marco A.Lopez-Cruz Biometrics and Statistics Unit International Maize and Wheat Improvement Center(CIMMYT)MexicoDF 6-64106600Mexico Centro de Investigación en matemáticas(CImAT)A.C. Jalisco S/NCol.ValencianaGuanajuatoGto 40236023Mexico Universidad Autónoma Chapingo Carretera Federal México-Texcoco km 38.5TexcocoMéxico 6356230Mexico Colegio de Postgraduados Carretera México-Texcoco Km.36.5MontecilloTexcoco 6356231Mexico Department of Plant Soil and Microbial SciencesMichigan State University1066 Bogue StEast LansingMI 48824USA

mETA-R(multi-environment trial analysis in R)is a suite of R scripts linked by a graphical user interface(GUI)designed in Java *** objective of mETA-R is to accurately analyze multi-environment plant breeding trials(mETs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(RCBD)and the alpha-lattice/lattice ***-R simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense *** parameters are very important in the selection of top performing genotypes in plant ***-R also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical *** genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated ***-R performs multi-environment analyses by using the residual maximum likelihood(REmL)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability.

关键词： environments breeding variance

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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

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Evaluation of vaccine rollout strategies for emerging infectious diseases:A model-based approach including protection attitudes

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Infectious Disease modelling 2023年第4期8卷 1032-1049页

作者： mauricio Paton Juan m.Acuna Jorge rodríguez Department of Chemical Engineering College of EngineeringKhalifa UniversitySAN Campus PO Box 127788Abu DhabiUnited Arab Emirates Department of Epidemiology and Public Health College of Medicine.Khalifa UniversityPO Box 127788Abu DhabiUnited Arab Emirates

Vaccine allocation strategies become crucial during vaccine shortages,especially in the face of potential outbreaks of new infectious diseases,as witnessed during the COVID-19 *** address this,a specialized compartmental model is created,which simulates an emerging infectious disease similar to *** model divides the population into different age groups and is used to compare various vaccine prioritisation approaches,aiming to minimize the total number of *** model is an improvement upon previous ones as it incorporates essential behavioural factors and is adapted to account for the protective effects of vaccination against both disease infection and *** takes into account human behaviors such as mask-wearing and social distancing by utilizing specific parameters related to self-protection,awareness levels,and the frequency of daily person-to-person interactions within each age ***,a novel method for dynamic vaccine prioritisation was introduced in this *** approach is model-independent and relies on the dynamic R *** is the first time such a method has been developed,offering a decision-making approach that is not tied to any specific *** innovation provides a flexible and adaptable strategy for determining vaccine priorities based on real-time data and the current state of the *** findings reveal crucial insights into vaccine allocation *** the daily rollout rates are fast(0.75%or higher)and children are eligible for vaccination,prioritising groups with high daily person-to-person interactions can lead to substantial reductions in total fatalities(up to approximately 40%lower).On the other hand,if rollout rates are slower and overall vaccination coverage is high,focusing on vaccinating elders emerges as the most effective strategy,resulting in up to approximately 10%fewer ***,the scenario changes significantly when children are not eligible for vaccination

关键词： behaviour slower utilizing

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Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate

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Journal of Integrative Agriculture 2015年第1期14卷 131-139页

作者： Abdelfattah Z m Salem German Buendía-rodríguez mona m m Elghandour maría A mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego Juan C V Chagoyán maría A Cerrillo miguel A rodríguez Faculty of Veterinary medicine and Animal Science Autonomous University of the State of Mexico National Center of Disciplinary Research in Animal Physiology and Improvement INIFAP Ajuchitlán Institute of Agricultural Sciences Autonomous University of HidalgoEx-Hda. of Aquetzalpa Faculty of Veterinary medicine and Animal Science Juárez University of the Durango State

An in vitro gas production （GP） technique was used to investigate the effects of combining different doses of Salix babylonica extract （SB） with exogenous fibrolytic enzymes （EZ） based on xylanase （X） and cellulase （C）, or their mixture （XC; 1：1 v/v） on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture （50：50, w/w） as substrate. Four levels of SB （0, 0.6, 1.2 and 1.8 mL g-1 dry matter （Dm）） and four supplemental styles of EZ （1 μL g-1 Dm; control （no enzymes）, X, C and XC （1：1, v/v） were used in a 4×4 factorial arrangement. In vitro GP （mL g-1 Dm） were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant pH was determined, and then filtered to determine dry matter degradability （DmD）. Fermentation parameters, such as the 24 h gas yield （GY24）, in vitro organic matter digestibility （OmD）, metabolizable energy （mE）, short chain fatty acid concentrations （SCFA）, and microbial crude protein production （mCP） were also estimated. Results indicated that there was a SBxEZ interaction （P〈0.0001） for the asymptotic gas production （b）, the rate of gas production （c）, GP from 6 to 72 h, GP2 （P=0.0095）, and GP4 （P=0.02）. The SB and different combination of enzymes supplementation influenced （P〈0.001） in vitro GP parameters after 12 h of incubation; the highest doses of SB （i.e., 1.8 mL g-1 Dm）, in the absence of any EZ, quadratically increased （P〈0.05） the initial delay before GP begins （L） and GP at different incubation times, with lowering b （quadratic effect, P〈0.0001 ） and c （quadratic effect, P〈0.0001 ; linear effect, P=0.0018）. The GP was the lowest （P〈0.05） when the highest SB level was combined with cellulose. There were SBxEZ interactions （P〈0.001） for OmD, mE, the partitioning factor at 72 h of incubation （PF72）, GY24, SCFA, mCP （P=0.0143）, and pH （P=0.0008）. The OmD, mE, GY24 and SCFA with supplementation of SB extract at 1.8 mL g-1 Dm were h

关键词： cellulase degradability gas production Salix babylonica xylanase

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Observation of performance measures of STEmI in elderly after implementation of an updated protocol:results from a single center without coronary interventions

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Journal of Geriatric Cardiology 2022年第11期19卷 930-936页

作者： miguel rodríguez-Ramos General Hospital Camilo Cienfuegos Bartolome Maso and Mirto Streets Sancti SpiritusCuba

As life expectancy increases,heart conditions,and especially acute coronary syndromes(ACS),are becoming a greater health issue.[1-3]Accordingly,the number of elderly patients in registries of myocardial infarction,is increasingly growing.[4,5]However,elderly patients are less likely to be treated with invasive strategy compared to younger patients,despite their intrinsic greater risk.[6,7]Several reports have described how quality initiatives improve treatment of ST elevation myocardial infarction(STEmI).

关键词： coronary STEmI Observation

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machine learning applications on lunar meteorite minerals:From classification to mechanical properties prediction

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International Journal of mining Science and Technology 2024年第9期34卷 1283-1292页

作者： Eloy Peña-Asensio Josep m.Trigo-rodríguez Jordi Sort Jordi Ibáñez-Insa Albert Rimola Department of Aerospace Science and Technology Politecnico di MilanoMilano 20156Italy Institut de Ciències de l’Espai(ICE-CSIC) Campus UAB08193 Cerdanyola del VallèsSpain Institut d’Estudis Espacials de Catalunya(IEEC) Barcelona 08034Spain Departament de Física Universitat Autònoma de BarcelonaCerdanyola del Vallès E-08193Spain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Barcelona E-08010Spain Geosciences Barcelona(GEO3BCN-CSIC) E-08028 BarcelonaSpain Departament de Química Universitat Autònoma de BarcelonaBellaterra 08193Spain

Amid the scarcity of lunar meteorites and the imperative to preserve their scientific value,nondestructive testing methods are *** translates into the application of microscale rock mechanics experiments and scanning electron microscopy for surface composition *** study explores the application of machine Learning algorithms in predicting the mineralogical and mechanical properties of DHOFAR 1084,JAH 838,and NWA 11444 lunar meteorites based solely on their atomic percentage *** a prior-data fitted network model,we achieved near-perfect classification scores for meteorites,mineral groups,and individual *** regressor models,notably the KNeighbor model,provided an outstanding estimate of the mechanical properties—previously measured by nanoindentation tests—such as hardness,reduced Young’s modulus,and elastic *** considerations on the nature and physical properties of the minerals forming these meteorites,including porosity,crystal orientation,or shock degree,are essential for refining *** findings underscore the potential of machine Learning in enhancing mineral identification and mechanical property estimation in lunar exploration,which pave the way for new advancements and quick assessments in extraterrestrial mineral mining,processing,and research.

关键词： meteorites moon mineralogy machine learning mechanical properties

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Saxicolous lichen communities in three basins associated with mining activity in northwestern Argentina

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Journal of Arid Land 2023年第8期15卷 989-1005页

作者： Juan m HERNÁNDEZ Renato A GARCÍA Edith R FILIPPINI Cecilia ESTRABOU martha S CAÑAS Juan m rodrÍguez Faculty of Technology and Applied Sciences Regional Centre of Energy and Environment for Sustainable DevelopmentNational University of CatamarcaCatamarca 4700Argentina Laboratory of Biodiversity and Environmental Genetics National University of AvellanedaAvellaneda 1870Argentina Institute of Biological and Technological Research Centre for Ecology and Renewable Natural ResourcesFaculty of ExactPhysical and Natural SciencesNational University of CordobaCordoba 5000Argentina

mining activity affects the vegetation and soils of the ***,the effects of mining activity on saxicolous lichen communities are less ***,the aim of this study was to characterize saxicolous lichen communities in three basins(Vis-Vis River basin,Poteros River basin,and Capillitas River basin)surrounding metalliferous mining projects of different types of operation and at different stages of exploitation.A large-scale mine(Bajo de la Alumbrera)with more than 25 a of open-pit mining located in the Vis-Vis River basin(CRV).A pre-exploitation mine(Agua Rica)located in the Poteros River basin(CRP),and a small-scale mine(minas Capillitas)with more than 160 a of underground mining located in the Capillitas River basin(CAC).In each basin,species richness,cover,and frequency of lichen communities were measured on 40 rock ***,explanatory variables were recorded,i.e.,altitude,slope,aspect,vegetation cover,rock,and soil cover around the rocky area *** and total cover of lichen communities were analysed using linear models,and species composition was explored using multivariate ordination *** showed that a total of 118 lichen species were *** species richness differed among basins and the lichen composition present in areas close to mining sites responded mainly to basins,altitude,and microsite *** lichen cover showed no difference among basins,but it changed under different rock and vegetation *** was not possible to quantify the effects of mining activity on species richness and ***,the low richness values found in the downstream of minera Alumbrera could be associated with the negative impact of open-pit ***,the effects of large-scale mining activity on lichen communities needs more investigation.

关键词： lichen community altitude microsite metalliferous mining vegetation

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Weak Continuity of Riemann Integrable Functions in Lebesgue-Bochner Spaces

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Acta mathematica Sinica,English Series 2010年第2期26卷 241-248页

作者： J.m.CALABUIG J.rodríguez E.A.SNCHEZ-PREZ Instituto Universitario de matemlica Pura y Aplicada Universidad Politcnica de Valencia

In general, Banach space-valued Riemann integrable functions defined on [0, 1] （equipped with the Lebesgue measure） need not be weakly continuous almost everywhere. A Banach space is said to have the weak Lebesgue property if every Riemann integrable function taking values in it is weakly continuous almost everywhere. In this paper we discuss this property for the Banach space LX^1 of all Bochner integrable functions from [0, 1] to the Banach space X. We show that LX^1 has the weak Lebesgue property whenever X has the Radon-Nikodym property and X＊ is separable. This generalizes the result by Chonghu Wang and Kang Wan [Rocky mountain J. math., 31（2）, 697-703 （2001）] that L^1[0, 1] has the weak Lebesgue property.

关键词： Riemann integral Bochner integral Lebesgue-Bochner space weak Lebesgue property

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Erratum to “On a Classical Theorem on the Diameter and minimum Degree of a Graph”

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Acta mathematica Sinica,English Series 2018年第12期34卷 1907-1910页

作者： Vernica HERNáNDEZ Domingo PESTANA José m.rodríguez Departamento de matemáticas Universidad Carlos Ⅲ de Madrid

The original version of the article was published in [1]. Unfortunately, the original version of this article contains a mistake： in Theorem 6.2 appears that β（n, △） = （n-△ ＋ 5）/4 but the correct statement is... 详细信息

关键词： Extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs

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Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies

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Neural Regeneration Research 2022年第9期17卷 1867-1874页

作者： Ignacio rodríguez-Polo Rüdiger Behr Research Platform Degenerative Diseases German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany German Center for Cardiovascular Research(DZHK) Partner Site GöttingenGöttingenGermany

Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement *** stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected by degenerative ***,the methods to derive human induced pluripotent stem cell and embryonic stem cell lines following clinical standards have quickly developed in the last 15 *** the preclinical validation of cell replacement therapies in non-human primates,it is necessary to generate non-human primate pluripotent stem cell with a homologous quality to their human ***,pluripotent stem cell technologies have developed at a slower pace in non-human primates in comparison with human cell *** recent years,however,relevant progress has also been made with non-human primate pluripotent stem *** review provides a systematic overview of the progress and remaining challenges for the generation of non-human primate induced pluripotent stem cells/embryonic stem cells for the preclinical testing and validation of cell replacement *** focus on the critical domains of(1)reprogramming and embryonic stem cell line derivation,(2)cell line maintenance and characterization and,(3)application of non-human primate pluripotent stem cells in the context of selected preclinical studies to treat cardiovascular and neurodegenerative disorders performed in non-human primates.

关键词： embryonic stem cells induced pluripotent stem cells non-human primates pluripotent stem cells preclinical regeneration reprogramming translational research

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