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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu mao-Ju Tang man Luo Xiao-Wu Zhong Qiang ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory medicine&Translational medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μm and 39.59μm,*** values decreased to 37.22μm and 22.71μm,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATm)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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An improved pulse coupled neural networks model for semantic IoT

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Digital Communications and Networks 2024年第3期10卷 557-567页

作者： Rong ma Zhen Zhang Yide ma Xiping Hu Edith C.H.Ngai Victor C.m.Leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and Computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic communication has attracted great attention as a new communication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse Coupled Neural Network(PCNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PCNN are determined by trial and error,which limits its *** overcome this limitation,an Improved Pulse Coupled Neural Networks(IPCNN)model is proposed in this *** IPCNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPCNN on the gray images and natural images from the matlab and Berkeley Segmentation *** IPCNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

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美国技术封锁对中国技术型跨境并购的影响

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科学学研究 2025年第1期43卷 38-48页

作者：马述忠李诗燕吴鹏浙江大学中国数字贸易研究院浙江杭州310058 浙江财经大学经济学院浙江杭州310018

本文基于证券数据公司全球并购(SDC m&A)数据库,运用DID方法探究美国技术封锁对中国向第三方经济体技术型跨境并购的影响。研究发现:美国对华技术封锁总体上促进了中国向第三方经济体实施技术型跨境并购,这一结论在变换识别策略、变换... 详细信息

本文基于证券数据公司全球并购(SDC m&A)数据库,运用DID方法探究美国技术封锁对中国向第三方经济体技术型跨境并购的影响。研究发现:美国对华技术封锁总体上促进了中国向第三方经济体实施技术型跨境并购,这一结论在变换识别策略、变换样本、伪证检验等一系列稳健性检验后以然成立。机制分析表明,美国技术封锁刺激了中国投资者向高可替代性或与中国高技术部门联系密切的经济体的技术型跨境并购,因此可以认为技术封锁带来的替代效应大于消极示范效应。此外,东道国与美国的政治经济关系并不构成美国技术封锁影响中国向第三方经济体技术型并购的重要因素。异质性分析发现,美国技术封锁显著促进了中国在电信软件和医疗领域对第三方经济体的跨境并购,但在能源和交通领域的影响不显著。

关键词：技术型跨境并购技术封锁双重差分

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Effects of Zr/mo addition on He bubble formation in Y_(2)O_(3)-added W alloys

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Tungsten 2022年第3期4卷 203-211页

作者： Qiu Xu m.miyamoto Lai-ma Luo Institute for Integrated Radiation and Nuclear Science Kyoto UniversityOsaka590-0494Japan Shimane University Shimane690-8504Japan School of materials Science and Engineering Hefei University of TechnologyHefei230031China

To improve the mechanical properties of the Y_(2)O_(3)-added W alloy,mo and Zr were independently added to a sample of W-Y_(2)O_(3).In this study,the effects of minor additions of elemental mo and Zr on He bubble formation in the Y_(2)O_(3)added W alloys were investigated at 773 K,973 K,and 1173 K,where the maximum irradiation fluence of the samples using 5 keV He ions was 1.8×10^(21) He m^(−2).He bubbles were observed at all temperatures for both alloys;however,the irradiation fluences at which He bubbles could be observed differed at each *** increase in irradiation temperature,the He irradiation fluence for which the formation of He bubbles could be observed *** the relatively low temperature of 773 K,the void swelling in the W-mo-Y_(2)O_(3)and W-Zr-Y_(2)O_(3)alloys was slightly lower than that of W-Y_(2)O_(3)***,at high temperature of 973 K and 1173 K,the He irradiation resistances of both W-mo-Y_(2)O_(3)and W-Zr-Y_(2)O_(3)were worse than that of W-Y_(2)O_(3).The addition of Zr enhanced the interaction between vacancies and He,enhancing the formation of He ***,the addition of mo coarsened the Y_(2)O_(3)particles,reducing the suppression of vacancy cluster formation due to the dispersion of Y_(2)O_(3)*** is,therefore,necessary to fully consider mechanical properties and T-retention in addition to the irradiation resistance of He to select an alloy as the plasma-facing material for fusion applications.

关键词： W-Y_(2)O_(3)alloy He bubble mo Zr

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Effect of alpha-lipoic acid and Silybum marianum supplementation with a mediterranean diet on metabolic dysfunction-associated steatosis

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World Journal of Hepatology 2025年第1期17卷 86-95页

作者： Ana D Cano Contreras maría Del Rocío Francisco Jose L Vargas Basurto Kevin D Gonzalez-Gomez mercedes Amieva-Balmori Federico Roesch Dietlen Josém Remes-Troche Instituto de Investigaciones médico-Biológicas Universidad VeracruzanaVeracruz 91700Mexico

BACKGROUND The treatment of metabolic dysfunction-associated steatotic liver disease(ma-SLD)has focused on the control of *** marianum(Sm)and alpha-lipoic acid(ALA)have shown antioxidant and adjuvant effects on the control of metabolic *** To evaluate whether the Sm-ALA formulation(LUDLEV®),in combination with the mediterranean diet(mD),could improve maSLD-related liver *** A randomized,double-blind clinical trial was conducted on patients with *** of Sm-ALA plus mD(group A)vs placebo plus mD(group B)was compared for 24 *** baseline and weeks 12 and 24,anthropometric measurements,metabolic parameters,and liver function were *** effectiveness was evaluated through transient *** Fifty patients aged 54±10 years were included,and the majority(74%)were *** visceral fat and umbilical circumference were reported in both groups,with significance in group A(P=0.045 and 0.003,respectively).The de-crease in controlled attenuation parameter was gradual and maintained at 12 and 24 weeks in group A(P=0.026),whereas in group B the decrease was greater at week 12 and remained unchanged at week 24(∆controlled attenuation parameter:-27 dB/m).mild adverse effects were reported in 4 patients in group A(16%)and 4 patients in group B(16%),with no significant differences between groups(P=0.641).CONCLUSION Sm-ALA(LUDLEV®)combined with the mD can promote the improvement of metabolic parameters,reducing visceral fat and hepatic steatosis in mexican patients with maSLD.

关键词： Steatotic liver disease Silybum marianum Alpha-lipoic acid mediterranean diet Fatty liver

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Simultaneous removal of chromium and arsenate from contaminated groundwater by ferrous sulfate:Batch uptake behavior

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Journal of Environmental Sciences 2011年第3期23卷 372-380页

作者： Xiaohong Guan Haoran Dong Jun ma Irene m. C. Lo State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin 150090 China Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Hong Kong 999077 China

Chromium and/or arsenate removal by Fe（Ⅱ） as a function of pH, Fe（Ⅱ） dosage and initial Cr（Ⅵ）/As（Ⅴ） ratio were examined in batch tests. The presence of arsenate reduced the removal efficiency of chromium by Fe（Ⅱ）, while the presence of chromate significantly increased the removal efficiency of arsenate by Fe（Ⅱ） at pH 6-8, In the absence of arsenate, chromium removal by Fe（Ⅱ） increased to a maximum with increasing pH from 4 to 7 and then decreased with a further increase in pH. The increment in Fe（Ⅱ） dosage resulted in an improvement in chromium removal and the improvement was more remarkable under alkaline conditions than that under acidic conditions. Chromium removal by Fe（Ⅱ） was reduced to a larger extent under neutral and alkaline conditions than that under acidic conditions due to the presence of 10 μtmol/L arsenate. The presence of 20 μmol/L arsenate slightly improved chromium removal by Fe（Ⅱ） at pH 3.9-5,8, but had detrimental effects at pH 6.7-9.8. Arsenate removal was improved significantly at pH 4-9 due to the presence of 10μmol/L chromate at Fe（Ⅱ） dosages of 20-60 μmol/L. Elevating the chromate concentration from 10 to 20μmol/L resulted in a further improvement in arsenate removal at pH 4.0-4.6 when Fe（Ⅱ） was dosed at 30-60 μmol/L.

关键词： chromium removal arsenate removal ferrous iron groundwater treatment

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Effect of Y Addition on microstructure and mechanical Properties of Friction Stir Welded ZK60 Alloy

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Journal of materials Science & Technology 2009年第3期25卷 351-355页

作者： G.m. Xie Z.Y. ma L. Geng School of materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Shenyang National Laboratory for materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

6 mm thick ZK60 and ZK60-Y alloy plates were successfully friction stir welded （FSW） at a tool rotation rate of 1200 r/min and a traverse speed of 100 mm/min. FSW resulted in the dissolution of mgZn2 particles in the ZK60 and the breakup and dispersion of W-phase （mg3Zn3Y2） particles in the ZK60-Y alloy, thereby leading; to a decrease in the hardness of the nugget zone （NZ） for the ZK60 alloy and an increase in the hardness of the NZ for the ZK60-Y alloy, respectively. While two FSW joints exhibited similar joint efficiency （87%-89% of ultimate tensile strengths of the parent materials）, the yield strength of the FSW ZK60-Y joint was substantially higher than that of the FSW ZK60 joint. The fracture occurred in the NZ and the heat affected zone for the ZK60 and ZK60-Y joints, respectively, which were consistent with the lowest hardness distribution of the welded joints.

关键词： Friction stir welding magnesium microstructure mechanical properties

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Formability of friction stir processed low carbon steels used in shipbuilding

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Journal of materials Science & Technology 2018年第1期34卷 237-244页

作者： D.m. Sekban S.m. Akterer O. Saray Z.Y. ma G. Purcek Department of Naval Architecture and marine Engineering Karadeniz Technical University Trahzon Turkey Department of Autumotive Technology RecepTayyip Erdogan University Rize Turkey Department of mechanical Engineering Bursa Technical University. Bursa Turkey Shenyang National Laboratory for materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Department of mechanical Engineering. Karadeniz Technical University Trabzon Turkey Engineering Faculty Giresun University Giresun Turkey

The stretch formability of a low carbon steel processed by friction stir processing （FSP） was studied under biaxial loading condition applied by a miniaturized Erichsen test. One-pass FSP decreased the ferritic grain size in the processed zone from 25 μm to about 3 μm, which also caused a remarkable increase in strength values without considerable decrease in formability under uniaxial loading. A coarse-grained （CG） sample before FSP reflected a moderate formability with an Erichsen index （EI） of 2.73 mm. FSP slightly decreased the stretch formability of the sample to 2.66 ram. However, FSP increased the required punch load （FEI） due to the increased strength by grain refinement. FSP reduced considerably the roughness of the free surface of the biaxial stretched samples with reduced orange peel effect. The average roughness value （Ra） decreased from 2.90 in the CG sample down to about 0.65 μm in fine-grained （FG） sample after FSP. It can be concluded that the FG microstructure in low carbon steels sheets or plates used generally in shipbuilding provides a good balance between strength and formability.

关键词： Friction stir processing Low carbon shipbuilding steel Formability microstructure mechanical properties

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一种客观评价上睑皮肤松弛程度的分级量表初探

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中华整形外科杂志 2025年第1期41卷 26-31页

作者：马坤侯团结李平松陈啸马乐扬州大学附属苏北人民医院整形烧伤科-医学美容科扬州225001

目的探讨一种新的评估上睑皮肤松弛程度的临床分级量表的可行性。方法前瞻性纳入扬州大学附属苏北人民医院整形烧伤科-医学美容科2022年5月至2023年10月接受上睑皮肤松弛整形手术的患者作为研究对象。术前及术后由3名未参与手术的整形... 详细信息

目的探讨一种新的评估上睑皮肤松弛程度的临床分级量表的可行性。方法前瞻性纳入扬州大学附属苏北人民医院整形烧伤科-医学美容科2022年5月至2023年10月接受上睑皮肤松弛整形手术的患者作为研究对象。术前及术后由3名未参与手术的整形外科医生依据临床分级量表利用患者面部照片独立完成上睑皮肤松弛程度评估分级。该分级量表通过分析上睑皮肤最下缘相对于上睑边缘和瞳孔位置的变化情况,将皮肤松弛程度分为0~3度4个等级,分级越高表示皮肤松弛程度越重。若为双侧上睑皮肤松弛,评估时以松弛程度较重一侧的分级作为该例患者上睑皮肤松弛程度的等级。分别计算术前和术后3名医生分级结果的Kendall系数(范围-1~1),数值越接近1表示3名医生的一致性越好,分级量表的稳定性越佳;手术前后的上睑皮肤松弛程度分级以m(Q 1,Q 3)表示,采用配对Wilcoxon符号秩检验进行比较。结果共纳入50例女性患者,年龄32~67岁,平均45.3岁,均接受双侧上睑皮肤松弛整形手术。术前和术后3名医生对50例患者上睑皮肤松弛程度分级结果的Kendall系数分别为0.975、0.882(P均<0.01),3名医生评级结果的一致性较高。50例患者术前和术后上睑皮肤松弛程度分级分别为2(1,2)度、0(0,0)度,提示术后上睑皮肤松弛程度明显改善。Wilcoxon符号秩检验结果显示,3名医生对患者术前及术后评级结果的差异均有统计学意义(P均<0.01)。结论该上睑皮肤松弛程度分级量表评级方法具有客观、简单易用的特点,评估结果稳定,具有可重复性,可以有效分析手术前后上睑皮肤松弛程度的变化。

关键词：眼睑皮肤松弛眼睑下垂眶周年轻化数码摄影效果评价评价方法

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Experimental studies on the energy dissipation of bolted structures with frictional interfaces:A review

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Friction 2024年第8期12卷 1623-1654页

作者： Yongfeng WANG Yanhong ma Jie HONG Giuseppe B.ATTIATO Christian m.FIRRONE School of Energy and Power Engineering Beihang UniversityBeijing 102206China Research Institute of Aero-Engine Beihang UniversityBeijing 102206China Politecnico di Torino Department of Mechanical and Aerospace EngineeringTorino 10139Italy

Bolted joints play a more and more important role in the structure with lighter weight and heavier *** paper aims to provide an overview of different experimental approaches for the dynamic behavior of structures in the presence of bolted joints,especially the energy dissipation or damping at frictional *** comprehension of energy dissipation mechanisms due to friction is provided first,while the key parameters and the measurement techniques,such as the excitation force,the preload of the bolt,or the pressure at the interfaces,are briefly ***,the round-robin systems aim to measure the hysteresis parameters of the frictional joints under tangential loads are reviewed,summarizing the basic theory and the strategies to apply the excitation force or acquire the response in different testing *** by parameter identification strategies for bolted structures,the test rigs with one or more simplified bolted joints are summarized to give an insight into the understanding of typical characteristics of bolted structures,which are affected by the presence of *** complex test rigs hosting real-like or actual engineering structures with bolted lap or flange joints are also introduced to show the identification process of the dynamic characteristics of bolted connections employed in specific *** on the review paper,researchers can get the basic knowledge about the experimental systems of the bolted structures,especially several classical round robin systems,such as the Gaul resonator and widely used Brake-Reußbeam *** can take advantage of this background for more creative and effective future studies,make more progress on the study of assembled structures and understand the influence of bolting frictional connections on the dynamic response better.

关键词： review study bolted joints frictional damping experimental rigs measurements

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