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Combined administration of platelet rich plasma and autologous bone marrow aspirate concentrate for spinal cord injury: a descriptive case series

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Neural Regeneration Research 2021年第2期16卷 362-366页

作者： Joseph A.Shehadi Steven m.Elzein Paul Beery m.Chance Spalding michelle Pershing Section of Neurosurgery at OhioHealth Grant medical Center Cedar Stem Cell InstituteColumbusOHUSA The Ohio State University College of medicine ColumbusOHUSA Division of Trauma and Acute Care Surgery OhioHealth Grant Medical CenterColumbusOHUSA OhioHealth Research Institute ColumbusOHUSA

Administration of platelet rich plasma(PRP) and bone marrow aspirate concentrate(BmAC) has shown some promise in the treatment of neurological conditions;however, there is limited information on combined administration. As such, the purpose of this study was to assess safety and functional outcomes for patients administered combined autologous PRP and BmAC for spinal cord injury(SCI). This retrospective case series included seven patients who received combined treatment of autologous PRP and BmAC via intravenous and intrathecal administration as salvage therapy for SCI. Patients were reviewed for adverse reactions and clinical outcomes using the Oswestry Disability Index(odi) for up to 1 year, as permitted by availability of follow-up data. Injury levels ranged from C3 through T11, and elapsed time between injury and salvage therapy ranged from 2.4 months to 6.2 years. Post-procedure complications were mild and rare, consisting only of self-limited headache and subjective memory impairment in one patient. Four patients experienced severe disability prior to PRP combined with BmAC injection, as evidenced by high(> 48/100) Oswestry Disability Index scores. Longitudinal Oswestry Disability Index scores for two patients with incomplete SCI at C6 and C7, both of whom had cervical spine injuries, demonstrated a decrease of 28–40% following salvage therapy, representing an improvement from severe to minimal disability. In conclusion, intrathecal/intravenous co-administration of PRP and BmAC resulted in no significant complications and may have had some clinical benefits. Larger clinical studies are needed to further test this method of treatment for patients with SCI who otherwise have limited meaningful treatment options. This study was reviewed and approved by the Ohio Health Institutional Review Board(IRB No. 1204946) on may 16, 2018.

关键词： bone marrow aspirate concentrate cell-based therapy neural regeneration Oswestry Disability Index platelet rich plasma spinal cord injury stem cells

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甲基强的松龙——用作治疗易患慢性肺疾病早产儿的地塞米松替代物

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德国医学 2001年第5期18卷 272-273页

作者： P.André B.Thébaud m.H.odièvre H.Razafimahefa V.Zupan m.Dehan T.Lacaze-masmonteil 方静 Service de Pediatrie et Reanimation Neonatales Hpital Antoine Beclere Assistance Publique-Hpitaux de Paris 157 rue de la Porte-de-Trivaux92141 Clamart France 华中科技大学同济医学院附属同济医院

支气管肺发育不良在极不成熟早产儿中是一种重点关注的疾病.地塞米松通常应用于治疗支气管肺发育不良和预防慢性肺部疾病,它有助于减少对氧气的依赖以及早期拔管,尽管其治疗呼吸系统疾病的长期疗效文献很少记载,但最近研究结果显示预防... 详细信息

支气管肺发育不良在极不成熟早产儿中是一种重点关注的疾病.地塞米松通常应用于治疗支气管肺发育不良和预防慢性肺部疾病,它有助于减少对氧气的依赖以及早期拔管,尽管其治疗呼吸系统疾病的长期疗效文献很少记载,但最近研究结果显示预防性应用地塞米松能减少慢性肺部疾病的发生率.然而,这种治疗方法的一些副面效应也有报道,包括葡萄糖不耐受、院内感染危险性增加、胃十二指肠出血以及体重增长延迟的发生,其中一些并发症在生后早期应用地塞米松治疗的患儿中更常见.

关键词：慢性肺疾病甲基强的松龙早产儿

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Surgical management of Spondylolisthesis by Pedicular Screw Rod System and Postero-Lateral Fusion

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Open Journal of Orthopedics 2015年第6期5卷 163-174页

作者： m. Chaitanya Ankur mittal Ramprasad Rallapalli Ravi Teja Y. Siva Prasad Department of Orthopaedics Narayana Medical College and Hospital Nellore India

Introduction: Incidence of spondylolisthesis in general population is 5% - 7%. No matter what the etiology is, patients usually have significant functional disability. Few studies have investigated the long term effect of posterolateral fusion on functional outcome. Objectives: To study the efficacy of posterolateral fusion in spondylolisthesis especially in terms of functional outcome. methodology: From July 2010 to June 2012, a total of 86 patients, operated with postero-lateral fusion were followed up and evaluated based on VAS for low back pain, odi and neurological deficits. Results: Follow up was 83% of original study population (86). Average follow up was 13 months. The mean difference between pre-operative and post-operative VAS at final follow up was 3.5 cms (SD = 2.94);odi was 28% at 4 months and 36% at 8 months. Claudication pain relieved in all;functional outcome was good in 67%, fair in 27.5% and failed in 5.5%;75% had fusion at an average of 5.5 months. Conclusion: Posteriolateral fusion is still a safe, promising and appealing technique.

关键词： Spondylolisthesis Posterolateral Fusion Functional Outcome

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骨水泥强化椎弓根螺钉内固定治疗胸腰椎经皮椎体后凸成形术后手术椎体再骨折的疗效分析

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中华创伤杂志 2017年第11期33卷 1005-1010页

作者：王远政李波郭涛彭智戴涛 Edward m.Sehwarz 解超贵州省人民医院骨科贵阳550002 美国纽约州罗切斯特大学医学中心骨科、骨科研究中心

目的探讨运用骨水泥强化椎弓根螺钉内固定治疗老年骨质疏松性胸腰椎压缩骨折经皮椎体后凸成形术（PKP）后手术椎体再骨折并发下肢神经症状的临床疗效。方法采用回顾性病例系列研究分析2013年12月-2016年12月收治的123例骨质疏松性胸腰... 详细信息

目的探讨运用骨水泥强化椎弓根螺钉内固定治疗老年骨质疏松性胸腰椎压缩骨折经皮椎体后凸成形术（PKP）后手术椎体再骨折并发下肢神经症状的临床疗效。方法采用回顾性病例系列研究分析2013年12月-2016年12月收治的123例骨质疏松性胸腰椎压缩骨折行PKP治疗患者临床资料，共12例术后发生手术椎体再次骨折并压迫脊髓或马尾神经，其中男5例，女7例；年龄（69．2±7．1）岁。伤椎分布：T12 5例，L1 5例，L2 2例，均采用脊柱后路椎管减压、骨水泥强化椎弓根螺钉内固定术手术。比较术前、术后1周及末次随访时视觉模拟评分（VAS）、Oswestry功能障碍指数（odi）、椎体前缘压缩率、椎体后凸Cobb角、术中和术后并发症。结果12例患者获随访12～36个月，平均26．7个月。术中无神经损伤或硬膜撕裂，无明显骨水泥渗漏、骨水泥毒性反应或肺栓塞，术后X线片示骨水泥分布于钉道及周围松质骨中，无椎体外渗漏。术后1周腰痛VAS、下肢痛VAS及odi分别为（2．2±0．7）分、（2．2±0．4）分和（33．3±8．9）分，与术前比较，差异有统计学意义（P均〈0．01）。椎体前缘压缩率由术前（71．5±11．7）％下降到术后1周的（18．7±10．3）％（P〈0．01）。后凸Cobb角从术前（28．3±7．6）。纠正至术后1周的（7．1±2．3）。（P〈0．01）。患者腰痛、双下肢麻木及无力症状明显缓解。末次随访时各评价指标与术后1周比较差异均无统计学意义（P〉0．05）。结论对于胸腰椎压缩性骨折、PKP术后手术椎体再次骨折并引起脊髓或马尾神经压迫症状的老年骨质疏松患者，采用后路骨水泥强化椎弓根螺钉内固定可有效矫正后凸畸形，缓解神经症状及恢复脊柱稳定性。

关键词：脊柱骨折胸椎腰椎内固定器椎体再骨折

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Association between facet joint osteoarthritis and the Oswestry Disability Index

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World Journal of Radiology 2014年第11期6卷 881-885页

作者： Adel maataoui Thomas J Vogl marcus middendorp Konstantinos Kafchitsas m Fawad Khan Institute for Diagnostic and Interventional Radiology Goethe University60590 Frankfurt/MainGermany Department of Nuclear medicine Goethe University60590 Frankfurt/MainGermany Spine Surgery Asklepios Clinic Lindenlohe92421 SchwandorfGermany

AIm:To investigate the correlation of facet joint osteoarthritis(FJOA) at lumbar levels L4/L5 and L5/S1 and the Oswestry Disability Index(odi).mETHODS:The study involved lumbar mRIs of 591 patients with a mean age of 47.3 *** mRIs of the lumbar spine were performed on a 1.5 Tesla scanner(magnetom Avanto,Siemens AG,Erlangen,Germany) using a dedicated receive only spine *** initial blinding,each dataset was evaluated by 2 board certified radiologist with more than 5 years experience in musculoskeletal *** total 2364 facet joints were *** changes of the facet joints were evaluated according to the 4-point scale as proposed by Weishaupt et al Functional status was assessed using the *** index is scored from 0 to 100 and interpreted as follows:0%-20%,minimaldisability; 20%-40%,moderate disability; 40%-60%,severe disability; 60%-80%,crippled; 80%-100%,patients are ***’s coefficient of rank correlation was used for statistical analysis,with significance set at P mbar levels L4/5 and L5/S1 were analysed in 591 *** was present in 97%(L4/L5) and 98%(L5/S1).At level L4/5(left/right) 17/15(2.9%/2.5%) were described as grade 0,146/147(24.7%/24.9%) as grade 1,290/302(49.1%/51.1%) as grade 2 and 138/127(23.4%/21.5%) as grade *** level L5/S1(left/right) 10/11(1.7%/1.9%) were described as grade 0,136/136(23.0%/23.0%) as grade 1,318/325(53.8%/55.0%) as grade 2 and 127/119(21.5%/20.1%) as grade *** the odi scores,patients’ disability had a minimum of 0% and a maximum of 91.11% with an arithmetic mean of 32.77% ± 17.02%.The majority of patients(48.39%) had moderate functional disability(21%-40%).There was no significant correlation between FJOA and odi on both sides of lumbar level L4/5 and on the left side of lumbar level L5/S1.A weak positive correlation was evaluated between odi and FJOA on the right side of lumbar level L5/***:The missing correlat

关键词： Spine Facet joint osteoarthritis magnetic resonance imaging Low back pain Oswestry Disability Index

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Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms

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World Journal of Radiology 2017年第5期9卷 223-229页

作者： Annina SplettstoBer m Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann marcus middendorp Adel maataoui Radprax mVZ Institute for Diagnostic and Interventional Radiology Goethe University Institute of Biostatistics and mathematical modeling Goethe University Department of Nuclear medicine Goethe University

AIm To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(odi).mETHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled *** magnetic resonance images(mRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or *** symptoms and disability were assessed using *** Spearman's rank correlation coefficient was used for statistical analysis(P mately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root *** odi score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between odi and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho mRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on mRI and clinical *** can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS.

关键词： Low back pain Lumbar spine magnetic resonance imaging Lateral recess stenosis Oswestry Disability Score Lumbar spinal canal stenosis

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快速动眼睡眠相关性阻塞性睡眠呼吸暂停事件的临床研究

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临床耳鼻咽喉头颈外科杂志 2017年第10期31卷 744-748页

作者：蒋康伦赵琳李姝娜林志强马永明 Iqbal m A 钱炜江苏大学附属人民医院耳鼻咽喉头颈外科江苏镇江212002

目的:探讨一种基于快速动眼睡眠期(REm)相关的阻塞性睡眠呼吸暂停事件(OSA)发生特征的分型方法及潜在临床意义。方法:250例OSA患者根据PSG分型:REm期相关组[RrOSA,REm期AHI与非REm期AHI(NREm-AHI)比值(R)>1,113例],非REm期相关组(NRrOS... 详细信息

目的:探讨一种基于快速动眼睡眠期(REm)相关的阻塞性睡眠呼吸暂停事件(OSA)发生特征的分型方法及潜在临床意义。方法:250例OSA患者根据PSG分型:REm期相关组[RrOSA,REm期AHI与非REm期AHI(NREm-AHI)比值(R)>1,113例],非REm期相关组(NRrOSA,R≤1,137例);RrOSA组进一步分为RrOSAⅠ型(R≥2,34例)与RrOSAⅡ型(R>1,79例)。RrOSAⅠ型再根据非REm期AHI分为2个亚型:RrOASⅠa型(NREm_AHIm_AHI≥15,10例)。比较各分组PSG与临床数据。结果:RrOSA组患者AHI、odi、NREm_AHI、NREm_odi、REm期最大氧减、REm期最长氧减时间、NREm期最长氧减时间均显著低于NRrOSA组患者(均Pm期AHI或odi 2组间无差异(P>0.05)。RrOSA各亚组之间REm期(AHI、odi、最大氧减、最长氧减时间)、NREm期(AHI、odi、最大氧减、最长氧减时间)均存在逐渐升高趋势。部分RrOSAⅠa组患者不耐受CPAP治疗,改用APAP治疗后效果满意。结论:对RrOSA进行进一步分组分析不同分期睡眠参数改变有助于了解OSA病程发生、发展。RrOSAⅠa分组对CPAP治疗模式选择可能存在指导意义。RrOSA可能是OSA患者中的一种特殊类型,这种类型可能随着病情严重而发展为其他类型。

关键词：阻塞性睡眠呼吸暂停综合征快速动眼睡眠正压通气治疗

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The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 41-48页

作者： Anvesh R.Kompelli Jonathan S.Ni Shaun A.Nguyen Eric J.Lentsch David m.Neskey Ted A.meyer Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA

Objectives:Obstructive sleep apnea (OSA) is a prevalent disease with significant health *** first line therapy is CPAP,long-term compliance is low and device misuse is common,highlighting the need for alternative *** airway surgery is one alternative,but substantial side effects hamper efficacy.A new alternative is an implantable hypoglossal nerve stimulator (HNS).These devices utilize neuromodulation to dilate/reinforce the airway and reduce side effects associated with traditional *** recent trials investigated the efficacy of these *** purpose of this study was to perform meta-analysis of available HNS studies investigating treatment of OSA to analyze objective and subjective outcomes and side ***:A comprehensive literature search of Pubmed and Scopus was *** independent reviewers examined clinical trials investigating HNS in treatment of sleep apnea in *** with objective and subjective endpoints in sleep were included for *** events from trials were also ***:Across 16 studies,381 patients were *** 6 months (p =0.008),mean SAQLI improved by 3.1 (95%CI,2.6-3.7).At 12 months (p mean AHI was reduced by 21.1 (95%Cl,16.9-25.3),mean odi was reduced by 15.0 (95%CI,12.7-17.4),mean ESS was reduced by 5.0 (95%CI,4.2-5.8),mean FOSQ improved by 3.1 (95%CI,2.6-3.4).Pain (6.2%:0.7-16.6),tongue abrasion (11.0%:1.2-28.7),and internal (3.0%:0.3-8.4)/external device (5.8%:0.3-17.4) malfunction were common adverse ***:HNS is a safe and effective treatment for CPAP refractory *** study comparing HNS to other therapies is required.

关键词： Surgical treatment of obstructive sleep apnea Sleep medicine Obstructive sleep apnea

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基于苝酰亚胺的大平面共轭分子的设计、合成及应用

基于苝酰亚胺的大平面共轭分子的设计、合成及应用

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2016年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十四届全国高分子液晶态与超分子有序结构学术论文报告会）

作者：袁忠义陈义旺肖义钱旭红 Klaus müllen 南昌大学化学学院大连理工大学精细化工国家重点实验室 max Planck Institute for Polymer Research

本文合成了三类具有大平面共轭体系的分子,分别是萘嵌苯酰亚胺(QDI、HDI和odi)、二聚苝酰亚胺DPDI和基于苝酰亚胺的梯形聚合物LCPT。研究了它们的光谱、电化学、自组装等基本性质,并尝试将其用于有机薄膜太阳能电池和场效应晶体管。这... 详细信息

关键词：共轭体系苝酰亚胺有机半导体电子受体

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基于苝酰亚胺的大平面共轭分子的设计、合成及应用

基于苝酰亚胺的大平面共轭分子的设计、合成及应用

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中国化学会第30届学术年会

作者：袁忠义陈义旺肖义钱旭红 Klaus müllen 南昌大学化学学院大连理工大学精细化工国家重点实验室 max Planck Institute for Polymer Research

本文合成了三类具有大平面共轭体系的分子,分别是萘嵌苯酰亚胺(QDI、HDI和odi)、二聚苝酰亚胺DPDI和基于苝酰亚胺的梯形聚合物LCPT。研究了它们的光谱、电化学、自组装等基本性质,并尝试将其用于有机薄膜太阳能电池和场效应晶体管。这些化合物具有很强的吸收光谱,较低的LUmO能级,是一类很有潜力的电子受体。HDI和odi具有强烈的近红外吸收,在有机溶剂中的最大吸收波长分别达到908nm和1007nm。QDI和odi在高规整石墨(HOPG)表面能组装成有序的结构,并且可以通过溶剂的流动来控制组装体系的结构,通过扫描隧道显微镜(STm)清晰地观测这些有序的结构。DPDI在300-600nm之间具有很强的吸收,最大摩尔消光系数超过120000 mcm。LCPT的热稳定温度高达380℃,荧光量子产率达到O.2。

关键词：共轭体系苝酰亚胺有机半导体电子受体

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