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Contribution of <sup>99m</sup>Tc-DPD Scintigraphy in the Diagnosis of Cardiac Amyloidosis in Black Africans

Open Journal of Biophysics 2022年第1期12卷 27-37页

作者： djigo mamoudou salif Ndong Boucar Bathily El Hadji Amadou Lamine Diop Ousseynou Gueye Kalidou Thiaw Gora Ndoye Oumar mbodj m.m.dou Department de medecine Nucleaire Hô pital General Idrissa Pouye Dakar Senegal Department de medecine Nucleaire Hô pital Dalal JAmm Dakar Senegal

Cardiac amyloidosis presents a picture of hypertrophic cardiomyopathy with heart failure with preserved ejection fraction. It is largely underdiagnosed, especially in black Africans, and therefore falls under the category of heart disease classified as idiopathic. Light chain amyloidosis (AL) is mainly found in Caucasian subjects and the mutant variant of transthyretin (TTRm) in negroid subjects. Numerous studies have shown that ATTRm was found predominantly in black American and black British patients. In African countries the entity of idiopathic heart failure is quite important because of lack of diagnosis, ETT, mRI and immuno-histochemistry are expensive or not available. We can probably assume that the proportion of cardiac amyloidosis is quite important in black Africans. The question is if 99mTc-DPD really easy to perform, can probably help to investigate in the nuclear medicine department in Africa. No large-scale study has been able to demonstrate the prevalence or not of cardiac amyloidosis in black-African subjects and by extension reduce this nosological entity of idiopathic heart disease. The 99mTc-DPD scintigraphy using Perrugini’s visual sore allows localization and classification of amyloid damage. The mechanism of binding of 99mTc-DPD to amyloid fibril deposits is not well known, its binding to TTR-type (mutated or wild type) amyloidosis is greater than the AL variant. In the diagnostic algorithm, endomyocardial biopsy is the gold standard but remains invasive, ETT with the strain allows a presumptive diagnosis and remains an operative examination dependent and is not reproducible. Cardiac mRI allows some localization of amyloid deposits but still remains less sensitive than scintigraphy. In addition, performing the whole-body mRI is very restrictive (time, antenna change and cost). The aim of this literature review was to show the superiority of 99mTc-DPD scintigraphy compared to other diagnostic modaliti

关键词： Amyloidosis TTRm AL 99mTc-DPD Bone Scintigraphy

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Contribution of Scintigraphy in the Assessment of Extension of Osteophilic Cancers in Senegal from 2018 to 2021

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Open Journal of Biophysics 2023年第1期13卷 1-13页

作者： Olatoundé Herbert Fachinan El Hadji Lamine Bathily m.m.dou salif djigo Gilles David Houndétoungan Djibrillou moussa Issoufou Boucar Ndong Kuassi marcellin Amoussou-Guénou m.m.dou mbodj Institut de Formation en Soins Infirmiers et Obstétricaux Université de Parakou Parakou Bénin Service de médecine Nucléaire H&ocirc pital Général Idrissa Pouye Dakar Sénégal Laboratoire de Biophysique Médecine Nucléaire Université Cheikh Anta Diop Dakar Sénegal Unité D’Enseignement et de Recherche de Biophysique et médecine Nucléaire Faculté des Sciences de Santé Université d’Abomey-Calavi Cotonou Bénin Département de médecine Nucléaire Institut des Radio-Isotopes Niamey Niger

The aim of this study was to highlight the contribution of bone scintigraphy in the assessment of extension of osteophilic cancers in Senegal. This was a retrospective study, with a descriptive and analytical purpose, carried out over a period of four (04) years between January 01, 2018 and December 31, 2021. It focused on the files of patients who underwent bone scintigraphy for extension assessment of an osteophilic cancer during the study period. According to the study, prostate cancer was by far the most representative primary cancer (86.9%). Scintigraphy contributed in 75% of cases (362 cases) with 35% positive scintigraphy and 40% negative scintigraphy. The result was doubtful in 25% of cases (120 cases). The metastatic lesions were located preferentially at the level of the axial skeleton and only one case was of an exclusive appendicular site. more than half of patients with metastases (70%) had a poor prognosis with the SOLOWAY score greater than or equal to II. With the improvement of the nuclear imaging technical platform in Senegal (performance of SPECT/CT examinations), doubtful cases in our sample could be better explored with the advantage of adequate patient care.

关键词： Bone Scintigraphy Osteophilic Cancers Bone metastases

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Inventory of Radiation Protection in Hospitals of Level III in Senegal

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Open Journal of Biophysics 2021年第4期11卷 397-406页

作者： Boucar Ndong Sidi Ahmed Dia m.m.dou salif djigo Herbert Fachinan El Hadji Lamine Bathily Ousseynou Diop Kanta Ka Gérard Léra Kelvin Akpo El Hadji Fallou Diouf Louis Auguinstin Diaga Diouf Pape mady Sy Alphonse Djiboune Gora mbaye maguette Diagne Omar Ndoye m.m.dou mbodji Laboratoire de Biophysique Médecine Nucléaire Universite Cheikh Anta Diop Dakar Senegal Service de médecine du Travail Universite Cheikh Anta Diop Dakar Senegal Faculté de médecine Université de Parakou Parakou Benin Service de Radiothérapie de Dalal Jamm Dakar Senegal Service de Radiologie de l’Hô pital Aristide Le Dantec Dakar Senegal Laboratoire de Physique Pharmaceutique Universite Cheikh Anta Diop Dakar Senegal Service de Radiothérapie de l’Hô pital Aristide Le Dantec Dakar Senegal

The aim of this study was to evaluate the level of protection of employees who are exposed to radiation in a level III hospital establishment. It was a descriptive cross-sectional survey of six months’ duration, involving eight level III Hospitals (Aristide Le Dantec, Fann, Hoggy, Hear, Abass Ndao, Pikine, Touba, and Thiès) in Senegal. Sixty-one of the one hundred questionnaires were recovered (overall response rate of 61%). The population of the study was mainly female (54.1%). The average age was 38.57 with extremes ranging from 23 to 65 years old. In the places where ionizing radiation sources are handled, only at the Aristide Le Dantec Hospital did we find a “competent person in radiation protection”. This explained the lack of a classification of employees and work areas. Forty out of sixty-one (73.77%) had no knowledge of the basic principles of radiation protection (justification, optimisation, dose limitation) and had not ever taken radiation holidays. For radiovigilance, exposure time limits to ionizing radiation concerned only 29/61 or 47.54% of the study population. The inverse square law of distance was known by only 40 workers, of whom 15 had no compliance. We found the presence of dosifilms in only 7/61 or 11.47% of the workers. On the other hand, the use of lead aprons was well established and concerned 57/61 workers,m> i.e.m>, 93.44%. In sum, ionizing radiation causes adverse health effects. The absence of a good radiation protection culture in Senegal requires the presence of at least 4 to 5 competent persons in radiation protection for quality training of workers in radiobiology, radiopathology and radiation protection.

关键词： Ionizing Radiation Radiation Protection Workers Senegal

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