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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Discrete biological modeling for the immune response to dengue virus

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International Journal of modeling, Simulation, and Scientific Computing 2022年第1期13卷 214-234页

作者： Khaled A.Al-Utaibi m.muzamil Ayesha Sohail Fatima alam Alessandro Nutini Sadiq m.Sait Computer Science and Software Engineering Department University of Ha’il Ha’ilSaudi Arabia Quaid e Azam medical College BahawalpurPakistan Department of mathematics Comsats University Islamabad Lahore 54000Pakistan Biology and Biomechanics Department Centro Studi Attivita Motorie via di Tiglio 9455100 LuccaItaly Center for Communications and IT Research Research Institute King Fahd University of Petroleum and minerals Dhahran 31261 Saudi Arabia

Dengue infection affects more than half of the world’s population,with 1 billion symp-tomatic cases identified per year and several distinct genetic serotypes:DENV 1–*** via the mosquito bite,the dengue virus infects Langerhans ***,B lymphocytes,and mast cells infected with dengue virus produce various cytokines although it is not clear which ones are predominant during DHF disease.A mathemat-ical model of the Dengue virus infection is developed according to complex dynamics determined by many *** from a state of equilibrium that we could define as“virus-free”asymptotically stable with a viral reproduction number lower than one which means a very effective action of the innate immune system:it stops the infectious process,the mathematical analysis of stability in the presence of the virus demonstrates that the proposed model is dynamically *** fever affects more than half of the world’s population,with 1 billion symptomatic cases and multiple genetic serotypes confirmed each year,which simulates a network of interactions between the various populations involved without considering the speeds of the processes in question which are indicated in a separate *** this research,a hybrid approach of petri nets is utilized to connect the discrete models of dengue.

关键词： modeling scientific computing DENV cytokines petri nets infected cell

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Synthesis,Structural and Optical Properties of mn-Doped Ceria Nanoparticles:A Promising Catalytic material

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Acta metallurgica Sinica(English Letters) 2016年第3期29卷 265-273页

作者： Anees A.Ansari Joselito P.Labis manawwer alam Shahid m.Ramay Naushad Ahmad Asif mahmood King Abdullah Institute for Nanotechnology King Saud University Research Center College of ScienceKing Saud University Department of Physics King Saud University College of Engineering Department of Chemical EngineeringKing Saud University

The structure,the morphology and the thermal,optical and the surface properties of nanocrystalline CeO_2 doped with mn have been studied by X-ray diffraction（XRD）,field-emission transmission electron microscopy（FE-TEm）,energy-dispersive X-ray analysis,thermogravimetric analysis,UV–Vis absorption spectroscopy and Fourier transform infrared *** XRD results confirmed the successful incorporation of mn into the CeO_2 lattice through the formation of nanoscale face-centered cubic solid *** FE-TEm observations supported the nanocrystalline nature of the solid *** presence of structural defects and their role on the band gap have been discussed on the basis of absorption spectral *** structural differences correlate with results from temperature-programmed reaction（TPR）experiments with H_2 *** TPR measurements showed an enhanced bulk reduction at much lower temperatures,indicating increased oxygen mobility in the samples,which enable to enhanced oxygen diffusion at lower temperatures.

关键词： Cerium oxide nanoparticle manganese Band gap energy Redox property

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Darcy-Forchheimer mangetized flow based on differential type nanoliquid capturing Ohmic dissipation effects

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Propulsion and Power Research 2023年第3期12卷 443-455页

作者： m.Waqas Yunjie Xu m.Nasir md mottahir alam Amjad Ali Pasha Kashif Irshad Bandar m.Fadhl m.S.Kausar NUTECH School of Applied Science and Humanities National University of TechnologyIslamabad 44000Pakistan Department of mechanical Engineeing Lebanese American UniversityBeirutLebanon School of Engineering Huzhou UniversityHuzhou 313000China Faculty of Informatics and Computing University Sultan Zainal AbidinBesut Campus22200 BesutTereng-ganuMalaysia Department of Electrical and Computer Engineering King Abdulaziz UniversityJeddah 21589Saudi Arabia Aerospace Engineering Department King Abdulaziz UniversityJeddah 21589Saudi Arabia Interdisciplinary Research Centre for Renewable Energy and Power System(IRC-REPS) Research InstituteKing Fahd University of Petroleum and Minerals(KFUPM)Dhahran 31261Saudi Arabia mechanical Engineering Department College of Engineering and Islamic ArchitectureUmm Al-Qura UniversityP.O.Box 5555Makkah 21955Saudi Arabia

Hydromagnetic nanoliquid establish an extraordinary category of nanoliquids that unveil both liquid and magnetic *** interest in the utilization of hydromagnetic nanoliquids as a heat transporting medium stem from a likelihood of regulating its flow along with heat transportation process subjected to an externally imposed magnetic *** analysis reports the hydromagnetic nanoliquid impact on differential type(second-grade)liquid from a convectively heated extending *** well-known Darcy-Forchheimer aspect capturing porosity characteristics is introduced for nonlinear *** conditions elaborating heat-mass transportation effect are *** addition,Ohmic dissipation and suction/injection aspects are also a part of this *** analysis is done by implementing the basic relations of fluid *** modeled physical problem is simplified through order *** resulting systems(partial differential expressions)are rendered to the ordinary ones by utilizing the apposite *** solutions are constructed employing homotopy *** and numeric result are addressed comprehensively to elaborate the nature of sundry parameters against physical *** velocity profile is suppressed with increasing Hartmann number(magnetic parameter)whereas it is enhanced with increment in material parameter(second-grade).With the elevation in thermophoresis parameter,temperature and concentration of nanoparticles are accelerated.

关键词： Darcy-Forchheimer magnetized flow Differential type nanoliquid Ohimc dissipation Robin conditions Homotopy algorithm

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Tagetes erecta *** its mosquitocidal potency against Culex quinquefasciatus

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 186-188页

作者： Farjana Nikkon m Rowshanul Habib Zahangir alam Saud m Rezaul Karim Department of Biochemistry and molecular Biology Rajshahi University

Objective:To investigate mosquitocidal effects of ethanolic extract of(lowers of Tagetes erecta(***) and its chloroform and petroleum ether soluble fractions against the larvae of Culex quinquefasciatus(***).methods:The fresh flowers of *** were extracted in cold with ethanol(5.0 L) and after concentration,the ethanol extract was fractionated with chloroform and petroleum ether to afford a brownish syrupy suspension of ethanol extract(50.0 g),petroleum ether soluble fraction(18.6 g) and chloroform soluble fraction(23.8 g).The larvicidal effect of ethanol extract and their solvent fractions were determined by the standard procedure of WHO against different instars of ***:Among the tested samples the chloroform soluble fractions showed the highest toxicity and consequently,the lowest LC_(50) values(14.14 μ g/mL,17.06 μ g/mL.36.88 μ g/mL and 75.48 μ g/mL) for all the instars larvae of *** larvae showed comparative tolerance in the course of increasing age and ***:It can be concluded that the flowers of *** are very effective natural larvicide and could be useful against ***.

关键词： Tagetes erecta Linn. Culex quinquefasciatus Say mosquitocidal Larvae Larvicidal effect Toxicity

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macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of methodology 2025年第1期15卷 88-94页

作者： Chinmay mahatme madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna m Shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NmOSD)or myelin oligodendrocyte glycoprotein antibody disease(mOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NmOSD and 17 mOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(mVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in mVD in NmOSD and mOGAD affected as well as unaffected eyes when compared with healthy *** and mOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to mOGAD unaffected *** comparing NmOSD with mOGAD,there was no significant difference in terms of mVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NmOSD and mOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis macular microvascular changes Neuromyelitis optica spectrum disorders myelin oligodendrocyte glycoprotein antibody disorder

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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Effect of metal Contact and Rapid Thermal Annealing on Electrical Characteristics of Graphene matrix

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Chinese Physics Letters 2017年第10期34卷 65-69页

作者： S, Fahad m. Ali S. Ahmed S. Khan S. alam S. Akhtar Advanced Electronics Laboratories International Islamic University Islamabad Pakistan Department of Physics Federal Urdu University of Arts Sciences & Technology Karachi Pakistan

Development of graphene field effect transistors （GFETs） faces a serious challenge of graphene interface to the dielectric material. A single layer of intrinsic graphene has an average sheet resistance of the order of 1-5 kΩ/□. The intrinsic nature of graphene leads to higher contact resistance yielding into the outstanding properties of the material. We design a graphene matrix with minimized sheet resistance of 0.185 kΩ/□ with Ag contacts. The developed matrices on silicon substrates provide a variety of transistor design options for subsequent fabrication. The graphene layer is developed over 400 nm nickel in such a way as to analyze hypersensitive electrical properties of the interface for exfoliation. This work identifies potential of the design in the applicability of few-layer GFETs with less process steps with the help of analyzing the effect of metal contact and post-process anneming on its electrical fabrication.

关键词： Effect of metal Contact and Rapid Thermal Annealing on Electrical Characteristics of Graphene matrix

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Artificial Intelligence Based Reliable Load Balancing Framework in Software-Defined Networks

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Computers, materials & Continua 2022年第1期70卷 251-266页

作者： mohammad Riyaz Belgaum Fuead Ali Zainab Alansari Shahrulniza musa muhammad mansoor alam m.S.mazliham malaysian Institute of Information Technology Universiti Kuala LumpurKuala Lumpur50250Malaysia majan University College Muscat710Oman Institute of Business management KarachiPakistan malaysia France Institute Universiti Kuala LumpurKuala Lumpur43650Malaysia

Software-defined networking(SDN)plays a critical role in transforming networking from traditional to intelligent *** increasing demand for services from cloud users has increased the load on the *** efficient system must handle various loads and increasing needs representing the relationships and dependence of businesses on automated measurement systems and guarantee the quality of service(QoS).Themultiple paths from source to destination give a scope to select an optimal path by maintaining an equilibrium of load using some best ***,the requests need to be transferred to reliable network *** address SDN’s current and future challenges,there is a need to know how artificial intelligence(AI)optimization techniques can efficiently balance the *** study aims to explore two artificial intelligence optimization techniques,namely Ant Colony Optimization(ACO)and Particle Swarm Optimization(PSO),used for load balancing in ***,we identified that a modification to the existing optimization technique could improve the performance by using a reliable link and node to form the path to reach the target node and improve load ***,we propose a conceptual framework for SDN futurology by evaluating node and link reliability,which can balance the load efficiently and improve QoS in SDN.

关键词： Ant colony optimization load balancing particle swarm optimization quality of service reliability software-defined networking

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