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EFFECT OF GAmmA RAYS IN THE PREPARATION OF POLYmER AND HYDROGEL FROm ACRYLAmIDE mONOmER

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Chinese Journal of Polymer Science 2003年第4期21卷 437-442页

作者： m.m.alam m.F.mina F.Akhtar NRCD INST AERE GPO Box-3787 Dhaka BangladeshNRCD INST AERE GPO Box-3787 Dhaka BangladeshNRCD INST AERE GPO Box-3787 Dhaka Bangladesh

The formation of polymer and hydrogel from aqueous solutions having 20, 30 and 40% concentrations ofacrylamide monomer by γ-ray irradiation processing in the dose range 0.06-30 kGy using a Co-60 source and theircharacterization have been observed. Polymer conversion and gel fraction are found to depend on radiation doses. Polymerconversion increases with the increase of dose, depending on the solution concentration, where maximum conversion isachieved at 0.18, 0.16 and 0.10 kGy for 20%, 30% and 40% concentrations, respectively. On the other hand, gel fractionincreases with dose from the gel point (0.12 kGy) for all concentrations, where 100% conversion of gel occurs at doses≥5 kGy. Tensile strength, viscosity and molecular weight (m_w) of polymer samples increase with both the dose and theconcentration, showing a high value of m_w up to≈10~8. Swelling of hydrogels under water with respect to time varies due tothe variation of cross-linking density formed in the gels and the maximum swelling mainly occurs within 24 h. A remarkable change of surface morphology reveals characteristic features of monomer, polymer and hydrogel films.

关键词： Polymer Hydrogel γ-Radiation Cross-linking Swelling

Plasma Treatment of Natural Jute Fibre by RIE 80 plus Plasma Tool

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Plasma Science and Technology 2010年第3期12卷 325-329页

作者： m.m.mORSHED m.m.alam S.m.DANIELS National Centre for Plasma Science and Technology Dublin City University Nanomaterials Processing Laboratory School of Electronic EngineeringDublin City University

Plasma treatment can be used to modify the structure of natural fibre like jute for a variety of applications. Environmentally friendly jute fibre was treated with argon and oxygen plasma. The treated samples were characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR） and optical microscope. The macromolecular and microstructural changes in cellulose confirmed the change by plasma treatment. The XRD results confirmed that the crystal size and the crystallinity of the plasma treated fibre increased. Argon plasma treated fibre had a smooth and compact surface, compared to oxygen plasma treated fibre. The maximum stain （i.e. stress） concentrated in the oxygen plasma treated fibre. Optical micrographs showed the oxygen plasma treated fibre tended to rupture due to higher strain （i.e., stress） compared to fibre with argon plasma treatment. FTIR results also provided the evidence of change in the chemical constituents with plasma treatment.

关键词： natural jute fibre plasma treatment crystallinity chemical composition

Intensity of parasitic infestation in silver carp,Hypophthalmichthys molitrix

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 1024-1028页

作者： m.m.alam m.A.KHAN m.A.HUSSAIN D.mOUmITA A.G.mAZLAN K.D.SImON Department of Fisheries University of RajshahiRajshahi 6205Bangladesh School of Environmental and Natural Resource Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorD.E.Malaysia

Silver carp,Hypopthalmichthys molitrix is one of the most economically valuable fish species in ***,its production is often hindered by parasite-induced *** present study reports the intensity of parasitic infestation in 216 specimens of *** collected from different fish markets in Rajshahi City,*** different parasite species (Trichodina pediculatus,Dactylogyrus vastator,Ichthyophthirius multifilis,Gyrodactylus elegans,Lernaea sp.,Apiosoma sp.,myxobolus rohitae,Camallanus ophiocephali,and Pallisentis ophiocephali) were recovered from the gill,skin,stomach,and intestine of host *** highest level of infection was observed for host skin,while lower levels were observed for host gill,stomach,and *** results also revealed that the intensity of parasite infection in different organs of *** varied with the *** particular,the highest levels of infection were recorded during the winter period (November-February),when fish are most susceptible to *** findings of the study will help in the management and conservation of ***.

关键词： Freshwater fish Disease Parasites Carpfishery Infestation Aquaculture Bangladesh

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Performance of m-QAm, m-DPSK and m-PSK with mRC diversity in a Nakagami-m fading channel

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Journal of Central South University 2014年第4期21卷 1347-1352页

作者： alam S.m.Shamsul alam Choi GoangSeog Department of Information and Communication Engineering Chosun University

The nature of a wireless communication channel is very unpredictable. To design a good communication link, it is required to know the statistical model of the channel accurately. The average symbol error probability(ASER) was analyzed for different modulation schemes. A unified analytical framework was presented to obtain closed-form solutions for calculating the ASER of m-ary differential phase-shift keying(m-DPSK), coherent m-ary phase-shift keying(m-PSK), and quadrature amplitude modulation(QAm) over single or multiple Nakagami-m fading channels. moreover, the ASER was estimated and evaluated by using the maximal ratio-combining(mRC) diversity technique. Simulation results show that an error rate of the fading channel typically depends on Nakagami parameters(m), space diversity(N), and symbol rate(m). A comparison between m-PSK, m-DPSK, and m-QAm modulation schemes was shown, and the results prove that m-ary QAm(m-QAm) demonstrates better performance compared to m-DPSK and m-PSK under all fading and non-fading conditions.

关键词： m-ary differential phase-shift keying(m-DPSK) m-ary phase shift keying(m-PSK) Nakagami-m fading channel probability density function(PDF) symbol error rate(SER) m-ary quadrature amplitude modulation(m-QAm)

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death