检索结果-南通市图书馆

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi min Li Jiazhi Chen Zhuyong Wang Huantao wen ming Zhou minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(m1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional m1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the m1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

Classical Electromagnetic Field Theory in the Presence of magnetic Sources

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2003年第3期20卷 321-324页

作者： Li Kang Chen wen-Jun Carlos m. Naón Department of Physics Hangzhou Teacher's College Hangzhou 310036 Department of Physics Zhejiang University Hangzhou 310027 Instituto de Física La Plata Departamento de Física Facultad de Ciencias Exactas Universidad Nacional de La Plata CC 67 1900 La Plata Argentina

Using two new well-defined four-dimensional potential vectors, we formulate the classical maxwell field theory in a form which has manifest Lorentz covariance and SO(2) duality symmetry in the presence of magnetic sources. We set up a consistent Lagrangian for the theory. Then from the action principle we obtain both maxwell's equation and the equation of motion of a dyon moving in the electromagnetic field.

关键词： maxwell equations

PROXImAL POINT ALGORITHm FOR mINImIZATION OF DC FUNCTION

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational mathematics 2003年第4期21卷 451-462页

作者： wen-yuSun Raimundo.J.B.Sampaio m.A.B.Candido SchoolofmathematicsandComputerScience NanjingNormalUniversityNanjing2100g7China ProgramadePos-GraduacaoemInformaticaAplicada PontificiaUniversidadeCatolicadoParana(PUCPR)CEP:80215-g01CuritibaPRBrazil ProgramadePos-GraduacaoemInformaticaAplicada PontificiaUniversidadeCatolicadoParana(PUCPR)CEP:80215-g01CuritibaPRBrazil

In this paper we present some algorithms for minimization of DC function (difference of two convex functions). They are descent methods of the proximal-type which use the convex properties of the two convex functions separately. We also consider an approximate proximal point algorithm. Some properties of the ε-subdifferential and the ε-directional derivative are discussed. The convergence properties of the algorithms are established in both exact and approximate forms. Finally, we give some applications to the concave programming and maximum eigenvalue problems.

关键词： Nonconvex optimization Nonsmooth optimization DC function Proximal point algorithm ε-subgradient.

Adaptive Parameter Selection for Total Variation Image Deconvolution

在线全文

学校读者我要写书评

暂无评论

Numerical mathematics(Theory,methods and Applications) 2009年第4期2卷 427-438页

作者： You-Wei wen Andy m. Yip Faculty of Science South China Agricultural University Guangzhou China Temasek Laboratories National University of Singapore 3 Science Drive 2 117543 Singapore Department of mathematics National University of Singapore 3 Science Drive 2 117543 Singapore

In this paper,we propose a discrepancy rule-based method to automatically choose the regularization parameters for total variation image restoration problems. The regularization parameters are adjusted dynamically in ... 详细信息

关键词： Image restoration regularization parameter total variation.

Baculovirus Host-Range

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2009年第5期24卷 436-457页

作者： Suzanne m. Thien Xiao-wen Cheng Department of Entomology and Department of Microbiology and Molecular Genetics Michigan State University East Lansing MI 48824 USA Department of microbiology Miami University Oxford OH 45056 USA

Baculoviruses are used as microbial insecticides, protein expression vectors, epitope display platforms, and most recently as vectors for gene therapy. Understanding the mechanisms that control baculovirus host-range and tissue tropisms are important for assessing their safety and for improving their properties for these biotechnology applications. In the past two decades some progress has been made and several baculovirus genes that influence host-range have been identified. Despite this progress, our understanding of the underlying mechanisms that restrict baculovirus host-range is still limited. Here we review what is currently known about baculovirus genes that influence virus host-range.

关键词： Apoptosis Translation arrest p35 hrf-1 p143

Electronic properties of 2H-stacking bilayer moS_(2)measured by terahertz time-domain spectroscopy

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2023年第5期18卷 161-171页

作者： Xingjia Cheng wen Xu Hua wen Jing Zhang Heng Zhang Haowen Li Francois m.Peeters Qingqing Chen Key Laboratory of materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China micro Optical Instruments Inc. Shenzhen 518118China School of Physics and Astronomy and Yunnan Key Laboratory of Quantum Information of Yunnan Province Yunnan UniversityKunming 650091China Department of Physics University of AntwerpGroenenborgerlaan 171B-2020 AntwerpenBelgium

Bilayer (BL) molybdenum disulfide (moS_(2)) is one of the most important electronic structures not only in valleytronics but also in realizing twistronic systems on the basis of the topological mosaics in moiré superlattices. In this work, BL moS_(2) on sapphire substrate with 2H-stacking structure is fabricated. We apply the terahertz (THz) time-domain spectroscopy (TDS) for examining the basic optoelectronic properties of this kind of BL moS_(2). The optical conductivity of BL moS_(2) is obtained in temperature regime from 80 K to 280 K. Through fitting the experimental data with the theoretical formula, the key sample parameters of BL moS_(2) can be determined, such as the electron density, the electronic relaxation time and the electronic localization factor. The temperature dependence of these parameters is examined and analyzed. We find that, similar to monolayer (mL) moS_(2), BL moS_(2) with 2H-stacking can respond strongly to THz radiation field and show semiconductor-like optoelectronic features. The theoretical calculations using density functional theory (DFT) can help us to further understand why the THz optoelectronic properties of BL moS_(2) differ from those observed for mL moS_(2). The results obtained from this study indicate that the THz TDS can be applied suitably to study the optoelectronic properties of BL moS_(2) based twistronic systems for novel applications as optical and optoelectronic materials and devices.

关键词： terahertz time-domain spectroscopy bilayer moS_(2) optoelectronics

Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第46期11卷 7308-7313页

作者： Ismail H mallick wen-Xuan Yang marc C Winslet Alexander m Seifalian GI and Hepatobiliary Research Unit University Department of Surgery Royal Free and University College Medical School University College London LondonUnited Kingdom Department of Surgery Royal Free Hospital Hampstead NHS Trust London United Kingdom

AIm： To evaluate whether pyrrolidine dithiocarbamate （PDTC）, an enhancer of HO production, attenuates intestinal IR injury. mETHODS： Eighteen male rats were randomly allocated into three groups：（a） sham; （b） IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and （c） PDTC treatment before IR. Intestinal microvascular perfusion （ImP） was monitored continuously by laser Doppler flowmetry. At the end of the reperfusion, serum samples for lactate dehydrogenase （LDH） levels and biopsies of ileum were obtained. HO activity in the ileum was assessed at the end of the reperfusion period. RESULTS： At the end of the reperfusion in the IR group, ImP recovered partially to 42.5% of baseline （P〈0.05 vs sham）, whereas PDTC improved ImP to 67.3% of baseline （P〈0.01 vs IR）. There was a twofold increase in HO activity in PDTC group （2 062.66±106.11） as compared to IR （842.3±85.12）（P〈0.001）. LDH was significantly reduced （P〈0.001） in PDTC group （585.6±102.4） as compared to IR group （1 973.8±306.5）. Histological examination showed that the ileal mucosa was significantly less injured in PDTC group as compared with IR group. CONCLUSION： Our study demonstrates that PDTC improves the ImP and attenuates IR injury of the intestine possibly via HO production. Additional studies are warranted to evaluate the clinical efficacy of PDTC in the prevention of IR injury of the small intestine.

关键词： Intestine Ischemia-reperfusion injury Heme oxygenase Pyrrolidine

Driving factors of direct greenhouse gas emissions from China's pig industry from 1976 to 2016

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2021年第1期20卷 319-329页

作者： DAI Xiao-wen Zhanli SUN Daniel mULLER Sichuan Center for Rural Development Research Sichuan Agricultural UniversityChengdu 611130P.R.China Leibniz Institute of Agricultural Development in Transition Economies(IAmO) Halle(Saale)06120Germany Geography Department Humboldt-Universitat zu BerlinBerlin 10099Germany Integrative Research Institute on Transformations of Human-Environment Systems(IRI THESys) Humboldt-Universitat zu BerlinBerlin 10099Germany

Livestock cultivation is a significant source of greenhouse gas(GHG) emissions, accounting for 14.5% of the total anthropogenic emissions. China is responsible for a considerable share of the global livestock emissions, particularly caused by pork production. We used the Kaya identity and the logarithmic mean Divisia index(LmDI) to decompose the national annual GHG emissions from enteric fermentation and manure management in pig farming in China from 1976 to 2016. We decomposed the sources of the emissions into five driving factors:(1) technological progress(e.g., feed improvement);(2) structural adjustment in the livestock sector;(3) structural adjustment in agriculture;(4) affluence;and(5) population growth. The results showed that the net GHG emissions from the pig sector in China increased 16 million tons(mt) of carbon dioxide equivalents(CO2 eq) during the study period. The decomposition analysis revealed that structural adjustment in agriculture, growing affluence, and population growth contributed to an increase of the GHG emissions of pork production by 23, 41, and 13 mt CO2 eq, respectively. The technological progress and structural changes in animal husbandry mitigated emissions by –51 and –11 mt CO2 eq, respectively. Further technological progress in pig production and optimizing the economic structures are critical for further reducing GHG emissions in China's pig industry. Our results highlight the dominant role of technological changes for emission reductions in the pig farming.

关键词： livestock production carbon emissions manure management pig farming LmDI decomposition