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Effect of tilt angle on the performance and electrical parameters of a PV module:Comparative indoor and outdoor experimental investigation

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Energy and Built Environment 2022年第3期3卷 278-290页

作者： m.A.A.mamun m.m.islam m.Hasanuzzaman Jeyraj Selvaraj Higher Institution Centre of Excellence(HICoE) UM Power Energy Dedicated Advanced Centre(UMPEDAC)Level 4Wisma R&DUniversity of MalayaJalan Pantai Baharu59990 Kuala LumpurMalaysia

Photovoltaic(PV)system’s performance is significantly affected by its orientation and tilt *** investigation(indoor and outdoor)has been carried out to trace the variation in PV performance and electrical parameters at varying tilt angles in malaysian *** were two experimental modus:1)varying module tilt under constant irradiation level,2)varying irradiation intensity at the optimum tilt set *** the former scheme,the irradiation level was maintained at 750 W/m^(2),and for the later arrangement,the module tilt angle was varied from 0 o to 80 o by means of a single-axis *** show that under constant irradiation of 750 W/m^(2),every 5 o increase in tilt angle causes a power drop of 2.09 W at indoor and 3.45 W at *** contrast,for the same condition,efficiency decreases by 0.54%for indoor case and by 0.76%at *** the other hand,for every 100 W/m^(2)increase in irradiation,solar cell temperature rises by 7.52℃at indoor and by 5.67℃at *** of module electrical parameters,open-circuit voltage,short-circuit current,maximum power point voltage and maximum power point current drops substantially with increasing tilt angle,whereas fill factor drops rather *** experimental investigation confirms that the optimum tilt angle at malaysian conditions is 15 o and orienting a PV module this angle will maximize the sun’s energy captured and thereby enhance its performance.

关键词： Photovoltaic Irradiation intensity Tilt angle PV performance module electrical parameters

Development of IDF Curve for Dhaka City Based on Scaling Theory under Future Precipitation Variability Due to Climate Change

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Development of IDF Curve for Dhaka City Based on Scaling The...

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

作者： S.Afrin m.m.islam m.m.Rahman the Department of Civil Engineering Bangladesh University of Engineering and Technology(BUET)

Bangladesh is one of the most vulnerable countries of the world to climate change. The magnitude and frequency of extreme events such as high intensity rainfall, flash flooding, severe droughts, etc. are expected to be altered in future as a consequence of this change. This can introduce an element of uncertainty in the design of hydraulic structures, urban drainage systems, and other water-sensitive structures, if the variability is not taken into consideration. This study aims at developing a regional Intensity-Duration-Frequency(IDF) relationship for Dhaka city for present as well as future climatic scenarios. The scaling properties of extreme rainfall are examined to establish scaling relationship behavior of statistical moments over different durations. The results show that a rainfall property in time does follow a simple scaling process. A scale invariance concept is explored for disaggregation(or downscaling) of rainfall intensity from low to high resolution and is applied to the derivation of scaling IDF curves. These curves are developed based on scaling of the generalized extreme value(GEV) and Gumbel probability distributions. It is seen that scaled estimates are relatively close to observed estimates.

关键词： Climate change extreme values IDF curves scaling exponent simple scaling

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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纤维组合夹芯梁的平放、侧放抗弯性能

钢结构(中英文) 2010年第4期 88-88页

作者： A.C.manalo T.Aravinthan W.Karunasena m.m.islam

对由玻纤增强聚合物蒙皮及改进酚醛核所组成的新型纤维组合夹芯梁进行抗弯性能研究。采用4点弯曲静力试验确定组合夹芯梁在平放和侧放时的强度和破坏机制。研究结果显示:组合夹芯梁在侧放位置时的破坏荷载比平放位置时高。在弯曲荷载下... 详细信息

对由玻纤增强聚合物蒙皮及改进酚醛核所组成的新型纤维组合夹芯梁进行抗弯性能研究。采用4点弯曲静力试验确定组合夹芯梁在平放和侧放时的强度和破坏机制。研究结果显示:组合夹芯梁在侧放位置时的破坏荷载比平放位置时高。在弯曲荷载下,侧放的组合夹芯梁的破坏是由于蒙皮的连续破坏造成的,而平放的组合夹芯梁的破坏是由于核的剪切破坏或蒙皮和核之间剥离使蒙皮受压而产生的脆性破坏。分析预测及数值模拟结果与试验吻合较好。

关键词：组合夹芯梁纤维组合改进酚醛核抗弯平放侧放

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词： Galerkin methods